IGH (Immunoglobulin Heavy)

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IGH (Immunoglobulin Heavy)

Written	2000-07	Marie-Paule Lefranc
		IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)	IGH@ (Immunoglobulin Heavy)
HGNC (Hugo)	IGH
HGNC Previous name	IGHDY1
	IGH@
LocusID (NCBI)	3492
Atlas_Id	40
Location	14q32.33 [Link to chromosome band 14q32]


	for complete Figure, see: chromosome 14, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark



	IGH (Immunoglobulin Heavy) Hybridization with Vysis LSI IGH break apart rearrangement probe (Abbott Molecular, US) showing IGH on 14q32.33 (red-green or a fused yellow signal) - Courtesy Adriana Zamecnikova.

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note	The human IGH locus is located on the chromosome 14 at band 14q32.33, at the telomeric extremity of the long arm; the orientation of the locus has been determined by the analysis of translocations, involving the IGH locus, in leukemia and lymphoma

DNA/RNA



	IGH V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Grey triangle: Not sequenced, not found. D-GENE: Blue: Functional; Blue open box: Open reading frame. J-GENE: Grey: Functional . C-GENE: Blue: Functional; Blue dashed box: Open reading frame; Blue open box: Pseudogene. GENES NOT RELATED: Purple open box: Pseudogene. for complete Figure, see: locus IGH, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Description	The human IGH locus at 14q32.33 spans 1250 kilobases (kb). It consists of 123 to 129 IGHV genes, depending from the haplotypes, 27 IGHD segments belonging to 7 subgroups, 9 IGHJ segments, and 11 IGHC genes. Eighty-two to 88 IGHV genes belong to 7 subgroups, whereas 41 pseudogenes, which are too divergent to be assigned to subgroups, have been assigned to 4 clans. Seven non-mapped IGHV genes have been described as insertion/deletion polymorphism but have not yet been precisely located. The most 5' IGHV genes occupy a position very close to the chromosome 14q telomere whereas the IGHC genes are in a more centromeric position. The potentiel genomic IGH repertoire is more limited since it comprises 38-46 functional IGHV genes belonging to 6 or 7 subgroups depending from the haplotypes 23 IGHD, 6 IGHJ, and 9 IGHC genes. Thirty-five IGH genes have been found outside the main locus in other chromosomal localizations. These genes designated as orphons cannot contribute to the synthesis of the immunoglobulin chains, even if they have an Open Reading Frame (ORF). 9 IGHV orphons and 10 IGHD orphons have been described on chromosome 15 (15q11.2), and 16 IGHV orphons on chromosome 16 (16p11.2). In addition, one IGHC processed gene, IGHEP2 is localised on chromosome 9 (9p24.2-p24.1) This is so far the only processed Ig gene described. The total number of human IGH genes per haploid genome is 170 to 176 (206 to 212 genes, if the orphons and the processed gene are included) of which 77 to 84 genes are functional. List of the human IGH genes

Protein

Description

Proteins encoded by the IGH locus are the immunoglobulin heavy chains. They result from the recombination (or rearrangement), at the DNA level, of three genes: IGHV, IGHD and IGHJ, with deletion of the intermediary DNA to create a rearranged IGHV-D-J gene.

The rearranged IGHV-D-J gene is transcribed with the IGHM gene and translated into an immunoglobulin mu chain. The gamma, alpha or epsilon heavy chains, result from a new recombination (or switch), again at the DNA level, between sequences designated as "Switch" and localized upstream of the IGHM and of each of the functional IGHG, IGHA and IGHE constant genes.

This recombination, accompanied by the deletion of the intermediary DNA, allows the IGHV-D-J initially transcribed with the IGHM, to be now transcribed with a IGHG, IGHA or IGHE gene, and translated into a gamma, alpha or epsilon chain.

Translation of the variable germline genes involved in the IGHV-D-J rearrangements are available at IMGT Repertoire Protein displays. Compared to the germline genes, the rearranged variable genes will acquire somatic mutations during the B cell differentiation in the lymph nodes, which will considerably increase their diversity. These somatic mutations can be analysed using IMGT/V-QUEST tool

Note

Entity	Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements, or from errors of the switch enzyme. IGHV, IGHD or IGHJ recombination signals or isolated heptamer (first case) or switch sequences (second case) are observed at the breakpoints


	c-Immunoglobulin genes IgH at 14q32.33, in normal cells: PAC 998D24 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.



