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MIR30A (microRNA 30a)

Written2012-07Xiao-Bin Lv
Dept of Breast Surgery, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, China

(Note : for Links provided by Atlas : click)

Identity

Alias_namesMIRN30A
Alias_symbol (synonym)hsa-mir-30a
Other alias
HGNC (Hugo) MIR30A
LocusID (NCBI) 407029
Atlas_Id 51667
Location 6q13  [Link to chromosome band 6q13]
Location_base_pair Starts at 71403551 and ends at 71403621 bp from pter ( according to hg19-Feb_2009)  [Mapping MIR30A.png]
Local_order Based on Mapviewer, genes flanking MIR30A oriented from centromere to telomere on 6q13 are:
- B3GAT2, beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
- MIR30C2, microRNA 30c-2
- MIR30A, microRNA 30a
- RIMS1, regulating synaptic membrane exocytosis 1
- KCNQ5, potassium voltage-gated channel, KQT-like subfamily, member 5
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

DNA/RNA

 
Description miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as ~70 nucleotide stem-loop precursor and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30) and 5' (mir-97-6) arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA. A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs. Members of the miR-30 family have been found to be highly expressed in heart cells.
Transcription miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA.
Pre-miR Length: 71 bases.
gcgactgtaa acatcctcga ctggaagctg tgaagccaca gatgggcttt cagtcggatg tttgcagctg c
Pseudogene No reported pseudogenes.

Protein

Note miRNAs are not translated into amino acids.

Mutations

Note Gene mutations have not been described.

Implicated in

Note
  
Entity Breast cancer
Disease Overexpression of miR-30a suppressed the migration and invasiveness phenotypes of breast cancer cell lines. Moreover, reduced tumor expression of miR-30a in breast cancer patients was associated with an unfavorable outcome, including late tumor stage, lymph node metastasis, and worse progression (Cheng et al., 2012).
Prognosis Higher expression levels of hsa-miR-30a-3p, hsa-miR-30c, and hsa-miR-182 were significantly associated with benefit of tamoxifen treatment and with longer PFS (Rodríguez-González et al., 2011).
  
  
Entity Colon carcinoma
Disease miR-30a-5p was shown to be down-regulated in human colorectal cancer compared with normal colon mucosa. Overexpression of miR-30-5p suppresses proliferation colon cancer cell lines by targeting denticleless protein homolog (DTL) (Baraniskin et al., 2012).
  
  
Entity Non-small cell lung cancer
Disease microRNA-30a expression was found inversely proportional to the invasive potential of various NSCLC cell lines, correlating positively with E-cadherin (epithelial marker) and negatively with N-cadherin (mesenchymal marker) expression. Lucerfise reporter assay indicates snail was a potential target of miR-30a (Kumarswamy et al., 2012).
  
  
Entity Squamous cell carcinoma
Note Diagnosis: a 5-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a, and hsa-miR-140-3p) that could distinguish SCC from normal lung tissues (Tan et al., 2011).
  
  
Entity Gastric cancer
Prognosis Li et al identified seven-miRNA signature (miR-10b, miR-21, miR-223, miR-338, let-7a, miR-30a-5p, miR-126) for overall survival (p=0,0009) and relapse-free survival (p=0,0005) of gastric cancer patients (2010).
  
  
Entity Thyroid carcinomas
Disease miR-30a-5p was down-regulated in Thyroid carcinomas in comparison to normal thyroid tissue (Visone, 2007).
  
  
Entity Chemotherapy resistance
Note miR-30a in regulating beclin 1 expression and autophagy reveals a novel function for miRNA in a critical cellular event with significant impacts in cancer development, progression and treatment (Zhu et al., 2009).
miR-30a can sensitize tumor cells to cis-DDP via reducing beclin 1-mediated autophagy and that increasing miR-30a level in tumor cells represents a novel approach to enhance the efficacy of chemotherapy during cancer treatment (Zou et al., 2012).
Imatinib markedly inhibits expression of miR-30a in human CML cells. miR-30a is a potent inhibitor of autophagy by downregulating Beclin 1 and ATG5 expression. miR-30a mimic or knockdown of autophagy genes (ATGs) such as Beclin 1 and ATG5 by short hairpin RNA enhances imatinib-induced cytotoxicity and promotes mitochondria-dependent intrinsic apoptosis. In contrast, knockdown of miR-30a by antagomir-30a increases the expression of Beclin 1 and ATG5, and inhibits imatinib-induced cytotoxicity (Yu et al., 2012)
  

Bibliography

MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer.
Cheng CW, Wang HW, Chang CW, Chu HW, Chen CY, Yu JC, Chao JI, Liu HF, Ding SL, Shen CY.
Breast Cancer Res Treat. 2012 Aug;134(3):1081-93. Epub 2012 Apr 4.
PMID 22476851
 
MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer.
Kumarswamy R, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J, Papotti M, Allgayer H.
Int J Cancer. 2012 May 1;130(9):2044-53. doi: 10.1002/ijc.26218. Epub 2011 Aug 8.
PMID 21633953
 
Survival prediction of gastric cancer by a seven-microRNA signature.
Li X, Zhang Y, Zhang Y, Ding J, Wu K, Fan D.
Gut. 2010 May;59(5):579-85. Epub 2009 Nov 30.
PMID 19951901
 
MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer.
Rodriguez-Gonzalez FG, Sieuwerts AM, Smid M, Look MP, Meijer-van Gelder ME, de Weerd V, Sleijfer S, Martens JW, Foekens JA.
Breast Cancer Res Treat. 2011 May;127(1):43-51. Epub 2010 May 19.
PMID 20490652
 
A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis.
Tan X, Qin W, Zhang L, Hang J, Li B, Zhang C, Wan J, Zhou F, Shao K, Sun Y, Wu J, Zhang X, Qiu B, Li N, Shi S, Feng X, Zhao S, Wang Z, Zhao X, Chen Z, Mitchelson K, Cheng J, Guo Y, He J.
Clin Cancer Res. 2011 Nov 1;17(21):6802-11. Epub 2011 Sep 2.
PMID 21890451
 
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A.
Oncogene. 2007 Nov 29;26(54):7590-5. Epub 2007 Jun 11.
PMID 17563749
 
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells.
Yu Y, Yang L, Zhao M, Zhu S, Kang R, Vernon P, Tang D, Cao L.
Leukemia. 2012 Aug;26(8):1752-60. doi: 10.1038/leu.2012.65. Epub 2012 Mar 7.
PMID 22395361
 
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells.
Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, Liu CG, Yang JM.
Autophagy. 2009 Aug;5(6):816-23. Epub 2009 Aug 20.
PMID 19535919
 
MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy.
Zou Z, Wu L, Ding H, Wang Y, Zhang Y, Chen X, Chen X, Zhang CY, Zhang Q, Zen K.
J Biol Chem. 2012 Feb 3;287(6):4148-56. Epub 2011 Dec 8.
PMID 22157765
 

Citation

This paper should be referenced as such :
Lv, XB
MIR30A (microRNA 30a)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(1):32-34.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MIR30AID51667ch6q13.html


External links

Nomenclature
HGNC (Hugo)MIR30A   31624
Cards
AtlasMIR30AID51667ch6q13
Entrez_Gene (NCBI)MIR30A  407029  microRNA 30a
AliasesMIRN30A; mir-30a
GeneCards (Weizmann)MIR30A
Ensembl hg19 (Hinxton)ENSG00000207827 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000207827 [Gene_View]  chr6:71403551-71403621 [Contig_View]  MIR30A [Vega]
ICGC DataPortalENSG00000207827
TCGA cBioPortalMIR30A
AceView (NCBI)MIR30A
Genatlas (Paris)MIR30A
WikiGenes407029
SOURCE (Princeton)MIR30A
Genetics Home Reference (NIH)MIR30A
miRBaseMIR30A
dbDEMCMIR30A
Genomic and cartography
GoldenPath hg38 (UCSC)MIR30A  -     chr6:71403551-71403621 -  6q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIR30A  -     6q13   [Description]    (hg19-Feb_2009)
EnsemblMIR30A - 6q13 [CytoView hg19]  MIR30A - 6q13 [CytoView hg38]
Mapping of homologs : NCBIMIR30A [Mapview hg19]  MIR30A [Mapview hg38]
OMIM612329   
Gene and transcription
Genbank (Entrez)AF480535 AF480569 AJ421752 LM608177
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MIR30A
Alternative Splicing GalleryENSG00000207827
Gene ExpressionMIR30A [ NCBI-GEO ]   MIR30A [ EBI - ARRAY_EXPRESS ]   MIR30A [ SEEK ]   MIR30A [ MEM ]
Gene Expression Viewer (FireBrowse)MIR30A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)407029
GTEX Portal (Tissue expression)MIR30A
Human Protein AtlasENSG00000207827-MIR30A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MIR30A
DMDM Disease mutations407029
Blocks (Seattle)MIR30A
Human Protein Atlas [tissue]ENSG00000207827-MIR30A [tissue]
Protein Interaction databases
FunCoupENSG00000207827
BioGRIDMIR30A
STRING (EMBL)MIR30A
ZODIACMIR30A
Ontologies - Pathways
Huge Navigator MIR30A [HugePedia]
snp3D : Map Gene to Disease407029
BioCentury BCIQMIR30A
ClinGenMIR30A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD407029
Chemical/Pharm GKB GenePA164722641
Clinical trialMIR30A
Miscellaneous
canSAR (ICR)MIR30A (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMIR30A
EVEXMIR30A
GoPubMedMIR30A
iHOPMIR30A
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:56:06 CET 2017

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