Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IL17F (interleukin 17F)

Written2013-09Seon Hee Chang
Department of Immunology, Center for Inflammation, Cancer, MD Anderson Cancer Center, Houston, TX, USA

(Note : for Links provided by Atlas : click)


HGNC (Hugo) IL17F
HGNC Alias symbIL-17F
LocusID (NCBI) 112744
Atlas_Id 42935
Location 6p12.2  [Link to chromosome band 6p12]
Location_base_pair Starts at 52236684 and ends at 52244500 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping IL17F.png]
Local_order Centromere - PKHD1 (polycystic kidney and hepatic diseases 1) - MIR206 (microRNA 206) - MIR133B (microRNA 133b) - IL17A (interleukin 17) - IL17F - SLC25A20P1 (solute carrier family 25, member 20 pseudogene 1) - MCM3 (minichromosome maintenance complex component 3) - Telomere.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
USP38 (4q31.21) / IL17F (6p12.2)


  IL17F gene. The IL17F gene spans a region of 7.86 kb composed of the three exons (untranslated region (UTR), light blue; coding region, red) and two introns (green). Exons 1, 2, and 3 are 141 bp (108 bp 5' UTR plus 33 bp coding region), 221 bp (all coding region), and 488 bp (238 bp coding region plus 250 bp 3' UTR) in length, respectively. The two introns are 5446 bp and 1561 bp in length, respectively.
Description The gene spans a region of 7857 bases and the coding part is divided into three exons.
Transcription The 492-nucleotide transcript encodes a protein of 163 amino acid residues. The first and last exons are partially untranslated.
Pseudogene None described so far.


  Crystal structure of IL-17F at 2.85 A resomution. Adapted from PDB (access number: 1JPY).
Description Each IL-17F monomer forms homodimer with another IL-17F or heteromer with IL-17A (Chang and Dong, 2007; Wright et al., 2007). Calculated molecular weight of IL-17F monomer is a 15-kD. In non-reducing SDS-PAGE gel, IL-17F homodimer runs between 35 to 50kD depending on the level of glycosylation (Wright et al., 2007).
  IL-17F protein. IL-17F protein (163 amino acids) is composed of a signal peptide (orange, 30 amino acids) and a mature peptide (blue, 133 amino acids). Four conserved cysteine residues form intra-chain disulfide bonds (Cys102/Cys152 and Cys107/Cys154). Other two cysteines (Cys47 and Cys137) participate in homodimer formation via inter-chain disulfide bonds (Hymowitz et al., 2001). There is an intersubunit disulfide linkage between Cys47 from IL-17F and Cys129 from IL-17A. The presence of another intersubunit disulfide bond between Cys137 (IL-17F) and Cys33 (IL-17A) was also reported (Wright et al., 2007).
Expression Compared to IL-17 expression, IL-17F was detected more broadly in different tissues (Kawaguchi et al., 2001). In lymphoid lineages, IL-17F expression is tightly regulated. Results from IL-17FRFP reporter mouse or intracellular cytokine staining of IL-17F indicate that differentiated CD4 helper T cell Th17 cells, lamina propria CD4 T cells, memory CD4 T cells, γδ T cells, iNKT cells, and innate lymphoid cells (ILC3) produce IL-17F (Cua and Tato, 