Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MLF1 (myelodysplasia/myeloid leukemia factor 1)

Identity

HGNC (Hugo) MLF1
LocusID (NCBI) 4291
Location 3q25
Location_base_pair Starts at 158288953 and ends at 158324249 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27

DNA/RNA

Transcription alternate splicing: 1.4 and 2.4 kb

Protein

Description 267 amino acids; 31 KDa; do not contain known functional motifs
Expression MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation cytoplasmic localisation
Homology none is known, apart from MLF2 (40% homology)

Implicated in

Entity t(3;5)(q25;q34)/ANLL or MDS--> NPM1 - MLF1
Disease ANLL, MDS, BC-CML; trilineage involvement
Prognosis very poor
Cytogenetics location of breakpoints difficult to ascertain
Hybrid/Mutated Gene 5' NPM1-3' MLF1 on der(5)
Abnormal Protein nuclear protein
  

External links

Nomenclature
HGNC (Hugo)MLF1   7125
Entrez_Gene (NCBI)MLF1  4291  myeloid leukemia factor 1
Cards
AtlasMLF1
GeneCards (Weizmann)MLF1
Ensembl (Hinxton)ENSG00000178053 [Gene_View]  chr3:158288953-158324249 [Contig_View]  MLF1 [Vega]
AceView (NCBI)MLF1
Genatlas (Paris)MLF1
euGene (Indiana)4291
SOURCE (Stanford)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443
Genomic and cartography
GoldenPath (UCSC)MLF1  -  3q25   chr3:158288953-158324249 +  3q25.1   [Description]    (hg19-Feb_2009)
EnsemblMLF1 - 3q25.1 [CytoView]
Mapping of homologs : NCBIMLF1 [Mapview]
OMIM601402   601626   
Gene and transcription
Genbank (Entrez)AA707847 AK056948 AK096889 AK297488 AK315402
RefSeq transcript (SRS)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443
RefSeq transcript (Entrez)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443
RefSeq genomic (SRS)AC_000135 NC_000003 NG_027720 NT_005612 NW_001838884
RefSeq genomic (Entrez)AC_000135 NC_000003 NG_027720 NT_005612 NW_001838884
Consensus coding sequences : CCDS (NCBI)MLF1
Cluster EST : UnigeneHs.85195 [ SRS ] Hs.85195 [ NCBI ]
Alternative Splicing : Fast-db (Paris)14322
Alternative Splicing GalleryENSG00000178053
Gene ExpressionMLF1 [ NCBI-GEO ]   MLF1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58340 (SRS) P58340 (Uniprot)
With graphics : InterProP58340
Splice isoforms : SwissVarP58340(Swissvar)
Domains : Interpro (SRS)Myeloid_leukemia_factor   
Domains : Interpro (EBI)Myeloid_leukemia_factor   
Related proteins : CluSTrP58340
Domain families : Pfam (SRS)Mlf1IP (PF10248)   
Domain families : Pfam (Sanger)Mlf1IP (PF10248)   
Domain families : Pfam (NCBI)pfam10248   
Blocks (Seattle)P58340
PDB (SRS)3UAL    3UBW   
PDB (PDBSum)3UAL    3UBW   
PDB (IMB)3UAL    3UBW   
PDB (RSDB)3UAL    3UBW   
Human Protein AtlasENSG00000178053
HPRD03239
IPIIPI00036554   IPI00171189   IPI00794703   IPI00719604   IPI00744606   IPI00792821   IPI00946907   IPI00946208   IPI00793467   IPI00946526   
Protein Interaction databases
DIP (DOE-UCLA)P58340
IntAct (EBI)P58340
FunCoupENSG00000178053
REACTOMEMLF1
BioGRIDMLF1
InParanoidP58340
Interologous Interaction database P58340
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MLF1
SNP (GeneSNP Utah)MLF1
SNP : HGBaseMLF1
Genetic variants : HAPMAPMLF1
Cancer Gene: CensusMLF1 
Somatic Mutations in Cancer : COSMICMLF1 
CONAN: Copy Number AnalysisMLF1 
Mutations and Diseases : HGMDMLF1
OMIM601402    601626   
GENETests601402    601626   
Disease Genetic AssociationMLF1
Huge Navigator MLF1 [HugePedia]  MLF1 [HugeCancerGEM]
Genomic VariantsMLF1
snp3D : Map Gene to Disease4291
General knowledge
Homologs : HomoloGeneMLF1
Homology/Alignments : Family Browser (UCSC)MLF1
Phylogenetic Trees/Animal Genes : TreeFamMLF1
Chemical/Protein Interactions : CTD4291
Chemical/Pharm GKB GenePA30843
Clinical trialMLF1
Cancer Resource (Charite)ENSG00000178053
Ontology : AmiGOmyeloid progenitor cell differentiation  myeloid progenitor cell differentiation  DNA binding  DNA binding  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  transcription, DNA-dependent  transcription, DNA-dependent  cell cycle  cell cycle arrest  multicellular organismal development  protein domain specific binding  cell differentiation  
Ontology : EGO-EBImyeloid progenitor cell differentiation  myeloid progenitor cell differentiation  DNA binding  DNA binding  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  transcription, DNA-dependent  transcription, DNA-dependent  cell cycle  cell cycle arrest  multicellular organismal development  protein domain specific binding  cell differentiation  
Other databases
Probes
Probes : ImagenesMLF1 Related clones (RZPD - Berlin)
Litterature
PubMed19 Pubmed reference(s) in Entrez
PubGeneMLF1
iHOPMLF1

Bibliography

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996 ; 12 (2) : 265-275.
PMID 8570204
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written12-1997Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . MLF1 (myelodysplasia/myeloid leukemia factor 1). Atlas Genet Cytogenet Oncol Haematol. December 1997 .
URL : http://AtlasGeneticsOncology.org/Genes/MLF1.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/handle/2042/32056/12-1997-MLF1.pdf   [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 28 15:03:51 CEST 2012
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