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MAPK14 (mitogen-activated protein kinase 14)

Written2010-12Almudena Porras, Carmen Guerrero
Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, UCM, Ciudad Universitaria, 28040 Madrid, Spain (AP); Centro de Investigacion del Cancer, IBMCC, Universidad de Salamanca-CSIC, 37007 Salamanca, Spain (CG)

(Note : for Links provided by Atlas : click)

Identity

Alias_namesCSPB1
CSBP1
CSBP2
Alias_symbol (synonym)PRKM14
p38
Mxi2
PRKM15
Other aliasEXIP
RK
SAPK2A
p38ALPHA
HGNC (Hugo) MAPK14
LocusID (NCBI) 1432
Atlas_Id 41292
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 36027677 and ends at 36111236 bp from pter ( according to hg19-Feb_2009)  [Mapping MAPK14.png]
 
  Schematic representation of human chromosome 6 indicating the position of MAPK14 locus (p21.31) (red bar).
Fusion genes
(updated 2016)
LEMD3 (12q14.3) / MAPK14 (6p21.31)MAPK14 (6p21.31) / MAPK14 (6p21.31)MAPK14 (6p21.31) / MEMO1 (2p23.1)
MAPK14 (6p21.31) / MICU2 (13q12.11)MAPK14 (6p21.31) / POP5 (12q24.31)TPI1 (12p13.31) / MAPK14 (6p21.31)

DNA/RNA

 
  MAPK14 gene locus. Representation of the MAPK14 gene organization indicating the position of the exons (coding region) and untranslated regions.
Description The gene spans a region of 83.53 kb and the coding part is divided into 41 different exons. Larger transcripts contain 12 or 13 exons. (GATExplorer).
Transcription 9 types of transcripts have been described, although only 5 are protein coding transcripts. The larger 4319-nucleotide transcript encodes a protein of 360 amino acid residues. The first and last exons are partially untranslated.
Pseudogene None described so far.

Protein

 
  MAPK14 protein domains. Schematic representation of MAPK14 protein indicating the position of its functional domains. 30-54: protein kinase ATP signature, ATP-binding region; 59-162: MAPK signature; 24-308: protein kinase domain.
Description MAPK14 is a Ser/Thr kinase composed of 90 to 360 residues depending on the transcript variant.
 
  Crystal structure of MAPK14 at 2.3 A resolution. From PDB (access number: 1WFC).
Expression p38alpha MAPK is ubiquitously expressed, being the p38 most abundant isoform.
Localisation p38alpha is mainly present in the cytosol, but it can translocate to the nucleus. In addition, it can be localized in the mitochondria or in other subcellular compartments.
Function p38alpha is mainly activated by various environmental stresses and proinflammatory cytokines, but many other extracellular signals, including growth factors, also lead to p38alpha activation. The canonical activation requires its phosphorylation in threonine and tyrosine residues by dual-specificity MAP kinase kinases (MKKs), MKK3, MKK6 and MKK4. Substrates of this kinase include transcription factors, such as ATF1, ATF2, ATF6, p53, MEF2 or C/EBPbeta and protein kinases, such as MAPKAP-K2 and MAPKAP-K3 (also known as MK-2 and MK-3), MSK-1, MNK-1/MNK-2 and other proteins. p38alpha MAPK is essential for embryonic development and it regulates different cellular functions such as proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways, among others. It does so through regulation of transcription, mRNA stability, chromatin remodelling, protein synthesis, etc. Concerning cell death, although p38alpha plays an important role as a pro-apoptotic signal, it can play a dual role, acting as either a mediator of cell survival or of cell death, depending on the cell type and the stimuli. Related with its function as a negative regulator of proliferation and a mediator of apoptosis, p38alpha acts as a tumor suppressor in the initial stages of a tumorigenic process, while at later stages it can promote metastasis.
 
  Signaling through p38alphaMAPK. Signaling through MAPK14 cascade and its role in the regulation of cellular functions. MAPK14 is involved in signaling pathways triggered by a variety of stimuli such as growth factors, oxidative stress, UV, cytokines and DNA damage. Depending on the stimulus, different receptors and intermediates (adaptors, GTPases or kinases) are activated leading to the activation of the p38alpha MAPK cascade. This cascade is initiated by activation of MAPKKKs, which phosphorylate and activate MAPKKs (MKK3/6/4), which in turn lead to activation of MAPK14 through dual phosphorylation in Tyr and Thr. Once phosphorylated, MAPK14 phosphorylates a number of cytosolic and nuclear substrates, including transcription factors, which lead to the control of many cellular responses.