2010; Pantelyushin et al., 2012; Yang et al., 2008b). Regulation of IL-17F closely resembles its homologous protein IL-17A. In addition to TCR stimulation, TGFβ, IL-6, IL-23 and IL-1β are necessary to shape naïve CD4 T cells to Th17 cells. Transcription factors STAT3 and RORγτ are essential for production of IL-17F as well as IL-17 (Martinez et al., 2008; Peters et al., 2011; Zhou and Littman, 2009). IL-17F expression by either ILC3 or γδ T is induced by IL-1β or IL-23 (Geremia et al., 2011; Sutton et al., 2009). While IL-17A production from iNKT cells is independent from IL-6 (Doisne et al., 2009) and required TGFβ and IL-1β (Monteiro et al., 2013), it is not clear whether IL-17F expression is regulated by the same cytokines in iNKT cells.
Distinctive regulatory pathways of IL-17F have been reported. Itk-mediated activation of NFATc1 upon TCR stimulation induces IL-17A but not IL-17F (Gomez-Rodriguez et al., 2009). Conserved noncoding sites (CNS)2 in the Il17-Il17f locus is required for IL-17A expression but partially required for IL-17F expression, indicating other regulatory elements are involved in the regulation of IL-17F expression (Wang et al., 2012). While signaling pathways or transcription factors governing γδ T cells (Korn and Petermann, 2012) or iNKT cells producing IL-17A (Engel et al., 2012; Watarai et al., 2012) were reported before, the specific regulatory pathways of IL-17F in these innate cells remain elusive.
IL-17A production is restricted to lymphoid lineages but IL-17F was reported to be expressed by non-lymphoid cells that do not express IL-17A, such as human colonic epithelial cells (Tong et al., 2012). IL-17F is produced by non-T, non-B innate immune cells and mouse colonic epithelial cells in response to infection with C. rodentium (Ishigame et al., 2009). IL-17F is predominantly expressed in bronchial epithelial cells in addition to the infiltrating inflammatory cells upon asthma induction (Suzuki et al., 2007).
Localisation IL-17F is a secreted protein.
Function IL-17F exerts its biological effects through the IL-17RA/RC signaling complex. While the expression of IL-17RA is universal, IL-17RC expression is largely restricted to epithelial cells, fibroblasts and other stromal cells. IL-17RA/RC complex recruits an adaptor molecule, Act1, for signaling (Chang et al., 2006; Qian et al., 2007). Upon binding IL-17F, IL-17RA/RC can activate NF-kB and MAPK pathways. IL-17F shares the receptor complex with IL-17A homodimer and IL-17A/F heterodimer. They do not compete for the binding to the receptor complex since these cytokines together in the culture resulted in additive effects on production of pro-inflammatory molecules. Binding affinity of IL-17F to IL-17RA is weaker compared to IL-17F binding to IL-17RC (Kuestner et al., 2007). A crystal structure revealed that IL-17RA bound to IL-17F in a 1:2 stoichiometry and IL-17RA - IL-17F complex prefers to form heterodimers with a second receptor, IL-17RC, possibly due to steric hindrance (Ely et al., 2009).
Homology IL-17A is the most homologues protein.


