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IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1)

Written2010-11Theoni Trangas, Panayotis Ioannidis
Department of Biological Applications, Technologies University of Ioannina, Ioannina, Greece (TT); National Reference Center for Mycobacteria, Sotiria Hospital, Athens, Greece (PI)

(Note : for Links provided by Atlas : click)

Identity

Alias_namesinsulin-like growth factor 2 mRNA binding protein 1
Alias_symbol (synonym)IMP-1
HGNC (Hugo) IGF2BP1
LocusID (NCBI) 10642
Atlas_Id 40969
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47074774 and ends at 47133507 bp from pter ( according to hg19-Feb_2009)  [Mapping IGF2BP1.png]
Local_order The IGF2BP1 gene is located on the plus strand on chromosome 17, at 17q21.32. This gene starts at 47074774 and ends at 47133507 bp from pter, encompasses 58734 bp and lies 5' of the gene B4GALNT2, encoding beta-1,4-N-acetyl-galactosaminyl transferase 2.
 
Fusion genes
(updated 2016)
IGF2BP1 (17q21.32) / IGF2BP1 (17q21.32)IGH (14q32.33) / IGF2BP1 (17q21.32)KAT7 (17q21.33) / IGF2BP1 (17q21.32)
NCL (2q37.1) / IGF2BP1 (17q21.32)PRKCA (17q24.2) / IGF2BP1 (17q21.32)RAI1 (17p11.2) / IGF2BP1 (17q21.32)
ZBTB8OS (1p35.1) / IGF2BP1 (17q21.32)
Note The IGF2BP1 gene encodes a member of the IGF-II mRNA-binding protein (IMP) family (RRM IMP/VICKZ family).

DNA/RNA

 
Description There are 4 probable alternative promoters driving transcription of IGF2BP1 and two of them have been experimentally confirmed (Gu et al., 2008). The upstream (promoter) region contains binding sites for the following transcription factors: delta CREB, CREB, NF-kappaB1, NF-kappaB, AP-1, HNF4 alpha2, FOXO1a, MZF-1, Max and c-Myc. Beta-catenin/TCF4 binding and activation of transcription has been experimentally confirmed (Gu et al., 2008).
Transcription Two protein coding transcripts exist resulting from alternative splicing:
Transcript variant 1 (NM_006546). The length of this transcript is 8769 nt and encompasses all 15 exons (exon 1: 509 bp, exon 2: 60 bp, exon 3: 48 bp, exon 4: 51 bp, exon 5: 63 bp, exon 6: 281 bp, exon 7: 134 bp, exon 8: 122 bp, exon 9: 135 bp, exon 10: 122 bp, exon 11: 119 bp, exon 12: 74 bp, exon 13: 131 bp, exon14: 113 bp, exon 15: 6973 bp).
Several alternative 3' ends (polyadenylation sites) exist at exon 15 3'-UTR (marked by flags in the figure above). Translation starts at +335 and ends at +2068.
Transcript variant 2 (NM_001160423.1). It encompasses 8352 bp and lacks two consecutive in-frame exons (6 and 7).
Other spliced variants have been reported without corresponding protein product recorded.

Protein

 
  IGF2BP1 protein translated from transcript 1 variant.
Description The IGF2BP1 protein translated from the transcript variant 1 consists of 577 aa (63,48 kD) and has 2 highly conserved RRM motifs belonging to the RNA recognition motif (RRM) superfamily and 4 KH domains (NP_006537.3). The third and fourth KH domains constitute both the protein dimerization motif and the RNA binding domain. The four KH domains promote granule formation and stress granule targeting (Stöhr et al., 2006). Two nuclear export signals (NES) exist within the second and fourth KH domains (Nielsen et al., 2003). The KH domains have been implicated in the suppression of HIV-1 infectivity (Zhou et al., 2008). Phosphorylation sites are marked (Bennetzen et al., 2010; Dephoure et al., 2008). Phosphorylation of Tyrosine 396 prevents RNA binding and translation inhibition of beta-actin mRNA (Hüttelmaier et al., 2005).
The IGF2BP1 protein translated from transcript 2 variant is predicted to consist of 438 aa (48.597 kD) and contain 2 RRM and 3 KH domains (NP_001153895.1).
 
