Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HRAS (Harvey rat sarcoma viral oncogene homolog)

Identity

Other namesc-Ha-ras 1
HGNC (Hugo) HRAS
LocusID (NCBI) 3265
Location 11p15.5
Location_base_pair Starts at 532242 and ends at 535550 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Note more on the RAS family is available as a deep insight.

DNA/RNA

Note to be quoted is the existence of a pseudogene, c-Ha-ras 2, inactivated, processed pseudogene which is located on Chromosome X.
 
  H-ras splicing variants : alternative splicing of H-ras precursor mRNA leads to the two transcripts p19 and p21 which differ by the ex- or inclusion of the Intron D Exon (IDX); Exons that encode protein are shown as black boxes, untranslated exons as white boxes; the upstream untranslated exon is indicated as Exon -1
Description consists of six exons, spread over 6.6kb of genomic DNA
Transcription alternative RNA splicing reveals two different transcripts (see Fig); if the Intron D Exon (IDX) is skipped exon 4 is directly joined to exon 3

Protein

Description 170 amino acids; 19kDa; shares a common effector region with regular RAS proteins; absence of residues 152-165, abrogating the GDP/GTP binding, and lack of a cysteine residue in the carboxy-terminus preventing the posttranslational modifications essential for the attachment of RAS proteins to the cytoplasmic membrane regular RAS protein - characterized in the RAS family page
Expression p19H-ras is expected to be produced at a much higher level than p21H-ras; the surprising low abundance of p19H-ras could be explained by instability of mRNA or unproductive splicing ubiquitously expressed
Localisation cytoplasmic anchored to the inner surface of the plasma membrane
Function no oncogenic ability; it has been assumed, that p19H-ras might act as a antagonist to p21H-ras; due to the intact effector region it would interact constitutively with candidate effector molecules or regulators such as GAP, thereby suppressing the biological function of p21H-ras; additionally the expression of p19H-ras was found to limit the production of p21H-ras analogously to other GTP-binding proteins (such as Translation Elongation Factor EFTu or signal transducing G-Proteins) RAS proteins are involved in signal transduction pathways
Homology RAS, RAL, RAC, RHO, RAP, and RAB ras gene family is part of the ras superfamily including the mammalian RAS, RAL, RAC, RHO, RAP, and RAB gene families and the yeast homologs like SEC4 and YPT1 genes; genes encode small monomeric proteins of low molecular mass (20-30 kDa) which share at least 30% homology with RAS proteins.

Implicated in

Entity tumor (frequency of H-RAS mutations); references in Full Bibliography
  
Entity stomach (0-40%)
  
Entity urinary bladder (0-65%)
  
Entity prostate (0-10%)
  
Entity skin (0-45%)
  
Entity thyroid (0-60%)
  
Entity breast (0-10%)
  
Entity head and neck (0-30%)
  
Entity endometrium (5%)
  