Note Familial chronic mucocutaneous candidiasis-6 (CANDF6) is caused by heterozygous ser65-to-leu mutation in the IL17F gene (Puel et al., 2011).
Chronic mucocutaneous candidiasis (CMC) is characterized by infections of the skin, nails, and oral and genital mucosae with Candida albicans, which is commensal in healthy individuals. S65L IL-17F behaves dominant-negative IL17F allele, which impairs the receptor binding and bioactivity of both IL-17F homodimers and IL-17A - IL-17F heterodimers.
A coding region variant (His161Arg) of IL-17F gene, possibly encoding an antagonist for IL-17F, has been linked to asthma patients in Japanese populations (Kawaguchi et al., 2006).

Implicated in

Entity Host defense against infections
Note IL-17F expression has been detected in various types of infections. So far, IL-17F has been mainly involved in mucosal host defense mechanisms. IL-17F deficient mice are susceptible in C. rodentium infection and defective in producing β defensin during the infection (Ishigame et al., 2009). IL-17F is also required to protect the mice against mucocutaneous S. aureus infections (Ishigame et al., 2009).
Entity Intestinal inflammation
Note In acute colitis model using dextran sulfate sodium, IL-17F deficiency resulted in reduced colitis symptoms (Yang et al., 2008a). This phenotype is opposite to IL-17 deficiency, where IL-17 knockout mice developed more severe colitis. However, in chronic colitis using CD4 transfer system, pathology was mediated by redundant effects of IL-17A and IL-17F (Leppkes et al., 2009), suggesting therapeutic blocking of both IL-17A and IL-17F is likely to be required to suppress the inflammation in colon.
Entity Colon cancer
Note IL-17F deficiency resulted in increased colonic tumor numbers. IL-17F is expressed in normal human colonic epithelial cells, but this expression is greatly decreased in colon cancer tissues in this study (Tong et al., 2012).
Entity Autoimmune diseases
Note In experimental autoimmune encephalitis, IL-17F is not required for the initiation of the disease (Yang et al., 2008a) and may play a redundant role in promoting inflammation (Haak et al., 2009). IL-17F is not required to induce inflammation either in collagen induced arthritis model, or arthritis model using IL-1rn deficient mice (Ishigame et al., 2009).
Entity Lung inflammations
Note IL-17F has been detected in the lungs from asthma and COPD. IL-17F was detected in BALF of allergic patients (Kawaguchi et al., 2001) or bronchial epithelial cells after asthma induction (Suzuki et al., 2007). The role of IL-17F in allergic asthma has been argued. While several studies have shown that IL-17A and IL-17F are dispensable or negative regulator in eosinophilia of allergic asthma (Schnyder-Candrian et al., 2006; Suzukawa et al., 2012), asthmatic inflammation is heterogeneous. Steroid-resistant airway inflammation, airway remodeling, or airway hyperreactivity during asthmatic inflammation were reported to be dependent on Th17 or IL-17A (Kudo et al., 2012; Lajoie et al., 2010; McKinley et al., 2008; Pichavant et al., 2008). IL-17F, on the other hand, was required for neutrophil recruitment upon acute allergen challenge (Yang et al., 2008a).


