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MIR200B (microRNA 200b)

Written2015-08Yaguang Xi, Hong Chang
Mitchell Cancer Institute, University of South Alabama, USA.;

Abstract Review on MIR200B, with data on RNA, and where it is implicated.

Keywords MIR200B

(Note : for Links provided by Atlas : click)


HGNC (Hugo) MIR200B
HGNC Alias symbhsa-mir-200b
HGNC Previous nameMIRN200B
LocusID (NCBI) 406984
Atlas_Id 51137
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1167104 and ends at 1167198 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MIR200B.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note NOTE MicroRNA 200b belongs to microRNA 200 family. MicroRNA 200 family consists of five microRNAs, microRNA 200b, microRNA 200a, microRNA 429, microRNA 200c and microRNA 141. MicroRNA 200b, microRNA 200a and microRNA 429 were transcribed as a single ploycistronic transcript from chromosome 1. And microRNA 200 family were demonstrated important roles in EMT (epithelial-mesenchymal transition) progress.


Description microRNA 200b located in chromosome 1 and microRNA 200b was transcribed with microRNA 200a and microRNA 429 as a ploycistronic transcript. The putative transcription start site locates about 4228 bp upstream of the precursor of microRNA 200b.
Pseudogene No pseudogene was found.


Note microRNAs are not translated into proteins.

Implicated in

Entity Tumor cell proliferation
Note Multiple roles of miR-200b in cell cycles regulation and tumor cell proliferation were reported in human cancers. MiR-200b could directly target RND3 which could induce expression of cyclin D1 thereby promoting S-phase entry (Xia, Li et al. 2010). MiR-200b could also regulate cell cycle by targeting GATA4 and its downstream protein cyclin D1 which could affect cell proliferation (Yao, Wei et al. 2013). In human TGFBR2-null colorectal cancers, miR-200b could stimulate tumor growth by targeting CDKN1B (p27/kip1). It was also found that miR-200b could promoter cell proliferation by targeting p27/kip1 (Fu, Liu et al. 2014).
Entity Tumor cells invasion and cancer metastasis
Note Abnormal expressions of miR-200b were found in various cancers, including breast cancer, colon cancer, nasopharyngeal carcinoma, urothelial carcinoma and prostate cancer. MiR-200b could directly targeting SUZ12 and ROCK2 thus inhibit cholangiocarcinoma tumourigenesis and metastasis (Peng, Jiang et al. 2013). In gastric carcinoma, miR-200b was found to target ZEB2 and thereby repress tumor cell invasion and migration (Kurashige, Kamohara et al. 2012).
Entity Repression of epithelial-mesenchymal transition (EMT)
Note EMT is an important pathological progression and studies revealed vital roles of miR-200b in EMT regulation. MiR-200b could inhibit TGFB1-induced epithelial-mesenchymal transition by targeting SMAD2 intestinal epithelial cells and SMAD2 could repress expression of vimentin, which indicated regulation role of miR-200b on vimentin (Chen, Xiao et al. 2013). Also, the role of miR-200b in EMT regulation was observed in EMT induced by transforming growth factor-beta1 in kidney proximal tubular cells by directly target the 3'-UTR of fibronectin (Tang, Chen et al. 2013).
Entity Chemoresistance
Note Chemoresistance is the main cause of tumor relapse. Ectopic expression of miR-200b could reduce the chemoresistance of cells by targeting BIM1 in human tongue cancer cells. In human lung adenocarcinoma cells, miR-200b could target E2F3 to sensitize tumor cells to chemotherapy agents.


miR-200b inhibits TGF-1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells
Chen Y, Xiao Y, Ge W, Zhou K, Wen J, Yan W, Wang Y, Wang B, Qu C, Wu J, Xu L, Cai W
Cell Death Dis 2013 Mar 14;4:e541
PMID 23492772
MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1
Fu Y, Liu X, Zhou N, Du L, Sun Y, Zhang X, Ge Y
J Cell Physiol 2014 Jun;229(6):772-82
PMID 24151081
MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma
Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H
Ann Surg Oncol 2012 Jul;19 Suppl 3:S656-64
PMID 22311119
Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis
Peng F, Jiang J, Yu Y, Tian R, Guo X, Li X, Shen M, Xu M, Zhu F, Shi C, Hu J, Wang M, Qin R
Br J Cancer 2013 Dec 10;109(12):3092-104
PMID 24169343
MiRNA-200b represses transforming growth factor-1-induced EMT and fibronectin expression in kidney proximal tubular cells
Tang O, Chen XM, Shen S, Hahn M, Pollock CA
Am J Physiol Renal Physiol 2013 May 15;304(10):F1266-73
PMID 23408168
TGF-1 stimulates human Tenon's capsule fibroblast proliferation by miR-200b and its targeting of p27/kip1 and RND3
Tong J, Fu Y, Xu X, Fan S, Sun H, Liang Y, Xu K, Yuan Z, Ge Y
Invest Ophthalmol Vis Sci 2014 Apr 28;55(4):2747-56
PMID 24667864
MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells
Xia W, Li J, Chen L, Huang B, Li S, Yang G, Ding H, Wang F, Liu N, Zhao Q, Fang T, Song T, Wang T, Shao N
Mol Cell Biochem 2010 Nov;344(1-2):261-6
PMID 20683643
miR-200b targets GATA-4 during cell growth and differentiation
Yao CX, Wei QX, Zhang YY, Wang WP, Xue LX, Yang F, Zhang SF, Xiong CJ, Li WY, Wei ZR, Zou Y, Zang MX
RNA Biol 2013 Apr;10(4):465-80
PMID 23558708


This paper should be referenced as such :
Yaguang Xi, Hong Chang
MIR200B (microRNA 200b)
Atlas Genet Cytogenet Oncol Haematol. 2016;20(5):273-274.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)MIR200B   31579
Entrez_Gene (NCBI)MIR200B    microRNA 200b
AliasesMIRN200B; mir-200b
GeneCards (Weizmann)MIR200B
Ensembl hg19 (Hinxton)ENSG00000207730 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000207730 [Gene_View]  ENSG00000207730 [Sequence]  chr1:1167104-1167198 [Contig_View]  MIR200B [Vega]
ICGC DataPortalENSG00000207730
TCGA cBioPortalMIR200B
AceView (NCBI)MIR200B
Genatlas (Paris)MIR200B
SOURCE (Princeton)MIR200B
Genetics Home Reference (NIH)MIR200B
Genomic and cartography
GoldenPath hg38 (UCSC)MIR200B  -     chr1:1167104-1167198 +  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIR200B  -     1p36.33   [Description]    (hg19-Feb_2009)
GoldenPathMIR200B - 1p36.33 [CytoView hg19]  MIR200B - 1p36.33 [CytoView hg38]
Genome Data Viewer NCBIMIR200B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)LM608401
RefSeq transcript (Entrez)
Consensus coding sequences : CCDS (NCBI)MIR200B
Gene ExpressionMIR200B [ NCBI-GEO ]   MIR200B [ EBI - ARRAY_EXPRESS ]   MIR200B [ SEEK ]   MIR200B [ MEM ]
Gene Expression Viewer (FireBrowse)MIR200B [ Firebrowse - Broad ]
GenevisibleExpression of MIR200B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)406984
GTEX Portal (Tissue expression)MIR200B
Human Protein AtlasENSG00000207730-MIR200B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MIR200B
Human Protein Atlas [tissue]ENSG00000207730-MIR200B [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed236 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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