Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor)

Identity

Other namesBB2
CD54
ICAM-1
P3.58
HGNC (Hugo) ICAM1
LocusID (NCBI) 3383
Location 19p13.2
Location_base_pair Starts at 10381517 and ends at 10397291 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description ICAM1 gene maps on chromosome 19p13.3-p13.2 scanning 15512 bp.
Transcription 7 exon; mRNA 3249 bp.

Protein

Description A transmembrane glycoprotein of 532 amino acids, which has a molecular mass ranging from 75 to 115 kDa. ICAM-1 is a member of the immunoglobulin supergenge family, and contains five extracellular immunoglobulin-like domains.
Expression ICAM-1 is expressed on various cells of both hematopoietic and non-hematopoietic cells, including endothelial cells, leukocytes other than basophilic granulocytes, T cells, B cells, fibroblasts, and cancer cells.
Function ICAM-1, a member of adhesion molecules, binds to two integrins belonging to the beta2 subfamily CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on the surface of leukocytes. ICAM1 is a key molecule in immune-mediated and inflammatory processes and function as a co-stimulatory signal which is important for the trans-endothelial migration of leukocytes and the activation of T cells. ICAM-1 can be induced under inflammatory condition by TNF-alpha in a process that involves IKK-beta. ICAM1 on target cells leads to recruitment of the MHC-I proteins to the contact area and enhances presentation of cognate peptide MHC-I complex to cytotoxic T cells. ICAM-1 interacts with important factors involved in many kinds of human cancers. ICAM-1 is involved in transmembrane signal transduction in the regulatory process of cell proliferation through the mitogen-activated protein kinase (MAPK) pathway and eventually the AP-1 pathway (Springer, 1990; Dustin et al., 1998; Simmons et al., 1988; Caras et al., 1987; Rothlein et al., 1986; Dustin et al., 1986; Tsujisaki et al., 1991; Gardiner et D'Souza, 1999).

Implicated in

Entity Melanoma
Disease ICAM-1 expresses with a dose- and time-dependent increase in human malignant melanoma cells on stimulation of TNF-alpha. Inhibition of ICAM-1 expression on melanoma cells reduces the metastatic ability of the melanoma cells, indicating an important role of ICAM-1 in metastasis (Miele et al., 1994).
  
Entity Hepatocellular carcinoma
Disease Serum concentration of ICAM-1 (sICAM-1) in patients with hepatocellular carcinoma is a marker for disease progression and prognosis. Higher sICAM-1 levels are more frequently observed in those patients with multiple lesions and intra-hepatic metastasis (Mei et al., 2000).
  
Entity Prostate cancer
Disease Two polymorphisms and a common haplotype within the ICAM-1 gene cluster were correlated with prostate cancer risk among men with family history of the disease (Chen et al., 2006).
  
Entity Colon cancer
Disease ICAM-1 expression is decreased in colorectal cancer (Berndt et al., 2008).
  
Entity Gastric cancer
Disease Decreased ICAM expression leads to lymph node metastasis, suggesting that ICAM-1 gene transfection can inhibit lymph node metastasis (Tanaka et al., 2002; Yashiro et al., 2005).
  
Entity Head and neck cancer
Disease sICAM-1 shows a significant elevation in the sera of patients with nasopharyngeal carcinoma compared to healthy controls (Liu et al., 1999).
  
Entity Leukemia
Disease A high expression of ICAM-1 may identify high-risk MDS (Graf et al., 2005).
  
Entity Breast Cancer
Disease ICAM-1 down-regulation at the mRNA and protein levels led to a suppression of breast cells invasion (Rosette et al., 2005).
  

