IL3 (interleukin-3)

Identity

Hugo	IL3
Location	5q31

DNA/RNA

Description	5 exons
Transcription	674 bp transcript with a 458 bp of coding sequence

Protein

Description	152 amino acids; 17 kDa
Expression	IL3 is produced by activated T cells, monocytes/macrophages and stroma cells
Function	cytokine; multipotent hematopoietic growth factor; induces proliferation, maturation and probably self-renewal of pluripotent hematopoietic stem cells and cells of myeloid, erythroid and megakaryocytic lineages; IL-3 plays a more specialized role on basophil and mast cells; role through activation of the IL-3 receptor (IL-3R) complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5 , and induction of c-myc (cell-cycle progression and DNA synthesis), and activation of the Ras pathway (suppression of apoptosis); IL3 and GM-CSF have overlapping but distinct biological properties

Implicated in

Entity	t(5;14)(q31;q32)
Disease	B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Prognosis	poor
Cytogenetics	t(5;14) may be the sole anomaly or accompanied with other anomalies
Hybrid/Mutated Gene	break in the promoter region of IL3 and in the Jh region of IgH
Abnormal Protein	the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis	over-expression of IL3

External links

	Nomenclature
Hugo	IL3
GDB	IL3
Entrez_Gene	IL3  3562  interleukin 3 (colony-stimulating factor, multiple)
	Cards
Atlas	IL3ID60
GeneCards	IL3
Ensembl	IL3 [Search_View]   ENSG00000164399 [Gene_View]
Genatlas	IL3
GeneLynx	IL3
eGenome	IL3
euGene	3562
	Genomic and cartography
GoldenPath	IL3  -  5q31   chr5:131424246-131426795 +  5q31.1   [Description]    (hg18-Mar_2006)
Ensembl	IL3 - 5q31.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	IL3
	Gene and transcription
Genbank	BC066272 [ ENTREZ ]
Genbank	BC066273 [ ENTREZ ]
Genbank	BC066274 [ ENTREZ ]
Genbank	BC066275 [ ENTREZ ]
Genbank	BC066276 [ ENTREZ ]
RefSeq	NM_000588 [ SRS ]    NM_000588 [ ENTREZ ]
RefSeq	AC_000048 [ SRS ]    AC_000048 [ ENTREZ ]
RefSeq	NC_000005 [ SRS ]    NC_000005 [ ENTREZ ]
RefSeq	NT_034772 [ SRS ]    NT_034772 [ ENTREZ ]
RefSeq	NW_922784 [ SRS ]    NW_922784 [ ENTREZ ]
AceView	IL3 AceView - NCBI
Unigene	Hs.694 [ SRS ]    Hs.694 [ NCBI ]     HS694 [ spliceNest ]
Fast-db	9454 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P08700 [ SRS]    P08700 [ EXPASY ]     P08700 [ INTERPRO ]
Interpro	IPR012351 4_helix_cytokine_core [ SRS ]    IPR012351 4_helix_cytokine_core [ EBI ]
Interpro	IPR002183 Interleukin_3 [ SRS ]    IPR002183 Interleukin_3 [ EBI ]
CluSTr	P08700
Pfam	PF02059 IL3 [ SRS ]    PF02059 IL3 [ Sanger ]    pfam02059 [ NCBI-CDD ]
Blocks	P08700
PDB	1JLI [ SRS ]    1JLI [ PdbSum ],   1JLI [ IMB ]   1JLI [ RSDB ]
HPRD	00987
	Protein Interaction databases
DIP	P08700
IntAct	P08700
	Polymorphism : SNP, mutations, diseases
OMIM	147740    [ map ]
GENECLINICS	147740
SNP	IL3 [dbSNP-NCBI]
SNP	NM_000588 [SNP-NCI]
SNP	IL3 [GeneSNPs - Utah]  IL3] [HGBASE - SRS]
HAPMAP	IL3 [HAPMAP]
HGMD	IL3
	General knowledge
Family Browser	IL3 [UCSC Family Browser]
SOURCE	NM_000588
SMD	Hs.694
SAGE	Hs.694
GO	regulation of cell growth [Amigo]  regulation of cell growth
GO	cytokine activity [Amigo]  cytokine activity
GO	interleukin-3 receptor binding [Amigo]  interleukin-3 receptor binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	immune response [Amigo]  immune response
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	nervous system development [Amigo]  nervous system development
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	response to hormone stimulus [Amigo]  response to hormone stimulus
GO	cytokine and chemokine mediated signaling pathway [Amigo]  cytokine and chemokine mediated signaling pathway
GO	hemopoiesis [Amigo]  hemopoiesis
GO	negative regulation of apoptosis [Amigo]  negative regulation of apoptosis
GO	positive regulation of survival gene product activity [Amigo]  positive regulation of survival gene product activity
GO	positive regulation of JNK cascade [Amigo]  positive regulation of JNK cascade
GO	positive regulation of peptidyl-tyrosine phosphorylation [Amigo]  positive regulation of peptidyl-tyrosine phosphorylation
BIOCARTA	Regulation of BAD phosphorylation    [Genes]
BIOCARTA	Cytokine Network    [Genes]
BIOCARTA	Dendritic cells in regulating TH1 and TH2 Development    [Genes]
BIOCARTA	The Role of Eosinophils in the Chemokine Network of Allergy    [Genes]
BIOCARTA	Erythrocyte Differentiation Pathway    [Genes]
BIOCARTA	IL 17 Signaling Pathway    [Genes]
BIOCARTA	IL 3 signaling pathway    [Genes]
BIOCARTA	Cytokines and Inflammatory Response    [Genes]
BIOCARTA	Regulation of hematopoiesis by cytokines    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	Apoptosis
KEGG	Jak-STAT signaling pathway
KEGG	Hematopoietic cell lineage
KEGG	Fc epsilon RI signaling pathway
PubGene	IL3
TreeFam	IL3
CTD	3562 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	IL3 Related clones (RZPD - Berlin)
	PubMed
PubMed	56 Pubmed reference(s) in LocusLink

Bibliography

Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG

Cell. 1986 ; 47 (1) : 3-10.

PMID 3489530

The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.

Grimaldi JC, Meeker TC

Blood. 1989 ; 73 (8) : 2081-2085.

PMID 2499362

Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression.

Nimer SD, Uchida H

Stem cells (Dayton, Ohio). 1995 ; 13 (4) : 324-335.

PMID 7549890

Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis.

Hara T, Miyajima A

Stem cells (Dayton, Ohio). 1996 ; 14 (6) : 605-618.

PMID 8948019

The physiologic role of interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, and the beta c receptor system.

Burdach S, Nishinakamura R, Dirksen U, Murray R

Current opinion in hematology. 1998 ; 5 (3) : 177-180.

PMID 9664156

Interleukin-3 in hematology and oncology: current state of knowledge and future directions.

Mangi MH, Newland AC

Cytokines, cellular & molecular therapy. 1999 ; 5 (2) : 87-95.

PMID 10515681

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	12-1999	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . IL3 (interleukin-3). Atlas Genet Cytogenet Oncol Haematol. December 1999 . URL : http://AtlasGeneticsOncology.org/Genes/IL3ID60.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:24:12 2008