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MAPK13 (mitogen-activated protein kinase 13)

Written2009-12Maria Isabel Cerezo-Guisado, Ana Cuenda
Centro Nacional de Biotecnologia-CSIC, Department of Immunology, Oncology, Madrid, Spain

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPRKM13
Alias_symbol (synonym)SAPK4
p38delta
Other aliasMGC99536
HGNC (Hugo) MAPK13
LocusID (NCBI) 5603
Atlas_Id 41291
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 36130484 and ends at 36144524 bp from pter ( according to hg19-Feb_2009)  [Mapping MAPK13.png]
 
  MAPK13 genomic context (chromosome 6, location 6p21.31).
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

DNA/RNA

 
  Genomic organization of MAPK13 gene on chromosome 6p21.31. The boxes indicate coding regions (exon 1-12) of the gene.
Description The MAPK13 entire gene spans 9.58 Kb on the short arm of chromosome 6. It contains 12 exons.
Transcription The MAPK13 gene encodes a 365 amino-acid protein of about 40 KDa. No splice variants have been reported.
Pseudogene No human or mouse pseudogene known.

Protein

Note p38delta (MAPK13), also known as Stress-activated protein kinase 4 (SAPK4) belongs to the p38 subfamily of MAPKs. The p38MAPK subfamily is composed by four members encoded by different genes, which share high sequence homologues and are designated as p38alpha (MAPK14, or SAPK2a), p38beta (MAPK11 or SAPK2b), p38gamma (MAPK12 or SAPK3) and p38delta (MAPK13 or SAPK4). They are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities and sensitivities to chemical inhibitors (Iñesta-Vaquera et al., 2008). All p38 MAPKs are strongly activated in vivo by environmental stresses and inflammatory cytokines, and less by serum and growth factors.
 
  Schematic representation of the p38delta (MAPK13) protein structure. Kinase Domain, catalytic kinase domain; TGY, sequence motif containing the regulatory phosphorylation residues.
Description p38delta (MAPK13) is a Serine/Threonine protein kinase of 365 amino acids with a predicted molecular mass of 40 kDa. It possesses the conserved amino acid domains (I-XI) characteristic of protein kinases (Goedert et al., 1997). The Thr180 and Tyr182 residues in subdomain VIII are in an equivalent position to the TXY sequence in known MAPKs. The activation of p38delta (MAPK13) occurs via dual phosphorilation of its TGY motif, in the activation loop, by MKK3 and MKK6, although it is preferentially activated by MKK3 in mouse embryonic fibroblasts (Remy et al., 2009).
Expression p38delta (MAPK13) mRNA is widely expressed with high levels of expression in testes, pancreas, kidney and small intestine.
Localisation p38delta (MAPK13) localizes to the cytoplasm and nucleus of cultured cells.
Function p38delta (MAPK13) phosphorylates typical p38 MAPK substrates such as the transcription factors ATF2, Elk-1 or SAP1. However, it cannot phosphorylate MAPKAPK2 or MAPKAPK3, which are good substrates for other p38 MAPK isoforms (Cuenda et al., 1997; Goedert et al., 1997). p38delta possibly plays a role in cytoskeleton regulation as it has been reported to phosphorylate the cytoplasmic protein stathmin, which has been linked to regulation of microtubule dynamics (Parker et al., 1998). Microtubule-associated protein Tau is another protein substrate of p38delta (Goedert et al., 1997; Feijoo et al., 2005; Yoshida and Goedert, 2006). In addition p38delta plays a role in the regulation of protein translation by phosphorylating and inactivating the eukaryotic elongation factor 2 (eEF2) kinase (Knebel et al., 2001; Knebel et al., 2002). p38delta also plays a key role in the regulation of insulin secretion as well as in the survival of pancreatic beta cells, since p38delta catalyzes an inhibitory phosphorylation of the protein kinase D1 (PDK1), which controls insuline exocytosis in pancreatic beta cells (Sumara et al., 2009). p38delta has been suggested to play an important role in inducing keratinocyte differentiation by regulating the expression of involucrin, which is a protein expressed during keratinocyte differentiation (Eckert et al., 2003). Activation of exogenously expressed p38delta by differentiation-inducing agents such as a bioactive green tea polyphenol (EGCG), okadaic acid (OA) or the phorbol ester TPA, correlated with increased involucrin promoter activity in keratinocytes via increased activity at AP1, Sp1 and C/EBP sites (Balasubramanian et al., 2002; Efimova et al., 2003). The mechanisms by which p38delta may regulates keratinocyte differentiation is still unknown, although it has been reported that in keratinocytes expressing exogenous p38delta this forms a complex with ERK1/ERK2 (Efimova et al., 2003; Eckert et al., 2004). Additional data supporting the idea that p38delta may play a role in keratinocyte differentiation come from a study carried out in lesional psoriasis skin (Johansen et al., 2005). It has been shown that the activity of p38alpha, p38beta and p38delta are augmented in lesional psoriasis skin compared with nonlesional psoriasis skin (Johansen et al., 2005). Alternatively, it has been also claimed that p38delta may have a dual role in keratinocytes contributing not only to the differentiation process, but also to their apoptosis in a PKCdelta dependent manner, and in response to OA or H2O2 (Efimova et al., 2004; Kraft et al., 2007).
Homology p38delta (MAPK13) shows 70% identity with p38gamma (MAPK12), 60% sequence identity with p38alpha (MAPK14) and p38beta (MAPK11), 45% identity with HOG1 from S. cerevisiae, 47% identity with human SAP kinase-1 (JNK1) and 42% identity with p42 MAPkinase (ERK2).