External links

Nomenclature
HGNC (Hugo)ICAM1   5344
Cards
AtlasICAM1ID40909ch19p13
Entrez_Gene (NCBI)ICAM1  3383  intercellular adhesion molecule 1
GeneCards (Weizmann)ICAM1
Ensembl hg19 (Hinxton)ENSG00000090339 [Gene_View]  chr19:10381517-10397291 [Contig_View]  ICAM1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000090339 [Gene_View]  chr19:10381517-10397291 [Contig_View]  ICAM1 [Vega]
ICGC DataPortalENSG00000090339
cBioPortalICAM1
AceView (NCBI)ICAM1
Genatlas (Paris)ICAM1
WikiGenes3383
SOURCE (Princeton)ICAM1
Genomic and cartography
GoldenPath hg19 (UCSC)ICAM1  -     chr19:10381517-10397291 +  19p13.3-p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ICAM1  -     19p13.3-p13.2   [Description]    (hg38-Dec_2013)
EnsemblICAM1 - 19p13.3-p13.2 [CytoView hg19]  ICAM1 - 19p13.3-p13.2 [CytoView hg38]
Mapping of homologs : NCBIICAM1 [Mapview hg19]  ICAM1 [Mapview hg38]
OMIM147840   611162   
Gene and transcription
Genbank (Entrez)AF340038 AF340039 AK130659 AK298054 AK298983
RefSeq transcript (Entrez)NM_000201
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_012083 NT_011295 NW_001838483 NW_001842132 NW_004929414
Consensus coding sequences : CCDS (NCBI)ICAM1
Cluster EST : UnigeneHs.643447 [ NCBI ]
CGAP (NCI)Hs.643447
Alternative Splicing : Fast-db (Paris)GSHG0014568
Alternative Splicing GalleryENSG00000090339
Gene ExpressionICAM1 [ NCBI-GEO ]     ICAM1 [ SEEK ]   ICAM1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05362 (Uniprot)
NextProtP05362  [Medical]
With graphics : InterProP05362
Splice isoforms : SwissVarP05362 (Swissvar)
Domains : Interpro (EBI)ICAM    ICAM_N    ICAM_VCAM_N    Ig-like_fold    Ig_sub   
Related proteins : CluSTrP05362
Domain families : Pfam (Sanger)ICAM_N (PF03921)   
Domain families : Pfam (NCBI)pfam03921   
Domain families : Smart (EMBL)IG (SM00409)  
DMDM Disease mutations3383
Blocks (Seattle)P05362
PDB (SRS)1D3E    1D3I    1D3L    1IAM    1IC1    1IJ4    1MQ8    1P53    1Z7Z    2OZ4    3TCX   
PDB (PDBSum)1D3E    1D3I    1D3L    1IAM    1IC1    1IJ4    1MQ8    1P53    1Z7Z    2OZ4    3TCX   
PDB (IMB)1D3E    1D3I    1D3L    1IAM    1IC1    1IJ4    1MQ8    1P53    1Z7Z    2OZ4    3TCX   
PDB (RSDB)1D3E    1D3I    1D3L    1IAM    1IC1    1IJ4    1MQ8    1P53    1Z7Z    2OZ4    3TCX   
Human Protein AtlasENSG00000090339
Peptide AtlasP05362
HPRD00996
IPIIPI00008494   IPI00909039   IPI00910734   IPI00816354   IPI00385789   IPI01014451   
Protein Interaction databases
DIP (DOE-UCLA)P05362
IntAct (EBI)P05362
FunCoupENSG00000090339
BioGRIDICAM1
IntegromeDBICAM1
STRING (EMBL)ICAM1
Ontologies - Pathways
QuickGOP05362
Ontology : AmiGOovarian follicle development  virus receptor activity  immunological synapse  regulation of leukocyte mediated cytotoxicity  response to amphetamine  T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  T cell antigen processing and presentation  positive regulation of cellular extravasation  receptor activity  transmembrane signaling receptor activity  integrin binding  integrin binding  protein binding  extracellular space  plasma membrane  integral component of plasma membrane  cell adhesion  heterophilic cell-cell adhesion  leukocyte cell-cell adhesion  cell aging  regulation of cell shape  response to virus  external side of plasma membrane  response to ionizing radiation  response to sulfur dioxide  response to organic cyclic compound  membrane  cytokine-mediated signaling pathway  membrane to membrane docking  regulation of cell adhesion  extracellular matrix organization  positive regulation of actin filament polymerization  cellular response to nutrient levels  positive regulation of Rho GTPase activity  cell adhesion mediated by integrin  response to gonadotropin  response to drug  response to amino acid  adhesion of symbiont to host  positive regulation of nitric oxide biosynthetic process  response to ethanol  positive regulation of vasoconstriction  response to copper ion  receptor-mediated virion attachment to host cell  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  leukocyte migration  positive regulation of NF-kappaB transcription factor activity  negative regulation of calcium ion transport  interferon-gamma-mediated signaling pathway  establishment of endothelial barrier  extracellular vesicular exosome  positive regulation of ERK1 and ERK2 cascade  cellular response to lipopolysaccharide  cellular