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KRAS (Kirsten rat sarcoma 2 viral oncogene homolog)

Written1999-02Franz Watzinger, Thomas Lion
Children's Cancer Research Institute (CCRI), Kinderspitalgasse 6, A-1090 Vienna, Austria

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)K-RAS (Kirsten rat sarcoma 2 viral oncogene homolog)
c-Ki-ras 2
HGNC (Hugo) KRAS
HGNC Alias symbKRAS1
K-Ras4B
HGNC Previous nameKRAS2
HGNC Previous namev-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
 Kirsten rat sarcoma viral oncogene homolog
LocusID (NCBI) 3845
Atlas_Id 91
Location 12p12.1  [Link to chromosome band 12p12]
Location_base_pair Starts at 25205246 and ends at 25250929 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping KRAS.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC42SE1 (1q21.3)::KRAS (12p12.1)KRAS (12p12.1)::CDH13 (16q23.3)KRAS (12p12.1)::KMT2A (11q23.3)
KRAS (12p12.1)::LMNTD1 (12p12.1)KRAS (12p12.1)::RERGL (12p12.3)UBE2L3 (22q11.21)::KRAS (12p12.1)
Note more on the RAS family is available as a deep insight

DNA/RNA

 
  K-ras splicing variants alternative splicing of K-ras precursor mRNA leads to the two transcripts which differ by the ex- or inclusion of Exon 4a; Exons that encode protein are shown as black boxes, untranslated exons as white boxes; the upstream untranslated exon is indicated as Exon -1
Description consists of six exons, spread over 35kb of genomic DNA.
Transcription alternative RNA splicing reveals two different transcripts of 5.5 and 3.8kb (see Fig); if Exon 4a is skipped exon 4b is directly joined to exon 3; in 98% of the transcripts exon 4a is spliced out and only exon 4b is available for translation into protein.
Pseudogene c-Ki-ras 1, inactivated, processed pseudogene which is located on Chromosome 6

Protein

Description regular RAS protein - characterized in the RAS family page.
Expression ubiquitously expressed
Localisation anchored to the inner surface of the plasma membrane
Function analogously to other GTP-binding proteins (such as Translation Elongation Factor EFTu or signal transducing G-Proteins) RAS proteins are involved in signal transduction pathways
Homology ras gene family is part of the ras superfamily including the mammalian RAS, RAL, RAC, RHO, RAP, and RAB gene families and the yeast homologs like SEC4 and YPT1 genes; genes encode small monomeric proteins of low molecular mass (20-30 kDa) which share at least 30% homology to RAS proteins.

Implicated in

Note
  
Entity tumor (frequency of K-RAS mutations); references in Full Bibliography
  
  
Entity pancreas (80-90%)
  
  
Entity colon and rectum (25-60%)
  
  
Entity lung (25-60%)
  
  
Entity prostate (0-25%)
  
  
Entity skin (0-25%)
  
  
Entity thyroid (0-60%)
  
  
Entity liver (10-25%)
  
  
Entity ovary (0-50%)
  
  
Entity endometrium (10-40%)
  
  
Entity kidney (0-50%)
  
  
Entity brain (0-15%)
  
  
Entity (10-45%)
  
  
Entity acute non lymphocytic leukemia and myelodysplasia (5-15%)
  
  
Entity urinary bladder (5%)
  
  
Entity head and neck (10%)
  
  
Entity breast (10%)
  

Bibliography

ras oncogenes: their role in neoplasia.
Barbacid M
European journal of clinical investigation. 1990 ; 20 (3) : 225-235.
PMID 2114981
 
ras oncogenes in human cancer: a review.
Bos JL
Cancer research. 1989 ; 49 (17) : 4682-4689.
PMID 2547513
 
ras activation in experimental carcinogenesis.
Mangues R, Pellicer A
Seminars in cancer biology. 1992 ; 3 (4) : 229-239.
PMID 1421167
 
Human cancer and cellular oncogenes.
Nishimura S, Sekiya T
The Biochemical journal. 1987 ; 243 (2) : 313-327.
PMID 3307760
 

