Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MET met proto-oncogene (hepatocyte growth factor receptor)

Identity

Other namesc-met
hepatocyte growth factor receptor
HGNC (Hugo) MET
LocusID (NCBI) 4233
Location 7q31.2
Location_base_pair Starts at 116312459 and ends at 116438440 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order between DFNB17 (centromeric) and NAG14 (telomeric).

DNA/RNA

 
  The coding sequence (4173 bp) is represented as red boxes (exons coding for the extracellular domain), blue boxes (sequence coding for the intracellular part) and a green box (coding for the transmembrane domain). Black triangles indicate the splicing sites. Several structural/functional elements are indicated, described in the text.
Description The human MET gene spans more than 120 kb in length and consists of 21 exons separated by 20 introns . The size of the exons range from 81 bp (exon 16) to about 4kb (exon 21) The size of introns ranges from 0.1 to about 26 kb. The first exon encodes the 5' untranslated region (UTR) (394 bp) of the MET transcript and is separated by 26 kb circa from the second exon. Exon 2 is the largest coding exon, it contains14 bp of 5' UTR and encodes for 400 amino acids. The cleavage site that yields the a- and b-subunits from the precursor polypeptide is encoded by exon 2. Exon 13 contains the hydrophobic transmembrane domain, together with the end of the extracellular domain and the beginning of the intracellular domain. Exons 14 to 21 code for the intracellular part and exons 15 to 21 for the kinase domain. Exon 21 includes the region coding for the carboxy terminus of the protein and the large 3' UTR of the gene. The ATP binding site is encoded for by exon 16; the autophosphorylation site by exon 19; the SH2 docking site by exon 21.
Transcription Alternative splicing: Multiple MET transcripts of different size were identified in human cell lines and tissues. At least three 8-kb variants were described and presumed to be generated by alternative splicing. A MET isoform was described that lacks 18 amino acids in the extracellular region (exon 10) and is the most abundant form in a variety of tissues and cell lines . Alternative splicing of exon 14 generates another variant that has an in-frame deletion of 47 amino acids in the juxtamembrane cytoplasmic domain of the receptor. A possible mechanism of alternative splicing could be at the origin of a 85 kDa, N-terminally truncated form of MET found in malignant musculo-skeletal tumors, although this short form could also originate from alternative transcription start or proteolitic cleavage.

Protein

 
  Red: SEMA domain. Yellow: PSI domain. Green: IPT domains. Black: transmembrane domain. Blue: tyrosine kinase domain. Light blue: C-terminal region. Pink: cell membrane. Y1252, Y11253: autophosphorylation site. Y1367, Y1374: docking site.
Description The MET receptor (1408 amino acids) is initially synthesized as a partially glycosylated 170 kDa single chain precursor. Following further glycosylation, it is cleaved at a basic amino acid site into an a- and b-chain. The mature form is a transmembrane heterodimer composed of a- and b-chain linked together by disulphide bridges. The 50 kDa a-chain (amino acids 1-307) is located entirely extracellularly and contains the ligand binding pocket. The 140 kDa b-chain (amino acids 308-1408) comprises an extracellular part, the membrane spanning region and an intracellular C-terminal region that contains the tyrosine kinase domain. The C-terminal tail contains a conserved two-tyrosine multifunctional docking site that interacts with multiple SH2-containing intracellular signal transducers. The 5' alternative splicing leads to a form with 1390 amino acids.
Expression MET and its ligand hepatocyte growth factor/scatter factor (HGF/SF) are expressed in numerous tissues although predominantly in cells of epithelial and mesenchymal origin, respectively. MET is amplified and overexpressed in many types of tumors, including tumors of the kidney (see below), thyroid, pancreas and osteosarcoma.
Localisation MET is a transmembrane tyrosine kinase receptor. Upon ligand binding, the receptor is rapidly internalized, polyubiquitinated and degraded in a proteasome-dependent manner.
Function The tyrosine kinase MET is the high affinity receptor for HGF/SF, a multifunctional cytokine. Upon ligand binding, MET dimerizes and transphosphorylates tyrosine residues in the C-terminal domain, which then interacts with members of a variety of signaling pathways. These include Grb-2 associated binder 1, phosphoinositide 3' kinase and c-Src. Under physiological conditions, MET-HGF/SF signaling has been shown to affect a wide range of biological activities depending on the cell target. These activities vary from cell proliferation (mitogenesis) to cellular shaping (morphogenesis) and motility (motogenesis). The coordination of these diverse activities constitutes a genetic program of ³invasive growth² that allows branched morphogenesis (the formation of epithelial tubular structures), myoblast migration and neurite branching. MET/HGF cell targets comprise epithelial and mesenchymal cells, hematopoietic cells, myoblasts, spinal motor neurons. MET-HGF/SF signaling is also essential for normal development: mouse embryos carrying null mutations in both HGF alleles die in midgestation and show impaired liver formation.
Homology MET amino acid sequence shows overall 33% identity with RON (the macrophage stimulating protein (MSP) receptor), which increases to 64% in the kinase domain. MET and RON are grouped in the family of so called scatter factor receptors. However, some structural domains shared by MET and RON are also present in other proteins such as semaphorins and plexins (semaphorins receptors), so that these proteins altogether are thought to originate from a common ancestor. The common domains are: the SEMA domain, a conserved box encompassing about 500 amino acids, with several highly conserved cysteines, and the PSI domain (from Plexin Semaphorins Integrines), of about 50 amino acids with 8 conserved cysteines, found also in integrins. Another structural motif repeated four times in the extracellular region of MET is the IPT domain, an immunoglobulin-like fold shared also by plexins and transcription factors. The function of these domains is at present under investigation but they are thought to mediate protein-protein interactions possibly related to cell dissociations and motility.

