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ID1 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)

Written2012-09Eduardo Castañón, Ignacio Gil-Bazo
New target therapies laboratory, Division of Oncology, Center for Applied Medical Research, 31621 Pamplona, Spain

(Note : for Links provided by Atlas : click)


Alias (NCBI)ID
HGNC (Hugo) ID1
HGNC Alias symbdJ857M17.1.2
HGNC Alias nameDNA-binding protein inhibitor ID-1
 inhibitor of differentiation 1
HGNC Previous nameinhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LocusID (NCBI) 3397
Atlas_Id 40914
Location 20q11.21  [Link to chromosome band 20q11]
Location_base_pair Starts at 31605289 and ends at 31606510 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping ID1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


Description DNA contains 1239 bp encoding 2 coding exons.
Transcription Id1 gene has 2 transcripts, called Id1-001 (or Id1A) and Id-1-002 (or Id1B). mRNA Id1A contains 994 bps whereas mRNA Id1B contains 1233 bps. Id1A is considered the "canonical sequence".


Description ID1 belongs to the helix-loop-helix protein family. It is composed by 155 aa. It has a main domain located on 143-155 aa responsible for the helix-loop-helix conformation. Its main motif, encoded by 14 aa is responsible for the nuclear export signaling.
Expression High levels of ID1 are found in brain, liver, lung, skin and thyroid gland cells. It is also expressed in fetal cells and in the umbilical vein endothelial cell.
Localisation Nucleus.
Function Although it does not bind directly to DNA, by binding basic helix-loop-helix transcription factors through its HLH motif, ID1 may control tissue-specific genes related to cell growth, proliferation, differentiation and angiogenesis.
Homology H.sapiens: ID1; P.troglodytes: ID1; C.lupus: ID1; B.taurus: ID1; M.musculus: Id1; R.norvegicus: Id1; G.gallus: ID1; D.rerio: id1.


Germinal No germinal mutations have been reported.
Somatic No somatic mutations have been reported.