  IGF2BP1 protein translated from transcript 2 variant.
Expression IGF2BP1 is widely expressed in fetal tissues (liver, lung, kidney, thymus, etc), placenta and CD34+ cord blood cells (Nielsen et al., 1999; Ioannidis et al., 2001; Ioannidis et al., 2005). Postnatally it is expressed in ovary (oocytes and granulosa cells), in testis (spermatogonia), in semen (Hammer et al., 2005) and in intestinal crypts (Nielsen et al., 1999; Dimitriadis et al., 2007). It is expressed de novo in kidney, prostate, trachea, testis, ovarian and lung cancer, melanoma, mesenchymal and brain tumors. At protein level, it is expressed in testicular, lung and colon cancer.
Localisation IGF2BP1 has been detected in the nucleus, cytoplasm, cytoplasmic mRNPs, granules (Nielsen et al., 2002; Nielsen et al., 2003). In stress granules IGF2BP1 co localizes with G3BP1 and TIAL1 (Stöhr et al., 2006). It has also been detected in lamellipodia (Yaniv et al., 2003), growth cones and the leading edge of developing axons (Eom et al., 2003).
Function mRNA translation: IGF2BP1 regulates translation by binding the 5'-UTR of the mRNA of certain genes, including insulin-like growth factor 2 (Nielsen et al., 1999), and beta actin (Hüttelmaier et al., 2005). It has been identified in a HCV IRES-mediated translation complex along with EIF3C and RPS3, enhancing translation of the Hepatitis C virus (HCV) RNA-replicon via the internal ribosome entry site (IRES), without affecting 5'cap-dependent translation (Weinlich et al., 2009). IGF2BP1 binds the adenine-rich autoregulatory sequence (ARS) of the 5'-UTR of the PABPC1 mRNA in collaboration with CSDE1 and PABPC1 proteins and causes translational repression (Patel and Bag, 2006; Patel et al., 2005).

mRNA stabilization: IGF2BP1 binds to the coding region mRNA stability determinant (CRD) of c-myc mRNA and protects it from endonucleolytic cleavage (Doyle et al.,1998; Lemm and Ross, 2002). It protects MDR-1 mRNAs from endonucleolytic cleavage by binding to a coding region element (Sparanese and Lee, 2007). Also binds to the coding region of betaTrCP1 mRNA and stabilizes it by disrupting miRNA-dependent interaction with AGO2 (Noubissi et al., 2006; Elcheva et al., 2009). Binds and stabilizes GLI1 mRNA causing an elevation of GLI1 expression and transcriptional activity (Noubissi et al., 2009). IGF2BP1 binds to multiple elements in the 3'-UTR of the CD44 mRNAs and stabilizes this mRNA (Vikesaa et al., 2006). Binds to the 3'-UTR of Micropthalmia associated transcription factor mRNA and prevents the binding of miR-340 to its target sites, resulting in stabilization of the transcript, elevated expression and activity of this transcription factor (Goswami et al., 2010).

mRNA transportation: IGF2BP1 binds to the fourth and fifth exons of the oncofetal H19 RNA (Runge et al., 2000) and with ELAVL4 and G3BP to 3'-UTR of the neuron-specific TAU mRNA (Atlas et al., 2004; Atlas et al., 2007) and regulates their localization. In collaboration with IGF2BP2, IGF2BP1 binds to the conserved 54-nucleotide element in the 3'-UTR of the beta actin mRNA, known as the 'zip code'. IGF2BP1 promotes the localization of the beta-actin mRNA to dendrites (Eom et al., 2003). IGF2BP1 may act as a regulator of mRNA transport to activated synapses in response to synaptic activity.

Protein binding: IGF2BP1 interacts through the third and fourth KH domains with PABPC1 in a RNA-independent manner (Patel and Bag, 2006) and can form homo- and heterodimers with IGF2BP2 or IGF2BP3 (Nielsen et al., 2004). It interacts with fragile X metal retardation protein isoform 18 (Rackham and Brown, 2004). It interacts with DHX9, ELAVL2, HNRNPA2B1, HNRNPC, HNRNPH1, HNRNPU, IGF2BP2, IGF2BP3, ILF2 and YBX1 (Weindensdorfer et al., 2009). IGF2BP1 was identified in a mRNP granule complex, with hnRNP A1, hnRNP A2/B1, hnRNP D, hnRNP L, hnRNP Q, hnRNP R, hnRNP U, YB1/major core protein, interleukin enhancer-binding factor 2 and 3, PABP1, PABP2, PABP4, nucleolin, RNA helicase A, a series of 40 S ribosomal proteins, and the nuclear cap-binding protein CBP80 (Jønson et al., 2007). IGF2BP1 associates with HIV-1 particles. It interacts (via KH3 and KH4 domains) with HIV-1 GAG protein and diminishes viral RNA packaging, thwarts GAG processing to the cellular membranes, and impedes HIV-1 assembly (Zhou et al., 2008).

Homology The identity of human IGF2BP1 over an aligned region in UniGene is as follows:
- Pan troglodytes: 99.83%
- Canis lupas familiaris: 90.93%
- Bos taurus: 91.05%
- Mus musculus: 89.43%
- Rattus norvegicus: 89.43%

Implicated in

Note
Entity Lung cancer
Disease IGF2BP1 is expressed in lung cancer and its expression correlates with adverse histological and clinical features and is an indicator of poor prognosis. Suppression of its expression with siRNA suppresses growth of NSCLC cells in vitro (Ioannidis et al., 2004; Kato et al., 2007).
  
Entity Ovarian cancer
Disease Increased expression of IGF2BP1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer (Köbel et al., 2007).
  
Entity Testicular cancer
Disease Detected in testicular carcinomas even in early stage carcinoma in situ (Hammer et al., 2005).
  
Entity Melanoma
Disease IGF2BP1 is highly expressed in primary human malignant melanomas and melanoma cell line (Elcheva et al., 2008).
  
Entity Breast cancer
Disease The IGF2BP1 gene is amplified in breast cancer (Doyle et al., 2000). Significant associations are detected between IGF2BP1 expression and the absence of estrogen receptors. IGF2BP1 collaborates with c-myc amplification to render tumours more aggressive (Ioannidis et al., 2003). Tissue specific induced expression in transgenic mice promotes tumor formation (Tessier et al., 2004).
  
Entity Colon cancer
Disease IGF2BP1 is scarce or absent from normal colon but is over expressed in colorectal cancer. IGF2BP1 positive tumours associate with metastasis/recurrence and shorter survival (Ross et al., 2001; Dimitriadis et al., 2007).
  
Entity Hepatocellular carcinoma
Disease IGF2BP1 is detected as an autoantigen in hepatocellular carcinoma (Himoto et al., 2005).
  
Entity Oncogenesis
Note The oncogenic action of IGF2BP1 is effected through the stabilization of the mRNA of oncogenes such as c-myc, betaTrCP1, Gli and upregulation of their expression. IGF2BP1 expression may promote metastasis by shuttling requisite RNAs to the lamellipodia of migrating cells (Vikesaa et al., 2006; Vainer et al., 2008).
  

Bibliography

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Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer.
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PMID 18454174
 
Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses.
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PMID 14614102
 
MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein.
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PMID 20439467
 
Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells.
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PMID 18490442
 
Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.
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Reproduction. 2005 Aug;130(2):203-12.
PMID 16049158
 
Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma.
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Int J Oncol. 2005 Feb;26(2):311-7.
PMID 15645114
 
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.
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Nature. 2005 Nov 24;438(7067):512-5.
PMID 16306994
 
CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells.
Ioannidis P, Mahaira LG, Perez SA, Gritzapis AD, Sotiropoulou PA, Kavalakis GJ, Antsaklis AI, Baxevanis CN, Papamichail M.
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PMID 15769738
 
Molecular composition of IMP1 ribonucleoprotein granules.
Jonson L, Vikesaa J, Krogh A, Nielsen LK, Hansen T, Borup R, Johnsen AH, Christiansen J, Nielsen FC.
Mol Cell Proteomics. 2007 May;6(5):798-811. Epub 2007 Feb 7.
PMID 17289661
 
Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.
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Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):434-42.
PMID 17255263
 
Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma.
Kobel M, Weidensdorfer D, Reinke C, Lederer M, Schmitt WD, Zeng K, Thomssen C, Hauptmann S, Huttelmaier S.
Oncogene. 2007 Nov 29;26(54):7584-9. Epub 2007 Jun 4.
PMID 17546046
 
Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant.
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Mol Cell Biol. 2002 Jun;22(12):3959-69.
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Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains.
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Nuclear transit of human zipcode-binding protein IMP1.
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PMID 9891060
 
Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability.
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PMID 15314207
 
Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA.
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PMID 18385235
 

Citation

This paper should be referenced as such :
Trangas, T ; Ioannidis, P
IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2011;15(7):562-566.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/IGF2BP1ID40969ch17q21.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;17)(q32;q21) IGH/IGF2BP1


External links

Nomenclature
HGNC (Hugo)IGF2BP1   28866
Cards
AtlasIGF2BP1ID40969ch17q21
Entrez_Gene (NCBI)IGF2BP1  10642  insulin like growth factor 2 mRNA binding protein 1
AliasesCRD-BP; CRDBP; IMP-1; IMP1; 
VICKZ1; ZBP1
GeneCards (Weizmann)IGF2BP1
Ensembl hg19 (Hinxton)ENSG00000159217 [Gene_View]  chr17:47074774-47133507 [Contig_View]  IGF2BP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000159217 [Gene_View]  chr17:47074774-47133507 [Contig_View]  IGF2BP1 [Vega]
ICGC DataPortalENSG00000159217
TCGA cBioPortalIGF2BP1
AceView (NCBI)IGF2BP1
Genatlas (Paris)IGF2BP1
WikiGenes10642
SOURCE (Princeton)IGF2BP1
Genetics Home Reference (NIH)IGF2BP1
Genomic and cartography
GoldenPath hg19 (UCSC)IGF2BP1  -     chr17:47074774-47133507 +  17q21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IGF2BP1  -     17q21.32   [Description]    (hg38-Dec_2013)
EnsemblIGF2BP1 - 17q21.32 [CytoView hg19]  IGF2BP1 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIIGF2BP1 [Mapview hg19]  IGF2BP1 [Mapview hg38]
OMIM608288   
Gene and transcription
Genbank (Entrez)AF117106 AF198254 AK022617 AK022784 AK074915
RefSeq transcript (Entrez)NM_001160423 NM_006546
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGF2BP1
Cluster EST : UnigeneHs.144936 [ NCBI ]
CGAP (NCI)Hs.144936
Alternative Splicing GalleryENSG00000159217
Gene ExpressionIGF2BP1 [ NCBI-GEO ]   IGF2BP1 [ EBI - ARRAY_EXPRESS ]   IGF2BP1 [ SEEK ]   IGF2BP1 [ MEM ]
Gene Expression Viewer (FireBrowse)IGF2BP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10642
GTEX Portal (Tissue expression)IGF2BP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZI8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZI8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZI8
Splice isoforms : SwissVarQ9NZI8
PhosPhoSitePlusQ9NZI8
Domaine pattern : Prosite (Expaxy)KH_TYPE_1 (PS50084)    RRM (PS50102)   
Domains : Interpro (EBI)KH_dom    KH_dom_type_1    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)KH_1 (PF00013)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00013    pfam00076   
Domain families : Smart (EMBL)KH (SM00322)  RRM (SM00360)  
Conserved Domain (NCBI)IGF2BP1
DMDM Disease mutations10642
Blocks (Seattle)IGF2BP1
PDB (SRS)3KRM   
PDB (PDBSum)3KRM   
PDB (IMB)3KRM   
PDB (RSDB)3KRM   
Structural Biology KnowledgeBase3KRM   
SCOP (Structural Classification of Proteins)3KRM   
CATH (Classification of proteins structures)3KRM   
SuperfamilyQ9NZI8
Human Protein AtlasENSG00000159217
Peptide AtlasQ9NZI8
HPRD09752
IPIIPI00008557   IPI00930694   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZI8
IntAct (EBI)Q9NZI8
FunCoupENSG00000159217
BioGRIDIGF2BP1
STRING (EMBL)IGF2BP1
ZODIACIGF2BP1
Ontologies - Pathways
QuickGOQ9NZI8
Ontology : AmiGOnucleotide binding  mRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  gene expression  cytoplasmic stress granule  regulation of mRNA stability involved in response to stress  negative regulation of translation  pallium cell proliferation in forebrain  lamellipodium  filopodium  axon  growth cone  intracellular ribonucleoprotein complex  regulation of cytokine biosynthetic process  dendritic spine  poly(A) RNA binding  translation regulator activity  mRNA 5'-UTR binding  perinuclear region of cytoplasm  mRNA transport  CRD-mediated mRNA stabilization  CRD-mediated mRNA stability complex  neuronal stem cell population maintenance  
Ontology : EGO-EBInucleotide binding  mRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  gene expression  cytoplasmic stress granule  regulation of mRNA stability involved in response to stress  negative regulation of translation  pallium cell proliferation in forebrain  lamellipodium  filopodium  axon  growth cone  intracellular ribonucleoprotein complex  regulation of cytokine biosynthetic process  dendritic spine  poly(A) RNA binding  translation regulator activity  mRNA 5'-UTR binding  perinuclear region of cytoplasm  mRNA transport  CRD-mediated mRNA stabilization  CRD-mediated mRNA stability complex  neuronal stem cell population maintenance  
Pathways : KEGGMicroRNAs in cancer   
REACTOMEQ9NZI8 [protein]
REACTOME PathwaysR-HSA-5687128 [pathway]
NDEx NetworkIGF2BP1
Atlas of Cancer Signalling NetworkIGF2BP1
Wikipedia pathwaysIGF2BP1
Orthology - Evolution
OrthoDB10642
GeneTree (enSembl)ENSG00000159217
Phylogenetic Trees/Animal Genes : TreeFamIGF2BP1
HOVERGENQ9NZI8
HOGENOMQ9NZI8
Homologs : HomoloGeneIGF2BP1
Homology/Alignments : Family Browser (UCSC)IGF2BP1
Gene fusions - Rearrangements
Fusion : MitelmanIGH/IGF2BP1 [14q32.33/17q21.32]  [t(14;17)(q32;q21)]  
Fusion : MitelmanKAT7/IGF2BP1 [17q21.33/17q21.32]  [t(17;17)(q21;q21)]  
Fusion : MitelmanPRKCA/IGF2BP1 [17q24.2/17q21.32]  [t(17;17)(q21;q24)]  
Fusion : MitelmanRAI1/IGF2BP1 [17p11.2/17q21.32]  [t(17;17)(p11;q21)]  
Fusion : MitelmanZBTB8OS/IGF2BP1 [1p35.1/17q21.32]  [t(1;17)(p35;q21)]  
Fusion: TCGAKAT7 17q21.33 IGF2BP1 17q21.32 THCA
Fusion: TCGAPRKCA 17q24.2 IGF2BP1 17q21.32 BRCA
Fusion: TCGARAI1 17p11.2 IGF2BP1 17q21.32 BRCA
Fusion: TCGAZBTB8OS 1p35.1 IGF2BP1 17q21.32 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGF2BP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGF2BP1
dbVarIGF2BP1
ClinVarIGF2BP1
1000_GenomesIGF2BP1 
Exome Variant ServerIGF2BP1
ExAC (Exome Aggregation Consortium)IGF2BP1 (select the gene name)
Genetic variants : HAPMAP10642
Genomic Variants (DGV)IGF2BP1 [DGVbeta]
DECIPHER (Syndromes)17:47074774-47133507  ENSG00000159217
CONAN: Copy Number AnalysisIGF2BP1 
Mutations
ICGC Data PortalIGF2BP1 
TCGA Data PortalIGF2BP1 
Broad Tumor PortalIGF2BP1
OASIS PortalIGF2BP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGF2BP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGF2BP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch IGF2BP1
DgiDB (Drug Gene Interaction Database)IGF2BP1
DoCM (Curated mutations)IGF2BP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGF2BP1 (select a term)
intoGenIGF2BP1
NCG5 (London)IGF2BP1
Cancer3DIGF2BP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608288   
Orphanet
MedgenIGF2BP1
Genetic Testing Registry IGF2BP1
NextProtQ9NZI8 [Medical]
TSGene10642
GENETestsIGF2BP1
Huge Navigator IGF2BP1 [HugePedia]
snp3D : Map Gene to Disease10642
BioCentury BCIQIGF2BP1
ClinGenIGF2BP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10642
Chemical/Pharm GKB GenePA143485501
Clinical trialIGF2BP1
Miscellaneous
canSAR (ICR)IGF2BP1 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGF2BP1
EVEXIGF2BP1
GoPubMedIGF2BP1
iHOPIGF2BP1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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