| Identity |
| HGNC (Hugo) | IL3 |
| Location | 5q31 |
| Location_base_pair | Starts at 131396347 and ends at 131398896 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Description | 5 exons |
| Transcription | 674 bp transcript with a 458 bp of coding sequence |
| Protein |
| Description | 152 amino acids; 17 kDa |
| Expression | IL3 is produced by activated T cells, monocytes/macrophages and stroma cells |
| Function | cytokine; multipotent hematopoietic growth factor; induces proliferation, maturation and probably self-renewal of pluripotent hematopoietic stem cells and cells of myeloid, erythroid and megakaryocytic lineages; IL-3 plays a more specialized role on basophil and mast cells; role through activation of the IL-3 receptor (IL-3R) complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5 , and induction of c-myc (cell-cycle progression and DNA synthesis), and activation of the Ras pathway (suppression of apoptosis); IL3 and GM-CSF have overlapping but distinct biological properties |
| Implicated in |
| Entity | t(5;14)(q31;q32) |
| Disease | B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia |
| Prognosis | poor |
| Cytogenetics | t(5;14) may be the sole anomaly or accompanied with other anomalies |
| Hybrid/Mutated Gene | break in the promoter region of IL3 and in the Jh region of IgH |
| Abnormal Protein | the immunoglobulin gene promoter controls the expression of IL3 |
| Oncogenesis | over-expression of IL3 |
| External links |
| Bibliography |
| Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. |
| Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG |
| Cell. 1986 ; 47 (1) : 3-10. |
| PMID 3489530 |
| The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. |
| Grimaldi JC, Meeker TC |
| Blood. 1989 ; 73 (8) : 2081-2085. |
| PMID 2499362 |
| Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression. |
| Nimer SD, Uchida H |
| Stem cells (Dayton, Ohio). 1995 ; 13 (4) : 324-335. |
| PMID 7549890 |
| Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. |
| Hara T, Miyajima A |
| Stem cells (Dayton, Ohio). 1996 ; 14 (6) : 605-618. |
| PMID 8948019 |
| The physiologic role of interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, and the beta c receptor system. |
| Burdach S, Nishinakamura R, Dirksen U, Murray R |
| Current opinion in hematology. 1998 ; 5 (3) : 177-180. |
| PMID 9664156 |
| Interleukin-3 in hematology and oncology: current state of knowledge and future directions. |
| Mangi MH, Newland AC |
| Cytokines, cellular & molecular therapy. 1999 ; 5 (2) : 87-95. |
| PMID 10515681 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 12-1999 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . IL3 (interleukin-3). Atlas Genet Cytogenet Oncol Haematol. December 1999 . URL : http://AtlasGeneticsOncology.org/Genes/IL3ID60.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jul 15 14:46:08 CEST 2010 |
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