Implicated in

Entity Non small cell lung cancer
Note ID1 levels are correlated with a worse prognosis in lung adenocarcinoma in both, disease free survival and overall survival. A higher expression of Id1 has been reported in squamous cell carcinoma and adenocarcinoma of the lung. ID1 expression are detected in more resistant tumors to either chemo and radiation therapy. When silencing Id1 in in vitro models, a reversal of resistance to the treatment (both chemotherapy and radiation) was observed.
Entity Gastric cancer
Note Gastric cancer prognosis has also been linked to ID1 expression levels. Whereas poor differentiated gastric tumors express higher levels of ID1, those gastric cancers with a higher differentiation, and thus, a better prognosis, express a lower quantity of ID1. Nevertheless, the impact of ID1 expression on clinical outcome has not reached statistical significance when a multivariate analysis was carried out.
Entity Breast cancer
Note In breast cancer, especially in those node negative tumors, ID1 expression has become an independent prognostic factor. Higher levels of ID1 are related to a worse prognosis (measured by both, overall survival and disease free survival). This may be explained by the possible relation between ID1 and the steroid-receptor, this latter considered a factor which may change therapeutic options in breast cancer patients.
Entity Prostate cancer
Note In prostate cancer it has been observed that levels of ID1 are correlated to the grade of differentiation measured by the Gleason score, detecting higher levels of ID1 in those prostate tumors with a higher Gleason score. Comparing prostate cancer with benign prostate hyperplasia, ID1 expression differences may also be seen; ID1 is not expressed in benign prostate hyperplasia (BPH), whereas ID1 expression is remarkably higher in prostate cancer cells.
Entity Melanoma
Note In melanoma ID1 is also positively related to tumor thickness and also with overall survival. Also, ID1 is highly expressed in those BRAF mutated melanomas compared to BRAF wild type melanomas. ID1 negative regulates CDKN2A, which has been related to malignant melanoma development. ID1 is expressed in the earliest stages of melanoma.
Entity Glioblastoma
Note In recent studies, ID1 has been catalogued as a marker of brain stem cells localized at the perivascular niche. Those stem cells with higher levels of ID1 have a major capability of tumor initiation and therapeutic resistance.
Entity Hepatocarcinoma
Note In Hepatitis B virus-induced hepatocarcinoma, levels of ID1 may predict both disease free survival and overall survival, in a negative manner. Also, ID1 has been related to bad prognostic features such as portal vein invasion, lymph node metastasis and a worse Child Pugh grade.
Entity Anaplastic thyroid tumor
Note ID1 is highly expressed in anaplastic thyroid tumors rather than in regular thyroid cells; it may be explained by the role ID1 plays on cell growth and differentiation.
Entity Neurogenesis
Note Lacking of Id1 alleles (with simultaneous Id3 downregulation) triggers neural differentiation in mice embryos development resulting in a lethal event. It has also been reported that when Id1 and Id3 are not expressed, vascular sprouting in brain does not occur.
Entity Heart and vessel formation
Note Id1 has also being related to play a crucial role in heart development, since Id1 knockout mice showed ventricular defects and myocardium trabeculation impairment. ID1 is also expressed in endothelial progenitor cells, and its suppression is related to angiogenesis inhibition and in a blockade of endothelial cells mobilization.
Entity Hematopoiesis
Note Higher ID1 levels are found in pro-B cells, whereas it is downregulated in pre-B and mature cells. When blocking Id1 in those cells, B-cell development is disrupted.
Entity Metastasis
Note Higher levels of ID1 expression are found in those breast cancers which are more prone to metastasize to the lung. Id1 has been described as part of the genes signature for breast cancer metastasis to the lung.
Entity Stemcellness and selfrenewal
Note Satellite cells are muscle stem cells related to injured muscle renewal. ID1 expression has been recently correlated to muscle stem cell self-renewal ability, showing that when ID1 is expressed, a higher capability of self-renewal may be observed. Culture cells with high ID1 expression, may retain selfrenewal ability after several passages comparing to those cells with lower levels of ID1.
Stem cells are characterized by their anchorage to an special microenviroment, also known as niche. ID1, by repressing the activation of Rap1GAP (an inhibitor of an important neural cell adhesion protein known as RAP1) assure stem cell joints to the niche. When ID1 is downregulated, neural stem cells detach from the brain stem cell niches, such as the ventricular zone in embryonic brain and the subventricular zone of post-nata brain. This detachment from the niches, may also trigger neuronal and oligodendrogial differentiation.