A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses.
Chang SH, Dong C.
Cell Res. 2007 May;17(5):435-40.
PMID 17452998
Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor.
Chang SH, Park H, Dong C.
J Biol Chem. 2006 Nov 24;281(47):35603-7. Epub 2006 Oct 11.
PMID 17035243
Innate IL-17-producing cells: the sentinels of the immune system.
Cua DJ, Tato CM.
Nat Rev Immunol. 2010 Jul;10(7):479-89. doi: 10.1038/nri2800. Epub 2010 Jun 18. (REVIEW)
PMID 20559326
Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions.
Doisne JM, Becourt C, Amniai L, Duarte N, Le Luduec JB, Eberl G, Benlagha K.
J Immunol. 2009 Aug 1;183(3):2142-9. doi: 10.4049/jimmunol.0901059. Epub 2009 Jul 8.
PMID 19587013
Structural basis of receptor sharing by interleukin 17 cytokines.
Ely LK, Fischer S, Garcia KC.
Nat Immunol. 2009 Dec;10(12):1245-51. doi: 10.1038/ni.1813. Epub 2009 Oct 18.
PMID 19838198
The transcription factor Th-POK negatively regulates Th17 differentiation in V?14i NKT cells.
Engel I, Zhao M, Kappes D, Taniuchi I, Kronenberg M.
Blood. 2012 Nov 29;120(23):4524-32. doi: 10.1182/blood-2012-01-406280. Epub 2012 Oct 3.
PMID 23034280
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease.
Geremia A, Arancibia-Carcamo CV, Fleming MP, Rust N, Singh B, Mortensen NJ, Travis SP, Powrie F.
J Exp Med. 2011 Jun 6;208(6):1127-33. doi: 10.1084/jem.20101712. Epub 2011 May 16.
PMID 21576383
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Gomez-Rodriguez J, Sahu N, Handon R, Davidson TS, Anderson SM, Kirby MR, August A, Schwartzberg PL.
Immunity. 2009 Oct 16;31(4):587-97. doi: 10.1016/j.immuni.2009.07.009. Epub 2009 Oct 8.
PMID 19818650
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice.
Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, Becher B, Waisman A.
J Clin Invest. 2009 Jan;119(1):61-9. doi: 10.1172/JCI35997. Epub 2008 Dec 15.
PMID 19075395
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA.
EMBO J. 2001 Oct 1;20(19):5332-41.
PMID 11574464
Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.
Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y.
Immunity. 2009 Jan 16;30(1):108-19. doi: 10.1016/j.immuni.2008.11.009.
PMID 19144317
IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity.
Kawaguchi M, Takahashi D, Hizawa N, Suzuki S, Matsukura S, Kokubu F, Maeda Y, Fukui Y, Konno S, Huang SK, Nishimura M, Adachi M.
J Allergy Clin Immunol. 2006 Apr;117(4):795-801. Epub 2006 Feb 14.
PMID 16630936
Development and function of interleukin 17-producing ?? T cells.
Korn T, Petermann F.
Ann N Y Acad Sci. 2012 Jan;1247:34-45. doi: 10.1111/j.1749-6632.2011.06355.x. Epub 2012 Jan 12. (REVIEW)
PMID 22239719
IL-17A produced by ?? T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D.
Nat Med. 2012 Mar 4;18(4):547-54. doi: 10.1038/nm.2684.
PMID 22388091
Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.
Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD.
J Immunol. 2007 Oct 15;179(8):5462-73.
PMID 17911633
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.
Lajoie S, Lewkowich IP, Suzuki Y, Clark JR, Sproles AA, Dienger K, Budelsky AL, Wills-Karp M.
Nat Immunol. 2010 Oct;11(10):928-35. doi: 10.1038/ni.1926. Epub 2010 Aug 29.
PMID 20802484
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.
Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF.
Gastroenterology. 2009 Jan;136(1):257-67. doi: 10.1053/j.gastro.2008.10.018. Epub 2008 Oct 9.
PMID 18992745
Regulation and function of proinflammatory TH17 cells.
Martinez GJ, Nurieva RI, Yang XO, Dong C.
Ann N Y Acad Sci. 2008 Nov;1143:188-211. doi: 10.1196/annals.1443.021. (REVIEW)
PMID 19076351
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK.
J Immunol. 2008 Sep 15;181(6):4089-97.
PMID 18768865
Induced IL-17-producing invariant NKT cells require activation in presence of TGF-β and IL-1β.
Monteiro M, Almeida CF, Agua-Doce A, Graca L.
