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MVP ( major vault protein)

Identity

Other namesLRP (lung resistance-related protein)
HGNC (Hugo) MVP
Location 16p11.2
Location_base_pair Starts at 29739288 and ends at 29766842 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Note drug resistance gene, codes for a "lung resistance-related protein" (LRP) originally detected in a lung carcinoma cell line resistant to chemotherapy

DNA/RNA

Transcription coding sequence, corresponding to full mRNA, is 2840 bp long

Protein

Description 110 KD protein, 896 amino acids; major cytoplasmic vault protein; vaults are nucleoproteic complexes composed of the MVP associated with two high-molecular weight proteins p240 and p193 which surround a small 140 nucleotides RNA species
Expression expressed in a variety of human tumor cell lines, the major part being multidrug resistant; expressed also in primary solid tumors, mainly colon carcinoma or ovarian carcinoma, as well as in hematopoietic cancers (myelodysplastic syndrome, acute myeloid or lymphoid leukemia, multiple myeloma); in normal tissues, LRP expression has a wide distribution, with particularly high levels in epithelial cells of the digestive tract
Localisation cytoplasmic, in the cytosol, with a little fraction (approximately 5%) located in the nuclear membrane and nuclear pores
Function vault are cytoplasmic organelles which mediate bidirectional nucleocytoplasmic transport of a wide range of substrates, including cytotoxic drugs; vaults would be involved both in vesicule and cytosolic transport of molecules
Homology 104 kD rat MVP

Implicated in

Entity implicated in induced multidrug-resistance to anticancer chemotherapy
Disease it includes resistance to doxorubicin, vinca alkaloids, mitoxantrone and etoposide; the role of LRP by itself in multidrug-resistance is not completely clear because it is only a part of a nucleo-proteic complex involved in macromolecules transport; the introduction and expression of the LRP gene in cells by transfection does not confer a multidrug-resistance phenotype; overexpression of LRP has been associated with poor response to chemotherapy in various types of leukemia and in ovarian carcinoma, however the role of LRP as pronostic factor remains controversial; in multi-resistant cell lines, LRP amplification within a homogeneous staining region is exceptional
  

External links

Nomenclature
HGNC (Hugo)MVP   7531
Entrez_Gene (NCBI)MVP  9961  major vault protein
Cards
AtlasLRPID120
GeneCards (Weizmann)MVP
Ensembl (Hinxton)ENSG00000013364 [Gene_View]  MVP [Vega]
AceView (NCBI)MVP
Genatlas (Paris)MVP
euGene (Indiana)9961
SOURCE (Stanford)NM_005115 NM_017458
Genomic and cartography
GoldenPath (UCSC)MVP  -  16p11.2   chr16:29739288-29766842 +  16p11.2   [Description]    (hg18-Mar_2006)
EnsemblMVP - 16p11.2 [CytoView]
Mapping of homologs : NCBIMVP [Mapview]
OMIM605088   
Gene and transcription
Gene : Genbank (Entrez)AJ291366 AJ291367 AK293302 AK298238 AK301130
Reference sequence (RefSeq transcript) :SRSNM_005115 NM_017458
Reference transcript : EntrezNM_005115 NM_017458
RefSeq genomic : SRSAC_000059 AC_000148 NC_000016 NT_010393 NW_001838235 NW_926539
RefSeq genomic : EntrezAC_000059 AC_000148 NC_000016 NT_010393 NW_001838235 NW_926539
Consensus coding sequences : CCDS NCBIMVP
Cluster EST : UnigeneHs.632177 [ SRS ] Hs.632177 [ NCBI ]
Alternative Splicing : Fast-db (Paris)6887
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ14764 (SRS) Q14764 (Expasy) Q14764 (Uniprot)
With graphics : InterProQ14764
Splice isoforms : VarSplice FASTAQ14764(VarSplice FASTA)
Domaine pattern : Prosite (SRS)MVP (PS51224)   
Domain pattern : Prosite (Expaxy)MVP (PS51224)   
Domains : Interpro (SRS)Vault_N   
Domains : Interpro (EBI)Vault_N   
Related proteins : CluSTrQ14764
Domain families : Pfam SRSVault (PF01505)   
Domain families : Pfam SangerVault (PF01505)   
Domain families : Pfam NCBIpfam01505   
Blocks (Seattle)Q14764
Crystal structure of protein : PDB SRS1Y7X   
Crystal structure of protein : PDBSum1Y7X   
Crystal structure of protein : IMB1Y7X   
Crystal structure of protein : PDB RSDB1Y7X   
HPRD05475
Protein Interaction databases
DIP (DOE-UCLA)Q14764
IntAct (EBI)Q14764
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIMVP
SNP : GeneSNP UtahMVP
SNP : HGBaseMVP
Genetic variants : HAPMAPMVP
Mutations and Diseases : HGMDMVP
Hereditary diseases : OMIM605088   
Hereditary diseases : GENETests605088   
Diseases : Genetic AssociationMVP
General knowledge
Homologs : HomoloGeneMVP
Homology/Alignments : Family Browser UCSCMVP
Phylogenetic Trees/Animal Genes : TreeFamMVP
Chemical/Protein Interactions : CTD9961
Keywords Ontology : AmiGOprotein binding  nucleus  nuclear pore  cytoplasm  protein transport  ribonucleoprotein complex  response to drug  mRNA transport  intracellular protein transmembrane transport  
Keywords Ontology : EGO-EBIprotein binding  nucleus  nuclear pore  cytoplasm  protein transport  ribonucleoprotein complex  response to drug  mRNA transport  intracellular protein transmembrane transport  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesMVP Related clones (RZPD - Berlin)
Literature
PubMed54 Pubmed reference(s) in Entrez
PubGeneMVP

