| Identity |
| Other names | IK1 |
| LYF1 | |
| ZNFN1A1 (zinc finger protein, subfamily 1A, 1) | |
| HGNC (Hugo) | IKZF1 |
| LocusID (NCBI) | 10320 |
| Location | 7p12.2 |
| Location_base_pair | Starts at 50344378 and ends at 50472798 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Transcription | 3629 bp mRNA; coding sequence: 1559 bp; 6 different splicings (--> 6 isoform proteins: ik1-ik6) |
| Protein |
| Description | 519 amino acids; 58 kDa; possesses 2 Zinc-finger (C2H2-type) domains: one with 4 ZnF, the second with2 ZnF; DNA binding |
| Expression | specificity for hematopoietic organs in the foetus and in the adult as well |
| Localisation | nuclear |
| Function | transcription regulator; can repress transcription through the recruitment of histone deacetylase complexes; role in conjunction with Aiolos; hemopoietic-specific zinc finger protein regulator of B and T-cell differentiation |
| Implicated in |
| Entity | t(3;7)(q27;p12) diffuse large B-cell lymphoma (DLCL) --> BCL6 / Ikaros |
| Note | only 2 cases to date |
| Hybrid/Mutated Gene | 5' Ikaros - 3' BCL6 fusion transcript; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation |
| External links |
| Bibliography |
| Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. |
| Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG |
| Cell. 1997 ; 91 (6) : 845-854. |
| PMID 9413993 |
| The role of the Ikaros gene in lymphocyte development and homeostasis. |
| Georgopoulos K, Winandy S, Avitahl N |
| Annual review of immunology. 1997 ; 15 : 155-176. |
| PMID 9143685 |
| Ikaros in hemopoietic lineage determination and homeostasis. |
| Nichogiannopoulou A, Trevisan M, Friedrich C, Georgopoulos K |
| Seminars in immunology. 1998 ; 10 (2) : 119-125. |
| PMID 9618757 |
| Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. |
| Winandy S, Wu L, Wang JH, Georgopoulos K |
| The Journal of experimental medicine. 1999 ; 190 (8) : 1039-1048. |
| PMID 10523602 |
| Defects in hemopoietic stem cell activity in Ikaros mutant mice. |
| Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K |
| The Journal of experimental medicine. 1999 ; 190 (9) : 1201-1214. |
| PMID 10544193 |
| Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. |
| Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M |
| Oncogene. 1999 ; 18 (56) : 7994-7999. |
| PMID 10637510 |
| The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma. |
| Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Taniwaki M, Seto M |
| Blood. 2000 ; 95 (8) : 2719-2721. |
| PMID 10753856 |
| Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |
| Koipally J, Georgopoulos K |
| The Journal of biological chemistry. 2000 ; 275 (26) : 19594-19602. |
| PMID 10766745 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . IKZF1 (Ikaros family zinc finger 1). Atlas Genet Cytogenet Oncol Haematol. August 2000 . URL : http://AtlasGeneticsOncology.org/Genes/IkarosID258.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37660/1/08-2000-IkarosID258.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed May 1 13:02:33 CEST 2013 |
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