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IL3 (interleukin-3)

Identity

HGNC (Hugo) IL3
LocusID (NCBI) 3562
Location 5q31.1
Location_base_pair Starts at 131396347 and ends at 131398896 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description 5 exons
Transcription 674 bp transcript with a 458 bp of coding sequence

Protein

Description 152 amino acids; 17 kDa
Expression IL3 is produced by activated T cells, monocytes/macrophages and stroma cells
Function cytokine; multipotent hematopoietic growth factor; induces proliferation, maturation and probably self-renewal of pluripotent hematopoietic stem cells and cells of myeloid, erythroid and megakaryocytic lineages; IL-3 plays a more specialized role on basophil and mast cells; role through activation of the IL-3 receptor (IL-3R) complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5 , and induction of c-myc (cell-cycle progression and DNA synthesis), and activation of the Ras pathway (suppression of apoptosis); IL3 and GM-CSF have overlapping but distinct biological properties

Implicated in

Entity t(5;14)(q31;q32)
Disease B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Prognosis poor
Cytogenetics t(5;14) may be the sole anomaly or accompanied with other anomalies
Hybrid/Mutated Gene break in the promoter region of IL3 and in the Jh region of IgH
Abnormal Protein the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis over-expression of IL3
  

External links

Nomenclature
HGNC (Hugo)IL3   6011
Cards
AtlasIL3ID60
Entrez_Gene (NCBI)IL3  3562  interleukin 3 (colony-stimulating factor, multiple)
GeneCards (Weizmann)IL3
Ensembl (Hinxton)ENSG00000164399 [Gene_View]  chr5:131396347-131398896 [Contig_View]  IL3 [Vega]
AceView (NCBI)IL3
Genatlas (Paris)IL3
WikiGenes3562
SOURCE (Princeton)NM_000588
Genomic and cartography
GoldenPath (UCSC)IL3  -  5q31.1   chr5:131396347-131398896 +  5q23-q31   [Description]    (hg19-Feb_2009)
EnsemblIL3 - 5q23-q31 [CytoView]
Mapping of homologs : NCBIIL3 [Mapview]
OMIM147740   
Gene and transcription
Genbank (Entrez)BC066272 BC066273 BC066274 BC066275 BC066276
RefSeq transcript (Entrez)NM_000588
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NT_034772 NW_001838952 NW_004929323
Consensus coding sequences : CCDS (NCBI)IL3
Cluster EST : UnigeneHs.694 [ NCBI ]
CGAP (NCI)Hs.694
Alternative Splicing : Fast-db (Paris)GSHG0024217
Alternative Splicing GalleryENSG00000164399
Gene ExpressionIL3 [ NCBI-GEO ]     IL3 [ SEEK ]   IL3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08700 (Uniprot)
NextProtP08700  [Medical]
With graphics : InterProP08700
Splice isoforms : SwissVarP08700 (Swissvar)
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    IL-3   
Related proteins : CluSTrP08700
Domain families : Pfam (Sanger)IL3 (PF02059)   
Domain families : Pfam (NCBI)pfam02059   
DMDM Disease mutations3562
Blocks (Seattle)P08700
PDB (SRS)1JLI   
PDB (PDBSum)1JLI   
PDB (IMB)1JLI   
PDB (RSDB)1JLI   
Human Protein AtlasENSG00000164399
Peptide AtlasP08700
HPRD00987
IPIIPI00030336   
Protein Interaction databases
DIP (DOE-UCLA)P08700
IntAct (EBI)P08700
FunCoupENSG00000164399
BioGRIDIL3
InParanoidP08700
Interologous Interaction database P08700
IntegromeDBIL3
STRING (EMBL)IL3
Ontologies - Pathways
Ontology : AmiGOcytokine activity  interleukin-3 receptor binding  extracellular region  extracellular space  immune response  cell-cell signaling  nervous system development  growth factor activity  positive regulation of cell proliferation  embryonic hemopoiesis  positive regulation of tyrosine phosphorylation of Stat5 protein  positive regulation of DNA replication  positive regulation of peptidyl-tyrosine phosphorylation  
Ontology : EGO-EBIcytokine activity  interleukin-3 receptor binding  extracellular region  extracellular space  immune response  cell-cell signaling  nervous system development  growth factor activity  positive regulation of cell proliferation  embryonic hemopoiesis  positive regulation of tyrosine phosphorylation of Stat5 protein  positive regulation of DNA replication  positive regulation of peptidyl-tyrosine phosphorylation  
Pathways : BIOCARTAErythrocyte Differentiation Pathway [Genes]    Regulation of BAD phosphorylation [Genes]    Cytokine Network [Genes]    The Role of Eosinophils in the Chemokine Network of Allergy [Genes]    Cytokines and Inflammatory Response [Genes]    Regulation of hematopoiesis by cytokines [Genes]    IL 17 Signaling Pathway [Genes]    IL 3 signaling pathway [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Apoptosis    Jak-STAT signaling pathway    Hematopoietic cell lineage    Fc epsilon RI signaling pathway    Transcriptional misregulation in cancer    Asthma   
REACTOMEIL3
Protein Interaction DatabaseIL3
Wikipedia pathwaysIL3
Gene fusion - rearrangments
Rearrangement : TICdbIL3 [5q31.1]  -  Ig []
Rearrangement : TICdbIg [IL3]  -  5q31.1 []
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL3
SNP (GeneSNP Utah)IL3
SNP : HGBaseIL3
Genetic variants : HAPMAPIL3
1000_GenomesIL3 
ICGC programENSG00000164399 
Somatic Mutations in Cancer : COSMICIL3 
CONAN: Copy Number AnalysisIL3 
Mutations and Diseases : HGMDIL3
OMIM147740   
GENETestsIL3
Disease Genetic AssociationIL3
Huge Navigator IL3 [HugePedia]  IL3 [HugeCancerGEM]
Genomic VariantsIL3  IL3 [DGVbeta]
Exome VariantIL3
dbVarIL3
ClinVarIL3
snp3D : Map Gene to Disease3562
General knowledge
Homologs : HomoloGeneIL3
Homology/Alignments : Family Browser (UCSC)IL3
Phylogenetic Trees/Animal Genes : TreeFamIL3
Chemical/Protein Interactions : CTD3562
Chemical/Pharm GKB GenePA29830
Clinical trialIL3
Cancer Resource (Charite)ENSG00000164399
Other databases
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
CoreMineIL3
iHOPIL3