Implicated in

Note
  
Entity Skin cancer
Oncogenesis It has been suggested that p38delta functions as positive regulator of skin tumorogenesis by promoting cell proliferation and tumor development in epidermis (Schindler et al., 2009).
  
  
Entity Cholangiocarcinoma
Oncogenesis p38delta may serve as a diagnostic marker for expression cholangiocarcinoma (CC), since its expression is upregulated in CC relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissue (Li-Sher et al., 2009). It has been suggested that p38delta is important for motility and invasion of CC cells (Li-Sher et al., 2009).
  
  
Entity Malignant Pleural Mesothelioma
Oncogenesis MAPK13 gene is hypermethylated in Malignant Pleural Mesothelioma (MPM) cell lines (Goto et al., 2009).
  
  
Entity Alzheimer disease
Note The protein Tau is a good in vitro substrate for the p38 isoforms p38delta and p38gamma, and its phosphorylation by these two enzymes results in a reduction in its ability to promote microtubule assembly (Goedert et al., 1997b; Feijoo et al., 2005). Moreover, overexpression of p38gamma in neuroblastoma, induces Tau phosphorylation which correlates with a decrease on Tau associated to the cytoskeleton and an increase of soluble Tau (Jenkins et al., 2000). It has been reported as well that p38delta is the major Tau kinase in neuroblastoma in response to osmotic shock (Feijoo et al., 2005) and that the p38MAPK activator, MKK6, has also been found to be active in neurodegenerative diseases (Zhu et al., 2001). Moreover, oxidant agents implicated in Alzheimer's disease can cause hyperphosphorylation in rat brain and also induce the activation of p38delta, indicating that this kinase may be involved in Tau phosphorylation (Yin et al., 2006). On the other hand, it has been shown using phosphospecific antibodies that p38MAPKs phosphorylate Tau on residues phosphorylated in a Tau obtained from patients suffering Alzheimer's disease (Goedert et al., 1997b; Feijoo et al., 2005).
  
  
Entity Diabetes type 2 (diabetes mellitus)
Note p38delta plays a key role in the regulation of insulin secretion as well as in the survival of pancreatic beta cells (Sumara et al., 2009).
  

