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INGX (inhibitor of growth family, X-linked, pseudogene)

Written2013-12Audrey Mouche, Rémy Pedeux
INSERM U917, Microenvironnement et Cancer, Rennes, France, Universite de Rennes 1, Rennes, France (AM, RP); Etablissement Francais du Sang, Rennes, France (RP)

(Note : for Links provided by Atlas : click)

Identity

Alias_namesING2
inhibitor of growth family
Alias_symbol (synonym)ING1-like
Other alias
HGNC (Hugo) INGX
LocusID (NCBI) 27160
Atlas_Id 40976
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 70711531 and ends at 70712299 bp from pter ( according to hg19-Feb_2009)  [Mapping INGX.png]

DNA/RNA

 
  Chromosomal localization of the INGX gene in Homo sapiens.
Description The sex chromosome linked INGX gene, homolog to ING1 has been cloned for the first time by Jäger et al., 1999. The five human ING genes and the pseudogene INGX have been mapped to six different chromosomes. In addition, ING genes are located close to the telomeric region except for ING3 and INGX. This gene has been localised on the human X chromosome at locus Xq13.1 close to the centromeric region (He et al., 2005).
Transcription INGX gene has three transcripts and a unique exon. The sequence of this exon shares 72% of identity with exon 2 of ING1. RT-PCR analysis shows that INGX mRNA is expressed in normal tissue (brain, colon, testis, kidney, liver and breast). However, some tumor cell lines like melanoma or breast cancer showed a loss of INGX mRNA (Jäger et al., 1999).
Pseudogene INGX is the pseudogene of ING1 (He et al., 2005).

Protein

 
  A schematic representation of the different domain of ING1b, ING2 and INGX protein.
Description The amino acid sequence alignment of human ING proteins revealed several conserved regions: a leucine-zipper-like-region (LZL), a novel conserved region (NCR), a nuclear localization signal (NLS), a plant homeo domain (PHD) and a polybasic region (PBR). The ING proteins are characterized by the presence of a highly conserved PHD in their C-terminal part. This domain is commonly found in proteins involved in chromatin modification (Bienz, 2006; Mellor, 2006).
ING proteins are characterized by their PHD domain which is highly conserved. The longest ORF in INGX gene is only 129 bp length and would encode a predicted amino acid sequence of 42 amino acids, but there is no report about an INGX protein produced from a transcript. This INGX sequence has a high homology degree with the PHD amino acid sequence. INGX protein would have a partial PHD domain (He et al., 2005).
 
  Amino acid sequences alignment of ING1b, ING2 and INGX. Plant homeo domain (PHD) is indicated by box.
Localisation At present, there is no proof about the existence of the production of an INGX protein. Moreover, the predicted protein would not have a nuclear localization sequence (NLS) like the other members of the ING family. It could thus be located in the cytoplasm unlike the other ING proteins (for review, Guérillon et al., 2013).
Function The tumor suppressor ING genes are lost or misregulated in different types of human tumors. Unfortunately, few data about INGX are available. We actually know that INGX, unlike the other ING, is highly truncated. So it would be interesting to determine if it has the potential to act in a dominant negative manner (He et al., 2005).
Homology In databanks, INGX is also referred as ING1-like.

Implicated in

Note
  
Entity Melanoma and breast cancer
Note Several studies have shown that ING proteins are involved in critical cellular processes such as senescence, apoptosis, DNA repair, growth regulation, cell migration (for review, Guérillon et al., 2013). In tumor, ING expression is mostly lost at mRNA level (For review: Guérillon et al., 2013 and Ythier et al., 2008). Jäger et al., 1999 have shown a loss of INGX mRNA in some tumor cell lines like melanoma or breast cancer.
  

