Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
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IL3 (interleukin-3)


HGNC (Hugo) IL3
LocusID (NCBI) 3562
Location 5q31.1
Location_base_pair Starts at 131396347 and ends at 131398896 bp from pter ( according to hg19-Feb_2009)  [Mapping]


Description 5 exons
Transcription 674 bp transcript with a 458 bp of coding sequence


Description 152 amino acids; 17 kDa
Expression IL3 is produced by activated T cells, monocytes/macrophages and stroma cells
Function cytokine; multipotent hematopoietic growth factor; induces proliferation, maturation and probably self-renewal of pluripotent hematopoietic stem cells and cells of myeloid, erythroid and megakaryocytic lineages; IL-3 plays a more specialized role on basophil and mast cells; role through activation of the IL-3 receptor (IL-3R) complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5 , and induction of c-myc (cell-cycle progression and DNA synthesis), and activation of the Ras pathway (suppression of apoptosis); IL3 and GM-CSF have overlapping but distinct biological properties

Implicated in

Entity t(5;14)(q31;q32)
Disease B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Prognosis poor
Cytogenetics t(5;14) may be the sole anomaly or accompanied with other anomalies
Hybrid/Mutated Gene break in the promoter region of IL3 and in the Jh region of IgH
Abnormal Protein the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis over-expression of IL3

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030

External links

HGNC (Hugo)IL3   6011
Entrez_Gene (NCBI)IL3  3562  interleukin 3
GeneCards (Weizmann)IL3
Ensembl hg19 (Hinxton)ENSG00000164399 [Gene_View]  chr5:131396347-131398896 [Contig_View]  IL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164399 [Gene_View]  chr5:131396347-131398896 [Contig_View]  IL3 [Vega]
ICGC DataPortalENSG00000164399
AceView (NCBI)IL3
Genatlas (Paris)IL3
SOURCE (Princeton)IL3
Genomic and cartography
GoldenPath hg19 (UCSC)IL3  -     chr5:131396347-131398896 +  5q23-q31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IL3  -     5q23-q31   [Description]    (hg38-Dec_2013)
EnsemblIL3 - 5q23-q31 [CytoView hg19]  IL3 - 5q23-q31 [CytoView hg38]
Mapping of homologs : NCBIIL3 [Mapview hg19]  IL3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)BC066272 BC066273 BC066274 BC066275 BC066276
RefSeq transcript (Entrez)NM_000588
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NT_034772 NW_001838952 NW_004929323
Consensus coding sequences : CCDS (NCBI)IL3
Cluster EST : UnigeneHs.694 [ NCBI ]
CGAP (NCI)Hs.694
Alternative Splicing : Fast-db (Paris)GSHG0024217
Alternative Splicing GalleryENSG00000164399
Gene ExpressionIL3 [ NCBI-GEO ]     IL3 [ SEEK ]   IL3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08700 (Uniprot)
NextProtP08700  [Medical]
With graphics : InterProP08700
Splice isoforms : SwissVarP08700 (Swissvar)
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    IL-3   
Related proteins : CluSTrP08700
Domain families : Pfam (Sanger)IL3 (PF02059)   
Domain families : Pfam (NCBI)pfam02059   
DMDM Disease mutations3562
Blocks (Seattle)P08700
Human Protein AtlasENSG00000164399
Peptide AtlasP08700
Protein Interaction databases
IntAct (EBI)P08700
Ontologies - Pathways
Ontology : AmiGOcytokine activity  interleukin-3 receptor binding  extracellular region  extracellular space  immune response  cell-cell signaling  nervous system development  growth factor activity  positive regulation of cell proliferation  embryonic hemopoiesis  positive regulation of tyrosine phosphorylation of Stat5 protein  positive regulation of DNA replication  positive regulation of peptidyl-tyrosine phosphorylation  
Ontology : EGO-EBIcytokine activity  interleukin-3 receptor binding  extracellular region  extracellular space  immune response  cell-cell signaling  nervous system development  growth factor activity  positive regulation of cell proliferation  embryonic hemopoiesis  positive regulation of tyrosine phosphorylation of Stat5 protein  positive regulation of DNA replication  positive regulation of peptidyl-tyrosine phosphorylation  
Pathways : BIOCARTAErythrocyte Differentiation Pathway [Genes]    Regulation of BAD phosphorylation [Genes]    Cytokine Network [Genes]    The Role of Eosinophils in the Chemokine Network of Allergy [Genes]    Cytokines and Inflammatory Response [Genes]    Regulation of hematopoiesis by cytokines [Genes]    IL 17 Signaling Pathway [Genes]    IL 3 signaling pathway [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Apoptosis    Jak-STAT signaling pathway    Hematopoietic cell lineage    Fc epsilon RI signaling pathway    Transcriptional misregulation in cancer    Asthma   
REACTOMEP08700 [protein]
REACTOME PathwaysREACT_6900 Immune System [pathway]
Protein Interaction DatabaseIL3
DoCM (Curated mutations)IL3
Wikipedia pathwaysIL3
Gene fusion - rearrangements
Rearrangement : TICdb- [-]  -  IL3 [2q33.2]
Polymorphisms : SNP, variants
NCBI Variation ViewerIL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL3
Exome Variant ServerIL3
SNP (GeneSNP Utah)IL3
Genetic variants : HAPMAPIL3
Genomic Variants (DGV)IL3 [DGVbeta]
ICGC Data PortalENSG00000164399 
Somatic Mutations in Cancer : COSMICIL3 
CONAN: Copy Number AnalysisIL3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
DECIPHER (Syndromes)5:131396347-131398896
Mutations and Diseases : HGMDIL3
NextProtP08700 [Medical]
Disease Genetic AssociationIL3
Huge Navigator IL3 [HugePedia]  IL3 [HugeCancerGEM]
snp3D : Map Gene to Disease3562
DGIdb (Drug Gene Interaction db)IL3
General knowledge
Homologs : HomoloGeneIL3
Homology/Alignments : Family Browser (UCSC)IL3
Phylogenetic Trees/Animal Genes : TreeFamIL3
Chemical/Protein Interactions : CTD3562
Chemical/Pharm GKB GenePA29830
Clinical trialIL3
Cancer Resource (Charite)ENSG00000164399
Other databases
PubMed122 Pubmed reference(s) in Entrez


Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.
Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG
Cell. 1986 ; 47 (1) : 3-10.
PMID 3489530
The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.
Grimaldi JC, Meeker TC
Blood. 1989 ; 73 (8) : 2081-2085.
PMID 2499362
Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression.
Nimer SD, Uchida H
Stem cells (Dayton, Ohio). 1995 ; 13 (4) : 324-335.
PMID 7549890
Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis.
Hara T, Miyajima A
Stem cells (Dayton, Ohio). 1996 ; 14 (6) : 605-618.
PMID 8948019
The physiologic role of interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, and the beta c receptor system.
Burdach S, Nishinakamura R, Dirksen U, Murray R
Current opinion in hematology. 1998 ; 5 (3) : 177-180.
PMID 9664156
Interleukin-3 in hematology and oncology: current state of knowledge and future directions.
Mangi MH, Newland AC
Cytokines, cellular & molecular therapy. 1999 ; 5 (2) : 87-95.
PMID 10515681
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI


Written12-1999Jean-Loup Huret


This paper should be referenced as such :
Huret, JL
IL3 (interleukin-3)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):183-184.
Free journal version : [ pdf ]   [ DOI ]

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indexed on : Tue Feb 17 20:20:58 CET 2015

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