Bibliography

Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.
Balasubramanian S, Efimova T, Eckert RL.
J Biol Chem. 2002 Jan 18;277(3):1828-36. Epub 2001 Nov 6.
PMID 11698415
 
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).
Cuenda A, Cohen P, Buee-Scherrer V, Goedert M.
EMBO J. 1997 Jan 15;16(2):295-305.
PMID 9029150
 
p38 MAP-kinases pathway regulation, function and role in human diseases.
Cuenda A, Rousseau S.
Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24. (REVIEW)
PMID 17481747
 
Antioxidants regulate normal human keratinocyte differentiation.
Eckert RL, Crish JF, Efimova T, Balasubramanian S.
Biochem Pharmacol. 2004 Sep 15;68(6):1125-31.
PMID 15313409
 
p38 Mitogen-activated protein kinases on the body surface--a function for p38 delta.
Eckert RL, Efimova T, Balasubramanian S, Crish JF, Bone F, Dashti S.
J Invest Dermatol. 2003 May;120(5):823-8. (REVIEW)
PMID 12713588
 
Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex.
Efimova T, Broome AM, Eckert RL.
Mol Cell Biol. 2004 Sep;24(18):8167-83.
PMID 15340077
 
Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.
Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A.
J Cell Sci. 2005 Jan 15;118(Pt 2):397-408. Epub 2005 Jan 4.
PMID 15632108
 
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P.
EMBO J. 1997a Jun 16;16(12):3563-71.
PMID 9218798
 
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P.
FEBS Lett. 1997b Jun 2;409(1):57-62.
PMID 9199504
 
Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.
Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H, Gao W, An B, Fujii M, Murakami H, Osada H, Taniguchi T, Usami N, Kondo M, Hasegawa Y, Shimokata K, Matsuo K, Hida T, Fujimoto N, Kishimoto T, Issa JP, Sekido Y.
Cancer Res. 2009 Dec 1;69(23):9073-82. Epub 2009 Nov 3.
PMID 19887624
 
Alternative p38MAPK pathways. Stress activated protein kinases.
Inesta-Vaquera F., Sabio G., Kuma Y, Cuenda A
Topics in Current Genetics. Springer-Verlag Berlin Heidelberg (DOI 10-1007/978-3-540-75569-2) 2008; 20:17-26
 
Modulation of tau phosphorylation and intracellular localization by cellular stress.
Jenkins SM, Zinnerman M, Garner C, Johnson GV.
Biochem J. 2000 Jan 15;345 Pt 2:263-70.
PMID 10620503
 
The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin.
Johansen C, Kragballe K, Westergaard M, Henningsen J, Kristiansen K, Iversen L.
Br J Dermatol. 2005 Jan;152(1):37-42.
PMID 15656798
 
Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
Knebel A, Haydon CE, Morrice N, Cohen P.
Biochem J. 2002 Oct 15;367(Pt 2):525-32.
PMID 12171600
 
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
Knebel A, Morrice N, Cohen P.
EMBO J. 2001 Aug 15;20(16):4360-9.
PMID 11500363
 
Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis.
Kraft CA, Efimova T, Eckert RL.
Arch Dermatol Res. 2007 May;299(2):71-83. Epub 2007 Jan 26.
PMID 17256148
 
Identification of stathmin as a novel substrate for p38 delta.
Parker CG, Hunt J, Diener K, McGinley M, Soriano B, Keesler GA, Bray J, Yao Z, Wang XS, Kohno T, Lichenstein HS.
Biochem Biophys Res Commun. 1998 Aug 28;249(3):791-6.
PMID 9731215
 
Differential activation of p38MAPK isoforms by MKK6 and MKK3.
Remy G, Risco AM, Inesta-Vaquera FA, Gonzalez-Teran B, Sabio G, Davis RJ, Cuenda A.
Cell Signal. 2009 Dec 11. [Epub ahead of print]
PMID 20004242
 
p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.
Schindler EM, Hindes A, Gribben EL, Burns CJ, Yin Y, Lin MH, Owen RJ, Longmore GD, Kissling GE, Arthur JS, Efimova T.
Cancer Res. 2009 Jun 1;69(11):4648-55. Epub 2009 May 19.
PMID 19458068
 