Citation

This paper should be referenced as such :
Watzinger, F ; Lion, T
KRAS (Kirsten rat sarcoma viral oncogene homolog)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):66-67.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 16 ]
  Burkitt's lymphoma (BL)
Classification of myelodysplastic syndromes 2015
Chronic Myelomonocytic Leukemia (CMML)
Early T-cell precursor acute lymphoblastic leukemia
Juvenile myelomonocytic leukemia (JMML)
Acute basophilic leukemia::t(X;6)(p11;q23) MYB::GATA1
Acute lymphoblastic leukemia in Down syndrome
Mixed phenotype acute leukemia (MPAL)
Myelodysplastic::myeloproliferative neoplasms
Plasma cell leukemia (PCL)
t(3;21)(q26;q22) RUNX1::MECOM
t(4;11)(q21;p15) NUP98::RAP1GDS1
t(4;11)(q23;p15) NUP98::RAP1GDS1
t(6;11)(q27;q23) KMT2A::AFDN
t(14;16)(q32;q23) IGH::MAF
t(11;12)(q23;p12) KRAS::KMT2A


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Noonan syndrome


External links

 

Nomenclature
HGNC (Hugo)KRAS   6407
LRG (Locus Reference Genomic)LRG_344
Cards
AtlasKRASID91
Entrez_Gene (NCBI)KRAS    KRAS proto-oncogene, GTPase
Aliases'C-K-RAS; C-K-RAS; CFC2; K-RAS2A; 
K-RAS2B; K-RAS4A; K-RAS4B; K-Ras; K-Ras; KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2; c-Ki-ras; c-Ki-ras2
GeneCards (Weizmann)KRAS
Ensembl hg19 (Hinxton)ENSG00000133703 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133703 [Gene_View]  ENSG00000133703 [Sequence]  chr12:25205246-25250929 [Contig_View]  KRAS [Vega]
ICGC DataPortalENSG00000133703
TCGA cBioPortalKRAS
AceView (NCBI)KRAS
Genatlas (Paris)KRAS
SOURCE (Princeton)KRAS
Genetics Home Reference (NIH)KRAS
Genomic and cartography
GoldenPath hg38 (UCSC)KRAS  -     chr12:25205246-25250929 -  12p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KRAS  -     12p12.1   [Description]    (hg19-Feb_2009)
GoldenPathKRAS - 12p12.1 [CytoView hg19]  KRAS - 12p12.1 [CytoView hg38]
ImmunoBaseENSG00000133703
Genome Data Viewer NCBIKRAS [Mapview hg19]  
OMIM108010   109800   114480   137215   163200   190070   211980   260350   600268   601626   609942   614470   615278   
Gene and transcription
Genbank (Entrez)AA812162 AF493917 AI539465 AK292510 AW117295
RefSeq transcript (Entrez)NM_001369786 NM_001369787 NM_004985 NM_033360
Consensus coding sequences : CCDS (NCBI)KRAS
Gene ExpressionKRAS [ NCBI-GEO ]   KRAS [ EBI - ARRAY_EXPRESS ]   KRAS [ SEEK ]   KRAS [ MEM ]
Gene Expression Viewer (FireBrowse)KRAS [ Firebrowse - Broad ]
GenevisibleExpression of KRAS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3845
GTEX Portal (Tissue expression)KRAS
Human Protein AtlasENSG00000133703-KRAS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01116   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01116
PhosPhoSitePlusP01116
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras-type   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)KRAS
PDB (RSDB)1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
PDB Europe1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
PDB (PDBSum)1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
PDB (IMB)1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
Structural Biology KnowledgeBase1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
SCOP (Structural Classification of Proteins)1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