Mutations

Germinal Germline mutations in the MET proto-oncogene are responsible for hereditary papillary renal carcinoma (HPRC) type 1 (see below). 10 known mutations are clustered in exons 16-19 of the tyrosine kinase domain and all are missense mutations which change the amino acid (V1110I, H1112R, H1112Y, M1149T, V1206L, V1238I, D1246N, Y1248C, Y1248D, M1268T). Mutations at four codons (V1110, D1246, Y1248, M1268) are homologous to sites of disease-associated activating mutations in other RTKs ( RET, c-kit, c-erbB. Two unrelated North American families have been identified with the H1112R mutation and shared flanking genotyping data, suggesting a founder effect. Most HPRC-associated MET mutations are constitutively activating, causing phosphorylation on tyrosine in a ligand-independent manner when transfected into NIH3T3 cells, and oncogenic when the mutant MET transfected cell lines are injected into nude mice. Other mutations with only weak transforming potential (Y1248C, L1213V) confer anchorage-independent growth and an invasive phenotype in transfected cells.
Somatic Somatic missense mutations (H1112Y, H1112L, H1124D, L1213V, D1246H, Y1248H, Y1248C, M1268T) were identified in the TK domain of MET in 13% (17/129) of sporadic papillary renal carcinoma (PRC) type 1; 15 different germline and somatic MET mutations in 10 codons of the TK domain were identified in PRC. Infrequently, MET mutations have been identified in childhood hepatocellular carcinoma (3/10 in TK domain, T1191I, K1262R, M1268I), gastric carcinoma (1/85 in juxtamembrane domain, P1009S), glioma (1/11 in TK domain, G1137V;) and lymph node metastases (4/15 head and neck squamous cell carcinomas, Y1253D, Y1248C).

Implicated in

Entity Hereditary papillary renal carcinoma and Sporadic papillary renal carcinoma (HPRC, SPRC)
Disease An inherited autosomal dominant form of renal carcinoma with reduced penetrance comprising 10% of all carcinomas of the kidney. Affected family members develop, in the fourth or fifth decade of life, bilateral, multifocal renal tumors with a papillary growth pattern which can be subdivided by histology into type 1 and type 2. Multiple tumors were shown to arise from independent clones. Sporadic PRCs are usually solitary tumors with microscopic papillary lesions in the surrounding renal parenchyma. It is important to note that patients with germline mutations in the MET gene are predisposed to develop papillary renal carcinoma type 1 specifically. These mutations are not known to predispose to any other type of malignant disease.
Prognosis HPRC is a rare disease with an estimate incidence of 1 in 1 million. The age of development of PRCs is best studied in patients with H1112R mutation, because an elevated number of them has been described. By age 55, one half of H1112R mutation carriers have developed a detectable disease. Also, in H1112R mutation carriers has been observed that 26 % of patients develop distant metastases. The complete expression of the PRC phenotype may be affected by modifier genes. In fact, not only the age of onset varies among individuals but also the severity of the disease: in one patient were found at least 100 renal tumors, whereas his two brothers had a total of 1.
Cytogenetics Papillary renal tumors are characterized by trisomy of chromosome 7 and 17, loss of Y in males. Only type 1 sporadic and hereditary PRCs harbor MET mutations with nonrandom duplication of the chromosome 7 bearing the mutant MET allele.
Hybrid/Mutated Gene MET was first identified as the product of a human oncogene, tpr-MET, which derives from the fusion of two distinct genetic loci: tpr (translocated promoter region), which contributes two leucine zipper motifs (a protein-protein dimerization domain), and MET, which contributes the intracellular kinase domain of the MET receptor. The tpr gene sequence involved in the tpr-MET fusion is found on 1q25, though this gene is located at 1q31 in a database
Abnormal Protein The tpr-MET chimeric protein is dimerized and activated in ligand-independent manner and therefore possesses constitutive kinase activity and transforming ability.
 