response to alkaloid  cellular response to glucose stimulus  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to hypoxia  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIovarian follicle development  virus receptor activity  immunological synapse  regulation of leukocyte mediated cytotoxicity  response to amphetamine  T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  T cell antigen processing and presentation  positive regulation of cellular extravasation  receptor activity  transmembrane signaling receptor activity  integrin binding  integrin binding  protein binding  extracellular space  plasma membrane  integral component of plasma membrane  cell adhesion  heterophilic cell-cell adhesion  leukocyte cell-cell adhesion  cell aging  regulation of cell shape  response to virus  external side of plasma membrane  response to ionizing radiation  response to sulfur dioxide  response to organic cyclic compound  membrane  cytokine-mediated signaling pathway  membrane to membrane docking  regulation of cell adhesion  extracellular matrix organization  positive regulation of actin filament polymerization  cellular response to nutrient levels  positive regulation of Rho GTPase activity  cell adhesion mediated by integrin  response to gonadotropin  response to drug  response to amino acid  adhesion of symbiont to host  positive regulation of nitric oxide biosynthetic process  response to ethanol  positive regulation of vasoconstriction  response to copper ion  receptor-mediated virion attachment to host cell  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  leukocyte migration  positive regulation of NF-kappaB transcription factor activity  negative regulation of calcium ion transport  interferon-gamma-mediated signaling pathway  establishment of endothelial barrier  extracellular vesicular exosome  positive regulation of ERK1 and ERK2 cascade  cellular response to lipopolysaccharide  cellular response to alkaloid  cellular response to glucose stimulus  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to hypoxia  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAB Lymphocyte Cell Surface Molecules [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    CTL mediated immune response against target cells [Genes]    Monocyte and its Surface Molecules [Genes]    T Helper Cell Surface Molecules [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    Adhesion Molecules on Lymphocyte [Genes]    Neutrophil and Its Surface Molecules [Genes]    T Cytotoxic Cell Surface Molecules [Genes]    Cells and Molecules involved in local acute inflammatory response [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Cell adhesion molecules (CAMs)    Natural killer cell mediated cytotoxicity    TNF signaling pathway    Leukocyte transendothelial migration    African trypanosomiasis    Malaria    Staphylococcus aureus infection    Influenza A    HTLV-I infection    Epstein-Barr virus infection    Rheumatoid arthritis    Viral myocarditis   
REACTOMEP05362 [protein]
REACTOME PathwaysREACT_118779 Extracellular matrix organization [pathway]
REACTOME PathwaysREACT_6900 Immune System [pathway]
Protein Interaction DatabaseICAM1
DoCM (Curated mutations)ICAM1
Wikipedia pathwaysICAM1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerICAM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ICAM1
dbVarICAM1
ClinVarICAM1
1000_GenomesICAM1 
Exome Variant ServerICAM1
SNP (GeneSNP Utah)ICAM1
SNP : HGBaseICAM1
Genetic variants : HAPMAPICAM1
Genomic VariantsICAM1  ICAM1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000090339 
Somatic Mutations in Cancer : COSMICICAM1 
CONAN: Copy Number AnalysisICAM1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:10381517-10397291
Mutations and Diseases : HGMDICAM1
OMIM147840    611162   
MedgenICAM1
NextProtP05362 [Medical]
GENETestsICAM1
Disease Genetic AssociationICAM1
Huge Navigator ICAM1 [HugePedia]  ICAM1 [HugeCancerGEM]
snp3D : Map Gene to Disease3383
DGIdb (Drug Gene Interaction db)ICAM1
General knowledge
Homologs : HomoloGeneICAM1
Homology/Alignments : Family Browser (UCSC)ICAM1
Phylogenetic Trees/Animal Genes : TreeFamICAM1
Chemical/Protein Interactions : CTD3383
Chemical/Pharm GKB GenePA29592
Clinical trialICAM1
Cancer Resource (Charite)ENSG00000090339
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineICAM1
GoPubMedICAM1
iHOPICAM1