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R.
Cell. 2009 Jan 23;136(2):235-48. Epub 2009 Jan 8.
PMID 19135240
 
p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion.
Tan FL, Ooi A, Huang D, Wong JC, Qian CN, Chao C, Ooi L, Tan YM, Chung A, Cheow PC, Zhang Z, Petillo D, Yang XJ, Teh BT.
Int J Cancer. 2009 Oct 8. [Epub ahead of print]
PMID 19816939
 
Signal integration by JNK and p38 MAPK pathways in cancer development.
Wagner EF, Nebreda AR.
Nat Rev Cancer. 2009 Aug;9(8):537-49. (REVIEW)
PMID 19629069
 
Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain.
Yin J, Liu YH, Xu YF, Zhang YJ, Chen JG, Shu BH, Wang JZ.
J Pineal Res. 2006 Sep;41(2):124-9.
PMID 16879317
 
Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.
Yoshida H, Goedert M.
J Neurochem. 2006 Oct;99(1):154-64.
PMID 16987243
 
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA.
J Neurochem. 2001 Oct;79(2):311-8.
PMID 11677259
 

Citation

This paper should be referenced as such :
Cerezo-Guisado, MI ; Cuenda, A
MAPK13 (mitogen-activated protein kinase 13)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(10):911-914.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MAPK13ID41291ch6p21.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dic(9;17)(p13;q11) PAX5/TAOK1
t(1;9)(q24;q34) RCSD1/ABL1


