Note | |
| |
Entity | Various cancers |
Note | For review: Ythier et al., 2008; Guérillon et al., 2014. Many genetics and epigenetics alterations of tumor suppressor genes (TSGs) or oncogenes contribute to cancerogenesis. Thus, the expression of tumor suppressor gene ING1 has been analysed in many tumor types. |
| |
| |
Entity | Adenocarcinoma of the esophagogastric junction |
Note | Among 19 adenocarcinoma of the esophagogastric junction (AdEGJs), two tumors presented ING1b alterations (11%). One missense mutation at codon 147 had a G to T transition resulting in serine to isoleucine substitution. The second silent mutation at codon 173 had a G to A transition with no amino acid change. In addition, p33ING1b mRNA expression was reduced in 63% of AdEGJs samples compared to normal esophageal tissues. Moreover, ING1b protein expression was frequently decreased or not detected in tumor samples, while all normal gastric mucosa had ING1b protein expression (Hara et al., 2003). |
| |
| |
Entity | Ameloblastoma |
Note | In the case of Ameloblastoma, a high frequency of loss of heterozygosity (33% - 72%) is found in the loci of each ING gene family member. In the case of ING1, 51% of 35 patients showed an allelic loss in the ING1 coding region. Different mechanisms, such as deletions, gene conversion or mitotic combination might be implicated to enhance INGs gene alterations and promote ameloblastoma tumorigenesis (Borkosky et al., 2010). |
| |
| |
Entity | Brain tumor |
Note | In human brain tumors, ING1b mislocalization is observed in all of the analyzed glioma samples and in some glioma cell lines. However, mutations of ING1 seem to be infrequent. A single point mutation was detected in 29 brain tumor specimens (3.5%) manifested by an arginine to histidine substitution. This amino acid change is caused by a G-to-A transition. Furthermore, this mutation does not affect the expression of ING1b mRNA, but it leads to a cytoplasmic shift of p33ING1b, according to taking place in a sequence of ING1 reported to target p33ING1b to the nucleus (Vieyra et al., 2003). |
| |
| |
Entity | Breast cancer |
Note | In breast cancer, expression of ING1 mRNA is decreased in 17 of 24 breast cancer tissues (71%), compared to normal tissues (Tokunaga et al., 2000). Furthermore, a downregulation of ING1 gene has been established in breast cancer cell lines. Mutations of ING1 are rare (1/377) in breast carcinomas (Toyama et al., 1999). In addition, 7 of 86 invasive breast carcinoma cases showed an increase of p33ING1b expression in the cytoplasm, while the 79 cases had a low p33ING1b cytoplasmic expression, with 33 of them lacking absolutely cytoplasmic expression of p33ING1b (Nouman et al., 2003). |
| |
| |
Entity | Childhood acute lymphoblastic leukemia |
Note | In childhood Acute Lymphoblastic Leukeamia (ALL), 78% of cases showed a decrease in the expression of nuclear p37ING1b which undergoes a shift to the cytoplasm. This translocation may attenuate the function of p37ING1b protein and plays an important role in pathogenesis of ALL (Nouman et al., 2002b). |
| |
| |
Entity | Colorectal carcinoma |
Note | In colorectal carcinomas, no loss of alleles has been detected in ING1 gene. Neither Loss Of Heterozygosity (LOH) nor mutations have been observed in 29 sporadic colorectal carcinomas samples. It suggests that another mechanism might be implicated in the loss of gene. For example, hypermethylation of the promoter might be responsible for the inactivation of tumour suppressor genes (Sarela et al., 1999). In addition, the ratios of p33ING1b and p47ING1a mRNA expression were significantly lower in human sporadic colorectal tissus than those in normal tissues (Chen et al., 2005). Moreover, 32 % of patients with Dukes'A colorectal cancer display a low expression of p33ING1b protein (Ahmed et al., 2008). |
