| Entity | Melanoma |
| Disease | ICAM-1 expresses with a dose- and time-dependent increase in human malignant melanoma cells on stimulation of TNF-alpha. Inhibition of ICAM-1 expression on melanoma cells reduces the metastatic ability of the melanoma cells, indicating an important role of ICAM-1 in metastasis (Miele et al., 1994). |
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| Entity | Hepatocellular carcinoma |
| Disease | Serum concentration of ICAM-1 (sICAM-1) in patients with hepatocellular carcinoma is a marker for disease progression and prognosis. Higher sICAM-1 levels are more frequently observed in those patients with multiple lesions and intra-hepatic metastasis (Mei et al., 2000). |
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| Entity | Prostate cancer |
| Disease | Two polymorphisms and a common haplotype within the ICAM-1 gene cluster were correlated with prostate cancer risk among men with family history of the disease (Chen et al., 2006). |
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| Entity | Colon cancer |
| Disease | ICAM-1 expression is decreased in colorectal cancer (Berndt et al., 2008). |
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| Entity | Gastric cancer |
| Disease | Decreased ICAM expression leads to lymph node metastasis, suggesting that ICAM-1 gene transfection can inhibit lymph node metastasis (Tanaka et al., 2002; Yashiro et al., 2005). |
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| Entity | Head and neck cancer |
| Disease | sICAM-1 shows a significant elevation in the sera of patients with nasopharyngeal carcinoma compared to healthy controls (Liu et al., 1999). |
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| Entity | Leukemia |
| Disease | A high expression of ICAM-1 may identify high-risk MDS (Graf et al., 2005). |
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| Entity | Breast Cancer |
| Disease | ICAM-1 down-regulation at the mRNA and protein levels led to a suppression of breast cells invasion (Rosette et al., 2005). |
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| Role of ICAM1 in invasion of human breast cancer cells. |
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| ICAM gene cluster SNPs and prostate cancer risk in African Americans. |
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| Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. |
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