Mutations

Somatic 4 somatic mutations according to Ensembl: COSM21366; COSM20563; COSM35409; COSM12875.

Implicated in

Note
  
Entity Hematopoietic malignancies
Disease p38 MAPK, mainly the p38alpha isoform, is a key player in the maintenance of hematopoiesis homeostasis, as it balances both proliferative and growth inhibitory signals triggered by the growth factors and cytokines that regulate normal hematopoiesis. Alterations in this p38 MAPK-controlled balance may result in either overproduction or depletion of myelosuppressive cytokines leading to the development of certain bone marrow failure syndromes. For example, p38alpha is responsible for the enhanced stem cell apoptosis characteristic of low grade myeolodysplastic syndromes (MDSs). On the other hand, imbalance toward the proliferative side may conduct to the development of myeloproliferative syndromes (MPSs), such as leukemia, lymphomas and myelomas. In particular, p38alpha MAPK plays a pro-apoptotic role in chronic myeloid leukemia (CML). In fact, p38alpha MAP kinase pathway mediates the growth inhibitory effects of IFNalpha and STI-571, two drugs used in the CML treatment, which underscores the importance of this pathway in the generation of antileukemic responses.
  
  
Entity Alzheimer's disease
Disease Alzheimer is an incurable, neurodegenerative disease characterized by a progressive deterioration of the cognitive, memory and learning ability due to the accumulation of plaques containing amyloidogenic Abeta proteins and tangles containing hyperphosphorylated tau protein. The ASK1-MKK6-p38 signaling pathway participates in amyeloid precursor protein (APP) and tau phosphorylation in response to oxidative stress and contributes to the expression of the beta-secretase gene and the induction of neuronal apoptosis triggered by ROS.
  
  
Entity Parkinson disease
Disease Parkinson is a degenerative disorder of the central nervous system characterized by muscle rigidity, tremor and loss of physical movement caused by a progressive loss of dopaminergic neurons. Mutations in alpha-synuclein are one of the main causes of Parkinson. alpha-synuclein activates p38alpha MAPK in human microglia promoting a potent inflammatory stimulation of microglial cells. Additionally, the p38alpha MAPK plays a role in dopaminergic neural apoptosis through the phosphorylation of p53 and expression of the pro-apoptotic protein Bax.
  
  
Entity Amyotrophic lateral sclerosis
Disease ALS is a progressive, lethal, degenerative disorder of motor neurons leading to paralysis of voluntary muscles. Numerous evidences point to a role of p38 MAPK in the development and progression of ALS induced by mutations in SOD1 (superoxide dismutase 1) gene. Mutant SOD1 provokes aberrant oxyradical reactions that increase the activation of p38 MAPK in motor neurons and glial cells. This increase in active p38 MAPK may phosphorylate cytoskeletal proteins and activate cytokines and nitric oxide, thus contributing to neurodegeneration through different mechanisms including apoptosis.
  

To be noted

See also the Deep Insight: "Role of p38alpha in apoptosis: implication in cancer development and therapy".

Bibliography

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.
Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR.
Mol Cell. 2000 Jul;6(1):109-16.
PMID 10949032
 
Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase.
Bendotti C, Bao Cutrona M, Cheroni C, Grignaschi G, Lo Coco D, Peviani M, Tortarolo M, Veglianese P, Zennaro E.
Neurodegener Dis. 2005;2(3-4):128-34. (REVIEW)
PMID 16909017
 
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.
Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr.
EMBO J. 1999 Dec 1;18(23):6845-54.
PMID 10581258
 
Mechanisms and functions of p38 MAPK signalling.
Cuadrado A, Nebreda AR.
Biochem J. 2010 Aug 1;429(3):403-17. (REVIEW)
PMID 20626350
 
p38 MAP-kinases pathway regulation, function and role in human diseases.
Cuenda A, Rousseau S.
Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24. (REVIEW)
PMID 17481747
 
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
D'Amico M, Hulit J, Amanatullah DF, Zafonte BT, Albanese C, Bouzahzah B, Fu M, Augenlicht LH, Donehower LA, Takemaru K, Moon RT, Davis R, Lisanti MP, Shtutman M, Zhurinsky J, Ben-Ze'ev A, Troussard AA, Dedhar S, Pestell RG.
J Biol Chem. 2000 Oct 20;275(42):32649-57.
PMID 10915780
 
Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine.
Huang Y, Yuan ZM, Ishiko T, Nakada S, Utsugisawa T, Kato T, Kharbanda S, Kufe DW.
Oncogene. 1997 Oct 16;15(16):1947-52.
PMID 9365241
 
Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.
Karunakaran S, Saeed U, Mishra M, Valli RK, Joshi SD, Meka DP, Seth P, Ravindranath V.
J Neurosci. 2008 Nov 19;28(47):12500-9.
PMID 19020042
 
Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.
Mathiasen JR, McKenna BA, Saporito MS, Ghadge GD, Roos RP, Holskin BP, Wu ZL, Trusko SP, Connors TC, Maroney AC, Thomas BA, Thomas JC, Bozyczko-Coyne D.
Brain Res. 2004 Apr 2;1003(1-2):86-97.
PMID 15019567
 
Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells.
Park JI, Choi HS, Jeong JS, Han JY, Kim IH.
Cell Growth Differ. 2001 Sep;12(9):481-6.
PMID 11571231
 
The p38 mitogen-activated protein kinase pathway and its role in interferon signaling.
Platanias LC.
Pharmacol Ther. 2003 May;98(2):129-42. (REVIEW)
PMID 12725866
 
P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.
Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR.
Mol Biol Cell. 2004 Feb;15(2):922-33. Epub 2003 Nov 14.
PMID 14617800
 
Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice.
Puig B, Gomez-Isla T, Ribe E, Cuadrado M, Torrejon-Escribano B, Dalfo E, Ferrer I.
Neuropathol Appl Neurobiol. 2004 Oct;30(5):491-502.
PMID 15488025
 
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.
Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR.
Cell. 1994 Sep 23;78(6):1027-37.
PMID 7923353
 
A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.
Sanchez-Prieto R, Rojas JM, Taya Y, Gutkind JS.
Cancer Res. 2000 May 1;60(9):2464-72.
PMID 10811125
 
Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.
Silva RM, Kuan CY, Rakic P, Burke RE.
Mov Disord. 2005 Jun;20(6):653-64. (REVIEW)
PMID 15719422
 
H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.
Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola M, Danni O.
Exp Neurol. 2003 Apr;180(2):144-55.
PMID 12684028
 
Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.
Tortarolo M, Veglianese P, Calvaresi N, Botturi A, Rossi C, Giorgini A, Migheli A, Bendotti C.
Mol Cell Neurosci. 2003 Jun;23(2):180-92.
PMID 12812752
 
Signal integration by JNK and p38 MAPK pathways in cancer development.
Wagner EF, Nebreda AR.
Nat Rev Cancer. 2009 Aug;9(8):537-49. (REVIEW)
PMID 19629069
 
Crystal structure of p38 mitogen-activated protein kinase.
Wilson KP, Fitzgibbon MJ, Caron PR, Griffith JP, Chen W, McCaffrey PG, Chambers SP, Su MS.
J Biol Chem. 1996 Nov 1;271(44):27696-700.
PMID 8910361
 
p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure.
Zhou L, Opalinska J, Verma A.
Cell Cycle. 2007 Mar 1;6(5):534-7. Epub 2007 Mar 25. (REVIEW)
PMID 17351344
 
Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1.
Zuluaga S, Alvarez-Barrientos A, Gutierrez-Uzquiza A, Benito M, Nebreda AR, Porras A.
Cell Signal. 2007 Jan;19(1):62-74. Epub 2006 Jul 14.
PMID 16844343
 

Citation

This paper should be referenced as such :
Porras, A ; Guerrero, C
MAPK14 (mitogen-activated protein kinase 14)
Atlas Genet Cytogenet Oncol Haematol. 2011;15(8):628-631.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MAPK14ID41292ch6p21.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dic(9;17)(p13;q11) PAX5/TAOK1
t(5;9)(q33;q22) ITK/SYK