CATH (Classification of proteins structures)1D8D    1D8E    1KZO    1KZP    1N4P    1N4Q    1N4R    1N4S    3GFT    4DSN    4DSO    4EPR    4EPT    4EPV    4EPW    4EPX    4EPY    4L8G    4LDJ    4LPK    4LRW    4LUC    4LV6    4LYF    4LYH    4LYJ    4M1O    4M1S    4M1T    4M1W    4M1Y    4M21    4M22    4NMM    4OBE    4PZY    4PZZ    4Q01    4Q02    4Q03    4QL3    4TQ9    4TQA    4WA7    5F2E    5KYK    5MLA    5MLB    5O2S    5O2T    5OCG    5OCO    5OCT    5TAR    5TB5    5UFE    5UFQ    5UK9    5UQW    5US4    5USJ    5V6S    5V6V    5V71    5V9L    5V9O    5V9U    5VBM    5VP7    5VPI    5VPY    5VPZ    5VQ0    5VQ1    5VQ2    5VQ6    5VQ8    5W22    5WHA    5WHB    5WHD    5WHE    5WLB    5WPM    5XCO    5YXZ    5YY1    6ARK    6ASA    6ASE    6B0V    6B0Y    6BOF    6BP1    6CC9    6CCH    6CCX    6CU6    6E6F    6E6G    6EPL    6EPM    6EPN    6EPO    6EPP    6F76    6FA1    6FA2    6FA3    6FA4    6GJ5    6GJ6    6GJ7    6GJ8    6GOD    6GOE    6GOF    6GOG    6GOM    6GQT    6GQW    6GQX    6GQY    6H46    6H47    6JTN    6JTO    6JTP    6M9W    6MBQ    6MBT    6MBU    6MNX    6MQG    6MQN    6MS9    6MTA    6N2J    6N2K    6O36    6O46    6O4Y    6O4Z    6O51    6O53    6OB2    6OB3    6OIM    6P0Z    6P8W    6P8X    6P8Y    6P8Z    6PGO    6PGP    6PQ3    6PTS    6PTW    6QUU    6QUV    6QUW    6QUX    6T5B    6T5U    6T5V    6TAM    6TAN    6USX    6USZ    6UT0    6V5L    6V65    6V6F    6W4E    6W4F    6WGN    6YR8    6YXW    6ZL5    6ZLI   
SuperfamilyP01116
AlphaFold pdb e-kbP01116   
Human Protein Atlas [tissue]ENSG00000133703-KRAS [tissue]
HPRD01817
Protein Interaction databases
DIP (DOE-UCLA)P01116
IntAct (EBI)P01116
BioGRIDKRAS
STRING (EMBL)KRAS
ZODIACKRAS
Ontologies - Pathways
QuickGOP01116
Ontology : AmiGOGolgi membrane  MAPK cascade  liver development  positive regulation of protein phosphorylation  stimulatory C-type lectin receptor signaling pathway  GTPase activity  G protein activity  protein binding  GTP binding  cytoplasm  mitochondrial outer membrane  endoplasmic reticulum membrane  cytosol  plasma membrane  plasma membrane  focal adhesion  Ras protein signal transduction  Ras protein signal transduction  female pregnancy  positive regulation of cell population proliferation  visual learning  positive regulation of gene expression  membrane  GMP binding  GDP binding  cytokine-mediated signaling pathway  forebrain astrocyte development  actin cytoskeleton organization  LRR domain binding  extrinsic component of cytoplasmic side of plasma membrane  regulation of protein stability  regulation of synaptic transmission, GABAergic  positive regulation of Rac protein signal transduction  response to isolation stress  endocrine signaling  positive regulation of MAP kinase activity  negative regulation of neuron apoptotic process  protein-containing complex binding  membrane raft  negative regulation of cell differentiation  regulation of long-term neuronal synaptic plasticity  homeostasis of number of cells within a tissue  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  response to glucocorticoid  response to mineralocorticoid  epithelial tube branching involved in lung morphogenesis  positive regulation of cellular senescence  
Ontology : EGO-EBIGolgi membrane  MAPK cascade  liver development  positive regulation of protein phosphorylation  stimulatory C-type lectin receptor signaling pathway  GTPase activity  G protein activity  protein binding  GTP binding  cytoplasm  mitochondrial outer membrane  endoplasmic reticulum membrane  cytosol  plasma membrane  plasma membrane  focal adhesion  Ras protein signal transduction  Ras protein signal transduction  female pregnancy  positive regulation of cell population proliferation  visual learning  positive regulation of gene expression  membrane  GMP binding  GDP binding  cytokine-mediated signaling pathway  forebrain astrocyte development  actin cytoskeleton organization  LRR domain binding  extrinsic component of cytoplasmic side of plasma membrane  regulation of protein stability  regulation of synaptic transmission, GABAergic  positive regulation of Rac protein signal