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ITK (IL2-inducible T-cell kinase)

Written2007-04Berthold Streubel
Department of Pathology, Medical University of Vienna, Waehringer, Guertel 18-20, A-1090 Vienna, Austria

(Note : for Links provided by Atlas : click)

Identity

Other aliasEMT
LYK
MGC126257
MGC126258
PSCTK2
LocusID (NCBI) 3702
Atlas_Id 43329
Location 5q33.3  [Link to chromosome band 5q33]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKR1B1 (7q33) / ITK (5q33.3)ITK (5q33.3) / SYK (9q22.2)SYK (9q22.2) / ITK (5q33.3)

DNA/RNA

Description centromere to telomere orientation; Exons: 17
Transcription Transcript length: 4,419 bps

Protein

 
  ITK protein
Description Number of residues: 620 residues; Molecular weight: 71 kDa; Conserved domains: PH-Tec, Tec pleckstrin homology (PH) domain; BTK, Bruton's tyrosine kinase Cys-rich motif; SH3, Src homology 3 domains; SH2, Src homology 2 domains; TyrKc, Tyrosine kinase, catalytic domain.
Function Although originally described as an important component of proximal TCR signaling pathways, the Tec family tyrosine kinase Itk has become increasingly recognized for its important role in regulating T-helper-cell differentiation. Itk has a crucial role in Th2 responses, both the protective responses to pathogenic infections in addition to the pathological responses resulting in allergic asthma. Itk is not required for Th2 differentiation per se, but effector Th2 cytokine production during recall responses is severely impaired in the absence of Itk.

Implicated in

Note
  
Entity t(5;9)(q33;q22)
Disease peripheral T-cell lymphomas, unspecified (PTCL-u). ITK-SYK transcripts were detected in 5 of 30 (17%) unspecified peripheral T-cell lymphomas, but not in cases of angioimmunoblastic T-cell lymphoma (n=9) and ALK-negative anaplastic large cell lymphoma (n=7)
Hybrid/Mutated Gene N-terminal pleckstrin homology domain and proline-rich region of ITK fused to the tyrosine kinase domain of SYK.
  

Bibliography

Regulatory intramolecular association in a tyrosine kinase of the Tec family.
Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL
Nature. 1997 ; 385 (6611) : 93-97.
PMID 8985255
 
Tec kinases: modulators of lymphocyte signaling and development.
Lewis CM, Broussard C, Czar MJ, Schwartzberg PL
Current opinion in immunology. 2001 ; 13 (3) : 317-325.
PMID 11406363
 
Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.
Liao XC, Littman DR
Immunity. 1995 ; 3 (6) : 757-769.
PMID 8777721
 
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells.
Liu KQ, Bunnell SC, Gurniak CB, Berg LJ
The Journal of experimental medicine. 1998 ; 187 (10) : 1721-1727.
PMID 9584150
 
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL
Science (New York, N.Y.). 1999 ; 284 (5414) : 638-641.
PMID 10213685
 
Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma.
Streubel B, Vinatzer U, Willheim M, Raderer M, Chott A
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2006 ; 20 (2) : 313-318.
PMID 16341044
 
Tec kinases: a family with multiple roles in immunity.
Yang WC, Collette Y, Nunès JA, Olive D
Immunity. 2000 ; 12 (4) : 373-382.
PMID 10795735
 

Citation

This paper should be referenced as such :
Streubel, Berthold
ITK (IL2-inducible T-cell kinase)
Atlas Genet Cytogenet Oncol Haematol. 2007;11(4):272-273.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ITKID43329ch5q33.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;9)(q33;q22) ITK/SYK
t(5;9)(q33;q22) ITK/SYK


External links

Nomenclature
Cards
AtlasITKID43329ch5q33.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3702
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:40:18 CEST 2018

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