| |
| |
Entity | Esophageal squamous cell cancer |
Note | In the case of Esophageal squamous cell cancer (ESCC), 59 % of 31 informative cases showed allelic loss at chromosome 13q33-34 where ING1 is mapped. Four somatic missense mutations are located between codons 214 and 270, and two somatic silent mutations are located between codons 219 and 223. All of the missense mutations found in ESCC were localised within the highly conserved PHD finger-like domain which is implicated in transcriptional regulation. Loss of ING1 protein expression has been observed in all ESCC samples, this absence of ING1 may contribute to ESCC carcinogenesis (Chen et al., 2001). |
| |
| |
Entity | Gastric cancer |
Note | It has been demonstrated that 75% of tumor samples tested showed a significant decrease in p33ING1 expression associated with gastric carcinogenesis. Moreover, a silent mutation is detected in 2/12 gastric cancer cells with no amino acid change in codon 188, and only one cell line(1/12) had a missense mutation in codon 172 resulting in glutamine to lysine amino acid substitution. However, these findings suggest that p33ING1 acts as a tumor suppressor gene even if it is preserved in the majority of gastric cancer (Oki et al., 1999). |
| |
| |
Entity | Haematological malignancies |
Note | 49 patients with heamatological malignancies and 5 normal patients showed a predominant expression of p33ING1b transcript, while p24/ING1 and p47/ING1 transcripts are very weakly expressed. In addition, no p33ING1b sequence variation has been observed in all of the 49 patients with heamatological malignancies, suggesting that neither p33ING1b mutation, nor dysregulation of alternative splicing of ING1 gene are significantly responsible of heamatological malignancies progression (Bromidge et al., 2002). |
| |
| |
Entity | Head and neck squamous cell carcinoma |
Note | In Head and Neck Squamous Cell Carcinomas (HNSCC), a deletion is found on chromosome 13q33-34, where ING1 gene is mapped. A loss of heterozigosity has been detected in 68 % of HNSCC cases. Six mutations were identified in the 23 tumors with allelic loss, 13% showed missense mutations with amino acid change and the other 3 samples showed an alteration at codon 173 of p33ING1b without an amino acid change. All these mutations are found in the PHD finger or NLS domain of ING1 (Gunduz et al., 2000). Another study showed that there is no somatic mutation in any of 20 primary tumors showing 13q LOH and in 5 head and neck cancer cell lines, suggesting an alternative factor implicated in this type of tumor (Sanchez-Cespedes et al., 2000). |
| |
| |
Entity | Hepatocellular carcinoma |
Note | In hepatocellular carcinoma (HCC), p33ING1 gene is not frequently altered (7%). This mutation resulted in G to C transversion, in the codon 215, with an amino change (cysteine to serine) in ING1b gene. However, 42 % of HCC tissus had an up-regulation of p33ING1b, whereas 58% showed a downregulation of p33ING1b protein. Although the rate of mutation in ING1 is low, loss or inactivation of p33ING1b may be an important mechanism for malignant transformation of HCC (Zhu et al., 2005). Another study suggests that ING1 protein was expressed in either hepatocarcinoma cells or hepatocytes, and localized in the nuclei of hepatocarcinoma cells. In advanced stage group, the general expression level of ING1 was increased in the tumor tissue. Besides, transcriptional levels showed that ING1b is up-regulated in HCC tissus, whereas ING1a expression level remains unchanged (Chen et al., 2009). |
| |
| |
Entity | Lung cancer |
