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JUNB (jun B proto-oncogene)

Written2003-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

HGNC (Hugo) JUNB
LocusID (NCBI) 3726
Atlas_Id 178
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 12902310 and ends at 12904125 bp from pter ( according to hg19-Feb_2009)  [Mapping JUNB.png]
Fusion genes
(updated 2016)
JUNB (19p13.2) / CAPZB (1p36.13)JUNB (19p13.2) / SEC63 (6q21)

DNA/RNA

Description The JUNB gene maps on chromosome 19p13.2 covering 1820 bp.
Transcription It contains no confirmed intron. Therefore, no alternative splicing transcripts have been identified.

Protein

 
Description JUNB has 347 amino acids with a predicted molecular weight 35,9 kD. Structurally, JUNB is similar to JUN, which contains a JNK docking site, nuclear localization signal, basic domain for DNA binding and a leucine zipper domain for dimerization. However, JUNB does not contain a JUNK phosphorylation site. Thus, the transactivation activity of JUNB is not regulated by JNK.
Expression Ubiquitously expressed.
Localisation Nuclear
Function JUNB is a member of JUN family (JUN, JUNB and JUND) that can dimerize with one another, or with members of Fos and ATF families, to form AP-1 transcription factor. Comparing with JUN, the transactivation activity of JUNB is much weaker. Due to the small differences on the amino acid sequences in the basic DNA bindind domain, and leucine zipper domain, JUNB requires multiple AP-1 DNA binding sites for sufficient DNA binding. A number of studies demonstrated that JUNB antagonizes the functions of JUN in cell cycle regulation, proliferation and transformation by competing with JUN to form less efficient transactivating dimers. Thus, JUNB was considered as a tumor suppressor.
In gene knockout studies, mice lacking Jun gene die during embryonic day 12.5 and 13.5, whereas embryos lacking JunB die earlier, around day 9.5, owing to vascular defects in the placenta and extraembryonic tissue. Interestingly; gene knock-in experiment indicated that JUNB could partially substitute the activities of JUN in mouse development and cell proliferation. As possible explanation for this is that in presence of JUN, JUNB is a negative regulator for JUN. In contrast, in the absence of JUN, JUNB may substitute JUN and activate AP-1 target genes required for development and cell proliferation.

Implicated in

Note
Entity Inflammation, cancer
Oncogenesis Decreased expression of JUNB has been observed in certain human cancer. However, no mutation, rearrangement or amplification of JunB gene has been reported.
  

Bibliography

JunB can substitute for Jun in mouse development and cell proliferation.
Passegué E, Jochum W, Behrens A, Ricci R, Wagner EF
Nature genetics. 2002 ; 30 (2) : 158-166.
PMID 11818961
 
JunB is essential for mammalian placentation.
Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF
The EMBO journal. 1999 ; 18 (4) : 934-948.
PMID 10022836
 

Citation

This paper should be referenced as such :
Chen, F
JUNB (jun B proto-oncogene)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):94-95.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/JUNBID178.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Mycosis fungoides/Sezary's syndrome
Primary cutaneous CD30+ anaplastic large cell lymphoma


