JUNB (jun B proto-oncogene)

2003-01-01   Fei Chen 

Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
AP-1
FUSION GENES

DNA/RNA

Description

The JUNB gene maps on chromosome 19p13.2 covering 1820 bp.

Transcription

It contains no confirmed intron. Therefore, no alternative splicing transcripts have been identified.

Proteins

Atlas Image

Description

JUNB has 347 amino acids with a predicted molecular weight 35,9 kD. Structurally, JUNB is similar to JUN, which contains a JNK docking site, nuclear localization signal, basic domain for DNA binding and a leucine zipper domain for dimerization. However, JUNB does not contain a JUNK phosphorylation site. Thus, the transactivation activity of JUNB is not regulated by JNK.

Expression

Ubiquitously expressed.

Localisation

Nuclear

Function

JUNB is a member of JUN family (JUN, JUNB and JUND) that can dimerize with one another, or with members of Fos and ATF families, to form AP-1 transcription factor. Comparing with JUN, the transactivation activity of JUNB is much weaker. Due to the small differences on the amino acid sequences in the basic DNA bindind domain, and leucine zipper domain, JUNB requires multiple AP-1 DNA binding sites for sufficient DNA binding. A number of studies demonstrated that JUNB antagonizes the functions of JUN in cell cycle regulation, proliferation and transformation by competing with JUN to form less efficient transactivating dimers. Thus, JUNB was considered as a tumor suppressor.
In gene knockout studies, mice lacking Jun gene die during embryonic day 12.5 and 13.5, whereas embryos lacking JunB die earlier, around day 9.5, owing to vascular defects in the placenta and extraembryonic tissue. Interestingly; gene knock-in experiment indicated that JUNB could partially substitute the activities of JUN in mouse development and cell proliferation. As possible explanation for this is that in presence of JUN, JUNB is a negative regulator for JUN. In contrast, in the absence of JUN, JUNB may substitute JUN and activate AP-1 target genes required for development and cell proliferation.

Implicated in

Entity name
Inflammation, cancer
Oncogenesis
Decreased expression of JUNB has been observed in certain human cancer. However, no mutation, rearrangement or amplification of JunB gene has been reported.

Bibliography

Pubmed IDLast YearTitleAuthors
118189612002JunB can substitute for Jun in mouse development and cell proliferation.Passegué E et al
100228361999JunB is essential for mammalian placentation.Schorpp-Kistner M et al

Other Information

Locus ID:

NCBI: 3726
MIM: 165161
HGNC: 6205
Ensembl: ENSG00000171223

Variants:

dbSNP: 3726
ClinVar: 3726
TCGA: ENSG00000171223
COSMIC: JUNB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171223ENST00000302754P17275
ENSG00000171223ENST00000302754Q5U079

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
121452102002Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.92
168805202006Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene.60
123719062003A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.42
173060252007The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies.38
176902532007The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling.35
269261072016Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition.30
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
123935032003Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas.25
184247182008SUMOylation regulates the transcriptional activity of JunB in T lymphocytes.25
129074532003JunB inhibits proliferation and transformation in B-lymphoid cells.24

Citation

Fei Chen

JUNB (jun B proto-oncogene)

Atlas Genet Cytogenet Oncol Haematol. 2003-01-01

Online version: http://atlasgeneticsoncology.org/gene/178/junb