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JUND (jun D proto-oncogene)

Written2003-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Other namesJUN-D proto-oncogene
HGNC (Hugo) JUND
LocusID (NCBI) 3727
Atlas_Id 179
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18390504 and ends at 18392466 bp from pter ( according to hg19-Feb_2009)  [Mapping JUND.png]
Fusion genes
(updated 2016)
JUND (19p13.11) / CNOT8 (5q33.2)JUND (19p13.11) / LOC100499227 ()JUND (19p13.11) / NASP (1p34.1)
JUND (19p13.11) / PHF5A (22q13.2)JUND (19p13.11) / S100B (21q22.3)

DNA/RNA

Description The gene for JUND is located on the region of chromosome 19p13.1-p12 covering 1409bp. Similar to other members of JUN family, the JunD gene is also intronless.

Protein

 
Description The JUND protein contains 347 amino acids with a predicted molecular weight 35.2 kD. From N-terminus to C-terminus, JUND has a JNK phosphorylating motif (Ser90/Ser100), DNA binding domain, nuclear localization signal (NLS), and a leucine zipper domain. Since this protein lacks the JNK docking site, JUND can only be weakly phosphorylated by JNK. Although the JunD gene has no introns and produces a single transcript, the JUND mRNA translates two JUND protein isoforms, JUND-L and JUND-S. By using a different in-frame translational initiation site, the third AUG codon in JUND mRNA, the short version of JUND, JUND-S, was generated that lacks the N-terminal 43 amino acids. Due to this N-terminal truncation, the JUND-S is unable to associate with Menin, another tumor suppressor protein.
Expression JUND is the most broadly expressed member of the JUN family but expressed at low level.
Localisation The subcellular location of this protein is most likely in the nucleus. Less likely possibilities are in the cytoplasm and in the mitochondria.
Function JUND is a member of the JUN family of basic region leucine zipper (bZIP) DNA-binding proteins. Analysis of the protein expression levels demonstrated an opposite expression pattern between JUN and JUND. When cells entry into the G0 phase of the cell cycle by serum starvation, JUN level decreases and JUND level increases. Similar to JUNB, JUND has been shown as an antagonist of JUN in the induction of cyclin D1. Therefore, increasing the abundance of JUND may maintain the cells in a quiescent state. Transformation studies demonstrated that excess JUND protein could partially suppress the transformed phenotype mediated by JUN in cooperation with Ras. The effect of JUND in development appears to be marginal. Mice lacking JUND are viable with only mild defects in growth and spermatogenesis, whereas mice lacking JUN or JUNB die in embryo.

Bibliography

c-jun is essential for normal mouse development and hepatogenesis.
Hilberg F, Aguzzi A, Howells N, Wagner EF
Nature. 1993 ; 365 (6442) : 179-181.
PMID 8371760
 
Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts.
Lallemand D, Spyrou G, Yaniv M, Pfarr CM
Oncogene. 1997 ; 14 (7) : 819-830.
PMID 9047389
 
The mammalian Jun proteins: redundancy and specificity.
Mechta-Grigoriou F, Gerald D, Yaniv M
Oncogene. 2001 ; 20 (19) : 2378-2389.
PMID 11402334
 
Two proteins translated by alternative usage of initiation codons in mRNA encoding a JunD transcriptional regulator.
Okazaki S, Ito T, Ui M, Watanabe T, Yoshimatsu K, Iba H
Biochemical and biophysical research communications. 1998 ; 250 (2) : 347-353.
PMID 9753632
 
Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.
Pfarr CM, Mechta F, Spyrou G, Lallemand D, Carillo S, Yaniv M
Cell. 1994 ; 76 (4) : 747-760.
PMID 8124713
 
JunB is essential for mammalian placentation.
Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF
The EMBO journal. 1999 ; 18 (4) : 934-948.
PMID 10022836
 
Translational regulation of the JunD messenger RNA.
Short JD, Pfarr CM
The Journal of biological chemistry. 2002 ; 277 (36) : 32697-32705.
PMID 12105216
 
Targeted disruption of the murine junD gene results in multiple defects in male reproductive function.
Thépot D, Weitzman JB, Barra J, Segretain D, Stinnakre MG, Babinet C, Yaniv M
Development (Cambridge, England). 2000 ; 127 (1) : 143-153.
PMID 10654608
 
Differential binding of the Menin tumor suppressor protein to JunD isoforms.
Yazgan O, Pfarr CM
Cancer research. 2001 ; 61 (3) : 916-920.
PMID 11221882
 

Citation

This paper should be referenced as such :
Chen, F
JUND (JUN-D proto-oncogene)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):96-97.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/JUNDID179.html