External links

Nomenclature
HGNC (Hugo)MAPK14   6876
Cards
AtlasMAPK14ID41292ch6p21
Entrez_Gene (NCBI)MAPK14  1432  mitogen-activated protein kinase 14
AliasesCSBP; CSBP1; CSBP2; CSPB1; 
EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA
GeneCards (Weizmann)MAPK14
Ensembl hg19 (Hinxton)ENSG00000112062 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112062 [Gene_View]  chr6:36027677-36111236 [Contig_View]  MAPK14 [Vega]
ICGC DataPortalENSG00000112062
TCGA cBioPortalMAPK14
AceView (NCBI)MAPK14
Genatlas (Paris)MAPK14
WikiGenes1432
SOURCE (Princeton)MAPK14
Genetics Home Reference (NIH)MAPK14
Genomic and cartography
GoldenPath hg38 (UCSC)MAPK14  -     chr6:36027677-36111236 +  6p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPK14  -     6p21.31   [Description]    (hg19-Feb_2009)
EnsemblMAPK14 - 6p21.31 [CytoView hg19]  MAPK14 - 6p21.31 [CytoView hg38]
Mapping of homologs : NCBIMAPK14 [Mapview hg19]  MAPK14 [Mapview hg38]
OMIM600289   
Gene and transcription
Genbank (Entrez)AB074150 AF100544 AK291709 AK303414 BC000092
RefSeq transcript (Entrez)NM_001315 NM_139012 NM_139013 NM_139014
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAPK14
Cluster EST : UnigeneHs.485233 [ NCBI ]
CGAP (NCI)Hs.485233
Alternative Splicing GalleryENSG00000112062
Gene ExpressionMAPK14 [ NCBI-GEO ]   MAPK14 [ EBI - ARRAY_EXPRESS ]   MAPK14 [ SEEK ]   MAPK14 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1432
GTEX Portal (Tissue expression)MAPK14
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16539   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16539  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16539
Splice isoforms : SwissVarQ16539
PhosPhoSitePlusQ16539
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    MAP_kinase_CS    MAPK_p38    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPK14
DMDM Disease mutations1432
Blocks (Seattle)MAPK14
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyQ16539
Human Protein AtlasENSG00000112062
Peptide AtlasQ16539
HPRD02619
IPIIPI00002857   IPI00221141   IPI00221142   IPI00221143   IPI00945296   IPI00984307   IPI00945931   
Protein Interaction databases
DIP (DOE-UCLA)Q16539
IntAct (EBI)Q16539
FunCoupENSG00000112062
BioGRIDMAPK14
STRING (EMBL)MAPK14
ZODIACMAPK14
Ontologies - Pathways
QuickGOQ16539
Ontology : AmiGODNA damage checkpoint  activation of MAPK activity  cell morphogenesis  spindle pole  cartilage condensation  angiogenesis  placenta development  chondrocyte differentiation  positive regulation of cytokine secretion involved in immune response  protein serine/threonine kinase activity  MAP kinase activity  MAP kinase kinase activity  protein binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  cytosol  glucose metabolic process  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  apoptotic process  movement of cell or subcellular component  chemotaxis  signal transduction  cell surface receptor signaling pathway  transmembrane receptor protein serine/threonine kinase signaling pathway  Ras protein signal transduction  skeletal muscle tissue development  positive regulation of gene expression  positive regulation of macrophage chemotaxis  positive regulation of myotube differentiation  myoblast differentiation involved in skeletal muscle regeneration  nuclear speck  peptidyl-serine phosphorylation  fatty acid oxidation  enzyme binding  protein phosphatase binding  regulation of ossification  osteoclast differentiation  positive regulation of cyclase activity  lipopolysaccharide-mediated signaling pathway  response to muramyl dipeptide  secretory granule lumen  intracellular signal transduction  cellular response to vascular endothelial growth factor stimulus  response to muscle stretch  p38MAPK cascade  positive regulation of protein import into nucleus  signal transduction in response to DNA damage  neutrophil degranulation  positive regulation of blood vessel endothelial cell migration  positive regulation of erythrocyte differentiation  positive regulation of myoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of glucose import  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  mitogen-activated protein kinase p38 binding  regulation of sequence-specific DNA binding transcription factor activity  striated muscle cell differentiation  positive regulation of muscle cell differentiation  NFAT protein binding  positive regulation of cardiac muscle cell proliferation  extracellular exosome  3'-UTR-mediated mRNA stabilization  cellular response to lipopolysaccharide  cellular response to ionizing radiation  negative regulation of canonical Wnt signaling pathway  positive regulation of brown fat cell differentiation  stress-induced premature senescence  cellular response to virus  regulation of cytokine production involved in inflammatory response  positive regulation of myoblast fusion  regulation of signal transduction by p53 class mediator  ficolin-1-rich granule lumen  positive regulation of metallopeptidase activity  positive regulation of reactive oxygen species metabolic process  positive regulation of interleukin-12 secretion  