Note | In lung cancer, 6/31 of primary lung cancer tumors and 1/30 human lung cancer cell lines showed a G to A transition that occurred in codon 173 located in the NLS domain of ING1. This substitution does not result in amino acid change. There is no point mutation detected in ING1b gene. An up-regulation of ING1b mRNA expression is detected in 7 of 8 lung cancer cell lines having a p53 mutation (Okano et al., 2006). In the case of non-small cell lung cancer (NSCLC), another study demonstrated that only 2 % had point mutations in the coding regions of ING1b, but there was no missense mutation detected in ING1b coding region. In addition, 42 % showed a reduction of ING1b gene expression associated with p53 mutations (Kameyama et al., 2003). |
| |
| |
Entity | Lymphoid malignancies |
Note | In lymphoid malignancies, many deletions and chromosomal translocations were observed in q33-34 region of chromosome 13 where ING1 gene is mapped. A decrease in the expression of ING1 gene is found in 4/5 T-cell lines derived from acute lymphocytic leukemia. A decrease of ING1 expression was also found in 5/11 B- cell lines including 2 myeloma and 2 Burkitt lymphoma cell lines. Moreover, no point mutation or deletion was detected in the 9 cell lines having reduced ING1 expression. These findings suggest that transcriptional or post-transcriptional mechanisms are responsible of ING1 decreased expression which contributes to the development of lymphoid malignancies (Ohmori et al., 1999). |
| |
| |
Entity | Mantle cell lymphoma |
Note | The genetic alteration of mantle cell lymphoma (MCL) is a translocation t(11;14)(q13;q32), detected in all MCL cases. Additional aberrations are implicated in lymphoma malignancies, such as the inactivation of tumor suppressor genes. For example, the expression of ING1 is decreased in all the cell lines. No evidence of promoter methylation of ING1 gene has been found in MCL cell lines (Ripperger et al., 2007). |
| |
| |
Entity | Melanoma |
Note | The p33ING1b protein expression level is significantly increased in 14 melanoma cell lines studied. An overexpression of p33ING1b mRNA was also found in all 6 melanoma cell lines examined, but it was absent in normal melanocytes. There is a low mutation rate (14 %) in melanoma cell lines. Two silent nucleotide changes have been detected in exon 1a in Sk-mel-110, whereas, in Sk-mel-24, 8 nucleotide alterations in exon 2 were found. Seven alterations were silent and 1 missense alteration at codon 260 results in an aspargine to serine amino acid subsitution. No mutation has been detected in 25 samples of healthy volunteers suggesting that these nucleotide alterations in the 2 melanoma cell lines are not due to a polymorphism. Thus, ING1 gene is not frequently mutated in melanoma cells. These findings demonstrated that other mechanisms, such as DNA hypomethylation, may contribute to the overexpression of ING1 (Campos et al., 2002). Another study showed a loss of nuclear p33ING1b expression associated with a strong or intermediate cytoplasmic p33ING1b expression in 35 % of the invasive malignant melanomas. Also, 47 % showed a complete loss of nuclear p33ING1b expression. The translocation or the shift to the cytoplasm may result in a loss of p33ING1b function (Nouman et al., 2002a). |
| |
| |
Entity | Oral squamous cell carcinoma |
Note | Few studies about p33ING1b role and expression in oral squamous cell carcinoma (OSCC) have been published. In normal squamous cells, p33ING1b showed only a nuclear expression, whereas 24 % of OSCC showed a shift of p33ING1b protein from the nucleus to the cytoplasm with a weak nuclear staining, and 76 % of OSCC had a negative expression of p33ING1b. Furthemore, p33ING1b shift to the cytoplasm may result in an unfonctional protein that enhances oncogenesis of OSCC. Besides, it is demonstrated that the tumors with p33ING1b cytoplasmic expression are more aggressive, however the reason is still unknown (Zhang et al., 2008). |