TGF-b Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma.
Anido J, Saez-Borderias A, Gonzalez-Junca A, Rodon L, Folch G, Carmona MA, Prieto-Sanchez RM, Barba I, Martinez-Saez E, Prudkin L, Cuartas I, Raventos C, Martinez-Ricarte F, Poca MA, Garcia-Dorado D, Lahn MM, Yingling JM, Rodon J, Sahuquillo J, Baselga J, Seoane J.
Cancer Cell. 2010 Dec 14;18(6):655-68.
PMID 21156287
The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes.
Asp J, Thornemo M, Inerot S, Lindahl A.
FEBS Lett. 1998 Oct 30;438(1-2):85-90.
PMID 9821964
The protein Id: a negative regulator of helix-loop-helix DNA binding proteins.
Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H.
Cell. 1990 Apr 6;61(1):49-59.
PMID 2156629
The Id proteins and angiogenesis.
Benezra R, Rafii S, Lyden D.
Oncogene. 2001 Dec 20;20(58):8334-41.
PMID 11840326
Role of Id proteins in embryonic and tumor angiogenesis.
Benezra R.
Trends Cardiovasc Med. 2001 Aug;11(6):237-41.
PMID 11673054
Id1 promotes tumor cell migration in nonsmall cell lung cancers.
Bhattacharya R, Kowalski J, Larson AR, Brock M, Alani RM.
J Oncol. 2010;2010:856105. Epub 2010 Apr 18.
PMID 20414347
Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway.
Cheng YJ, Tsai JW, Hsieh KC, Yang YC, Chen YJ, Huang MS, Yuan SS.
Cancer Lett. 2011 Aug 28;307(2):191-9. Epub 2011 May 4.
PMID 21536374
Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells.
Cheung HW, Ling MT, Tsao SW, Wong YC, Wang X.
Carcinogenesis. 2004 Jun;25(6):881-7. Epub 2004 Jan 23.
PMID 14742319
Id1 restrains p21 expression to control endothelial progenitor cell formation.
Ciarrocchi A, Jankovic V, Shaked Y, Nolan DJ, Mittal V, Kerbel RS, Nimer SD, Benezra R.
PLoS One. 2007 Dec 19;2(12):e1338.
PMID 18092003
A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1.
Desprez PY, Lin CQ, Thomasset N, Sympson CJ, Bissell MJ, Campisi J.
Mol Cell Biol. 1998 Aug;18(8):4577-88.
PMID 9671467
Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma.
Ding R, Han S, Lu Y, Guo C, Xie H, Zhang N, Song Z, Cai L, Liu J, Dou K.
Cancer Biol Ther. 2010 Aug;10(3):299-307. Epub 2010 Aug 24.
PMID 20574154
The gene for the helix-loop-helix protein, Id, is specifically expressed in neural precursors.
Duncan M, DiCicco-Bloom EM, Xiang X, Benezra R, Chada K.
Dev Biol. 1992 Nov;154(1):1-10.
PMID 1426618
Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer.
Gautschi O, Tepper CG, Purnell PR, Izumiya Y, Evans CP, Green TP, Desprez PY, Lara PN, Gandara DR, Mack PC, Kung HJ.
Cancer Res. 2008 Apr 1;68(7):2250-8.
PMID 18381431
ID genes mediate tumor reinitiation during breast cancer lung metastasis.
Gupta GP, Perk J, Acharyya S, de Candia P, Mittal V, Todorova-Manova K, Gerald WL, Brogi E, Benezra R, Massague J.
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19506-11. Epub 2007 Nov 28.
PMID 18048329
Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.
Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K.
J Biol Chem. 1994 Jan 21;269(3):2139-45.
PMID 8294468
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells.
Jankovic V, Ciarrocchi A, Boccuni P, DeBlasio T, Benezra R, Nimer SD.
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1260-5. Epub 2007 Jan 16.
PMID 17227850
Inhibition of tumourigenicity of small cell lung cancer cells by suppressing Id3 expression.
Kamalian L, Forootan SS, Bao ZZ, Zhang Y, Gosney JR, Foster CS, Ke Y.
Int J Oncol. 2010 Sep;37(3):595-603.
PMID 20664928
Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers.
Lee KT, Lee YW, Lee JK, Choi SH, Rhee JC, Paik SS, Kong G.
Br J Cancer. 2004 Mar 22;90(6):1198-203.
PMID 15026801
Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway.
Lee TK, Man K, Ling MT, Wang XH, Wong YC, Lo CM, Poon RT, Ng IO, Fan ST.
Carcinogenesis. 2003 Nov;24(11):1729-36. Epub 2003 Aug 29.
PMID 12949053
The multiple roles of Id-1 in cancer progression.
Ling MT, Wang X, Zhang X, Wong YC.
Differentiation. 2006 Dec;74(9-10):481-7.
PMID 17177845
Downregulation of Id1 by small interfering RNA in prostate cancer PC3 cells in vivo and in vitro.
Ling YX, Tao J, Fang SF, Hui Z, Fang QR.
Eur J Cancer Prev. 2011 Jan;20(1):9-17.
PMID 20881502
Expression and prognostic relevance of Id1 in stage III esophageal squamous cell carcinoma.
Liu J, Hu Y, Hu W, Xie X, Ela Bella A, Fu J.
Cancer Biomark. 2010-2011;8(2):67-72. doi: 10.3233/DMA-2011-0831.
PMID 21896993
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.
Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R.
Nature. 1999 Oct 14;401(6754):670-7.
PMID 10537105
Chromosomal assignment of human ID1 and ID2 genes.
Mathew S, Chen W, Murty VV, Benezra R, Chaganti RS.
Genomics. 1995 Nov 20;30(2):385-7.
PMID 8586447
Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth.
Mellick AS, Plummer PN, Nolan DJ, Gao D, Bambino K, Hahn M, Catena R, Turner V, McDonnell K, Benezra R, Brink R, Swarbrick A, Mittal V.
Cancer Res. 2010 Sep 15;70(18):7273-82. Epub 2010 Aug 31.
PMID 20807818
Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells.
Mern DS, Hoppe-Seyler K, Hoppe-Seyler F, Hasskarl J, Burwinkel B.
Breast Cancer Res Treat. 2010 Dec;124(3):623-33. Epub 2010 Feb 27.
PMID 20191379
High levels of Id1 expression define B1 type adult neural stem cells.