Entity	t(1;14)(p21;q32); involve IGH - BCL10 in 1p21
Disease	marginal zone B-cell lymphoma


Entity	t(3;14)(q27;q32); involve IGH -BCL6 in 3q27
Disease	B-cell non-Hodgkin lymphomas (NHL), mainly diffuse large cell lymphoma; adult aggressive lymphoma
Prognosis	controversial


Entity	t(4;14)(p16;q32); involve IGH - FGFR3 in 4p16
Disease	plasma cell leukaemia and multiple myeloma
Prognosis	yet poorly described


Entity	t(5;14)(q31;q32); involve IGH - IL3 in 5q31
Disease	B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Prognosis	prognosis appears to be poor


Entity	t(8;14)(q11;q32)
Disease	B-cell acute lymphoblastic leukemia (ALL); chronic myelogenous leukemia (CML)
Prognosis	still unknown


Entity	t(8;14)(q24;q32) ; involve IGH - C-MYC in 8q24
Disease	B-cell acute lymphoblastic leukemia (ALL3) and non-Hodgkin lymphomas (NHL), especially in the Burkitt lymphoma
Prognosis	the prognosis has evolved with new treatments


Entity	t(9;14)(p13;q32); involve IGH - PAX5 in 9p13
Disease	lymphoplasmatic lymphoma


Entity	t(10;14)(q24;q32); involve IGH - HOX 11 in 10q24
Disease	B-cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
Prognosis	not unfavourable


Entity	t(11;14)(q13;q32); involve IGH - BCL1 in 11q13
Disease	t(11;14) is mainly found in mantle cell lymphoma; B-prolymphocytic leukaemia, chronic lymphocytic leukaemia, splenic lymphoma with villous lymphocytes, and multiple myeloma other B-cell lymphoproliferations


Entity	t(14;18)(q32;q21); involve IGH - BCL2 in 18q21
Disease	follicle centre cell lymphoma mainly, and also diffuse large cell lyphoma; rarely in other B-cell lymphoproliferations
Prognosis	the t(14;18) may have little or no prognostic significance


Entity	t(14;19)(q32;q13.1); involve IGH - BCL3 in 19q13
Disease	chronic lymphocytic leukaemia (CLL) mainly, and other B-cell lymphoproliferations
Prognosis	t(14;19) is an adverse prognostic factor in CLL, compared to the usual prognosis in CLL

	Nomenclature
HGNC (Hugo)	IGH 5477
	Cards
Atlas	IgHID40
Entrez_Gene (NCBI)	IGH immunoglobulin heavy locus
Aliases	IGD1; IGH.1@; IGH@; IGHD@;
	IGHDY1; IGHJ; IGHJ@; IGHV; IGHV@
GeneCards (Weizmann)	IGH
Ensembl hg19 (Hinxton)	[Gene_View]
Ensembl hg38 (Hinxton)	[Gene_View] [Sequence] - [Contig_View] IGH [Vega]
TCGA cBioPortal	IGH
AceView (NCBI)	IGH
Genatlas (Paris)	IGH
SOURCE (Princeton)	IGH
Genetics Home Reference (NIH)	IGH
	Genomic and cartography
GoldenPath hg38 (UCSC)	IGH -
GoldenPath hg19 (UCSC)	IGH -
GoldenPath	IGH - [CytoView hg19] IGH - [CytoView hg38]
genome Data Viewer NCBI	IGH [Mapview hg19]
OMIM	146910 147010 147070
	Gene and transcription
Genbank (Entrez)	AK123975 AK125079 AK126352 BC066594 BX538066
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)	NC_000014 NG_001019 NT_187600
Consensus coding sequences : CCDS (NCBI)	IGH
Gene Expression	IGH [ NCBI-GEO ] IGH [ EBI - ARRAY_EXPRESS ] IGH [ SEEK ] IGH [ MEM ]
Gene Expression Viewer (FireBrowse)	IGH [ Firebrowse - Broad ]
Genevisible	Expression of IGH in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	3492
GTEX Portal (Tissue expression)	IGH
	Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)	IGH
Blocks (Seattle)	IGH
IPI	IPI00382678 IPI00382682 IPI00936563
	Protein Interaction databases
BioGRID	IGH
STRING (EMBL)	IGH
ZODIAC	IGH
	Ontologies - Pathways
	Litterature
PubMed	128 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
EVEX	IGH

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed