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| Entity | Breast cancer |
| Note | miR-744-5p was able to suppress the cancer cell growth by reducing proto-oncogene eukaryotic translation elongation factor 1A(eEF1A2) expression in MCF7 cells. Moreover, over-expression of this microRNA could be induced by candidate anti-tumor agent resveratrol, suggesting that miR-744-5p could perform as a novel regulator involved in the resveratrol-related therapy (Vislovukh et al., 2013). |
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| Entity | Cervical carcinoma |
| Note | Expression of miR-744-5p is responsive to the administration of 1'S-1'-acetoxychavicol acetate (ACA) and cisplatin (CDDP) in cervical carcinoma cell line Ca Ski (low sensitivity to cisplatin) and HeLa (high sensitivity to cisplatin). Cervical cancer cell lines treated with ACA and/ or CDDP over two hours exhibited an enhancement on expression in miR-744-5p. Further, the predicted target transcripts are involved in signaling pathways regulating apoptosis and cell cycle progression (Phuah et al., 2013). In HeLa cells transfected with siRNA against T-cell intracellular antigen 1 (TIA1) and TIA1 related/like (TIAR/TIAL1), significant increase in miR-744-5p was observed (Sánchez-Jiménez et al., 2013) |
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| Entity | Gastric cancer (GC) |
| Note | In GC, serum miR-744-5p quantity could act as early cancer marker. High circulating miR-744-5p level was found in early GC patients. Comparing the diagnostic efficacy with the other candidate markers, miR-744-5p showed the greatest area under the curve (AUC) value (Song et al., 2012). In a retrospective study using pre-diagnosis serum collected at different time-point before confirmation of GC, serum miR-744-5p level was shown to be elevated gradually during GC development (Song et al., 2012). |
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| Entity | Hepatocellular carcinoma (HCC) |
| Note | Under-expression of miR-744-5p was observed in HCC tissues compared with the normal counterparts (Tan et al, 2014; Lin et al., 2014). Furthermore, reduced miR-744-5p exhibited a significant linkage with HCC cases demonstrating multiple tumor nodes or microvascular invasion (Tan et al., 2014). In HCC cell lines with low endogenous miR-744-5p expression, introduction of miR-744 mimics reduced HCC growth (Lin et al., 2014). Using luciferase reporter assays, it was demonstrated that miR-744-5p was able to suppress the HCC cell growth by targeting c-Myc (Lin et al., 2014). HCC tissues with low miR-744-5p had higher c-Myc protein expression (Lin et al., 2014). |
| Prognosis | The HCC cases with relative lower miR-744-5p expression level had higher recurrence rate after receiving liver transplantation. Mature miR-744-5p could serve as an independent prognostic predictor for the overall survival and recurrence-free survival in HCC patients (Tan et al., 2014). |
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| Entity | Head and neck cancer (HNC) |
| Disease | High expression of miR-744-5p was found in head and neck cancer (Nurul-Syakima et al., 2011). |
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| Entity | Multiple myeloma (MM) |
| Note | Reduced circulating miR-744-5p level is linked to MM. Compared with the healthy controls, MM patients exhibited a significantly lower circulating level of serum miR-744-5p, especially in the cases at advanced stage. Quantity of miR-744-5p was positively related with the seral level of albumin, hemoglobin and thrombocytes. In contrast, it was negatively correlated with the level of ?2-microglobulin, creatinine and lactate dehydrogenase. It is suggested that miR-744-5p is involved in the regulation of tumor mass and tumor activity (Kubiczkova et al., 2014). |
| Prognosis | MM patients with relatively higher serum miR-744-5p level had a better chance to survive than the serum miR-744-5p reduced group (Kubiczkova et al., 2014). Low miR-744-5p level was associated with poor overall survival and time to progression (Kubiczkova et al., 2014). |
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| Entity | Prostate adenocarcinoma |
| Note | Prolonged overexpression of miR-744-5p exerted a suppression on tumorigenesis in vivo, which might be due to chromosomal instability in prostate adenocarcinoma cells caused by prolonged activation of Ccnb1 (Huang et al., 2012). In prostate adenocarcinoma cell line, miR-744-5p overexpression, however, was found to be able to promote the cancer cell growth by enhancing the Cyclin B1 (Ccnb1) expression. |
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| Entity | Chronic hepatitis B infection (CHB) |
| Note | Down-regulation of miR-744-5p was positively correlated with the severity of liver injury (Zhang et al., 2012). Serum miR-744-5p level was found to be a precise marker for distinguishing CHB, non-alcohlic steatohepatitis (NASH) patients from healthy controls. Further, miR-744-5p level was correlated with liver functional parameters (Zhang et al., 2012). |
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| Entity | Chikungunya Virus (CHIKV) Infection |
| Note | In NEK293T cells (origin: human embryonic kidney cells) and human dermal fibroblasts infected with CHIKV, significant increase in miR-755-5p expression is observed in 12 hour (Sexena T et al., 2013). |
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| Entity | Early onset pre-eclampsia (EOPE) |
| Note | In chorioamniotic membranes tissue collected from early onset pre-eclampsia cases, promoter of miR-744-5p gene was found to be hypermethylated (Ching et al., 2014). The functions of miR-744-5p in pre-eclampsia remains to be elucidated. |
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| Entity | Breast cancer |
| Note | MiR-744-3p was found to be one of the microRNAs significantly down-regulated in HER2-positive breast cancers compared with the HER2-negative ones. Furthermore, overexpression of miR-744-3p resulted in the suppression of growth in HER2-positive breast cancer cell line KLP-4 and downregulation of HER2 expression (Leivonen et al., 2014). |
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| Genome-wide hypermethylation coupled with promoter hypomethylation in the chorioamniotic membranes of early onset pre-eclampsia |
| Ching T, Song MA, Tiirikainen M, Molnar J, Berry M, Towner D, Garmire LX |
| Mol Hum Reprod 2014 Sep;20(9):885-904 |
| PMID 24944161 |
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| Upregulation of Cyclin B1 by miRNA and its implications in cancer |
| Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC |
| Nucleic Acids Res 2012 Feb;40(4):1695-707 |
| PMID 22053081 |
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| Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance |
| Kubiczkova L, Kryukov F, Slaby O, Dementyeva E, Jarkovsky J, Nekvindova J, Radova L, Greslikova H, Kuglik P, Vetesnikova E, Pour L, Adam Z, Sevcikova S, Hajek R |
| Haematologica 2014 Mar;99(3):511-8 |
| PMID 24241494 |
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| High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth |
| Leivonen SK, Sahlberg KK, Mäkelä R, Due EU, Kallioniemi O, Børresen-Dale AL, Perälä M |
| Mol Oncol 2014 Feb;8(1):93-104 |
| PMID 24148764 |
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| Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma |
| Lin F, Ding R, Zheng S, Xing D, Hong W, Zhou Z, Shen J |
| Cancer Cell Int 2014 Jun 22;14:58 |
| PMID 24991193 |
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| Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers |
| Nurul-Syakima AM, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A, Learn-Han L |
| Int J Mol Med 2011 Sep;28(3):327-36 |
| PMID 21637912 |
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| Alterations of microRNA expression patterns in human cervical carcinoma cells (Ca Ski) toward 1'S-1'-acetoxychavicol acetate and cisplatin |
| Phuah NH, In LL, Azmi MN, Ibrahim H, Awang K, Nagoor NH |
| Reprod Sci 2013 May;20(5):567-78 |
| PMID 23012319 |
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| Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling |
| Sánchez-Jimé C, Carrascoso I, Barrero J, Izquierdo JM |
| BMC Mol Biol 2013 Feb 6;14:4 |
| PMID 23387986 |
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| Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells |
| Saxena T, Tandon B, Sharma S, Chameettachal S, Ray P, Ray AR, Kulshreshtha R |
| PLoS One 2013 Nov 21;8(11):e79886 |
| PMID 24278205 |
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| Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer |
| Song MY, Pan KF, Su HJ, Zhang L, Ma JL, Li JY, Yuasa Y, Kang D, Kim YS, You WC |
| PLoS One 2012;7(3):e33608 |
| PMID 22432036 |
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| miR-744 is a potential prognostic marker in patients with hepatocellular carcinoma |
| Tan YL, Bai ZG, Zou WL, Ma XM, Wang TT, Guo W, Liu J, Li JS, Jie-Yin, Zang YJ, Zhang ZT |
| Clin Res Hepatol Gastroenterol 2014 Dec 17 |
| PMID 25543521 |
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| Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744 |
| Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I |
| Br J Cancer 2013 Jun 11;108(11):2304-11 |
| PMID 23695020 |
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| Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B |
| Zhang H, Li QY, Guo ZZ, Guan Y, Du J, Lu YY, Hu YY, Liu P, Huang S, Su SB |
| World J Gastroenterol 2012 Oct 7;18(37):5188-96 |
| PMID 23066312 |
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