| Written | 2008-07 | Masakazu Yashiro |
| The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan |
| Identity |
| Alias_symbol (synonym) | BB2 |
| CD54 | |
| Other alias | ICAM-1 |
| P3.58 | |
| HGNC (Hugo) | ICAM1 |
| LocusID (NCBI) | 3383 |
| Atlas_Id | 40909 |
| Location | 19p13.2 [Link to chromosome band 19p13] |
| Location_base_pair | Starts at 10270841 and ends at 10286615 bp from pter ( according to hg19-Feb_2009) [Mapping ICAM1.png] |
| Fusion genes (updated 2016) | ICAM1 (19p13.2) / ABCF3 (3q27.1) | ICAM1 (19p13.2) / RTN4 (2p16.1) | ICAM1 (19p13.2) / TMSB10 (2p11.2) |
| SMARCA4 (19p13.2) / ICAM1 (19p13.2) |
| DNA/RNA |
| Description | ICAM1 gene maps on chromosome 19p13.3-p13.2 scanning 15512 bp. |
| Transcription | 7 exon; mRNA 3249 bp. |
| Protein |
| Description | A transmembrane glycoprotein of 532 amino acids, which has a molecular mass ranging from 75 to 115 kDa. ICAM-1 is a member of the immunoglobulin supergenge family, and contains five extracellular immunoglobulin-like domains. |
| Expression | ICAM-1 is expressed on various cells of both hematopoietic and non-hematopoietic cells, including endothelial cells, leukocytes other than basophilic granulocytes, T cells, B cells, fibroblasts, and cancer cells. |
| Function | ICAM-1, a member of adhesion molecules, binds to two integrins belonging to the beta2 subfamily CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on the surface of leukocytes. ICAM1 is a key molecule in immune-mediated and inflammatory processes and function as a co-stimulatory signal which is important for the trans-endothelial migration of leukocytes and the activation of T cells. ICAM-1 can be induced under inflammatory condition by TNF-alpha in a process that involves IKK-beta. ICAM1 on target cells leads to recruitment of the MHC-I proteins to the contact area and enhances presentation of cognate peptide MHC-I complex to cytotoxic T cells. ICAM-1 interacts with important factors involved in many kinds of human cancers. ICAM-1 is involved in transmembrane signal transduction in the regulatory process of cell proliferation through the mitogen-activated protein kinase (MAPK) pathway and eventually the AP-1 pathway (Springer, 1990; Dustin et al., 1998; Simmons et al., 1988; Caras et al., 1987; Rothlein et al., 1986; Dustin et al., 1986; Tsujisaki et al., 1991; Gardiner et D'Souza, 1999). |
| Implicated in |
| Note | |
| Entity | Melanoma |
| Disease | ICAM-1 expresses with a dose- and time-dependent increase in human malignant melanoma cells on stimulation of TNF-alpha. Inhibition of ICAM-1 expression on melanoma cells reduces the metastatic ability of the melanoma cells, indicating an important role of ICAM-1 in metastasis (Miele et al., 1994). |
| Entity | Hepatocellular carcinoma |
| Disease | Serum concentration of ICAM-1 (sICAM-1) in patients with hepatocellular carcinoma is a marker for disease progression and prognosis. Higher sICAM-1 levels are more frequently observed in those patients with multiple lesions and intra-hepatic metastasis (Mei et al., 2000). |
| Entity | Prostate cancer |
| Disease | Two polymorphisms and a common haplotype within the ICAM-1 gene cluster were correlated with prostate cancer risk among men with family history of the disease (Chen et al., 2006). |
| Entity | Colon cancer |
| Disease | ICAM-1 expression is decreased in colorectal cancer (Berndt et al., 2008). |
| Entity | Gastric cancer |
| Disease | Decreased ICAM expression leads to lymph node metastasis, suggesting that ICAM-1 gene transfection can inhibit lymph node metastasis (Tanaka et al., 2002; Yashiro et al., 2005). |
| Entity | Head and neck cancer |
| Disease | sICAM-1 shows a significant elevation in the sera of patients with nasopharyngeal carcinoma compared to healthy controls (Liu et al., 1999). |
| Entity | Leukemia |
| Disease | A high expression of ICAM-1 may identify high-risk MDS (Graf et al., 2005). |
