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MIR200A (microRNA 200a)

Written2015-08Yaguang Xi, Hong Chang
Mitchell Cancer Institute, University of South Alabama, USA.;

Abstract Review on MIR200A, with data on RNA, and where it is implicated.

Keywords MIR200A

(Note : for Links provided by Atlas : click)


HGNC (Hugo) MIR200A
HGNC Alias symbhsa-mir-200a
HGNC Previous nameMIRN200A
LocusID (NCBI) 406983
Atlas_Id 53347
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1167863 and ends at 1167952 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MIR200A.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note MicroRNA 200a belongs to microRNA 200 family. MicroRNA 200 family consists of five microRNAs, microRNA 200b, microRNA 200a, microRNA 429, microRNA 200c and microRNA 141. MicroRNA 200b, microRNA 200a and microRNA 429 were transcribed as a single ploycistronic transcript from chromosome 1. And microRNA 200 family were demonstrated important roles in EMT (epithelial-mesenchymal transition) progress.


Description microRNA 200a located in chromosome 1 and microRNA 200a was transcribed with microRNA 200b and microRNA 429 as a ploycistronic transcript. The putative transcription start site locates about 4987 bp upstream of the precursor of microRNA 200a.
Pseudogene No pseudogene was found.


Note microRNAs are not translated into proteins.

Implicated in

Entity Tumor cell proliferation
Note MiR-200a showed its roles in regulation of tumor cell proliferation. In human endometrial adenocarcinoma cell line HEC-1B, repression of miR-200a could increase the tumor suppressor gene PTEN and thus inhibit cell proliferation and promote cell apoptosis, which showed the oncogenic role of miR-200a (Li, He et al. 2014). However, studies in breast cancer also demonstrated that miR-200a could attenuate cell proliferation by targeting Mitochondrial Transcription Factor A (Yao, Zhou et al. 2014). As well, miR-200a was also proved to impair glioma cell growth by targeting SIM2-s (Su, He et al. 2014).
Entity Tumor cells invasion and cancer metastasis
Note As a member of miR-200 family, miR-200a showed its regulation roles in cancer cells invasion and migration. By targeting SIM-2, miR-200a could inhibit glioma cell migration and invasion (Su, He et al. 2014). In CD133/1+ ovarian cancer stem cells, miR-200a could inhibit cell migration and invasion by repressing expression of Zeb2 (which is a repressor of E-cadherin) (Wu, Guo et al. 2011). However, in human breast cancer cells, it was found that miR-200a could target YAP1 thus induce anoikis resistance and metastasis (Yu, Hu et al. 2013).
Entity Repression of epithelial-mesenchymal transition (EMT)
Note Roles of miR-200 family in EMT regulation were intensively studied. As miR-200a, it was reported that miR-200a could regulate EMT by targeting SIRT1 and mammary epithelial cells (Eades, Yao et al. 2011). In hepatic oval cells, downregulation of miR-200a induces EMT phenotypes and CSC-like signatures by directly targeting beta-catenin (Liu, Ruan et al. 2013).


miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
Eades G, Yao Y, Yang M, Zhang Y, Chumsri S, Zhou Q
J Biol Chem 2011 Jul 22;286(29):25992-6002
PMID 21596753
MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN
Li R, He JL, Chen XM, Long CL, Yang DH, Ding YB, Qi HB, Liu XQ
Mol Biol Rep 2014;41(4):1977-84
PMID 24413994
Downregulation of miR-200a induces EMT phenotypes and CSC-like signatures through targeting the -catenin pathway in hepatic oval cells
Liu J, Ruan B, You N, Huang Q, Liu W, Dang Z, Xu W, Zhou T, Ji R, Cao Y, Li X, Wang D, Tao K, Dou K
PLoS One 2013 Nov 15;8(11):e79409
PMID 24260215
MiR-200a impairs glioma cell growth, migration, and invasion by targeting SIM2-s
Su Y, He Q, Deng L, Wang J, Liu Q, Wang D, Huang Q, Li G
Neuroreport 2014 Jan 8;25(1):12-7
PMID 24162743
MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2
Wu Q, Guo R, Lin M, Zhou B, Wang Y
Gynecol Oncol 2011 Jul;122(1):149-54
PMID 21529905
microRNA-200a inhibits cell proliferation by targeting mitochondrial transcription factor A in breast cancer
Yao J, Zhou E, Wang Y, Xu F, Zhang D, Zhong D
DNA Cell Biol 2014 May;33(5):291-300
PMID 24684598
MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer
Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, Di GH, Wu J, Shen ZZ, Song HY, Shao ZM
Clin Cancer Res 2013 Mar 15;19(6):1389-99
PMID 23340296


This paper should be referenced as such :
Yaguang Xi, Hong Chang
MIR200A (microRNA 200a)
Atlas Genet Cytogenet Oncol Haematol. ;20(6):322-323.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)MIR200A   31578
Atlas Explorer : (Salamanque)MIR200A
Entrez_Gene (NCBI)MIR200A    microRNA 200a
AliasesMIRN200A; mir-200a
GeneCards (Weizmann)MIR200A
Ensembl hg19 (Hinxton)ENSG00000207607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000207607 [Gene_View]  ENSG00000207607 [Sequence]  chr1:1167863-1167952 [Contig_View]  MIR200A [Vega]
ICGC DataPortalENSG00000207607
TCGA cBioPortalMIR200A
AceView (NCBI)MIR200A
Genatlas (Paris)MIR200A
SOURCE (Princeton)MIR200A
Genetics Home Reference (NIH)MIR200A
Genomic and cartography
GoldenPath hg38 (UCSC)MIR200A  -     chr1:1167863-1167952 +  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIR200A  -     1p36.33   [Description]    (hg19-Feb_2009)
GoldenPathMIR200A - 1p36.33 [CytoView hg19]  MIR200A - 1p36.33 [CytoView hg38]
Genome Data Viewer NCBIMIR200A [Mapview hg19]  
Gene and transcription
Genbank (Entrez)LM608664
RefSeq transcript (Entrez)
Consensus coding sequences : CCDS (NCBI)MIR200A
Gene ExpressionMIR200A [ NCBI-GEO ]   MIR200A [ EBI - ARRAY_EXPRESS ]   MIR200A [ SEEK ]   MIR200A [ MEM ]
Gene Expression Viewer (FireBrowse)MIR200A [ Firebrowse - Broad ]
GenevisibleExpression of MIR200A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)406983
GTEX Portal (Tissue expression)MIR200A
Human Protein AtlasENSG00000207607-MIR200A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MIR200A
Human Protein Atlas [tissue]ENSG00000207607-MIR200A [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed211 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 14:11:47 CET 2022

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