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MVP (major vault protein)

Written2000-05Franck Vigué
Laboratoire de Cytogenetique - Service d'Hematologie Biologique, Hopital Hotel-Dieu - 75181 Paris Cedex 04, France

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)LRP
VAULT1
Other aliasLRP (lung resistance-related protein)
HGNC (Hugo) MVP
LocusID (NCBI) 9961
Atlas_Id 120
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 29830515 and ends at 29848039 bp from pter ( according to hg19-Feb_2009)  [Mapping MVP.png]
Fusion genes
(updated 2016)
MVP (16p11.2) / KIF22 (16p11.2)MVP (16p11.2) / MTPN (7q33)MVP (16p11.2) / ZNF267 (16p11.2)
PAGR1 (16p11.2) / MVP (16p11.2)REL (2p16.1) / MVP (16p11.2)
Note drug resistance gene, codes for a "lung resistance-related protein" (LRP) originally detected in a lung carcinoma cell line resistant to chemotherapy

DNA/RNA

Transcription coding sequence, corresponding to full mRNA, is 2840 bp long

Protein

Description 110 KD protein, 896 amino acids; major cytoplasmic vault protein; vaults are nucleoproteic complexes composed of the MVP associated with two high-molecular weight proteins p240 and p193 which surround a small 140 nucleotides RNA species
Expression expressed in a variety of human tumor cell lines, the major part being multidrug resistant; expressed also in primary solid tumors, mainly colon carcinoma or ovarian carcinoma, as well as in hematopoietic cancers (myelodysplastic syndrome, acute myeloid or lymphoid leukemia, multiple myeloma); in normal tissues, LRP expression has a wide distribution, with particularly high levels in epithelial cells of the digestive tract
Localisation cytoplasmic, in the cytosol, with a little fraction (approximately 5%) located in the nuclear membrane and nuclear pores
Function vault are cytoplasmic organelles which mediate bidirectional nucleocytoplasmic transport of a wide range of substrates, including cytotoxic drugs; vaults would be involved both in vesicule and cytosolic transport of molecules
Homology 104 kD rat MVP

Implicated in

Note
  
Entity implicated in induced multidrug-resistance to anticancer chemotherapy
Disease it includes resistance to doxorubicin, vinca alkaloids, mitoxantrone and etoposide; the role of LRP by itself in multidrug-resistance is not completely clear because it is only a part of a nucleo-proteic complex involved in macromolecules transport; the introduction and expression of the LRP gene in cells by transfection does not confer a multidrug-resistance phenotype; overexpression of LRP has been associated with poor response to chemotherapy in various types of leukemia and in ovarian carcinoma, however the role of LRP as pronostic factor remains controversial; in multi-resistant cell lines, LRP amplification within a homogeneous staining region is exceptional
  

Bibliography

P-glycoprotein and multidrug resistance-associated protein, but not lung resistance protein, lower the intracellular daunorubicin accumulation in acute myeloid leukaemic cells.
Borg AG, Burgess R, Green LM, Scheper RJ, Liu Yin JA
British journal of haematology. 2000 ; 108 (1) : 48-54.
PMID 10651723
 
Coexpression of multidrug resistance involve proteins: a flow cytometric analysis.
Boutonnat J, Bonnefoix T, Mousseau M, Seigneurin D, Ronot X
Anticancer research. 1998 ; 18 (4C) : 2993-2999.
PMID 9713498
 
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.
Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG
Science (New York, N.Y.). 1992 ; 258 (5088) : 1650-1654.
PMID 1360704
 
P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias.
Damiani D, Michieli M, Ermacora A, Candoni A, Raspadori D, Geromin A, Stocchi R, Grimaz S, Masolini P, Michelutti A, Scheper RJ, Baccarani M
Haematologica. 1998 ; 83 (4) : 290-297.
PMID 9592977
 
Expression of the lung resistance protein predicts poor outcome in patients with multiple myeloma.
Filipits M, Drach J, Pohl G, Schuster J, Stranzl T, Ackermann J, Königsberg R, Kaufmann H, Gisslinger H, Huber H, Ludwig H, Pirker R
Clinical cancer research : an official journal of the American Association for Cancer Research. 1999 ; 5 (9) : 2426-2430.
PMID 10499614
 
Expression of the human major vault protein LRP in acute myeloid leukemia.
Hart SM, Ganeshaguru K, Scheper RJ, Prentice HG, Hoffbrand AV, Mehta AB
Experimental hematology. 1997 ; 25 (12) : 1227-1232.
PMID 9357965
 
Major vault protein LRP-related multidrug resistance.
Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ
European journal of cancer (Oxford, England : 1990). 1996 ; 32A (6) : 979-984.
PMID 8763338
 
Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines.
Laurenç CM, Scheffer GL, Scheper RJ, Shoemaker RH
International journal of cancer. Journal international du cancer. 1997 ; 72 (6) : 1021-1026.
PMID 9378536
 
Multidrug resistance in leukemia.
Leith C
Current opinion in hematology. 1998 ; 5 (4) : 287-291.
PMID 9747635
 
Expression of lung resistance protein and correlation with other drug resistance proteins and outcome in myelodysplastic syndromes.
Lepelley P, Poulain S, Grardel N, Preudhomme C, Cosson A, Fenaux P
Leukemia & lymphoma. 1998 ; 29 (5-6) : 547-551.
PMID 9643568
 
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis.
Meijer GA, Schroeijers AB, Flens MJ, Meuwissen SG, van der Valk P, Baak JP, Scheper RJ
Journal of clinical pathology. 1999 ; 52 (6) : 450-454.
PMID 10562814
 
Expression of the lung resistance protein (LRP) in primary breast cancer.
Pohl G, Filipits M, Suchomel RW, Stranzl T, Depisch D, Pirker R
Anticancer research. 1999 ; 19 (6B) : 5051-5055.
PMID 10697509
 
Lung-resistance-related protein expression is a negative predictive factor for response to conventional low but not to intensified dose alkylating chemotherapy in multiple myeloma.
Raaijmakers HG, Izquierdo MA, Lokhorst HM, de Leeuw C, Belien JA, Bloem AC, Dekker AW, Scheper RJ, Sonneveld P
Blood. 1998 ; 91 (3) : 1029-1036.
PMID 9446666
 
The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.
Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, Broxterman HJ, Scheffer GL, Scheper RJ
Cancer research. 1995 ; 55 (19) : 4214-4219.
PMID 7671223
 
Multidrug resistance and its reversal.
Volm M
Anticancer research. 1998 ; 18 (4C) : 2905-2917.
PMID 9713485
 
Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia.
den Boer ML, Pieters R, Kazemier KM, Rottier MM, Zwaan CM, Kaspers GJ, Janka-Schaub G, Henze G, Creutzig U, Scheper RJ, Veerman AJ
Blood. 1998 ; 91 (6) : 2092-2098.
PMID 9490695
 

Citation

This paper should be referenced as such :
Viguié, F
MVP (major vault protein)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(2):68-69.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/LRPID120.html


