| Written | 2005-02 | Fei Chen |
| Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA |
| Identity |
| Alias (NCBI) | TNFb Tumor Necrosis Factor-b | TNFSF1 TNF Superfamily member 1 |
| HGNC (Hugo) | LTA |
| HGNC Alias symb | TNFSF1 | LT |
| HGNC Alias name | TNF superfamily member 1 |
| HGNC Previous name | TNFB |
| HGNC Previous name | lymphotoxin alpha (TNF superfamily, member 1) |
| LocusID (NCBI) | 4049 |
| Atlas_Id | 41209 |
| Location | 6p21.33 [Link to chromosome band 6p21] |
| Location_base_pair | Starts at 31572099 and ends at 31574323 bp from pter ( according to hg19-Feb_2009) [Mapping LTA.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| DNA/RNA |
| Description | The human TNFb gene is located next to HLA-C and HLA-B loci in chromosome 6 (6p21.3). The gene spans 2005bp with 4 exons, which transcribes a TNFb mRNA with size of 1386nt. |
| Protein |
 | |
| Description | The human TNFb protein contains 205 amino acids. The soluble form of TNFb is usually a homotrimer with a relative molecular mass of 60 to 70 kDa, whereas the membrane form of TNFb is a heteromeric complex with lymphotoxin b (TNFc, LTb, TNFSF3). The human TNFb shares 35% identity and 50% homology in amino acid sequence with the human TNFa. The biological function of TNFb is mediated largely by TNFa receptor 1 and TNFa receptor 2. Recent studies suggested that TNFb can also recognize LIGHT ( TNFSF14) receptor. |
| Expression | The main cellular source of TNFb is the activated lymphocytes in immune response. |
| Localisation | Cell membrane, extracellular soluble form, blood stream, and biological fluids. |
| Function | The human TNFb is an important cytokine involved in the development of secondary lymphoid organs and inflammatory responses. |
| Implicated in |
| Note | |
| Disease | The polymorphism of TNFb gene in either the coding region or the promoter region has been associated with Crohn disease and myocardial infarction. |
| Bibliography |
| Signalling pathways of the TNF superfamily: a double-edged sword. |
| Aggarwal BB |
| Nature reviews. Immunology. 2003 ; 3 (9) : 745-756. |
| PMID 12949498 |
| Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. |
| Gommerman JL, Browning JL |
| Nature reviews. Immunology. 2003 ; 3 (8) : 642-655. |
| PMID 12974479 |
| Citation |
| This paper should be referenced as such : |
| Chen, F |
| LTA (lymphotoxin-A) |
| Atlas Genet Cytogenet Oncol Haematol. 2005;9(2):119-119. |
| Free journal version : [ pdf ] [ DOI ] |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Sep 14 14:49:05 CEST 2020 |
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