Ontology : EGO-EBIDNA damage checkpoint  activation of MAPK activity  cell morphogenesis  spindle pole  cartilage condensation  angiogenesis  placenta development  chondrocyte differentiation  positive regulation of cytokine secretion involved in immune response  protein serine/threonine kinase activity  MAP kinase activity  MAP kinase kinase activity  protein binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  cytosol  glucose metabolic process  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  apoptotic process  movement of cell or subcellular component  chemotaxis  signal transduction  cell surface receptor signaling pathway  transmembrane receptor protein serine/threonine kinase signaling pathway  Ras protein signal transduction  skeletal muscle tissue development  positive regulation of gene expression  positive regulation of macrophage chemotaxis  positive regulation of myotube differentiation  myoblast differentiation involved in skeletal muscle regeneration  nuclear speck  peptidyl-serine phosphorylation  fatty acid oxidation  enzyme binding  protein phosphatase binding  regulation of ossification  osteoclast differentiation  positive regulation of cyclase activity  lipopolysaccharide-mediated signaling pathway  response to muramyl dipeptide  secretory granule lumen  intracellular signal transduction  cellular response to vascular endothelial growth factor stimulus  response to muscle stretch  p38MAPK cascade  positive regulation of protein import into nucleus  signal transduction in response to DNA damage  neutrophil degranulation  positive regulation of blood vessel endothelial cell migration  positive regulation of erythrocyte differentiation  positive regulation of myoblast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of glucose import  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  mitogen-activated protein kinase p38 binding  regulation of sequence-specific DNA binding transcription factor activity  striated muscle cell differentiation  positive regulation of muscle cell differentiation  NFAT protein binding  positive regulation of cardiac muscle cell proliferation  extracellular exosome  3'-UTR-mediated mRNA stabilization  cellular response to lipopolysaccharide  cellular response to ionizing radiation  negative regulation of canonical Wnt signaling pathway  positive regulation of brown fat cell differentiation  stress-induced premature senescence  cellular response to virus  regulation of cytokine production involved in inflammatory response  positive regulation of myoblast fusion  regulation of signal transduction by p53 class mediator  ficolin-1-rich granule lumen  positive regulation of metallopeptidase activity  positive regulation of reactive oxygen species metabolic process  positive regulation of interleukin-12 secretion  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
REACTOMEQ16539 [protein]
REACTOME PathwaysR-HSA-6804756 [pathway]   
NDEx NetworkMAPK14
Atlas of Cancer Signalling NetworkMAPK14
Wikipedia pathwaysMAPK14
Orthology - Evolution
OrthoDB1432
GeneTree (enSembl)ENSG00000112062
Phylogenetic Trees/Animal Genes : TreeFamMAPK14
HOVERGENQ16539
HOGENOMQ16539
Homologs : HomoloGeneMAPK14
Homology/Alignments : Family Browser (UCSC)MAPK14
Gene fusions - Rearrangements
Fusion : MitelmanMAPK14/MICU2 [6p21.31/13q12.11]  
Fusion: TCGAMAPK14 6p21.31 EFHA1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK14
dbVarMAPK14
ClinVarMAPK14
1000_GenomesMAPK14 
Exome Variant ServerMAPK14
ExAC (Exome Aggregation Consortium)MAPK14 (select the gene name)
Genetic variants : HAPMAP1432
Genomic Variants (DGV)MAPK14 [DGVbeta]
DECIPHERMAPK14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPK14 
Mutations
ICGC Data PortalMAPK14 
TCGA Data PortalMAPK14 
Broad Tumor PortalMAPK14
OASIS PortalMAPK14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPK14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPK14
DgiDB (Drug Gene Interaction Database)MAPK14
DoCM (Curated mutations)MAPK14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPK14 (select a term)
intoGenMAPK14
NCG5 (London)MAPK14
Cancer3DMAPK14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600289   
Orphanet
MedgenMAPK14
Genetic Testing Registry MAPK14
NextProtQ16539 [Medical]
TSGene1432
GENETestsMAPK14
Target ValidationMAPK14
Huge Navigator MAPK14 [HugePedia]
snp3D : Map Gene to Disease1432
BioCentury BCIQMAPK14
ClinGenMAPK14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1432
Chemical/Pharm GKB GenePA30621
Clinical trialMAPK14
Miscellaneous
canSAR (ICR)MAPK14 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPK14
EVEXMAPK14
GoPubMedMAPK14
iHOPMAPK14
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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