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MIR200B (microRNA 200b)

Written2015-08Yaguang Xi, Hong Chang
Mitchell Cancer Institute, University of South Alabama, USA. xi@health.southalabama.edu; hchang@health.southalabama.edu

Abstract Review on MIR200B, with data on RNA, and where it is implicated.

Keywords MIR200B

(Note : for Links provided by Atlas : click)

Identity

Alias_namesMIRN200B
Alias_symbol (synonym)hsa-mir-200b
Other alias
HGNC (Hugo) MIR200B
LocusID (NCBI) 406984
Atlas_Id 51137
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1167104 and ends at 1167198 bp from pter ( according to hg19-Feb_2009)  [Mapping MIR200B.png]
Note NOTE MicroRNA 200b belongs to microRNA 200 family. MicroRNA 200 family consists of five microRNAs, microRNA 200b, microRNA 200a, microRNA 429, microRNA 200c and microRNA 141. MicroRNA 200b, microRNA 200a and microRNA 429 were transcribed as a single ploycistronic transcript from chromosome 1. And microRNA 200 family were demonstrated important roles in EMT (epithelial-mesenchymal transition) progress.

DNA/RNA

 
Description microRNA 200b located in chromosome 1 and microRNA 200b was transcribed with microRNA 200a and microRNA 429 as a ploycistronic transcript. The putative transcription start site locates about 4228 bp upstream of the precursor of microRNA 200b.
Transcription MiR-200b precursor: 5'-CCAGCUCGGGCAGCCGUGGCCAUCUUACUGGGCAGCAUUGGAUGGAGUCAGGUCUCUAAUACUGCCUGGUAAUGAUGACGGCGGAGCCCUGCACG-3'
Mature miR-200b: 5'-UAAUACUGCCUGGUAAUGAUGA-3'
Pseudogene No pseudogene was found.

Protein

Note microRNAs are not translated into proteins.

Implicated in

Note
  
Entity Tumor cell proliferation
Note Multiple roles of miR-200b in cell cycles regulation and tumor cell proliferation were reported in human cancers. MiR-200b could directly target RND3 which could induce expression of cyclin D1 thereby promoting S-phase entry (Xia, Li et al. 2010). MiR-200b could also regulate cell cycle by targeting GATA4 and its downstream protein cyclin D1 which could affect cell proliferation (Yao, Wei et al. 2013). In human TGFBR2-null colorectal cancers, miR-200b could stimulate tumor growth by targeting CDKN1B (p27/kip1). It was also found that miR-200b could promoter cell proliferation by targeting p27/kip1 (Fu, Liu et al. 2014).
  
  
Entity Tumor cells invasion and cancer metastasis
Note Abnormal expressions of miR-200b were found in various cancers, including breast cancer, colon cancer, nasopharyngeal carcinoma, urothelial carcinoma and prostate cancer. MiR-200b could directly targeting SUZ12 and ROCK2 thus inhibit cholangiocarcinoma tumourigenesis and metastasis (Peng, Jiang et al. 2013). In gastric carcinoma, miR-200b was found to target ZEB2 and thereby repress tumor cell invasion and migration (Kurashige, Kamohara et al. 2012).
  
  
Entity Repression of epithelial-mesenchymal transition (EMT)
Note EMT is an important pathological progression and studies revealed vital roles of miR-200b in EMT regulation. MiR-200b could inhibit TGFB1-induced epithelial-mesenchymal transition by targeting SMAD2 intestinal epithelial cells and SMAD2 could repress expression of vimentin, which indicated regulation role of miR-200b on vimentin (Chen, Xiao et al. 2013). Also, the role of miR-200b in EMT regulation was observed in EMT induced by transforming growth factor-beta1 in kidney proximal tubular cells by directly target the 3'-UTR of fibronectin (Tang, Chen et al. 2013).
  
  
Entity Chemoresistance
Note Chemoresistance is the main cause of tumor relapse. Ectopic expression of miR-200b could reduce the chemoresistance of cells by targeting BIM1 in human tongue cancer cells. In human lung adenocarcinoma cells, miR-200b could target E2F3 to sensitize tumor cells to chemotherapy agents.
  