External links

Nomenclature
HGNC (Hugo)JUND   6206
Cards
AtlasJUNDID179
Entrez_Gene (NCBI)JUND  3727  jun D proto-oncogene
AliasesAP-1
GeneCards (Weizmann)JUND
Ensembl hg19 (Hinxton)ENSG00000130522 [Gene_View]  chr19:18390504-18392466 [Contig_View]  JUND [Vega]
Ensembl hg38 (Hinxton)ENSG00000130522 [Gene_View]  chr19:18390504-18392466 [Contig_View]  JUND [Vega]
ICGC DataPortalENSG00000130522
TCGA cBioPortalJUND
AceView (NCBI)JUND
Genatlas (Paris)JUND
WikiGenes3727
SOURCE (Princeton)JUND
Genomic and cartography
GoldenPath hg19 (UCSC)JUND  -     chr19:18390504-18392466 -  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)JUND  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblJUND - 19p13.2 [CytoView hg19]  JUND - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIJUND [Mapview hg19]  JUND [Mapview hg38]
OMIM165162   
Gene and transcription
Genbank (Entrez)AK223630 AW027337 BC169272 BC169273 BC169274
RefSeq transcript (Entrez)NM_001286968 NM_005354
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)JUND
Cluster EST : UnigeneHs.2780 [ NCBI ]
CGAP (NCI)Hs.2780
Alternative Splicing GalleryENSG00000130522
Gene ExpressionJUND [ NCBI-GEO ]   JUND [ EBI - ARRAY_EXPRESS ]   JUND [ SEEK ]   JUND [ MEM ]
Gene Expression Viewer (FireBrowse)JUND [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3727
GTEX Portal (Tissue expression)JUND
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17535 (Uniprot)
NextProtP17535  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17535
Splice isoforms : SwissVarP17535 (Swissvar)
PhosPhoSitePlusP17535
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    JNK    JunD    Leuzip_Jun    TF_DNA-bd   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    Jun (PF03957)   
Domain families : Pfam (NCBI)pfam00170    pfam03957   
Domain families : Smart (EMBL)BRLZ (SM00338)  
DMDM Disease mutations3727
Blocks (Seattle)JUND
PDB (SRS)3U86   
PDB (PDBSum)3U86   
PDB (IMB)3U86   
PDB (RSDB)3U86   
Structural Biology KnowledgeBase3U86   
SCOP (Structural Classification of Proteins)3U86   
CATH (Classification of proteins structures)3U86   
SuperfamilyP17535
Human Protein AtlasENSG00000130522
Peptide AtlasP17535
HPRD01304
IPIIPI00289547   
Protein Interaction databases
DIP (DOE-UCLA)P17535
IntAct (EBI)P17535
FunCoupENSG00000130522
BioGRIDJUND
STRING (EMBL)JUND
ZODIACJUND
Ontologies - Pathways
QuickGOP17535
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  chromatin  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  osteoblast development  transcription coactivator activity  protein binding  nucleus  transcription factor complex  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  aging  circadian rhythm  transcription factor binding  response to radiation  response to light stimulus  response to mechanical stimulus  regulation of cell death  ligand-dependent nuclear receptor binding  enzyme binding  response to lipopolysaccharide  cellular response to hormone stimulus  protein-DNA complex  response to cytokine  regulation of cell proliferation  response to drug  response to peptide hormone  transcription regulatory region DNA binding  positive regulation of cell differentiation  positive regulation of osteoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  response to cAMP  regulation of cell cycle  cellular response to calcium ion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  chromatin  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  osteoblast development  transcription coactivator activity  protein binding  nucleus  transcription factor complex  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  aging  circadian rhythm  transcription factor binding  response to radiation  response to light stimulus  response to mechanical stimulus  regulation of cell death  ligand-dependent nuclear receptor binding  enzyme binding  response to lipopolysaccharide  cellular response to hormone stimulus  protein-DNA complex  response to cytokine  regulation of cell proliferation  response to drug  response to peptide hormone  transcription regulatory region DNA binding  positive regulation of cell differentiation  positive regulation of osteoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  response to cAMP  regulation of cell cycle  cellular response to calcium ion  
Pathways : BIOCARTAFOSB gene expression and drug abuse [Genes]    B Cell Survival Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Osteoclast differentiation   
NDEx Network
Atlas of Cancer Signalling NetworkJUND
Wikipedia pathwaysJUND
Orthology - Evolution
OrthoDB3727
GeneTree (enSembl)ENSG00000130522
Phylogenetic Trees/Animal Genes : TreeFamJUND
Homologs : HomoloGeneJUND
Homology/Alignments : Family Browser (UCSC)JUND
Gene fusions - Rearrangements
Fusion Cancer (Beijing)JUND [19p13.11]  -  S100B [21q22.3]  [FUSC003836]
Polymorphisms : SNP, variants
NCBI Variation ViewerJUND [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JUND
dbVarJUND
ClinVarJUND
1000_GenomesJUND 
Exome Variant ServerJUND
ExAC (Exome Aggregation Consortium)JUND (select the gene name)
Genetic variants : HAPMAP3727
Genomic Variants (DGV)JUND [DGVbeta]
Mutations
ICGC Data PortalJUND 
TCGA Data PortalJUND 
Broad Tumor PortalJUND
OASIS PortalJUND [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICJUND 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch JUND
DgiDB (Drug Gene Interaction Database)JUND
DoCM (Curated mutations)JUND (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)JUND (select a term)
intoGenJUND
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:18390504-18392466  ENSG00000130522
CONAN: Copy Number AnalysisJUND 
Mutations and Diseases : HGMDJUND
OMIM165162   
MedgenJUND
Genetic Testing Registry JUND
NextProtP17535 [Medical]
TSGene3727
GENETestsJUND
Huge Navigator JUND [HugePedia]
snp3D : Map Gene to Disease3727
BioCentury BCIQJUND
ClinGenJUND
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3727
Chemical/Pharm GKB GenePA30008
Clinical trialJUND
Miscellaneous
canSAR (ICR)JUND (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineJUND
EVEXJUND
GoPubMedJUND
iHOPJUND
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Aug 10 18:59:22 CEST 2016

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