External links

Nomenclature
HGNC (Hugo)HRAS   5173
Entrez_Gene (NCBI)HRAS  3265  v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Cards
AtlasHRASID108
GeneCards (Weizmann)HRAS
Ensembl (Hinxton)ENSG00000174775 [Gene_View]  chr11:532242-535550 [Contig_View]  HRAS [Vega]
AceView (NCBI)HRAS
Genatlas (Paris)HRAS
euGene (Indiana)3265
SOURCE (Stanford)NM_001130442 NM_005343 NM_176795
Genomic and cartography
GoldenPath (UCSC)HRAS  -  11p15.5   chr11:532242-535550 -  11p15.5   [Description]    (hg19-Feb_2009)
EnsemblHRAS - 11p15.5 [CytoView]
Mapping of homologs : NCBIHRAS [Mapview]
OMIM109800   188470   190020   218040   
Gene and transcription
Genbank (Entrez)AB451336 AB451485 AF493916 AJ437024 BC006499
RefSeq transcript (SRS)NM_001130442 NM_005343 NM_176795
RefSeq transcript (Entrez)NM_001130442 NM_005343 NM_176795
RefSeq genomic (SRS)AC_000143 NC_000011 NG_007666 NT_009237 NW_001838016
RefSeq genomic (Entrez)AC_000143 NC_000011 NG_007666 NT_009237 NW_001838016
Consensus coding sequences : CCDS (NCBI)HRAS
Cluster EST : UnigeneHs.37003 [ SRS ] Hs.37003 [ NCBI ]
Alternative Splicing : Fast-db (Paris)290
Alternative Splicing GalleryENSG00000174775
Gene ExpressionHRAS [ NCBI-GEO ]   HRAS [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01112 (SRS) P01112 (Uniprot)
With graphics : InterProP01112
Splice isoforms : SwissVarP01112(Swissvar)
Domaine pattern : Prosite (SRS)RAS (PS51421)   
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (SRS)Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domains : Interpro (EBI)Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Related proteins : CluSTrP01112
Domain families : Pfam (SRS)Ras (PF00071)   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
Blocks (Seattle)P01112
PDB (SRS)121P    1AA9    1AGP    1BKD    1CLU    1CRP    1CRQ    1CRR    1CTQ    1GNP    1GNQ    1GNR    1HE8    1IAQ    1IOZ    1JAH    1JAI    1K8R    1LF0    1LF5    1LFD    1NVU    1NVV    1NVW    1NVX    1P2S    1P2T    1P2U    1P2V    1PLJ    1PLK    1PLL    1Q21    1QRA    1RVD    1WQ1    1XCM    1XD2    1XJ0    1ZVQ    1ZW6    221P    2C5L    2CE2    2CL0    2CL6    2CL7    2CLC    2CLD    2EVW    2GDP    2LCF    2Q21    2QUZ    2RGA    2RGB    2RGC    2RGD    2RGE    2RGG    2UZI    2VH5    2X1V    3DDC    3I3S    3K8Y    3K9L    3K9N    3KKM    3KKN    3KUD    3L8Y    3L8Z    3LBH    3LBI    3LBN    3LO5    3OIU    3OIV    3OIW    3RRY    3RRZ    3RS0    3RS2    3RS3    3RS4    3RS5    3RS7    3RSL    3RSO    3TGP    421P    4Q21    521P    5P21    621P    6Q21    721P    821P   
PDB (PDBSum)121P    1AA9    1AGP    1BKD    1CLU    1CRP    1CRQ    1CRR    1CTQ    1GNP    1GNQ    1GNR    1HE8    1IAQ    1IOZ    1JAH    1JAI    1K8R    1LF0    1LF5    1LFD    1NVU    1NVV    1NVW    1NVX    1P2S    1P2T    1P2U    1P2V    1PLJ    1PLK    1PLL    1Q21    1QRA    1RVD    1WQ1    1XCM    1XD2    1XJ0    1ZVQ    1ZW6    221P    2C5L    2CE2    2CL0    2CL6    2CL7    2CLC    2CLD    2EVW    2GDP    2LCF    2Q21    2QUZ    2RGA    2RGB    2RGC    2RGD    2RGE    2RGG    2UZI    2VH5    2X1V    3DDC    3I3S    3K8Y    3K9L    3K9N    3KKM    3KKN    3KUD    3L8Y    3L8Z    3LBH    3LBI    3LBN    3LO5    3OIU    3OIV    3OIW    3RRY    3RRZ    3RS0    3RS2    3RS3    3RS4    3RS5    3RS7    3RSL    3RSO    3TGP    421P    4Q21    521P    5P21    621P    6Q21    721P    821P   
PDB (IMB)121P    1AA9    1AGP    1BKD    1CLU    1CRP    1CRQ    1CRR    1CTQ    1GNP    1GNQ    1GNR    1HE8    1IAQ    1IOZ    1JAH    1JAI    1K8R    1LF0    1LF5    1LFD    1NVU    1NVV    1NVW    1NVX    1P2S    1P2T    1P2U    1P2V    1PLJ    1PLK    1PLL    1Q21    1QRA    1RVD    1WQ1    1XCM    1XD2    1XJ0    1ZVQ    1ZW6    221P    2C5L    2CE2    2CL0    2CL6    2CL7    2CLC    2CLD    2EVW    2GDP    2LCF    2Q21    2QUZ    2RGA    2RGB    2RGC    2RGD    2RGE    2RGG    2UZI    2VH5    2X1V    3DDC    3I3S    3K8Y    3K9L    3K9N    3KKM    3KKN    3KUD    3L8Y    3L8Z    3LBH    3LBI    3LBN    3LO5    3OIU    3OIV    3OIW    3RRY    3RRZ    3RS0    3RS2    3RS3    3RS4    3RS5    3RS7    3RSL    3RSO    3TGP    421P    4Q21    521P    5P21    621P    6Q21    721P    821P   