Nam HS, Benezra R.
Cell Stem Cell. 2009 Nov 6;5(5):515-26.
PMID 19896442
Id proteins synchronize stemness and anchorage to the niche of neural stem cells.
Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A.
Nat Cell Biol. 2012 Apr 22;14(5):477-87. doi: 10.1038/ncb2490.
PMID 22522171
Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis.
Nishiyama K, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato A, Ogawa H, Kurihara H.
Circulation. 2005 Nov 1;112(18):2840-50.
PMID 16267257
Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells.
Ogata T, Wozney JM, Benezra R, Noda M.
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9219-22.
PMID 8415680
Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle.
Ono Y, Masuda S, Nam HS, Benezra R, Miyagoe-Suzuki Y, Takeda S.
J Cell Sci. 2012 Mar 1;125(Pt 5):1309-17. Epub 2012 Feb 20.
PMID 22349695
Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway.
Ouyang XS, Wang X, Ling MT, Wong HL, Tsao SW, Wong YC.
Carcinogenesis. 2002 May;23(5):721-5.
PMID 12016143
Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody.
Perk J, Gil-Bazo I, Chin Y, de Candia P, Chen JJ, Zhao Y, Chao S, Cheong W, Ke Y, Al-Ahmadie H, Gerald WL, Brogi E, Benezra R.
Cancer Res. 2006 Nov 15;66(22):10870-7.
PMID 17108123
The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity.
Pesce S, Benezra R.
Mol Cell Biol. 1993 Dec;13(12):7874-80.
PMID 8247002
ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling.
Pillai S, Rizwani W, Li X, Rawal B, Nair S, Schell MJ, Bepler G, Haura E, Coppola D, Chellappan S.
Mol Cell Biol. 2011 Jul;31(14):3052-67. Epub 2011 May 23.
PMID 21606196
The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas.
Polsky D, Young AZ, Busam KJ, Alani RM.
Cancer Res. 2001 Aug 15;61(16):6008-11.
PMID 11507043
Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance.
Ponz-Sarvise M, Nguewa PA, Pajares MJ, Agorreta J, Lozano MD, Redrado M, Pio R, Behrens C, Wistuba II, Garcia-Franco CE, Garcia-Foncillas J, Montuenga LM, Calvo A, Gil-Bazo I.
Clin Cancer Res. 2011 Jun 15;17(12):4155-66. Epub 2011 May 3.
PMID 21540238
Id1 maintains embryonic stem cell self-renewal by up-regulation of Nanog and repression of Brachyury expression.
Romero-Lanman EE, Pavlovic S, Amlani B, Chin Y, Benezra R.
Stem Cells Dev. 2012 Feb 10;21(3):384-93. Epub 2011 Dec 1.
PMID 22013995
The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer.
Rothschild SI, Kappeler A, Ratschiller D, Betticher DC, Tschan MP, Gugger M, Gautschi O.
Lung Cancer. 2011 Mar;71(3):306-11. Epub 2010 Aug 14.
PMID 20709421
Id proteins in development, cell cycle and cancer.
Ruzinova MB, Benezra R.
Trends Cell Biol. 2003 Aug;13(8):410-8.
PMID 12888293
Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells.
Sakurai D, Tsuchiya N, Yamaguchi A, Okaji Y, Tsuno NH, Kobata T, Takahashi K, Tokunaga K.
J Immunol. 2004 Nov 1;173(9):5801-9.
PMID 15494533
ID1 inhibits USF2 and blocks TGF-b-induced apoptosis in mesangial cells.
Sato AY, Antonioli E, Tambellini R, Campos AH.
Am J Physiol Renal Physiol. 2011 Dec;301(6):F1260-9. Epub 2011 Sep 14.
PMID 21921026
Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer.
Schoppmann SF, Schindl M, Bayer G, Aumayr K, Dienes J, Horvat R, Rudas M, Gnant M, Jakesz R, Birner P.
Int J Cancer. 2003 May 10;104(6):677-82.
PMID 12640673
Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma.
Straume O, Akslen LA.
Br J Cancer. 2005 Oct 17;93(8):933-8.
PMID 16189525
Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription.
Subbaramaiah K, Benezra R, Hudis C, Dannenberg AJ.
J Biol Chem. 2008 Dec 5;283(49):33955-68. Epub 2008 Oct 8.
PMID 18842581
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.
Talora C, Campese AF, Bellavia D, Pascucci M, Checquolo S, Groppioni M, Frati L, von Boehmer H, Gulino A, Screpanti I.
EMBO Rep. 2003 Nov;4(11):1067-72. Epub 2003 Oct 17.
PMID 14566327
Cyclin D1, Id1 and EMT in breast cancer.
Tobin NP, Sims AH, Lundgren KL, Lehn S, Landberg G.
BMC Cancer. 2011 Sep 28;11:417.
PMID 21955753
Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1.
Tournay O, Benezra R.
Mol Cell Biol. 1996 May;16(5):2418-30.
PMID 8628310
Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer.
Tsuchiya T, Okaji Y, Tsuno NH, Sakurai D, Tsuchiya N, Kawai K, Yazawa K, Asakage M, Yamada J, Yoneyama S, Kitayama J, Osada T, Watanabe T, Tokunaga K, Takahashi K, Nagawa H.
Cancer Sci. 2005 Nov;96(11):784-90.
PMID 16271072
Expression and prognostic values of Id-1 and Id-3 in gastric adenocarcinoma.
Yang HY, Liu HL, Liu GY, Zhu H, Meng QW, Qu LD, Liu LX, Jiang HC.
J Surg Res. 2011 May 15;167(2):258-66. Epub 2009 Sep 9.
PMID 20080245
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT, Morrell NW.
Circ Res. 2010 Jul 23;107(2):252-62. Epub 2010 Jun 3.
PMID 20522807
Inhibitor of DNA binding-1 overexpression in prostate cancer: relevance to tumor differentiation.
Yu X, Xu X, Han B, Zhou R.
Pathol Oncol Res. 2009 Mar;15(1):91-6. Epub 2008 Aug 28.
PMID 18752043
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.
de Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB, Muller WJ, Rosen N, Benezra R.
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12337-42. Epub 2003 Oct 2.
PMID 14526102