| Entity | Breast Cancer |
| Disease | ICAM-1 down-regulation at the mRNA and protein levels led to a suppression of breast cells invasion (Rosette et al., 2005). |
| Bibliography |
| Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. |
| Berndt U, Philipsen L, Bartsch S, Wiedenmann B, Baumgart DC, Hammerle M, Sturm A. |
| Cancer Res. 2008 Feb 1;68(3):880-8. |
| PMID 18245490 |
| Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. |
| Caras IW, Davitz MA, Rhee L, Weddell G, Martin DW Jr, Nussenzweig V. |
| Nature. 1987 Feb 5-11;325(6104):545-9. |
| PMID 2433596 |
| ICAM gene cluster SNPs and prostate cancer risk in African Americans. |
| Chen H, Hernandez W, Shriver MD, Ahaghotu CA, Kittles RA. |
| Hum Genet. 2006 Aug;120(1):69-76. Epub 2006 May 30. |
| PMID 16733712 |
| Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). |
| Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. |
| J Immunol. 1986 Jul 1;137(1):245-54. |
| PMID 3086451 |
| Supergene families meet in the immune system. |
| Dustin ML, Staunton DE, Springer TA. |
| Immunol Today. 1988 Jul-Aug;9(7-8):213-5. |
| PMID 3076418 |
| Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis. |
| Gardiner EE, D'Souza SE. |
| J Biol Chem. 1999 Apr 23;274(17):11930-6. |
| PMID 10207014 |
| High expression of costimulatory molecules correlates with low relapse-free survival probability in acute myeloid leukemia (AML). |
| Graf M, Reif S, Hecht K, Pelka-Fleischer R, Kroell T, Pfister K, Schmetzer H. |
| Ann Hematol. 2005 May;84(5):287-97. Epub 2004 Dec 7. |
| PMID 15592672 |
| Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer. |
| Liu CM, Sheen TS, Ko JY, Shun CT. |
| Br J Cancer. 1999 Jan;79(2):360-2. |
| PMID 9888481 |
| Clinical significance of serum intercellular adhesion molecule-1 detection in patients with hepatocellular carcinoma. |
| Mei MH, Xu J, Shi QF, Yang JH, Chen Q, Qin LL. |
| World J Gastroenterol. 2000 Jun;6(3):408-410. |
| PMID 11819611 |
| Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides. |
| Miele ME, Bennett CF, Miller BE, Welch DR. |
| Exp Cell Res. 1994 Sep;214(1):231-41. |
| PMID 7915992 |
| Role of ICAM1 in invasion of human breast cancer cells. |
| Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J, Denissenko MF. |
| Carcinogenesis. 2005 May;26(5):943-50. Epub 2005 Mar 17. |
| PMID 15774488 |
| A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. |
| Rothlein R, Dustin ML, Marlin SD, Springer TA. |
| J Immunol. 1986 Aug 15;137(4):1270-4. |
| PMID 3525675 |
| ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. |
| Simmons D, Makgoba MW, Seed B. |
| Nature. 1988 Feb 18;331(6157):624-7. |
| PMID 3340213 |
| Adhesion receptors of the immune system. |
| Springer TA. |
| Nature. 1990 Aug 2;346(6283):425-34. |
| PMID 1974032 |
| Lipid-mediated gene transfection of intercellular adhesion molecule-1 suppresses the peritoneal metastasis of gastric carcinoma. |
| Tanaka H, Yashiro M, Sunami T, Ohira M, Hirakawa-Y S Chung K. |
| Int J Mol Med. 2002 Nov;10(5):613-7. |
| PMID 12373302 |
| Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. |
| Tsujisaki M, Imai K, Hirata H, Hanzawa Y, Masuya J, Nakano T, Sugiyama T, Matsui M, Hinoda Y, Yachi A. |
| Clin Exp Immunol. 1991 Jul;85(1):3-8. |
| PMID 1712683 |
| CD54 expression is predictive for lymphatic spread in human gastric carcinoma. |
| Yashiro M, Sunami T, Hirakawa K. |
| Dig Dis Sci. 2005 Dec;50(12):2224-30. |
| PMID 16416166 |
| Citation |
| This paper should be referenced as such : |
| Yashiro, M |
| ICAM1 (intercellular adhesion molecule 1 (CD54), human rhinovirus receptor) |
| Atlas Genet Cytogenet Oncol Haematol. 2009;13(6):415-416. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/ICAM1ID40909ch19p13.html |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Jun 30 11:08:57 CEST 2017 |
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