Bibliography

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.
Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG
Science (New York, N.Y.). 1992 ; 258 (5088) : 1650-1654.
PMID 1360704
 
The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.
Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, Broxterman HJ, Scheffer GL, Scheper RJ
Cancer research. 1995 ; 55 (19) : 4214-4219.
PMID 7671223
 
Major vault protein LRP-related multidrug resistance.
Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ
European journal of cancer (Oxford, England : 1990). 1996 ; 32A (6) : 979-984.
PMID 8763338
 
Expression of the human major vault protein LRP in acute myeloid leukemia.
Hart SM, Ganeshaguru K, Scheper RJ, Prentice HG, Hoffbrand AV, Mehta AB
Experimental hematology. 1997 ; 25 (12) : 1227-1232.
PMID 9357965
 
Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines.
Laurenˆßot CM, Scheffer GL, Scheper RJ, Shoemaker RH
International journal of cancer. Journal international du cancer. 1997 ; 72 (6) : 1021-1026.
PMID 9378536
 
Coexpression of multidrug resistance involve proteins: a flow cytometric analysis.
Boutonnat J, Bonnefoix T, Mousseau M, Seigneurin D, Ronot X
Anticancer research. 1998 ; 18 (4C) : 2993-2999.
PMID 9713498
 
P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias.
Damiani D, Michieli M, Ermacora A, Candoni A, Raspadori D, Geromin A, Stocchi R, Grimaz S, Masolini P, Michelutti A, Scheper RJ, Baccarani M
Haematologica. 1998 ; 83 (4) : 290-297.
PMID 9592977
 
Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia.
den Boer ML, Pieters R, Kazemier KM, Rottier MM, Zwaan CM, Kaspers GJ, Janka-Schaub G, Henze G, Creutzig U, Scheper RJ, Veerman AJ
Blood. 1998 ; 91 (6) : 2092-2098.
PMID 9490695
 
Expression of the lung resistance protein predicts poor outcome in de novo acute myeloid leukemia.
Filipits M, Pohl G, Stranzl T, Suchomel RW, Scheper RJ, Jˆ§ger U, Geissler K, Lechner K, Pirker R
Blood. 1998 ; 91 (5) : 1508-1513.
PMID 9473213
 
Multidrug resistance in leukemia.
Leith C
Current opinion in hematology. 1998 ; 5 (4) : 287-291.
PMID 9747635
 
Expression of lung resistance protein and correlation with other drug resistance proteins and outcome in myelodysplastic syndromes.
Lepelley P, Poulain S, Grardel N, Preudhomme C, Cosson A, Fenaux P
Leukemia & lymphoma. 1998 ; 29 (5-6) : 547-551.
PMID 9643568
 
Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma.
Raaijmakers HG, Izquierdo MA, Lokhorst HM, de Leeuw C, Belien JA, Bloem AC, Dekker AW, Scheper RJ, Sonneveld P
Blood. 1998 ; 91 (3) : 1029-1036.
PMID 9446666
 
Multidrug resistance and its reversal.
Volm M
Anticancer research. 1998 ; 18 (4C) : 2905-2917.
PMID 9713485
 
Expression of the lung resistance protein predicts poor outcome in patients with multiple myeloma.
Filipits M, Drach J, Pohl G, Schuster J, Stranzl T, Ackermann J, Kˆnigsberg R, Kaufmann H, Gisslinger H, Huber H, Ludwig H, Pirker R
Clinical cancer research : an official journal of the American Association for Cancer Research. 1999 ; 5 (9) : 2426-2430.
PMID 10499614
 
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis.
Meijer GA, Schroeijers AB, Flens MJ, Meuwissen SG, van der Valk P, Baak JP, Scheper RJ
Journal of clinical pathology. 1999 ; 52 (6) : 450-454.
PMID 10562814
 
Expression of the lung resistance protein (LRP) in primary breast cancer.
Pohl G, Filipits M, Suchomel RW, Stranzl T, Depisch D, Pirker R
Anticancer research. 1999 ; 19 (6B) : 5051-5055.
PMID 10697509
 
P-glycoprotein and multidrug resistance-associated protein, but not lung resistance protein, lower the intracellular daunorubicin accumulation in acute myeloid leukaemic cells.
Borg AG, Burgess R, Green LM, Scheper RJ, Liu Yin JA
British journal of haematology. 2000 ; 108 (1) : 48-54.
PMID 10651723
 
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Contributor(s)

Written05-2000Franck Viguié

Citation

This paper should be referenced as such :
Viguié F . MVP ( major vault protein). Atlas Genet Cytogenet Oncol Haematol. May 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/LRPID120.html

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indexed on : Sat Jun 27 16:37:52 CEST 2009
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