Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1)

Written2001-09Mathijs Baens, Peter Marynen
Center for Human Genetics, Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, Leuven, Belgium

(Note : for Links provided by Atlas : click)

Identity

Other aliasMLT
huParacaspase
LocusID (NCBI) 10892
Atlas_Id 240
Location 18q21.32  [Link to chromosome band 18q21]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL11A (2p16.1) / MALT1 (18q21.32)BIRC3 (11q22.2) / MALT1 (18q21.32)MALT1 (18q21.32) / BIRC3 (11q22.2)
MALT1 (18q21.32) / CYP19A1 (15q21.2)MALT1 (18q21.32) / MALT1 (18q21.32)MALT1 (18q21.32) / MAP4 (3p21.31)
MAP4 (3p21.31) / MALT1 (18q21.32)NEK7 (1q31.3) / MALT1 (18q21.32)NSD2 (4p16.3) / MALT1 (18q21.32)
SERPINF2 (17p13.3) / MALT1 (18q21.32)STPG1 (1p36.11) / MALT1 (18q21.32)

DNA/RNA

Description centromere to telomere orientation; 17 exons spread over 80 kb of genomic sequence, start codon in exon1, stop in exon 17
Transcription 2 alternative transcripts, probably due to alternative polyadenylation.

Protein

 
  MALT1 protein - Mathijs Baens , Peter Marynen
Description 92 kDa; 824 amino acids; The prodomain contains a Death Domain (homotypic interaction module), followed by two immunoglobulin-like domains, a predicted caspace-like proteolytic domain (p20) and a region with homology to the murine VDJ4 sequence
Localisation cytoplasmic
Homology with the predicted ORF from the C. elegans F22D3.6

Implicated in

Note
  
Entity t(11;18)(q21;q21) / marginal zone B-cell lymphoma ofMALT-type --> BIRC3 - MALT1
Disease B-cell non Hodgkin lymphoma (NHL); marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT); found in extranodal MZBCL or MALT-type (50%), absent in splenic and nodal MZBCL
Prognosis For gastric MALT-type lymphomas, t(11;18) is a clonal marker for resistance to Helicobacter pylori eradication therapy and antigen independent growth
Cytogenetics t(11;18) is frequently associated with deletions affecting 3' API2 on chromosome 11 or 5' MALT1 on chromosome 18.
Hybrid/Mutated Gene 5' API2 on chromosome 11q21 translocated on chromosome 18 in frame with 3' MALT1. Deletions often exclude the expression of the reciprocal 5' MLT   API2 3' transcript.
 
BIRC3/MALT1 fusion protein - Mathijs Baens, Peter Marynen
Abnormal Protein All MALT-type lymphomas reported with a t(11;18) express an 'in frame' API2-MLT fusion protein with consistently the three BIR domains of API2 fused to the caspace p20 domain and VDJ4-like domain of MLT.
Oncogenesis Transient expression of the API2-MLT fusion protein acitvates an NF-KB luciferase reporter construct, suggesting the involvement of this signaling cascade in MALT lymphomagenesis
  

Breakpoints

 

Bibliography

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M
Oncogene. 1999 ; 18 (42) : 5785-5794.
PMID 10523859
 
The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation.
Baens M, Maes B, Steyls A, Geboes K, Marynen P, De Wolf-Peeters C
The American journal of pathology. 2000 ; 156 (4) : 1433-1439.
PMID 10751367
 
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.
Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P
Genes, chromosomes & cancer. 2000 ; 29 (4) : 281-291.
PMID 11066071
 
Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes.
Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P
Blood. 2000 ; 96 (6) : 2215-2218.
PMID 10979968
 
The product of the t(11;18), an API2-MLT fusion, is an almost exclusive finding in marginal zone cell lymphoma of extranodal MALT-type.
Maes B, Baens M, Marynen P, De Wolf-Peeters C
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2000 ; 11 (5) : 521-526.
PMID 10907943
 
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.
Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM
Molecular cell. 2000 ; 6 (4) : 961-967.
PMID 11090634
 

Citation

This paper should be referenced as such :
Baens,M ; Marynen, P
MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1)
Atlas Genet Cytogenet Oncol Haematol. 2002;6(1):10-12.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MALT1ID240.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 14 ]
  t(11;18)(q21;q21) BIRC3/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(3;18)(p21;q21) MAP4/MALT1
t(3;18)(p21;q21) MALT1/MAP4
t(11;18)(q22;q21) BIRC3/MALT1
Classification of B-cell non-Hodgkin lymphomas (NHL)
Marginal Zone B-cell lymphoma
t(3;14)(p14;q32) IGH/FOXP1
t(11;18)(q21;q21) BIRC3/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(3;18)(p21;q21) MAP4/MALT1
t(3;18)(p21;q21) MALT1/MAP4
t(11;18)(q22;q21) BIRC3/MALT1
Waldenstrom's macroglobulinemia (published in 2002)


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 16 ]
  t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(11;18)(q22;q21) BIRC3/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(14;18)(q32;q21) IGH/MALT1
t(14;18)(q32;q21) IGH/MALT1


External links

Nomenclature
Cards
AtlasMALT1ID240.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)10892
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:42:03 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.