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Bone: Enchondroma


External links

Nomenclature
HGNC (Hugo)JUNB   6205
Cards
AtlasJUNBID178
Entrez_Gene (NCBI)JUNB  3726  jun B proto-oncogene
AliasesAP-1
GeneCards (Weizmann)JUNB
Ensembl hg19 (Hinxton)ENSG00000171223 [Gene_View]  chr19:12902310-12904125 [Contig_View]  JUNB [Vega]
Ensembl hg38 (Hinxton)ENSG00000171223 [Gene_View]  chr19:12902310-12904125 [Contig_View]  JUNB [Vega]
ICGC DataPortalENSG00000171223
TCGA cBioPortalJUNB
AceView (NCBI)JUNB
Genatlas (Paris)JUNB
WikiGenes3726
SOURCE (Princeton)JUNB
Genetics Home Reference (NIH)JUNB
Genomic and cartography
GoldenPath hg19 (UCSC)JUNB  -     chr19:12902310-12904125 +  19p13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)JUNB  -     19p13.13   [Description]    (hg38-Dec_2013)
EnsemblJUNB - 19p13.13 [CytoView hg19]  JUNB - 19p13.13 [CytoView hg38]
Mapping of homologs : NCBIJUNB [Mapview hg19]  JUNB [Mapview hg38]
OMIM165161   
Gene and transcription
Genbank (Entrez)AK222532 AK313737 BC004250 BC009465 BC009466
RefSeq transcript (Entrez)NM_002229
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)JUNB
Cluster EST : UnigeneHs.25292 [ NCBI ]
CGAP (NCI)Hs.25292
Alternative Splicing GalleryENSG00000171223
Gene ExpressionJUNB [ NCBI-GEO ]   JUNB [ EBI - ARRAY_EXPRESS ]   JUNB [ SEEK ]   JUNB [ MEM ]
Gene Expression Viewer (FireBrowse)JUNB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3726
GTEX Portal (Tissue expression)JUNB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17275   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17275  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17275
Splice isoforms : SwissVarP17275
PhosPhoSitePlusP17275
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    JNK    JunB    Leuzip_Jun    TF_DNA-bd   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    Jun (PF03957)   
Domain families : Pfam (NCBI)pfam00170    pfam03957   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)JUNB
DMDM Disease mutations3726
Blocks (Seattle)JUNB
SuperfamilyP17275
Human Protein AtlasENSG00000171223
Peptide AtlasP17275
HPRD01303
IPIIPI00013439   
Protein Interaction databases
DIP (DOE-UCLA)P17275
IntAct (EBI)P17275
FunCoupENSG00000171223
BioGRIDJUNB
STRING (EMBL)JUNB
ZODIACJUNB
Ontologies - Pathways
QuickGOP17275
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  chromatin  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  vasculogenesis  osteoblast differentiation  trophectodermal cell differentiation  DNA binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription factor binding  response to radiation  response to light stimulus  response to mechanical stimulus  regulation of cell death  osteoclast differentiation  response to lipopolysaccharide  response to progesterone  cellular response to hormone stimulus  osteoblast proliferation  response to cytokine  regulation of cell proliferation  response to drug  response to peptide hormone  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  decidualization  response to corticosterone  response to cAMP  regulation of cell cycle  embryonic process involved in female pregnancy  labyrinthine layer blood vessel development  cellular response to calcium ion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  chromatin  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  vasculogenesis  osteoblast differentiation  trophectodermal cell differentiation  DNA binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription factor binding  response to radiation  response to light stimulus  response to mechanical stimulus  regulation of cell death  osteoclast differentiation  response to lipopolysaccharide  response to progesterone  cellular response to hormone stimulus  osteoblast proliferation  response to cytokine  regulation of cell proliferation  response to drug  response to peptide hormone  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  decidualization  response to corticosterone  response to cAMP  regulation of cell cycle  embryonic process involved in female pregnancy  labyrinthine layer blood vessel development  cellular response to calcium ion  
Pathways : KEGGOsteoclast differentiation    TNF signaling pathway   
REACTOMEP17275 [protein]
REACTOME PathwaysR-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [pathway]
NDEx NetworkJUNB
Atlas of Cancer Signalling NetworkJUNB
Wikipedia pathwaysJUNB
Orthology - Evolution
OrthoDB3726
GeneTree (enSembl)ENSG00000171223
Phylogenetic Trees/Animal Genes : TreeFamJUNB
HOVERGENP17275
HOGENOMP17275
Homologs : HomoloGeneJUNB
Homology/Alignments : Family Browser (UCSC)JUNB
Gene fusions - Rearrangements
Fusion : MitelmanJUNB/SEC63 [19p13.2/6q21]  
Fusion: TCGAJUNB 19p13.2 SEC63 6q21 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJUNB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JUNB
dbVarJUNB
ClinVarJUNB
1000_GenomesJUNB 
Exome Variant ServerJUNB
ExAC (Exome Aggregation Consortium)JUNB (select the gene name)
Genetic variants : HAPMAP3726
Genomic Variants (DGV)JUNB [DGVbeta]
DECIPHER (Syndromes)19:12902310-12904125  ENSG00000171223
CONAN: Copy Number AnalysisJUNB 
Mutations
ICGC Data PortalJUNB 
TCGA Data PortalJUNB 
Broad Tumor PortalJUNB
OASIS PortalJUNB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICJUNB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDJUNB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch JUNB
DgiDB (Drug Gene Interaction Database)JUNB
DoCM (Curated mutations)JUNB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)JUNB (select a term)
intoGenJUNB
NCG5 (London)JUNB
Cancer3DJUNB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165161   
Orphanet
MedgenJUNB
Genetic Testing Registry JUNB
NextProtP17275 [Medical]
TSGene3726
GENETestsJUNB
Huge Navigator JUNB [HugePedia]
snp3D : Map Gene to Disease3726
BioCentury BCIQJUNB
ClinGenJUNB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3726
Chemical/Pharm GKB GenePA30007
Clinical trialJUNB
Miscellaneous
canSAR (ICR)JUNB (select the gene name)
Probes
Litterature
PubMed122 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineJUNB
EVEXJUNB
GoPubMedJUNB
iHOPJUNB
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 20:02:25 CET 2016

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