External links

Nomenclature
HGNC (Hugo)MAPK13   6875
Cards
AtlasMAPK13ID41291ch6p21
Entrez_Gene (NCBI)MAPK13  5603  mitogen-activated protein kinase 13
AliasesMAPK; MAPK-13; PRKM13; SAPK4; 
p38delta
GeneCards (Weizmann)MAPK13
Ensembl hg19 (Hinxton)ENSG00000156711 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156711 [Gene_View]  chr6:36130484-36144524 [Contig_View]  MAPK13 [Vega]
ICGC DataPortalENSG00000156711
TCGA cBioPortalMAPK13
AceView (NCBI)MAPK13
Genatlas (Paris)MAPK13
WikiGenes5603
SOURCE (Princeton)MAPK13
Genetics Home Reference (NIH)MAPK13
Genomic and cartography
GoldenPath hg38 (UCSC)MAPK13  -     chr6:36130484-36144524 +  6p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPK13  -     6p21.31   [Description]    (hg19-Feb_2009)
EnsemblMAPK13 - 6p21.31 [CytoView hg19]  MAPK13 - 6p21.31 [CytoView hg38]
Mapping of homologs : NCBIMAPK13 [Mapview hg19]  MAPK13 [Mapview hg38]
OMIM602899   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_002754
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAPK13
Cluster EST : UnigeneHs.178695 [ NCBI ]
CGAP (NCI)Hs.178695
Alternative Splicing GalleryENSG00000156711
Gene ExpressionMAPK13 [ NCBI-GEO ]   MAPK13 [ EBI - ARRAY_EXPRESS ]   MAPK13 [ SEEK ]   MAPK13 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK13 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5603
GTEX Portal (Tissue expression)MAPK13
Human Protein AtlasENSG00000156711-MAPK13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15264   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15264  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15264
Splice isoforms : SwissVarO15264
Catalytic activity : Enzyme2.7.11.24 [ Enzyme-Expasy ]   2.7.11.242.7.11.24 [ IntEnz-EBI ]   2.7.11.24 [ BRENDA ]   2.7.11.24 [ KEGG ]   
PhosPhoSitePlusO15264
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    MAP_kinase_CS    MAPK_p38    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPK13
DMDM Disease mutations5603
Blocks (Seattle)MAPK13
PDB (SRS)3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
PDB (PDBSum)3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
PDB (IMB)3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
PDB (RSDB)3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
Structural Biology KnowledgeBase3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
SCOP (Structural Classification of Proteins)3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
CATH (Classification of proteins structures)3COI    4EYJ    4EYM    4MYG    4YNO    5EKN    5EKO   
SuperfamilyO15264
Human Protein Atlas [tissue]ENSG00000156711-MAPK13 [tissue]
Peptide AtlasO15264
HPRD09113
IPIIPI00005741   IPI00604745   IPI00478699   IPI00645543   
Protein Interaction databases
DIP (DOE-UCLA)O15264
IntAct (EBI)O15264
FunCoupENSG00000156711
BioGRIDMAPK13
STRING (EMBL)MAPK13
ZODIACMAPK13
Ontologies - Pathways
QuickGOO15264
Ontology : AmiGOMAPK cascade  protein serine/threonine kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  response to stress  response to osmotic stress  cell cycle  regulation of gene expression  peptidyl-serine phosphorylation  positive regulation of interleukin-6 production  intracellular signal transduction  vascular endothelial growth factor receptor signaling pathway  positive regulation of inflammatory response  
Ontology : EGO-EBIMAPK cascade  protein serine/threonine kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  response to stress  response to osmotic stress  cell cycle  regulation of gene expression  peptidyl-serine phosphorylation  positive regulation of interleukin-6 production  intracellular signal transduction  vascular endothelial growth factor receptor signaling pathway  positive regulation of inflammatory response  
Pathways : BIOCARTAStathmin and breast cancer resistance to antimicrotubule agents [Genes]    Keratinocyte Differentiation [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGG   
REACTOMEO15264 [protein]
REACTOME PathwaysR-HSA-4420097 [pathway]   
NDEx NetworkMAPK13
Atlas of Cancer Signalling NetworkMAPK13
Wikipedia pathwaysMAPK13
Orthology - Evolution
OrthoDB5603
GeneTree (enSembl)ENSG00000156711
Phylogenetic Trees/Animal Genes : TreeFamMAPK13
HOVERGENO15264
HOGENOMO15264
Homologs : HomoloGeneMAPK13
Homology/Alignments : Family Browser (UCSC)MAPK13
Gene fusions - Rearrangements
Tumor Fusion PortalMAPK13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK13
dbVarMAPK13
ClinVarMAPK13
1000_GenomesMAPK13 
Exome Variant ServerMAPK13
ExAC (Exome Aggregation Consortium)ENSG00000156711
GNOMAD BrowserENSG00000156711
Genetic variants : HAPMAP5603
Genomic Variants (DGV)MAPK13 [DGVbeta]
DECIPHERMAPK13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPK13 
Mutations
ICGC Data PortalMAPK13 
TCGA Data PortalMAPK13 
Broad Tumor PortalMAPK13
OASIS PortalMAPK13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK13  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPK13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPK13
DgiDB (Drug Gene Interaction Database)MAPK13
DoCM (Curated mutations)MAPK13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPK13 (select a term)
intoGenMAPK13
NCG5 (London)MAPK13
Cancer3DMAPK13(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602899   
Orphanet
DisGeNETMAPK13
MedgenMAPK13
Genetic Testing Registry MAPK13
NextProtO15264 [Medical]
TSGene5603
GENETestsMAPK13
Target ValidationMAPK13
Huge Navigator MAPK13 [HugePedia]
snp3D : Map Gene to Disease5603
BioCentury BCIQMAPK13
ClinGenMAPK13
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5603
Chemical/Pharm GKB GenePA30620
Clinical trialMAPK13
Miscellaneous
canSAR (ICR)MAPK13 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPK13
EVEXMAPK13
GoPubMedMAPK13
iHOPMAPK13
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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