Bibliography

Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.
Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG
Cell. 1986 ; 47 (1) : 3-10.
PMID 3489530
 
The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.
Grimaldi JC, Meeker TC
Blood. 1989 ; 73 (8) : 2081-2085.
PMID 2499362
 
Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression.
Nimer SD, Uchida H
Stem cells (Dayton, Ohio). 1995 ; 13 (4) : 324-335.
PMID 7549890
 
Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis.
Hara T, Miyajima A
Stem cells (Dayton, Ohio). 1996 ; 14 (6) : 605-618.
PMID 8948019
 
The physiologic role of interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, and the beta c receptor system.
Burdach S, Nishinakamura R, Dirksen U, Murray R
Current opinion in hematology. 1998 ; 5 (3) : 177-180.
PMID 9664156
 
Interleukin-3 in hematology and oncology: current state of knowledge and future directions.
Mangi MH, Newland AC
Cytokines, cellular & molecular therapy. 1999 ; 5 (2) : 87-95.
PMID 10515681
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written12-1999Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . IL3 (interleukin-3). Atlas Genet Cytogenet Oncol Haematol. December 1999 .
URL : http://AtlasGeneticsOncology.org/Genes/IL3ID60.html

The various updated versions of this paper are referenced and archived by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37555/1/12-1999-IL3ID60.pdf   [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:27:58 CEST 2014

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