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JUND (jun D proto-oncogene)

Written2003-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Other aliasJUN-D proto-oncogene
LocusID (NCBI) 3727
Atlas_Id 179
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JUND (19p13.11) / CNOT8 (5q33.2)JUND (19p13.11) / KDM7A (7q34)JUND (19p13.11) / NASP (1p34.1)
JUND (19p13.11) / PHF5A (22q13.2)JUND (19p13.11) / S100B (21q22.3)

DNA/RNA

Description The gene for JUND is located on the region of chromosome 19p13.1-p12 covering 1409bp. Similar to other members of JUN family, the JunD gene is also intronless.

Protein

 
Description The JUND protein contains 347 amino acids with a predicted molecular weight 35.2 kD. From N-terminus to C-terminus, JUND has a JNK phosphorylating motif (Ser90/Ser100), DNA binding domain, nuclear localization signal (NLS), and a leucine zipper domain. Since this protein lacks the JNK docking site, JUND can only be weakly phosphorylated by JNK. Although the JunD gene has no introns and produces a single transcript, the JUND mRNA translates two JUND protein isoforms, JUND-L and JUND-S. By using a different in-frame translational initiation site, the third AUG codon in JUND mRNA, the short version of JUND, JUND-S, was generated that lacks the N-terminal 43 amino acids. Due to this N-terminal truncation, the JUND-S is unable to associate with Menin, another tumor suppressor protein.
Expression JUND is the most broadly expressed member of the JUN family but expressed at low level.
Localisation The subcellular location of this protein is most likely in the nucleus. Less likely possibilities are in the cytoplasm and in the mitochondria.
Function JUND is a member of the JUN family of basic region leucine zipper (bZIP) DNA-binding proteins. Analysis of the protein expression levels demonstrated an opposite expression pattern between JUN and JUND. When cells entry into the G0 phase of the cell cycle by serum starvation, JUN level decreases and JUND level increases. Similar to JUNB, JUND has been shown as an antagonist of JUN in the induction of cyclin D1. Therefore, increasing the abundance of JUND may maintain the cells in a quiescent state. Transformation studies demonstrated that excess JUND protein could partially suppress the transformed phenotype mediated by JUN in cooperation with Ras. The effect of JUND in development appears to be marginal. Mice lacking JUND are viable with only mild defects in growth and spermatogenesis, whereas mice lacking JUN or JUNB die in embryo.

Bibliography

c-jun is essential for normal mouse development and hepatogenesis.
Hilberg F, Aguzzi A, Howells N, Wagner EF
Nature. 1993 ; 365 (6442) : 179-181.
PMID 8371760
 
Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts.
Lallemand D, Spyrou G, Yaniv M, Pfarr CM
Oncogene. 1997 ; 14 (7) : 819-830.
PMID 9047389
 
The mammalian Jun proteins: redundancy and specificity.
Mechta-Grigoriou F, Gerald D, Yaniv M
Oncogene. 2001 ; 20 (19) : 2378-2389.
PMID 11402334
 
Two proteins translated by alternative usage of initiation codons in mRNA encoding a JunD transcriptional regulator.
Okazaki S, Ito T, Ui M, Watanabe T, Yoshimatsu K, Iba H
Biochemical and biophysical research communications. 1998 ; 250 (2) : 347-353.
PMID 9753632
 
Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.
Pfarr CM, Mechta F, Spyrou G, Lallemand D, Carillo S, Yaniv M
Cell. 1994 ; 76 (4) : 747-760.
PMID 8124713
 
JunB is essential for mammalian placentation.
Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF
The EMBO journal. 1999 ; 18 (4) : 934-948.
PMID 10022836
 
Translational regulation of the JunD messenger RNA.
Short JD, Pfarr CM
The Journal of biological chemistry. 2002 ; 277 (36) : 32697-32705.
PMID 12105216
 
Targeted disruption of the murine junD gene results in multiple defects in male reproductive function.
Thépot D, Weitzman JB, Barra J, Segretain D, Stinnakre MG, Babinet C, Yaniv M
Development (Cambridge, England). 2000 ; 127 (1) : 143-153.
PMID 10654608
 
Differential binding of the Menin tumor suppressor protein to JunD isoforms.
Yazgan O, Pfarr CM
Cancer research. 2001 ; 61 (3) : 916-920.
PMID 11221882
 

Citation

This paper should be referenced as such :
Chen, F
JUND (JUN-D proto-oncogene)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):96-97.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/JUNDID179.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;11)(p21;q24) MIR125B1/?


External links

Nomenclature
Cards
AtlasJUNDID179.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3727
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:40:33 CEST 2018

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