External links

Nomenclature
HGNC (Hugo)MVP   7531
Cards
AtlasLRPID120
Entrez_Gene (NCBI)MVP  9961  major vault protein
AliasesLRP; VAULT1
GeneCards (Weizmann)MVP
Ensembl hg19 (Hinxton)ENSG00000013364 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013364 [Gene_View]  chr16:29830515-29848039 [Contig_View]  MVP [Vega]
ICGC DataPortalENSG00000013364
TCGA cBioPortalMVP
AceView (NCBI)MVP
Genatlas (Paris)MVP
WikiGenes9961
SOURCE (Princeton)MVP
Genetics Home Reference (NIH)MVP
Genomic and cartography
GoldenPath hg38 (UCSC)MVP  -     chr16:29830515-29848039 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MVP  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblMVP - 16p11.2 [CytoView hg19]  MVP - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBIMVP [Mapview hg19]  MVP [Mapview hg38]
OMIM605088   
Gene and transcription
Genbank (Entrez)AJ291366 AJ291367 AK293302 AK298238 AK301130
RefSeq transcript (Entrez)NM_001293204 NM_001293205 NM_005115 NM_017458
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MVP
Cluster EST : UnigeneHs.632177 [ NCBI ]
CGAP (NCI)Hs.632177
Alternative Splicing GalleryENSG00000013364
Gene ExpressionMVP [ NCBI-GEO ]   MVP [ EBI - ARRAY_EXPRESS ]   MVP [ SEEK ]   MVP [ MEM ]
Gene Expression Viewer (FireBrowse)MVP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9961
GTEX Portal (Tissue expression)MVP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14764   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14764  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14764
Splice isoforms : SwissVarQ14764
PhosPhoSitePlusQ14764
Domaine pattern : Prosite (Expaxy)MVP (PS51224)   
Domains : Interpro (EBI)MVP_shoulder    Vault_N   
Domain families : Pfam (Sanger)MVP_shoulder (PF11978)    Vault (PF01505)   
Domain families : Pfam (NCBI)pfam11978    pfam01505   
Conserved Domain (NCBI)MVP
DMDM Disease mutations9961
Blocks (Seattle)MVP
PDB (SRS)1Y7X   
PDB (PDBSum)1Y7X   
PDB (IMB)1Y7X   
PDB (RSDB)1Y7X   
Structural Biology KnowledgeBase1Y7X   
SCOP (Structural Classification of Proteins)1Y7X   
CATH (Classification of proteins structures)1Y7X   
SuperfamilyQ14764
Human Protein AtlasENSG00000013364
Peptide AtlasQ14764
HPRD05475
IPIIPI00000105   IPI00911022   IPI00910019   
Protein Interaction databases
DIP (DOE-UCLA)Q14764
IntAct (EBI)Q14764
FunCoupENSG00000013364
BioGRIDMVP
STRING (EMBL)MVP
ZODIACMVP
Ontologies - Pathways
QuickGOQ14764
Ontology : AmiGOprotein binding  extracellular region  nucleus  nuclear pore  cytoplasm  cytosol  cytoskeleton  protein transport  membrane  protein kinase binding  protein phosphatase binding  negative regulation of signaling  intracellular ribonucleoprotein complex  negative regulation of protein autophosphorylation  secretory granule lumen  ERBB signaling pathway  identical protein binding  neutrophil degranulation  perinuclear region of cytoplasm  mRNA transport  negative regulation of protein tyrosine kinase activity  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIprotein binding  extracellular region  nucleus  nuclear pore  cytoplasm  cytosol  cytoskeleton  protein transport  membrane  protein kinase binding  protein phosphatase binding  negative regulation of signaling  intracellular ribonucleoprotein complex  negative regulation of protein autophosphorylation  secretory granule lumen  ERBB signaling pathway  identical protein binding  neutrophil degranulation  perinuclear region of cytoplasm  mRNA transport  negative regulation of protein tyrosine kinase activity  extracellular exosome  ficolin-1-rich granule lumen  
REACTOMEQ14764 [protein]
REACTOME PathwaysR-HSA-6798695 [pathway]   
NDEx NetworkMVP
Atlas of Cancer Signalling NetworkMVP
Wikipedia pathwaysMVP
Orthology - Evolution
OrthoDB9961
GeneTree (enSembl)ENSG00000013364
Phylogenetic Trees/Animal Genes : TreeFamMVP
HOVERGENQ14764
HOGENOMQ14764
Homologs : HomoloGeneMVP
Homology/Alignments : Family Browser (UCSC)MVP
Gene fusions - Rearrangements
Fusion : MitelmanMVP/KIF22 [16p11.2/16p11.2]  
Fusion : MitelmanMVP/ZNF267 [16p11.2/16p11.2]  [t(16;16)(p11;p11)]  
Fusion : MitelmanREL/MVP [2p16.1/16p11.2]  [t(2;16)(p16;p11)]  
Fusion: TCGAMVP 16p11.2 KIF22 16p11.2 BRCA
Fusion: TCGAMVP 16p11.2 ZNF267 16p11.2 HNSC
Fusion: TCGAREL 2p16.1 MVP 16p11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMVP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MVP
dbVarMVP
ClinVarMVP
1000_GenomesMVP 
Exome Variant ServerMVP
ExAC (Exome Aggregation Consortium)MVP (select the gene name)
Genetic variants : HAPMAP9961
Genomic Variants (DGV)MVP [DGVbeta]
DECIPHERMVP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMVP 
Mutations
ICGC Data PortalMVP 
TCGA Data PortalMVP 
Broad Tumor PortalMVP
OASIS PortalMVP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMVP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMVP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MVP
DgiDB (Drug Gene Interaction Database)MVP
DoCM (Curated mutations)MVP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MVP (select a term)
intoGenMVP
NCG5 (London)MVP
Cancer3DMVP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605088   
Orphanet
MedgenMVP
Genetic Testing Registry MVP
NextProtQ14764 [Medical]
TSGene9961
GENETestsMVP
Target ValidationMVP
Huge Navigator MVP [HugePedia]
snp3D : Map Gene to Disease9961
BioCentury BCIQMVP
ClinGenMVP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9961
Chemical/Pharm GKB GenePA31332
Clinical trialMVP
Miscellaneous
canSAR (ICR)MVP (select the gene name)
Probes
Litterature
PubMed116 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMVP
EVEXMVP
GoPubMedMVP
iHOPMVP
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:06:50 CEST 2017

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