| Note | |
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| Entity | Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements, or from errors of the switch enzyme. IGHV, IGHD or IGHJ recombination signals or isolated heptamer (first case) or switch sequences (second case) are observed at the breakpoints |
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| c-Immunoglobulin genes IgH at 14q32.33, in normal cells: PAC 998D24 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. |
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| Entity | t(1;14)(p21;q32); involve IGH - BCL10 in 1p21 |
| Disease | marginal zone B-cell lymphoma |
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| Entity | t(3;14)(q27;q32); involve IGH -BCL6 in 3q27 |
| Disease | B-cell non-Hodgkin lymphomas (NHL), mainly diffuse large cell lymphoma; adult aggressive lymphoma |
| Prognosis | controversial |
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| Entity | t(4;14)(p16;q32); involve IGH - FGFR3 in 4p16 |
| Disease | plasma cell leukaemia and multiple myeloma |
| Prognosis | yet poorly described |
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| Entity | t(5;14)(q31;q32); involve IGH - IL3 in 5q31 |
| Disease | B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia |
| Prognosis | prognosis appears to be poor |
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| Entity | t(8;14)(q11;q32) |
| Disease | B-cell acute lymphoblastic leukemia (ALL); chronic myelogenous leukemia (CML) |
| Prognosis | still unknown |
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| Entity | t(8;14)(q24;q32) ; involve IGH - C-MYC in 8q24 |
| Disease | B-cell acute lymphoblastic leukemia (ALL3) and non-Hodgkin lymphomas (NHL), especially in the Burkitt lymphoma |
| Prognosis | the prognosis has evolved with new treatments |
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| Entity | t(9;14)(p13;q32); involve IGH - PAX5 in 9p13 |
| Disease | lymphoplasmatic lymphoma |
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| Entity | t(10;14)(q24;q32); involve IGH - HOX 11 in 10q24 |
| Disease | B-cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) |
| Prognosis | not unfavourable |
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| Entity | t(11;14)(q13;q32); involve IGH - BCL1 in 11q13 |
| Disease | t(11;14) is mainly found in mantle cell lymphoma; B-prolymphocytic leukaemia, chronic lymphocytic leukaemia, splenic lymphoma with villous lymphocytes, and multiple myeloma other B-cell lymphoproliferations |
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| Entity | t(14;18)(q32;q21); involve IGH - BCL2 in 18q21 |
| Disease | follicle centre cell lymphoma mainly, and also diffuse large cell lyphoma; rarely in other B-cell lymphoproliferations |
| Prognosis | the t(14;18) may have little or no prognostic significance |
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| Entity | t(14;19)(q32;q13.1); involve IGH - BCL3 in 19q13 |
| Disease | chronic lymphocytic leukaemia (CLL) mainly, and other B-cell lymphoproliferations |
| Prognosis | t(14;19) is an adverse prognostic factor in CLL, compared to the usual prognosis in CLL |
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| A processed human immunoglobulin epsilon gene has moved to chromosome 9. |
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| PMID 114999 |
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| PMID 6299662 |
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| PMID 6804948 |
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| PMID 6287432 |
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| PMID 6817141 |
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| A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons. |
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| PMID 6801764 |
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| Instability of the human immunoglobulin heavy chain constant region locus indicated by different inherited chromosomal deletions. |
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| Molecular biology & medicine. 1983 ; 1 (2) : 207-217. |
| PMID 6438434 |
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| PMID 9841928 |
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| PMID 6288268 |
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| Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14. |
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| PMID 10087405 |
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| PMID 6795593 |
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| PMID 6101209 |
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| PMID 10394055 |
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| PMID 1935893 |
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