J Immunol. 2013 Jan 15;190(2):805-11. doi: 10.4049/jimmunol.1201010.
PMID 23293359
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice.
Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA, Becher B.
J Clin Invest. 2012 Jun 1;122(6):2252-6. doi: 10.1172/JCI61862. Epub 2012 May 1.
PMID 22546855
The many faces of Th17 cells.
Peters A, Lee Y, Kuchroo VK.
Curr Opin Immunol. 2011 Dec;23(6):702-6. doi: 10.1016/j.coi.2011.08.007. Epub 2011 Sep 6. (REVIEW)
PMID 21899997
Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.
Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, DeKruyff RH, Shore SA, Umetsu DT.
J Exp Med. 2008 Feb 18;205(2):385-93. doi: 10.1084/jem.20071507. Epub 2008 Feb 4.
PMID 18250191
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity.
Puel A, Cypowyj S, Bustamante J, Wright JF, Liu L, Lim HK, Migaud M, Israel L, Chrabieh M, Audry M, Gumbleton M, Toulon A, Bodemer C, El-Baghdadi J, Whitters M, Paradis T, Brooks J, Collins M, Wolfman NM, Al-Muhsen S, Galicchio M, Abel L, Picard C, Casanova JL.
Science. 2011 Apr 1;332(6025):65-8. doi: 10.1126/science.1200439. Epub 2011 Feb 24.
PMID 21350122
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.
Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D, Xiao J, Lu Y, Giltiay N, Liu J, Kordula T, Zhang QW, Vallance B, Swaidani S, Aronica M, Tuohy VK, Hamilton T, Li X.
Nat Immunol. 2007 Mar;8(3):247-56. Epub 2007 Feb 4.
PMID 17277779
Interleukin-17 is a negative regulator of established allergic asthma.
Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B.
J Exp Med. 2006 Nov 27;203(12):2715-25. Epub 2006 Nov 13.
PMID 17101734
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.
Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH.
Immunity. 2009 Aug 21;31(2):331-41. doi: 10.1016/j.immuni.2009.08.001. Epub 2009 Aug 13.
PMID 19682929
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S.
J Immunol. 2012 Oct 1;189(7):3641-52. Epub 2012 Aug 31.
PMID 22942422
Expression of interleukin-17F in a mouse model of allergic asthma.
Suzuki S, Kokubu F, Kawaguchi M, Homma T, Odaka M, Watanabe S, Ieki K, Matsukura S, Kurokawa M, Takeuchi H, Sasaki Y, Huang SK, Adachi M, Ota H.
Int Arch Allergy Immunol. 2007;143 Suppl 1:89-94. Epub 2007 May 1.
PMID 17541285
A protective role by interleukin-17F in colon tumorigenesis.
Tong Z, Yang XO, Yan H, Liu W, Niu X, Shi Y, Fang W, Xiong B, Wan Y, Dong C.
PLoS One. 2012;7(4):e34959. doi: 10.1371/journal.pone.0034959. Epub 2012 Apr 11.
PMID 22509371
Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.
Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten AM, Dong C.
Immunity. 2012 Jan 27;36(1):23-31. doi: 10.1016/j.immuni.2011.10.019. Epub 2012 Jan 12.
PMID 22244845
Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines.
Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M.
PLoS Biol. 2012 Feb;10(2):e1001255. doi: 10.1371/journal.pbio.1001255. Epub 2012 Feb 7.
PMID 22346732
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells.
Wright JF, Guo Y, Quazi A, Luxenberg DP, Bennett F, Ross JF, Qiu Y, Whitters MJ, Tomkinson KN, Dunussi-Joannopoulos K, Carreno BM, Collins M, Wolfman NM.
J Biol Chem. 2007 May 4;282(18):13447-55. Epub 2007 Mar 13.
PMID 17355969
Regulation of inflammatory responses by IL-17F.
Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C.
J Exp Med. 2008a May 12;205(5):1063-75. doi: 10.1084/jem.20071978. Epub 2008 Apr 14.
PMID 18411338
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.
Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C.
Immunity. 2008b Jul 18;29(1):44-56. doi: 10.1016/j.immuni.2008.05.007. Epub 2008 Jun 26.
PMID 18585065
Transcriptional regulatory networks in Th17 cell differentiation.
Zhou L, Littman DR.
Curr Opin Immunol. 2009 Apr;21(2):146-52. doi: 10.1016/j.coi.2009.03.001. Epub 2009 Mar 26. (REVIEW)
PMID 19328669