| |
| |
Entity | Ovarian cancer |
Note | Among the 111 cases of ovarian carcinoma analysed, 25 % are observed with a low or absent p33ING1b protein expression. Besides, a total of 32 cases showed a significant reduction of p33ING1b mRNA expression, with a decrease or absence of p33ING1b protein in 53 % of them. No mutation of p33ING1b has been detected in these samples. An allelic loss at the p33ING1b locus was detected in 25 % of the cases with a correlation between mRNA expression and p33ING1b protein decrease. Twenty four percent of 88 patients had p33ING1b promoter methylation. In addition, p33ING1b promoter methylation has been observed in two ovarian cancer cell lines, OVCA3 and SKOV3 (2/2). The absence of mutation suggests that other inactivation mechanisms can occur, such as histone deacetylation, and might contribute to p33ING1b silencing and tumorigenesis of ovarian cancer (Shen et al., 2005). |
| |
| |
Entity | Pancreatic carcinoma |
Note | Only 15 % of pancreatic carcinoma specimens showed a reduction of p33ING1b protein expression. This low percentage demonstrates that there is no correlation between p33ING1b expression and clinicopathological factors. In addition, a single germline missense mutation located at codon 215 has been identified in 1/40 pancreatic carcinoma cases. This mutation is manifested by a cysteine to serine substitution at codon 215 localised in the PHD domain of ING1. However, p33ING1b protein expression is still normal in this sample. 60 % of tumor cases showed a loss of heterozygosity (LOH) with no mutation detected. In addition, 2 of these samples have an absence of p33ING1b protein expression. These findings suggested that mutations are not the only reason for the loss of function of p33ING1b in pancreatic carcinomas (Yu et al., 2004). |
| |
The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer. |
Ahmed IA, Kelly SB, Anderson JJ, Angus B, Challen C, Lunec J. |
Colorectal Dis. 2008 May;10(4):344-51. Epub 2007 Oct 19. |
PMID 17949449 |
|
The PHD finger, a nuclear protein-interaction domain. |
Bienz M. |
Trends Biochem Sci. 2006 Jan;31(1):35-40. Epub 2005 Nov 16. (REVIEW) |
PMID 16297627 |
|
Allelic loss of the ING gene family loci is a frequent event in ameloblastoma. |
Borkosky SS, Gunduz M, Beder L, Tsujigiwa H, Tamamura R, Gunduz E, Katase N, Rodriguez AP, Sasaki A, Nagai N, Nagatsuka H. |
Oncol Res. 2010;18(10):509-18. |
PMID 20681410 |
|
ING1 induces apoptosis through direct effects at the mitochondria. |
Bose P, Thakur S, Thalappilly S, Ahn BY, Satpathy S, Feng X, Suzuki K, Kim SW, Riabowol K. |
Cell Death Dis. 2013 Sep 5;4:e788. doi: 10.1038/cddis.2013.321. |
PMID 24008732 |
|
Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies. |
Bromidge T, Lynas C. |
Leuk Res. 2002 Jul;26(7):631-5. |
PMID 12008079 |
|
The novel tumour suppressor gene ING1 is overexpressed in human melanoma cell lines. |
Campos EI, Cheung KJ Jr, Murray A, Li S, Li G. |
Br J Dermatol. 2002 Apr;146(4):574-80. |
PMID 11966686 |
|
Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer. |
Chen L, Matsubara N, Yoshino T, Nagasaka T, Hoshizima N, Shirakawa Y, Naomoto Y, Isozaki H, Riabowol K, Tanaka N. |
Cancer Res. 2001 Jun 1;61(11):4345-9. |
PMID 11389058 |
|
Genetic alterations and expression of inhibitor of growth 1 in human sporadic colorectal cancer. |
Chen LS, Wei JB, Zhou YC, Zhang S, Liang JL, Cao YF, Tang ZJ, Zhang XL, Gao F. |
World J Gastroenterol. 2005 Oct 21;11(39):6120-4. |
PMID 16273637 |
|
ING1a and ING1b different expressed in sporadic hepatocellular carcinoma. |
Chen X, Du J, Zhu T. |
Pathol Biol (Paris). 2009 May;57(3):e17-21. doi: 10.1016/j.patbio.2008.02.009. Epub 2008 May 2. |
PMID 18450387 |
|
