| Note | |
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| Entity | Tumor cell proliferation |
| Note | MiR-200a showed its roles in regulation of tumor cell proliferation. In human endometrial adenocarcinoma cell line HEC-1B, repression of miR-200a could increase the tumor suppressor gene PTEN and thus inhibit cell proliferation and promote cell apoptosis, which showed the oncogenic role of miR-200a (Li, He et al. 2014). However, studies in breast cancer also demonstrated that miR-200a could attenuate cell proliferation by targeting Mitochondrial Transcription Factor A (Yao, Zhou et al. 2014). As well, miR-200a was also proved to impair glioma cell growth by targeting SIM2-s (Su, He et al. 2014). |
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| Entity | Tumor cells invasion and cancer metastasis |
| Note | As a member of miR-200 family, miR-200a showed its regulation roles in cancer cells invasion and migration. By targeting SIM-2, miR-200a could inhibit glioma cell migration and invasion (Su, He et al. 2014). In CD133/1+ ovarian cancer stem cells, miR-200a could inhibit cell migration and invasion by repressing expression of Zeb2 (which is a repressor of E-cadherin) (Wu, Guo et al. 2011). However, in human breast cancer cells, it was found that miR-200a could target YAP1 thus induce anoikis resistance and metastasis (Yu, Hu et al. 2013). |
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| Entity | Repression of epithelial-mesenchymal transition (EMT) |
| Note | Roles of miR-200 family in EMT regulation were intensively studied. As miR-200a, it was reported that miR-200a could regulate EMT by targeting SIRT1 and mammary epithelial cells (Eades, Yao et al. 2011). In hepatic oval cells, downregulation of miR-200a induces EMT phenotypes and CSC-like signatures by directly targeting beta-catenin (Liu, Ruan et al. 2013). |
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| miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells |
| Eades G, Yao Y, Yang M, Zhang Y, Chumsri S, Zhou Q |
| J Biol Chem 2011 Jul 22;286(29):25992-6002 |
| PMID 21596753 |
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| MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN |
| Li R, He JL, Chen XM, Long CL, Yang DH, Ding YB, Qi HB, Liu XQ |
| Mol Biol Rep 2014;41(4):1977-84 |
| PMID 24413994 |
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| Downregulation of miR-200a induces EMT phenotypes and CSC-like signatures through targeting the -catenin pathway in hepatic oval cells |
| Liu J, Ruan B, You N, Huang Q, Liu W, Dang Z, Xu W, Zhou T, Ji R, Cao Y, Li X, Wang D, Tao K, Dou K |
| PLoS One 2013 Nov 15;8(11):e79409 |
| PMID 24260215 |
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| MiR-200a impairs glioma cell growth, migration, and invasion by targeting SIM2-s |
| Su Y, He Q, Deng L, Wang J, Liu Q, Wang D, Huang Q, Li G |
| Neuroreport 2014 Jan 8;25(1):12-7 |
| PMID 24162743 |
| |
| MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2 |
| Wu Q, Guo R, Lin M, Zhou B, Wang Y |
| Gynecol Oncol 2011 Jul;122(1):149-54 |
| PMID 21529905 |
| |
| microRNA-200a inhibits cell proliferation by targeting mitochondrial transcription factor A in breast cancer |
| Yao J, Zhou E, Wang Y, Xu F, Zhang D, Zhong D |
| DNA Cell Biol 2014 May;33(5):291-300 |
| PMID 24684598 |
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| MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer |
| Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, Di GH, Wu J, Shen ZZ, Song HY, Shao ZM |
| Clin Cancer Res 2013 Mar 15;19(6):1389-99 |
| PMID 23340296 |
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