This paper should be referenced as such :
Chang, SH
IL17F (interleukin 17F)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(4):264-268.
Free journal version : [ pdf ]   [ DOI ]

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;6)(q31;p12) USP38/IL17F

External links

HGNC (Hugo)IL17F   16404
LRG (Locus Reference Genomic)LRG_356
Entrez_Gene (NCBI)IL17F    interleukin 17F
AliasesCANDF6; IL-17F; ML-1; ML1
GeneCards (Weizmann)IL17F
Ensembl hg19 (Hinxton)ENSG00000112116 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112116 [Gene_View]  ENSG00000112116 [Sequence]  chr6:52236684-52244500 [Contig_View]  IL17F [Vega]
ICGC DataPortalENSG00000112116
TCGA cBioPortalIL17F
AceView (NCBI)IL17F
Genatlas (Paris)IL17F
SOURCE (Princeton)IL17F
Genetics Home Reference (NIH)IL17F
Genomic and cartography
GoldenPath hg38 (UCSC)IL17F  -     chr6:52236684-52244500 -  6p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL17F  -     6p12.2   [Description]    (hg19-Feb_2009)
GoldenPathIL17F - 6p12.2 [CytoView hg19]  IL17F - 6p12.2 [CytoView hg38]
genome Data Viewer NCBIIL17F [Mapview hg19]  
OMIM606496   613956   
Gene and transcription
Genbank (Entrez)AF332389 AF384857 BC070124 JF305974
RefSeq transcript (Entrez)NM_052872
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL17F
Alternative Splicing GalleryENSG00000112116
Gene ExpressionIL17F [ NCBI-GEO ]   IL17F [ EBI - ARRAY_EXPRESS ]   IL17F [ SEEK ]   IL17F [ MEM ]
Gene Expression Viewer (FireBrowse)IL17F [ Firebrowse - Broad ]
GenevisibleExpression of IL17F in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112744
GTEX Portal (Tissue expression)IL17F
Human Protein AtlasENSG00000112116-IL17F [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PD4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PD4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PD4
Splice isoforms : SwissVarQ96PD4
Domains : Interpro (EBI)Cystine-knot_cytokine    IL-17_chr    IL-17_fam   
Domain families : Pfam (Sanger)IL17 (PF06083)   
Domain families : Pfam (NCBI)pfam06083   
Conserved Domain (NCBI)IL17F
Blocks (Seattle)IL17F
PDB (RSDB)1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
PDB Europe1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
PDB (PDBSum)1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
PDB (IMB)1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
Structural Biology KnowledgeBase1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
SCOP (Structural Classification of Proteins)1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
CATH (Classification of proteins structures)1JPY    3JVF    5N92    5NAN    6HGO    6PPG   
Human Protein Atlas [tissue]ENSG00000112116-IL17F [tissue]
Peptide AtlasQ96PD4
Protein Interaction databases
IntAct (EBI)Q96PD4
Ontologies - Pathways
Ontology : AmiGOcytokine activity  cytokine receptor binding  protein binding  extracellular region  extracellular region  extracellular space  inflammatory response  negative regulation of angiogenesis  regulation of transforming growth factor beta receptor signaling pathway  cytokine-mediated signaling pathway  cytokine binding  cytokine biosynthetic process  lymphotoxin A biosynthetic process  protein homodimerization activity  regulation of interleukin-2 biosynthetic process  regulation of interleukin-6 biosynthetic process  regulation of interleukin-8 biosynthetic process  regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  positive regulation of transcription by RNA polymerase II  cartilage development  interleukin-17-mediated signaling pathway  positive regulation of cytokine production involved in inflammatory response  positive regulation of interleukin-6 secretion  
Ontology : EGO-EBIcytokine activity  cytokine receptor binding  protein binding  extracellular region  extracellular region  extracellular space  inflammatory response  negative regulation of angiogenesis  regulation of transforming growth factor beta receptor signaling pathway  cytokine-mediated signaling pathway  cytokine binding  cytokine biosynthetic process  lymphotoxin A biosynthetic process  protein homodimerization activity  regulation of interleukin-2 biosynthetic process  regulation of interleukin-6 biosynthetic process  regulation of interleukin-8 biosynthetic process  regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  positive regulation of transcription by RNA polymerase II  cartilage development  interleukin-17-mediated signaling pathway  positive regulation of cytokine production involved in inflammatory response  positive regulation of interleukin-6 secretion  
Pathways : KEGGInflammatory bowel disease (IBD)   
REACTOMEQ96PD4 [protein]
REACTOME PathwaysR-HSA-6785807 [pathway]   
NDEx NetworkIL17F
Atlas of Cancer Signalling NetworkIL17F
Wikipedia pathwaysIL17F
Orthology - Evolution
GeneTree (enSembl)ENSG00000112116
Phylogenetic Trees/Animal Genes : TreeFamIL17F
Homologs : HomoloGeneIL17F
Homology/Alignments : Family Browser (UCSC)IL17F
Gene fusions - Rearrangements
Fusion : MitelmanUSP38/IL17F [4q31.21/6p12.2]  
Fusion PortalUSP38 4q31.21 IL17F 6p12.2 BLCA
Fusion : Fusion_HubUSP38--IL17F   
Fusion : QuiverIL17F
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL17F [hg38]
Exome Variant ServerIL17F
GNOMAD BrowserENSG00000112116
Varsome BrowserIL17F
Genomic Variants (DGV)IL17F [DGVbeta]
DECIPHERIL17F [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL17F 
ICGC Data PortalIL17F 
TCGA Data PortalIL17F 
Broad Tumor PortalIL17F
OASIS PortalIL17F [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL17F  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL17F
Mutations and Diseases : HGMDIL17F
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch IL17F
DgiDB (Drug Gene Interaction Database)IL17F
DoCM (Curated mutations)IL17F (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL17F (select a term)
NCG6 (London) select IL17F
Cancer3DIL17F(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM606496    613956   
Genetic Testing Registry IL17F
NextProtQ96PD4 [Medical]
Target ValidationIL17F
Huge Navigator IL17F [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA29800
Clinical trialIL17F
canSAR (ICR)IL17F (select the gene name)
DataMed IndexIL17F
PubMed195 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Feb 19 17:52:49 CET 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us