Bibliography

miR-200b inhibits TGF-1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells
Chen Y, Xiao Y, Ge W, Zhou K, Wen J, Yan W, Wang Y, Wang B, Qu C, Wu J, Xu L, Cai W
Cell Death Dis 2013 Mar 14;4:e541
PMID 23492772
 
MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1
Fu Y, Liu X, Zhou N, Du L, Sun Y, Zhang X, Ge Y
J Cell Physiol 2014 Jun;229(6):772-82
PMID 24151081
 
MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma
Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H
Ann Surg Oncol 2012 Jul;19 Suppl 3:S656-64
PMID 22311119
 
Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis
Peng F, Jiang J, Yu Y, Tian R, Guo X, Li X, Shen M, Xu M, Zhu F, Shi C, Hu J, Wang M, Qin R
Br J Cancer 2013 Dec 10;109(12):3092-104
PMID 24169343
 
MiRNA-200b represses transforming growth factor-1-induced EMT and fibronectin expression in kidney proximal tubular cells
Tang O, Chen XM, Shen S, Hahn M, Pollock CA
Am J Physiol Renal Physiol 2013 May 15;304(10):F1266-73
PMID 23408168
 
TGF-1 stimulates human Tenon's capsule fibroblast proliferation by miR-200b and its targeting of p27/kip1 and RND3
Tong J, Fu Y, Xu X, Fan S, Sun H, Liang Y, Xu K, Yuan Z, Ge Y
Invest Ophthalmol Vis Sci 2014 Apr 28;55(4):2747-56
PMID 24667864
 
MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells
Xia W, Li J, Chen L, Huang B, Li S, Yang G, Ding H, Wang F, Liu N, Zhao Q, Fang T, Song T, Wang T, Shao N
Mol Cell Biochem 2010 Nov;344(1-2):261-6
PMID 20683643
 
miR-200b targets GATA-4 during cell growth and differentiation
Yao CX, Wei QX, Zhang YY, Wang WP, Xue LX, Yang F, Zhang SF, Xiong CJ, Li WY, Wei ZR, Zou Y, Zang MX
RNA Biol 2013 Apr;10(4):465-80
PMID 23558708
 

Citation

This paper should be referenced as such :
Xi Y, Chang H
MIR200B (microRNA 200b);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Genes/MIR200BID51137ch1p36.html


External links

Nomenclature
HGNC (Hugo)MIR200B   31579
Cards
AtlasMIR200BID51137ch1p36
Entrez_Gene (NCBI)MIR200B  406984  microRNA 200b
AliasesMIRN200B; mir-200b
GeneCards (Weizmann)MIR200B
Ensembl hg19 (Hinxton)ENSG00000207730 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000207730 [Gene_View]  chr1:1167104-1167198 [Contig_View]  MIR200B [Vega]
ICGC DataPortalENSG00000207730
TCGA cBioPortalMIR200B
AceView (NCBI)MIR200B
Genatlas (Paris)MIR200B
WikiGenes406984
SOURCE (Princeton)MIR200B
Genetics Home Reference (NIH)MIR200B
miRBaseMIR200B
dbDEMCMIR200B
Genomic and cartography
GoldenPath hg38 (UCSC)MIR200B  -     chr1:1167104-1167198 +  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIR200B  -     1p36.33   [Description]    (hg19-Feb_2009)
EnsemblMIR200B - 1p36.33 [CytoView hg19]  MIR200B - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBIMIR200B [Mapview hg19]  MIR200B [Mapview hg38]
OMIM612091   
Gene and transcription
Genbank (Entrez)LM608401
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MIR200B
Alternative Splicing GalleryENSG00000207730
Gene ExpressionMIR200B [ NCBI-GEO ]   MIR200B [ EBI - ARRAY_EXPRESS ]   MIR200B [ SEEK ]   MIR200B [ MEM ]
Gene Expression Viewer (FireBrowse)MIR200B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)406984
GTEX Portal (Tissue expression)MIR200B
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MIR200B
DMDM Disease mutations406984
Blocks (Seattle)MIR200B
Human Protein AtlasENSG00000207730
Protein Interaction databases
FunCoupENSG00000207730
BioGRIDMIR200B
STRING (EMBL)MIR200B
ZODIACMIR200B
Ontologies - Pathways
Huge Navigator MIR200B [HugePedia]
snp3D : Map Gene to Disease406984
BioCentury BCIQMIR200B
ClinGenMIR200B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD406984
Chemical/Pharm GKB GenePA164722576
Clinical trialMIR200B
Miscellaneous
canSAR (ICR)MIR200B (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMIR200B
EVEXMIR200B
GoPubMedMIR200B
iHOPMIR200B
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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