Bibliography

The PHD finger, a nuclear protein-interaction domain.
Bienz M.
Trends Biochem Sci. 2006 Jan;31(1):35-40. Epub 2005 Nov 16. (REVIEW)
PMID 16297627
 
The ING tumor suppressor genes: Status in human tumors.
Guerillon C, Bigot N, Pedeux R.
Cancer Lett. 2014 Apr 1;345(1):1-16. doi: 10.1016/j.canlet.2013.11.016. Epub 2013 Dec 11.
PMID 24333729
 
Phylogenetic analysis of the ING family of PHD finger proteins.
He GH, Helbing CC, Wagner MJ, Sensen CW, Riabowol K.
Mol Biol Evol. 2005 Jan;22(1):104-16. Epub 2004 Sep 8.
PMID 15356280
 
Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.
Jager D, Stockert E, Scanlan MJ, Gure AO, Jager E, Knuth A, Old LJ, Chen YT.
Cancer Res. 1999 Dec 15;59(24):6197-204.
PMID 10626813
 
It takes a PHD to read the histone code.
Mellor J.
Cell. 2006 Jul 14;126(1):22-4. (REVIEW)
PMID 16839870
 
The new tumor suppressor genes ING: genomic structure and status in cancer.
Ythier D, Larrieu D, Brambilla C, Brambilla E, Pedeux R.
Int J Cancer. 2008 Oct 1;123(7):1483-90. doi: 10.1002/ijc.23790. (REVIEW)
PMID 18636562
 

Citation

This paper should be referenced as such :
Mouche, A ; Pedeux, R
INGX (inhibitor of growth family, X-linked, pseudogene)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(8):556-558.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/INGXID40976chXq13.html


External links

Nomenclature
HGNC (Hugo)INGX   6064
Cards
AtlasINGXID40976chXq13
Entrez_Gene (NCBI)INGX  27160  inhibitor of growth family, X-linked (pseudogene)
AliasesING1-like; ING2
GeneCards (Weizmann)INGX
Ensembl hg19 (Hinxton)ENSG00000243468 [Gene_View]  chrX:70711531-70712299 [Contig_View]  INGX [Vega]
Ensembl hg38 (Hinxton)ENSG00000243468 [Gene_View]  chrX:70711531-70712299 [Contig_View]  INGX [Vega]
ICGC DataPortalENSG00000243468
TCGA cBioPortalINGX
AceView (NCBI)INGX
Genatlas (Paris)INGX
WikiGenes27160
SOURCE (Princeton)INGX
Genetics Home Reference (NIH)INGX
Genomic and cartography
GoldenPath hg19 (UCSC)INGX  -     chrX:70711531-70712299 -  Xq12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INGX  -     Xq12   [Description]    (hg38-Dec_2013)
EnsemblINGX - Xq12 [CytoView hg19]  INGX - Xq12 [CytoView hg38]
Mapping of homologs : NCBIINGX [Mapview hg19]  INGX [Mapview hg38]
OMIM300452   
Gene and transcription
Genbank (Entrez)AF149724 BC101123 BC101124 BC117297
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012771 NT_011651 NW_004929443
Consensus coding sequences : CCDS (NCBI)INGX
Cluster EST : UnigeneHs.721806 [ NCBI ]
CGAP (NCI)Hs.721806
Alternative Splicing GalleryENSG00000243468
Gene ExpressionINGX [ NCBI-GEO ]   INGX [ EBI - ARRAY_EXPRESS ]   INGX [ SEEK ]   INGX [ MEM ]
Gene Expression Viewer (FireBrowse)INGX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)27160
GTEX Portal (Tissue expression)INGX
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)INGX
DMDM Disease mutations27160
Blocks (Seattle)INGX
Human Protein AtlasENSG00000243468
HPRD02348
IPIIPI00002702   
Protein Interaction databases
FunCoupENSG00000243468
BioGRIDINGX
STRING (EMBL)INGX
ZODIACINGX
Ontologies - Pathways
Huge Navigator INGX [HugePedia]
snp3D : Map Gene to Disease27160
BioCentury BCIQINGX
ClinGenINGX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27160
Chemical/Pharm GKB GenePA142671659
Clinical trialINGX
Miscellaneous
canSAR (ICR)INGX (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineINGX
EVEXINGX
GoPubMedINGX
iHOPINGX
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:42:49 CET 2017

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