The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA. |
Cheung KJ Jr, Mitchell D, Lin P, Li G. |
Cancer Res. 2001 Jul 1;61(13):4974-7. |
PMID 11431327 |
|
HSP70 induction by ING proteins sensitizes cells to tumor necrosis factor alpha receptor-mediated apoptosis. |
Feng X, Bonni S, Riabowol K. |
Mol Cell Biol. 2006 Dec;26(24):9244-55. Epub 2006 Oct 9. |
PMID 17030616 |
|
The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. |
Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV. |
Nature. 1998 Jan 15;391(6664):295-8. |
PMID 9440695 |
|
Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. |
Gong W, Russell M, Suzuki K, Riabowol K. |
Mol Cell Biol. 2006 Apr;26(8):2947-54. |
PMID 16581770 |
|
The ING tumor suppressor genes: status in human tumors. |
Guerillon C, Bigot N, Pedeux R. |
Cancer Lett. 2014 Apr 1;345(1):1-16. doi: 10.1016/j.canlet.2013.11.016. Epub 2013 Dec 11. (REVIEW) |
PMID 24333729 |
|
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. |
Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K. |
Cancer Res. 2000 Jun 15;60(12):3143-6. |
PMID 10866301 |
|
ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction. |
Hara Y, Zheng Z, Evans SC, Malatjalian D, Riddell DC, Guernsey DL, Wang LD, Riabowol K, Casson AG. |
Cancer Lett. 2003 Mar 20;192(1):109-16. |
PMID 12637159 |
|
Phylogenetic analysis of the ING family of PHD finger proteins. |
He GH, Helbing CC, Wagner MJ, Sensen CW, Riabowol K. |
Mol Biol Evol. 2005 Jan;22(1):104-16. Epub 2004 Sep 8. |
PMID 15356280 |
|
Loss of heterozygosity of chromosome 13q33-34 region and molecular analysis of ING1 and p53 genes in bladder carcinoma. |
Igci M, Arslan A, Erturhan S, Igci YZ, Pala E, Gogebakan B, Karakok M, Cakmak EA, Cengiz B. |
Mol Biol Rep. 2015 Feb;42(2):507-16. doi: 10.1007/s11033-014-3794-1. Epub 2014 Oct 17. |
PMID 25324173 |
|
Reduced ING1b gene expression plays an important role in carcinogenesis of non-small cell lung cancer patients. |
Kameyama K, Huang CL, Liu D, Masuya D, Nakashima T, Sumitomo S, Takami Y, Kinoshita M, Yokomise H. |
Clin Cancer Res. 2003 Oct 15;9(13):4926-34. |
PMID 14581367 |
|
ING1 represses transcription by direct DNA binding and through effects on p53. |
Kataoka H, Bonnefin P, Vieyra D, Feng X, Hara Y, Miura Y, Joh T, Nakabayashi H, Vaziri H, Harris CC, Riabowol K. |
Cancer Res. 2003 Sep 15;63(18):5785-92. |
PMID 14522900 |
|
Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). |
Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D. |
Mol Cell Biol. 2002 Feb;22(3):835-48. |
PMID 11784859 |
|
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2. |
Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY. |
Cancer Res. 2002 Sep 1;62(17):4890-3. |
PMID 12208736 |
|
Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis. |
Li N, Zhao G, Chen T, Xue L, Ma L, Niu J, Tong T. |
Cell Death Dis. 2012 Mar 15;3:e283. doi: 10.1038/cddis.2012.22. |
PMID 22419112 |
|
It takes a PHD to read the histone code. |
Mellor J. |
Cell. 2006 Jul 14;126(1):22-4. (REVIEW) |
PMID 16839870 |
|
Downregulation of nuclear expression of the p33(ING1b) inhibitor of growth protein in invasive carcinoma of the breast. |
Nouman GS, Anderson JJ, Crosier S, Shrimankar J, Lunec J, Angus B. |
J Clin Pathol. 2003 Jul;56(7):507-11. |
PMID 12835295 |
|
Decreased expression of p33ING1 mRNA in lymphoid malignancies. |
Ohmori M, Nagai M, Tasaka T, Koeffler HP, Toyama T, Riabowol K, Takahara J. |
Am J Hematol. 1999 Oct;62(2):118-9. |
PMID 10577281 |
|
Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer. |
Okano T, Gemma A, Hosoya Y, Hosomi Y, Nara M, Kokubo Y, Yoshimura A, Shibuya M, Nagashima M, Harris CC, Kudoh S. |
Oncol Rep. 2006 Mar;15(3):545-9. |
PMID 16465410 |
|
Reduced expression of p33(ING1) and the relationship with p53 expression in human gastric cancer. |
