IL3 (interleukin-3)
1999-12-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
IL-3,MCGF,MULTI-CSF
FUSION GENES
DNA/RNA
Description
5 exons
Transcription
674 bp transcript with a 458 bp of coding sequence
Proteins
Description
152 amino acids; 17 kDa
Expression
IL3 is produced by activated T cells, monocytes/macrophages and stroma cells
Function
cytokine; multipotent hematopoietic growth factor; induces proliferation, maturation and probably self-renewal of pluripotent hematopoietic stem cells and cells of myeloid, erythroid and megakaryocytic lineages; IL-3 plays a more specialized role on basophil and mast cells; role through activation of the IL-3 receptor (IL-3R) complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5 , and induction of c-myc (cell-cycle progression and DNA synthesis), and activation of the Ras pathway (suppression of apoptosis); IL3 and GM-CSF have overlapping but distinct biological properties
Implicated in
Entity name
t(5;14)(q31;q32)
Disease
B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Prognosis
poor
Cytogenetics
t(5;14) may be the sole anomaly or accompanied with other anomalies
Hybrid gene
break in the promoter region of IL3 and in the Jh region of IgH
Fusion protein
the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis
over-expression of IL3
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9664156 | 1998 | The physiologic role of interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, and the beta c receptor system. | Burdach S et al |
| 2499362 | 1989 | The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. | Grimaldi JC et al |
| 8948019 | 1996 | Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. | Hara T et al |
| 10515681 | 1999 | Interleukin-3 in hematology and oncology: current state of knowledge and future directions. | Mangi MH et al |
| 7549890 | 1995 | Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression. | Nimer SD et al |
| 3489530 | 1986 | Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. | Yang YC et al |
Other Information
Locus ID:
NCBI: 3562
MIM: 147740
HGNC: 6011
Ensembl: ENSG00000164399
Variants:
dbSNP: 3562
ClinVar: 3562
TCGA: ENSG00000164399
COSMIC: IL3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164399 | ENST00000296870 | P08700 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | ||
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36729088 | 2023 | Conformational and binding mode assessment of the human IL-3 recognition by its alpha receptor. | 0 |
| 36911737 | 2023 | Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming. | 3 |
| 37160117 | 2023 | Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. | 4 |
| 37453342 | 2023 | Quantitative estimation of TNF-α and IL-3 by using ELISA from human lung tissue in fatal asphyxial deaths. | 1 |
| 36729088 | 2023 | Conformational and binding mode assessment of the human IL-3 recognition by its alpha receptor. | 0 |
| 36911737 | 2023 | Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming. | 3 |
| 37160117 | 2023 | Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. | 4 |
| 37453342 | 2023 | Quantitative estimation of TNF-α and IL-3 by using ELISA from human lung tissue in fatal asphyxial deaths. | 1 |
| 34506850 | 2022 | Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells. | 0 |
| 34619417 | 2022 | The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq. | 0 |
| 35281014 | 2022 | An Immunoregulatory Role of Interleukin-3 in Allergic Asthma. | 8 |
| 34506850 | 2022 | Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells. | 0 |
| 34619417 | 2022 | The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq. | 0 |
| 35281014 | 2022 | An Immunoregulatory Role of Interleukin-3 in Allergic Asthma. | 8 |
| 32327499 | 2021 | A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification. | 11 |
Citation
Jean-Loup Huret
IL3 (interleukin-3)
Atlas Genet Cytogenet Oncol Haematol. 1999-12-01
Online version: http://atlasgeneticsoncology.org/gene/60/il3