The hybrid protein is made of Tpr leucine zippers (red) ­ that mediate constitutive dimerization - and MET kinase domains (blue), that drive transphosphorylation and constitutive activation.
Oncogenesis MET/HGF signaling has been implicated in the generation and progression of a variety of tumors. The coexpression of wild type MET and HGF in the same cell (which generates an autocrine stimulatory loop) induces oncogenic transformation.
All investigated naturally occurring MET mutants show increased tyrosine phosphorylation level and enhanced kinase activity. In general, somatic mutations cause higher level of enzymatic activity compared to germline mutants. The kinase domain mutations cause ligand-independent activation and increase the tyrosine kinase activity. The juxtamembrane P1009I mutation does not cause ligand-independent activation but results in prolonged HGF-activated MET response.
The M1268T mutation identified in PRC ­ homologous to the M918T mutation of RET in multiple endocrine neoplasia type 2b ­ results not only in increased level of catalytic activity but also in a change of substrate specificity. Whereas c-Src is transiently activated by wild type MET, M1268T mutant MET is stably associated with c-Src, which is thereby constitutively phosphorylated and activated. Also, wild type MET does not phosphorylate substrate for cytosolic kinase c-Abl, whereas M1268T MET does. Moreover, expression of M1268T MET in NIH3T3 causes activation of the b-catenin pathway.
Different mutations act through distinct mechanisms and result in variable transforming activity. D1246H/N and M1268 mutants (that activate the Ras pathway) have high transforming ability. Y1248C and L1213V have less transforming ability but promote cell migration and invasion via activation of the PI3K/AKT pathway
3D molecular modeling studies using the crystal structure of the insulin receptor tyrosine kinase domain as a model suggest that disease-causing MET mutations interfere with the intrasteric mechanism of tyrosine kinase auto-inhibition to destabilize the inactive form and facilitate transition to the active form. Mutations V1110I, Y1248H/D/C, M1268T can affect contact between residues of the activation loop in its inhibitory conformation. Mutations M1149T and L1213V may increase flexibility of the tertiary structure. D1246N can stabilize the kinase in its active conformation. This structural work gives hints to understanding the switch of substrate specificity by mutant receptors.
  