transduction  response to isolation stress  endocrine signaling  positive regulation of MAP kinase activity  negative regulation of neuron apoptotic process  protein-containing complex binding  membrane raft  negative regulation of cell differentiation  regulation of long-term neuronal synaptic plasticity  homeostasis of number of cells within a tissue  positive regulation of nitric-oxide synthase activity  positive regulation of NF-kappaB transcription factor activity  striated muscle cell differentiation  response to glucocorticoid  response to mineralocorticoid  epithelial tube branching involved in lung morphogenesis  positive regulation of cellular senescence  
Pathways : BIOCARTATelomeres, Telomerase, Cellular Aging, and Immortality [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Dorso-ventral axis formation    Axon guidance    VEGF signaling pathway    Tight junction    Gap junction    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Serotonergic synapse    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Alcoholism    Hepatitis C    Hepatitis B    HTLV-I infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    MicroRNAs in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
REACTOMEP01116 [protein]
REACTOME PathwaysR-HSA-9634635 [pathway]   
NDEx NetworkKRAS
Atlas of Cancer Signalling NetworkKRAS
Wikipedia pathwaysKRAS
Orthology - Evolution
OrthoDB3845
GeneTree (enSembl)ENSG00000133703
Phylogenetic Trees/Animal Genes : TreeFamKRAS
Homologs : HomoloGeneKRAS
Homology/Alignments : Family Browser (UCSC)KRAS
Gene fusions - Rearrangements
Fusion : MitelmanKRAS::CDH13 [12p12.1/16q23.3]  
Fusion : MitelmanKRAS::LMNTD1 [12p12.1/12p12.1]  
Fusion : MitelmanKRAS::RERGL [12p12.1/12p12.3]  
Fusion : COSMICUBE2L3 [22q11.21]  -  KRAS [12p12.1]  [fusion_1298]  
Fusion : QuiverKRAS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKRAS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KRAS
dbVarKRAS
ClinVarKRAS
MonarchKRAS
1000_GenomesKRAS 
Exome Variant ServerKRAS
GNOMAD BrowserENSG00000133703
Varsome BrowserKRAS
ACMGKRAS variants
VarityP01116
Genomic Variants (DGV)KRAS [DGVbeta]
DECIPHERKRAS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKRAS 
Mutations
ICGC Data PortalKRAS 
TCGA Data PortalKRAS 
Broad Tumor PortalKRAS
OASIS PortalKRAS [ Somatic mutations - Copy number]
Cancer Gene: CensusKRAS 
Somatic Mutations in Cancer : COSMICKRAS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKRAS
Mutations and Diseases : HGMDKRAS
intOGen PortalKRAS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKRAS
DgiDB (Drug Gene Interaction Database)KRAS
DoCM (Curated mutations)KRAS
CIViC (Clinical Interpretations of Variants in Cancer)KRAS
OncoKBKRAS
NCG (London)KRAS
Cancer3DKRAS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108010    109800    114480    137215    163200    190070    211980    260350    600268    601626    609942    614470    615278   
Orphanet206    549    905    1559    19659    20165    2962    3245    3708    22213    22214    11747   
DisGeNETKRAS
MedgenKRAS
Genetic Testing Registry KRAS
NextProtP01116 [Medical]
GENETestsKRAS
Target ValidationKRAS
Huge Navigator KRAS [HugePedia]
ClinGenKRAS (curated)
Clinical trials, drugs, therapy
MyCancerGenomeKRAS
Protein Interactions : CTDKRAS
Pharm GKB GenePA30196
Pharm GKB PathwaysPA154423660   PA162356267   PA165959584   PA165980050   PA2032   
PharosP01116
Drug Sensitivity KRAS
Clinical trialKRAS
Miscellaneous
canSAR (ICR)KRAS
HarmonizomeKRAS
DataMed IndexKRAS
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=KRAS
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKRAS
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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