PDB (RSDB)121P    1AA9    1AGP    1BKD    1CLU    1CRP    1CRQ    1CRR    1CTQ    1GNP    1GNQ    1GNR    1HE8    1IAQ    1IOZ    1JAH    1JAI    1K8R    1LF0    1LF5    1LFD    1NVU    1NVV    1NVW    1NVX    1P2S    1P2T    1P2U    1P2V    1PLJ    1PLK    1PLL    1Q21    1QRA    1RVD    1WQ1    1XCM    1XD2    1XJ0    1ZVQ    1ZW6    221P    2C5L    2CE2    2CL0    2CL6    2CL7    2CLC    2CLD    2EVW    2GDP    2LCF    2Q21    2QUZ    2RGA    2RGB    2RGC    2RGD    2RGE    2RGG    2UZI    2VH5    2X1V    3DDC    3I3S    3K8Y    3K9L    3K9N    3KKM    3KKN    3KUD    3L8Y    3L8Z    3LBH    3LBI    3LBN    3LO5    3OIU    3OIV    3OIW    3RRY    3RRZ    3RS0    3RS2    3RS3    3RS4    3RS5    3RS7    3RSL    3RSO    3TGP    421P    4Q21    521P    5P21    621P    6Q21    721P    821P   
Human Protein AtlasENSG00000174775
HPRD01813
IPIIPI00000006   IPI00741763   IPI00979370   
dbDEPCIPI00741763   
Protein Interaction databases
DIP (DOE-UCLA)P01112
IntAct (EBI)P01112
FunCoupENSG00000174775
REACTOMEHRAS
BioGRIDHRAS
InParanoidP01112
Interologous Interaction database P01112
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HRAS
SNP (GeneSNP Utah)HRAS
SNP : HGBaseHRAS
Genetic variants : HAPMAPHRAS
Cancer Gene: CensusHRAS 
Somatic Mutations in Cancer : COSMICHRAS 
CONAN: Copy Number AnalysisHRAS 
Mutations and Diseases : HGMDHRAS
OMIM109800    188470    190020    218040   
GENETests109800    188470    190020    218040   
Disease Genetic AssociationHRAS
Huge Navigator HRAS [HugePedia]  HRAS [HugeCancerGEM]
Genomic VariantsHRAS
snp3D : Map Gene to Disease3265
General knowledge
Homologs : HomoloGeneHRAS
Homology/Alignments : Family Browser (UCSC)HRAS
Phylogenetic Trees/Animal Genes : TreeFamHRAS
Chemical/Protein Interactions : CTD3265
Chemical/Pharm GKB GenePA29444
Drug Sensitivity HRAS
Clinical trialHRAS
Cancer Resource (Charite)ENSG00000174775
Ontology : AmiGOGolgi membrane  MAPK cascade  nucleotide binding  activation of MAPKK activity  positive regulation of protein phosphorylation  GTPase activity  protein binding  GTP binding  membrane fraction  soluble fraction  nucleus  cytoplasm  microsome  Golgi apparatus  cytosol  plasma membrane  plasma membrane  endocytosis  apoptotic process  chemotaxis  cell cycle arrest  cell cycle arrest  signal transduction  cell surface receptor signaling pathway  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  synaptic transmission  axon guidance  blood coagulation  protein C-terminus binding  positive regulation of cell proliferation  negative regulation of cell proliferation  insulin receptor signaling pathway  visual learning  fibroblast growth factor receptor signaling pathway  induction of apoptosis by intracellular signals  organ morphogenesis  actin cytoskeleton organization  mitotic cell cycle G1/S transition checkpoint  regulation of synaptic transmission, GABAergic  positive regulation of Rac protein signal transduction  social behavior  positive regulation of MAPK cascade  negative regulation of neuron apoptosis  positive regulation of DNA replication  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  nerve growth factor receptor signaling pathway  regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  leukocyte migration  striated muscle cell differentiation  positive regulation of ERK1 and ERK2 cascade  cellular senescence  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  nucleotide binding  activation of MAPKK activity  positive regulation of protein phosphorylation  GTPase activity  protein binding  GTP binding  membrane fraction  soluble fraction  nucleus  cytoplasm  microsome  Golgi apparatus  cytosol  plasma membrane  plasma membrane  endocytosis  apoptotic process  chemotaxis  cell cycle arrest  cell cycle arrest  signal transduction  cell surface receptor signaling pathway  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  synaptic transmission  axon guidance  blood coagulation  