External links

Nomenclature
HGNC (Hugo)MET   7029
Cards
AtlasMETID131
Entrez_Gene (NCBI)MET  4233  met proto-oncogene
GeneCards (Weizmann)MET
Ensembl (Hinxton)ENSG00000105976 [Gene_View]  chr7:116312459-116438440 [Contig_View]  MET [Vega]
AceView (NCBI)MET
Genatlas (Paris)MET
WikiGenes4233
SOURCE (Princeton)NM_000245 NM_001127500
Genomic and cartography
GoldenPath (UCSC)MET  -  7q31.2   chr7:116312459-116438440 +  7q31   [Description]    (hg19-Feb_2009)
EnsemblMET - 7q31 [CytoView]
Mapping of homologs : NCBIMET [Mapview]
OMIM114550   164860   605074   611015   
Gene and transcription
Genbank (Entrez)AA278232 AB209898 AF075090 AI630755 AK025784
RefSeq transcript (Entrez)NM_000245 NM_001127500
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NG_008996 NT_007933 NT_079596 NW_001839071 NW_004929332
Consensus coding sequences : CCDS (NCBI)MET
Cluster EST : UnigeneHs.132966 [ NCBI ]
CGAP (NCI)Hs.132966
Alternative Splicing : Fast-db (Paris)GSHG0027663
Alternative Splicing GalleryENSG00000105976
Gene ExpressionMET [ NCBI-GEO ]     MET [ SEEK ]   MET [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08581 (Uniprot)
NextProtP08581  [Medical]
With graphics : InterProP08581
Splice isoforms : SwissVarP08581 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    Kinase-like_dom    Plexin-like_fold    Plexin_repeat    Prot_kinase_dom    Protein_kinase_ATP_BS    Semap_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_HGF/MSP_rcpt    WD40/YVTN_repeat-like_dom   
Related proteins : CluSTrP08581
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    PSI (PF01437)    Sema (PF01403)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam07714    pfam01437    pfam01403    pfam01833   
Domain families : Smart (EMBL)IPT (SM00429)  PSI (SM00423)  Sema (SM00630)  TyrKc (SM00219)  
DMDM Disease mutations4233
Blocks (Seattle)P08581
PDB (SRS)1FYR    1R0P    1R1W    1SHY    1SSL    1UX3    2G15    2RFN    2RFS    2UZX    2UZY    2WD1    2WGJ    2WKM    3A4P    3BUX    3C1X    3CCN    3CD8    3CE3    3CTH    3CTJ    3DKC    3DKF    3DKG    3EFJ    3EFK    3F66    3F82    3I5N    3L8V    3LQ8    3Q6U    3Q6W    3QTI    3R7O    3RHK    3U6H    3U6I    3ZXZ    3ZZE    4AOI    4AP7    4DEG    4DEH    4DEI    4EEV    4GG5    4GG7   
PDB (PDBSum)1FYR    1R0P    1R1W    1SHY    1SSL    1UX3    2G15    2RFN    2RFS    2UZX    2UZY    2WD1    2WGJ    2WKM    3A4P    3BUX    3C1X    3CCN    3CD8    3CE3    3CTH    3CTJ    3DKC    3DKF    3DKG    3EFJ    3EFK    3F66    3F82    3I5N    3L8V    3LQ8    3Q6U    3Q6W    3QTI    3R7O    3RHK    3U6H    3U6I    3ZXZ    3ZZE    4AOI    4AP7    4DEG    4DEH    4DEI    4EEV    4GG5    4GG7   
PDB (IMB)1FYR    1R0P    1R1W    1SHY    1SSL    1UX3    2G15    2RFN    2RFS    2UZX    2UZY    2WD1    2WGJ    2WKM    3A4P    3BUX    3C1X    3CCN    3CD8    3CE3    3CTH    3CTJ    3DKC    3DKF    3DKG    3EFJ    3EFK    3F66    3F82    3I5N    3L8V    3LQ8    3Q6U    3Q6W    3QTI    3R7O    3RHK    3U6H    3U6I    3ZXZ    3ZZE    4AOI    4AP7    4DEG    4DEH    4DEI    4EEV    4GG5    4GG7   
PDB (RSDB)1FYR    1R0P    1R1W    1SHY    1SSL    1UX3    2G15    2RFN    2RFS    2UZX    2UZY    2WD1    2WGJ    2WKM    3A4P    3BUX    3C1X    3CCN    3CD8    3CE3    3CTH    3CTJ    3DKC    3DKF    3DKG    3EFJ    3EFK    3F66    3F82    3I5N    3L8V    3LQ8    3Q6U    3Q6W    3QTI    3R7O    3RHK    3U6H    3U6I    3ZXZ    3ZZE    4AOI    4AP7    4DEG    4DEH    4DEI    4EEV    4GG5    4GG7   
Human Protein AtlasENSG00000105976
Peptide AtlasP08581
HPRD01280
IPIIPI00029273   IPI00294528   IPI00930286   IPI01009155   IPI00910535   IPI01010098   IPI00977342   IPI00795476   IPI00852650   IPI00892811   IPI00853590   
Protein Interaction databases
DIP (DOE-UCLA)P08581
IntAct (EBI)P08581
FunCoupENSG00000105976
BioGRIDMET
InParanoidP08581
Interologous Interaction database P08581
IntegromeDBMET
STRING (EMBL)MET
Ontologies - Pathways
Ontology : AmiGOactivation of MAPK activity  liver development  placenta development  protein tyrosine kinase activity  protein tyrosine kinase activity  hepatocyte growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  plasma membrane  integral to plasma membrane  signal transduction  cell surface receptor signaling pathway  axon guidance  brain development  skeletal muscle tissue development  cell proliferation  basal plasma membrane  positive regulation of glucose transport  muscle cell migration  myotube differentiation  integral to membrane  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  protein phosphatase binding  adult behavior  glucose homeostasis  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  branching morphogenesis of an epithelial tube  myoblast proliferation  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  negative regulation of hydrogen peroxide-mediated programmed cell death  
Ontology : EGO-EBIactivation of MAPK activity  liver development  placenta development  protein tyrosine kinase activity  protein tyrosine kinase activity  hepatocyte growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  plasma membrane  integral to plasma membrane  signal transduction  cell surface receptor signaling pathway  axon guidance  brain development  skeletal muscle tissue development  cell proliferation  basal plasma membrane  positive regulation of glucose transport  muscle cell migration  myotube differentiation  integral to membrane  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  protein phosphatase binding  adult behavior  glucose homeostasis  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  branching morphogenesis of an epithelial tube  myoblast proliferation  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  negative regulation of hydrogen peroxide-mediated programmed cell death  
Pathways : BIOCARTACBL mediated ligand-induced downregulation of EGF receptors [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    Endocytosis    PI3K-Akt signaling pathway    Axon guidance    Focal adhesion    Adherens junction    Bacterial invasion of epithelial cells    Epithelial cell signaling in Helicobacter pylori infection    Malaria    Pathways in cancer    Transcriptional misregulation in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Melanoma   
REACTOMEMET
Protein Interaction DatabaseMET
Wikipedia pathwaysMET
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MET
SNP (GeneSNP Utah)MET
SNP : HGBaseMET
Genetic variants : HAPMAPMET
1000_GenomesMET 
ICGC programENSG00000105976 
Cancer Gene: CensusMET 
Somatic Mutations in Cancer : COSMICMET 
CONAN: Copy Number AnalysisMET 
Mutations and Diseases : HGMDMET
OMIM114550    164860    605074    611015   
GENETestsMET
Disease Genetic AssociationMET
Huge Navigator MET [HugePedia]  MET [HugeCancerGEM]
Genomic VariantsMET  MET [DGVbeta]
Exome VariantMET
dbVarMET
ClinVarMET
snp3D : Map Gene to Disease4233
General knowledge
Homologs : HomoloGeneMET
Homology/Alignments : Family Browser (UCSC)MET
Phylogenetic Trees/Animal Genes : TreeFamMET
Chemical/Protein Interactions : CTD4233
Chemical/Pharm GKB GenePA30763
Drug Sensitivity MET
Clinical trialMET
Cancer Resource (Charite)ENSG00000105976
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineMET
iHOPMET