Bibliography

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA.
J Immunol. 1986 Jul 1;137(1):245-54.
PMID 3086451
 
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Rothlein R, Dustin ML, Marlin SD, Springer TA.
J Immunol. 1986 Aug 15;137(4):1270-4.
PMID 3525675
 
Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins.
Caras IW, Davitz MA, Rhee L, Weddell G, Martin DW Jr, Nussenzweig V.
Nature. 1987 Feb 5-11;325(6104):545-9.
PMID 2433596
 
Supergene families meet in the immune system.
Dustin ML, Staunton DE, Springer TA.
Immunol Today. 1988 Jul-Aug;9(7-8):213-5.
PMID 3076418
 
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.
Simmons D, Makgoba MW, Seed B.
Nature. 1988 Feb 18;331(6157):624-7.
PMID 3340213
 
Adhesion receptors of the immune system.
Springer TA.
Nature. 1990 Aug 2;346(6283):425-34.
PMID 1974032
 
Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.
Tsujisaki M, Imai K, Hirata H, Hanzawa Y, Masuya J, Nakano T, Sugiyama T, Matsui M, Hinoda Y, Yachi A.
Clin Exp Immunol. 1991 Jul;85(1):3-8.
PMID 1712683
 
Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides.
Miele ME, Bennett CF, Miller BE, Welch DR.
Exp Cell Res. 1994 Sep;214(1):231-41.
PMID 7915992
 
Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis.
Gardiner EE, D'Souza SE.
J Biol Chem. 1999 Apr 23;274(17):11930-6.
PMID 10207014
 
Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer.
Liu CM, Sheen TS, Ko JY, Shun CT.
Br J Cancer. 1999 Jan;79(2):360-2.
PMID 9888481
 
Clinical significance of serum intercellular adhesion molecule-1 detection in patients with hepatocellular carcinoma.
Mei MH, Xu J, Shi QF, Yang JH, Chen Q, Qin LL.
World J Gastroenterol. 2000 Jun;6(3):408-410.
PMID 11819611
 
Lipid-mediated gene transfection of intercellular adhesion molecule-1 suppresses the peritoneal metastasis of gastric carcinoma.
Tanaka H, Yashiro M, Sunami T, Ohira M, Hirakawa-Y S Chung K.
Int J Mol Med. 2002 Nov;10(5):613-7.
PMID 12373302
 
High expression of costimulatory molecules correlates with low relapse-free survival probability in acute myeloid leukemia (AML).
Graf M, Reif S, Hecht K, Pelka-Fleischer R, Kroell T, Pfister K, Schmetzer H.
Ann Hematol. 2005 May;84(5):287-97. Epub 2004 Dec 7.
PMID 15592672
 
Role of ICAM1 in invasion of human breast cancer cells.
Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J, Denissenko MF.
Carcinogenesis. 2005 May;26(5):943-50. Epub 2005 Mar 17.
PMID 15774488
 
CD54 expression is predictive for lymphatic spread in human gastric carcinoma.
Yashiro M, Sunami T, Hirakawa K.
Dig Dis Sci. 2005 Dec;50(12):2224-30.
PMID 16416166
 
ICAM gene cluster SNPs and prostate cancer risk in African Americans.
Chen H, Hernandez W, Shriver MD, Ahaghotu CA, Kittles RA.
Hum Genet. 2006 Aug;120(1):69-76. Epub 2006 May 30.
PMID 16733712
 
Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer.
Berndt U, Philipsen L, Bartsch S, Wiedenmann B, Baumgart DC, Hammerle M, Sturm A.
Cancer Res. 2008 Feb 1;68(3):880-8.
PMID 18245490
 
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Contributor(s)

Written07-2008Masakazu Yashiro
The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan

Citation

This paper should be referenced as such :
Yashiro, M
ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(6):415-416.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/ICAM1ID40909ch19p13.html

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