protein C-terminus binding  positive regulation of cell proliferation  negative regulation of cell proliferation  insulin receptor signaling pathway  visual learning  fibroblast growth factor receptor signaling pathway  induction of apoptosis by intracellular signals  organ morphogenesis  actin cytoskeleton organization  mitotic cell cycle G1/S transition checkpoint  regulation of synaptic transmission, GABAergic  positive regulation of Rac protein signal transduction  social behavior  positive regulation of MAPK cascade  negative regulation of neuron apoptosis  positive regulation of DNA replication  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  nerve growth factor receptor signaling pathway  regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  leukocyte migration  striated muscle cell differentiation  positive regulation of ERK1 and ERK2 cascade  cellular senescence  
Pathways : BIOCARTACalcium Signaling by HBx of Hepatitis B virus [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    EGF Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Keratinocyte Differentiation [Genes]    mCalpain and friends in Cell motility [Genes]    Inhibition of Matrix Metalloproteinases [Genes]    Influence of Ras and Rho proteins on G1 to S Transition [Genes]    BCR Signaling Pathway [Genes]    IL 2 signaling pathway [Genes]    How Progesterone Initiates the Oocyte Maturation [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    T Cell Receptor Signaling Pathway [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    Ras Signaling Pathway [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Integrin Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    IGF-1 Signaling Pathway [Genes]    IL 3 signaling pathway [Genes]    IL 6 signaling pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Trka Receptor Signaling Pathway [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    EPO Signaling Pathway [Genes]    Role of Erk5 in Neuronal Survival [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Regulation of transcriptional activity by PML [Genes]    Regulation of Splicing through Sam68 [Genes]    CCR3 signaling in Eosinophils [Genes]    TPO Signaling Pathway [Genes]    CXCR4 Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Growth Hormone Signaling Pathway [Genes]    Signaling Pathway from G-Protein Families [Genes]    Insulin Signaling Pathway [Genes]    The IGF-1 Receptor and Longevity [Genes]    p38 MAPK Signaling Pathway [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    Roles of ?-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    Transcription factor CREB and its extracellular signals [Genes]    METS affect on Macrophage Differentiation [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Nerve growth factor pathway (NGF) [Genes]    PDGF Signaling Pathway [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGInsulin signaling pathwayFc epsilon RI signaling pathwayB cell receptor signaling pathwayT cell receptor signaling pathwayVEGF signaling pathwayGnRH signaling pathwayTight junctionAxon guidanceLong-term depressionRegulation of actin cytoskeletonFocal adhesionLong-term potentiationMAPK signaling pathwayNatural killer cell mediated cytotoxicityGap junction
Other databases
Probes
ProbeCancer Cytogenetics (Bari)
Probes : ImagenesHRAS Related clones (RZPD - Berlin)
Litterature
PubMed475 Pubmed reference(s) in Entrez
PubGeneHRAS
iHOPHRAS

Bibliography

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Contributor(s)

Written02-1999Franz Watzinger and Thomas Lion
Childrenīs Cancer Research Institute, Kinderspitalgasse 6, A-1090 Vienna, Austria

Citation

This paper should be referenced as such :
Watzinger F and Lion T . HRAS (Harvey rat sarcoma viral oncogene homolog). Atlas Genet Cytogenet Oncol Haematol. February 1999 .
URL : http://AtlasGeneticsOncology.org/Genes/HRASID108.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37504/1/02-1999-HRASID108.pdf   [ Bibliographic record ]

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