Oki E, Maehara Y, Tokunaga E, Kakeji Y, Sugimachi K. |
Cancer Lett. 1999 Dec 1;147(1-2):157-62. |
PMID 10660101 |
|
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. |
Pena PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. |
J Mol Biol. 2008 Jul 4;380(2):303-12. doi: 10.1016/j.jmb.2008.04.061. Epub 2008 May 2. |
PMID 18533182 |
|
Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. |
Ran R, Lu A, Zhang L, Tang Y, Zhu H, Xu H, Feng Y, Han C, Zhou G, Rigby AC, Sharp FR. |
Genes Dev. 2004 Jun 15;18(12):1466-81. |
PMID 15198984 |
|
Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas. |
Ripperger T, von Neuhoff N, Kamphues K, Emura M, Lehmann U, Tauscher M, Schraders M, Groenen P, Skawran B, Rudolph C, Callet-Bauchu E, van Krieken JH, Schlegelberger B, Steinemann D. |
Haematologica. 2007 Apr;92(4):460-8. |
PMID 17488656 |
|
Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions. |
Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D. |
Genes Chromosomes Cancer. 2000 Mar;27(3):319-22. |
PMID 10679922 |
|
The candidate tumour suppressor gene, ING1, is retained in colorectal carcinomas. |
Sarela AI, Farmery SM, Markham AF, Guillou PJ. |
Eur J Cancer. 1999 Aug;35(8):1264-7. |
PMID 10615239 |
|
Epigenetic and genetic alterations of p33ING1b in ovarian cancer. |
Shen DH, Chan KY, Khoo US, Ngan HY, Xue WC, Chiu PM, Ip P, Cheung AN. |
Carcinogenesis. 2005 Apr;26(4):855-63. Epub 2005 Jan 27. |
PMID 15677627 |
|
The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways. |
Shi Y, Tu Z, Tang D, Zhang H, Liu M, Wang K, Calderwood SK, Xiao X. |
Shock. 2006 Sep;26(3):277-84. |
PMID 16912653 |
|
Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers. |
Tokunaga E, Maehara Y, Oki E, Kitamura K, Kakeji Y, Ohno S, Sugimachi K. |
Cancer Lett. 2000 Apr 28;152(1):15-22. |
PMID 10754201 |
|
Suppression of ING1 expression in sporadic breast cancer. |
Toyama T, Iwase H, Watson P, Muzik H, Saettler E, Magliocco A, DiFrancesco L, Forsyth P, Garkavtsev I, Kobayashi S, Riabowol K. |
Oncogene. 1999 Sep 16;18(37):5187-93. |
PMID 10498868 |
|
Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors. |
Vieyra D, Senger DL, Toyama T, Muzik H, Brasher PM, Johnston RN, Riabowol K, Forsyth PA. |
Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5952-61. |
PMID 14676120 |
|
Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues. |
Walzak AA, Veldhoen N, Feng X, Riabowol K, Helbing CC. |
Exp Cell Res. 2008 Jan 15;314(2):273-85. Epub 2007 Aug 2. |
PMID 17720155 |
|
Tumour suppressor ING1b maintains genomic stability upon replication stress. |
Wong RP, Lin H, Khosravi S, Piche B, Jafarnejad SM, Chen DW, Li G. |
Nucleic Acids Res. 2011 May;39(9):3632-42. doi: 10.1093/nar/gkq1337. Epub 2011 Jan 11. |
PMID 21227930 |
|
The new tumor suppressor genes ING: genomic structure and status in cancer. |
Ythier D, Larrieu D, Brambilla C, Brambilla E, Pedeux R. |
Int J Cancer. 2008 Oct 1;123(7):1483-90. doi: 10.1002/ijc.23790. (REVIEW) |
PMID 18636562 |
|
Genetic alterations and reduced expression of tumor suppressor p33(ING1b) in human exocrine pancreatic carcinoma. |
Yu GZ, Zhu MH, Zhu Z, Ni CR, Zheng JM, Li FM. |
World J Gastroenterol. 2004 Dec 15;10(24):3597-601. |
PMID 15534913 |
|
Nuclear to cytoplasmic shift of p33(ING1b) protein from normal oral mucosa to oral squamous cell carcinoma in relation to clinicopathological variables. |
Zhang JT, Wang DW, Li QX, Zhu ZL, Wang MW, Cui DS, Yang YH, Gu YX, Sun XF. |
J Cancer Res Clin Oncol. 2008 Mar;134(3):421-6. Epub 2007 Sep 6. |
PMID 17805569 |
|
Inhibitory effect of tumor suppressor p33(ING1b) and its synergy with p53 gene in hepatocellular carcinoma. |
Zhu Z, Lin J, Qu JH, Feitelson MA, Ni CR, Li FM, Zhu MH. |
World J Gastroenterol. 2005 Apr 7;11(13):1903-9. |
PMID 15800978 |
|