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The human hepatocyte growth factor receptor gene: complete structural organization and promoter characterization.
Liu Y
Gene. 1998 ; 215 (1) : 159-169.
PMID 9666114
 
Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.
Schmidt L, Junker K, Weirich G, Glenn G, Choyke P, Lubensky I, Zhuang Z, Jeffers M, Vande Woude G, Neumann H, Walther M, Linehan WM, Zbar B
Cancer research. 1998 ; 58 (8) : 1719-1722.
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Inherited carcinomas of the kidney.
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Advances in cancer research. 1998 ; 75 : 163-201.
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Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.
Zhuang Z, Park WS, Pack S, Schmidt L, Vortmeyer AO, Pak E, Pham T, Weil RJ, Candidus S, Lubensky IA, Linehan WM, Zbar B, Weirich G
Nature genetics. 1998 ; 20 (1) : 66-69.
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Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?
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Domains in plexins: links to integrins and transcription factors.
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Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth.
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Experimental cell research. 1999 ; 253 (1) : 88-99.
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Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype.
Lubensky IA, Schmidt L, Zhuang Z, Weirich G, Pack S, Zambrano N, Walther MM, Choyke P, Linehan WM, Zbar B
The American journal of pathology. 1999 ; 155 (2) : 517-526.
PMID 10433944
 
The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.
Maroun CR, Holgado-Madruga M, Royal I, Naujokas MA, Fournier TM, Wong AJ, Park M
Molecular and cellular biology. 1999 ; 19 (3) : 1784-1799.
PMID 10022866
 
Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family.
Olivero M, Valente G, Bardelli A, Longati P, Ferrero N, Cracco C, Terrone C, Rocca-Rossetti S, Comoglio PM, Di Renzo MF
International journal of cancer. Journal international du cancer. 1999 ; 82 (5) : 640-643.
PMID 10417759
 
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.
Park WS, Dong SM, Kim SY, Na EY, Shin MS, Pi JH, Kim BJ, Bae JH, Hong YK, Lee KS, Lee SH, Yoo NJ, Jang JJ, Pack S, Zhuang Z, Schmidt L, Zbar B, Lee JY
Cancer research. 1999 ; 59 (2) : 307-310.
PMID 9927037
 
Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid.
Scarpino S, Stoppacciaro A, Colarossi C, Cancellario F, Marzullo A, Marchesi M, Biffoni M, Comoglio PM, Prat M, Ruco LP
The Journal of pathology. 1999 ; 189 (4) : 570-575.
PMID 10629560
 
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.
Schmidt L, Junker K, Nakaigawa N, Kinjerski T, Weirich G, Miller M, Lubensky I, Neumann HP, Brauch H, Decker J, Vocke C, Brown JA, Jenkins R, Richard S, Bergerheim U, Gerrard B, Dean M, Linehan WM, Zbar B
Oncogene. 1999 ; 18 (14) : 2343-2350.
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Semaphorin signaling: a little less per-plexin.
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Neuron. 1999 ; 22 (1) : 11-14.
PMID 10027283
 
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas.
Di Renzo MF, Olivero M, Martone T, Maffe A, Maggiora P, Stefani AD, Valente G, Giordano S, Cortesina G, Comoglio PM
Oncogene. 2000 ; 19 (12) : 1547-1555.
PMID 10734314
 
Different point mutations in the met oncogene elicit distinct biological properties.
Giordano S, Maffe A, Williams TA, Artigiani S, Gual P, Bardelli A, Basilico C, Michieli P, Comoglio PM
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2000 ; 14 (2) : 399-406.
PMID 10657996
 
Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.
Kamikura DM, Khoury H, Maroun C, Naujokas MA, Park M
Molecular and cellular biology. 2000 ; 20 (10) : 3482-3496.
PMID 10779338
 
A novel germ line juxtamembrane Met mutation in human gastric cancer.
Lee JH, Han SU, Cho H, Jennings B, Gerrard B, Dean M, Schmidt L, Zbar B, Vande Woude GF
Oncogene. 2000 ; 19 (43) : 4947-4953.
PMID 11042681
 
Missense mutation of the MET gene detected in human glioma.
Moon YW, Weil RJ, Pack SD, Park WS, Pak E, Pham T, Karkera JD, Kim HK, Vortmeyer AO, Fuller BG, Zhuang Z
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2000 ; 13 (9) : 973-977.
PMID 11007037
 
Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.
Nakaigawa N, Weirich G, Schmidt L, Zbar B
Oncogene. 2000 ; 19 (26) : 2996-3002.
PMID 10871851
 
Expression of hepatocyte growth factor (HGF)/scatter factor and its receptor c-MET correlates with poor prognosis in synovial sarcoma.
Oda Y, Sakamoto A, Saito T, Kinukawa N, Iwamoto Y, Tsuneyoshi M
Human pathology. 2000 ; 31 (2) : 185-192.
PMID 10685632
 
The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation.
van der Voort R, Taher TE, Derksen PW, Spaargaren M, van der Neut R, Pals ST
Advances in cancer research. 2000 ; 79 : 39-90.
PMID 10818677
 
Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors.
Wallenius V, Hisaoka M, Helou K, Levan G, Mandahl N, Meis-Kindblom JM, Kindblom LG, Jansson JO
The American journal of pathology. 2000 ; 156 (3) : 821-829.
PMID 10702398
 
Inherited epithelial tumors of the kidney: old and new diseases.
Zbar B
Seminars in cancer biology. 2000 ; 10 (4) : 313-318.
PMID 10966853
 
Pathway specificity for Met signalling.
Comoglio PM
Nature cell biology. 2001 ; 3 (7) : E161-E162.
PMID 11433311
 
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway.
Danilkovitch-Miagkova A, Miagkov A, Skeel A, Nakaigawa N, Zbar B, Leonard EJ
Molecular and cellular biology. 2001 ; 21 (17) : 5857-5868.
PMID 11486025
 
Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies.
Miller M, Ginalski K, Lesyng B, Nakaigawa N, Schmidt L, Zbar B
Proteins. 2001 ; 44 (1) : 32-43.
PMID 11354004
 
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Contributor(s)

Written10-2001Debora Angeloni, Michael L. Nickerson, Laura Schmidt

Citation

This paper should be referenced as such :
Angeloni D, Nickerson ML, Schmidt L . MET met proto-oncogene (hepatocyte growth factor receptor). Atlas Genet Cytogenet Oncol Haematol. October 2001 .
URL : http://AtlasGeneticsOncology.org/Genes/METID131.html

The various updated versions of this paper are referenced and archived by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37809/1/10-2001-METID131.pdf   [ Bibliographic record ]

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