This paper should be referenced as such :
Castaòn, E ; Gil-Bazo, I
ID1 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(2):121-125.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)ID1   5360
Atlas Explorer : (Salamanque)ID1
Entrez_Gene (NCBI)ID1    inhibitor of DNA binding 1, HLH protein
AliasesID; bHLHb24
GeneCards (Weizmann)ID1
Ensembl hg19 (Hinxton)ENSG00000125968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125968 [Gene_View]  ENSG00000125968 [Sequence]  chr20:31605289-31606510 [Contig_View]  ID1 [Vega]
ICGC DataPortalENSG00000125968
TCGA cBioPortalID1
AceView (NCBI)ID1
Genatlas (Paris)ID1
SOURCE (Princeton)ID1
Genetics Home Reference (NIH)ID1
Genomic and cartography
GoldenPath hg38 (UCSC)ID1  -     chr20:31605289-31606510 +  20q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ID1  -     20q11.21   [Description]    (hg19-Feb_2009)
GoldenPathID1 - 20q11.21 [CytoView hg19]  ID1 - 20q11.21 [CytoView hg38]
Genome Data Viewer NCBIID1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AI304595 AK291152 AK313786 BC000613 BC012420
RefSeq transcript (Entrez)NM_002165 NM_181353
Consensus coding sequences : CCDS (NCBI)ID1
Gene ExpressionID1 [ NCBI-GEO ]   ID1 [ EBI - ARRAY_EXPRESS ]   ID1 [ SEEK ]   ID1 [ MEM ]
Gene Expression Viewer (FireBrowse)ID1 [ Firebrowse - Broad ]
GenevisibleExpression of ID1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3397
GTEX Portal (Tissue expression)ID1
Human Protein AtlasENSG00000125968-ID1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)ID1
Human Protein Atlas [tissue]ENSG00000125968-ID1 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed292 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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