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MLF1 (myelodysplasia/myeloid leukemia factor 1)

Identity

HGNC (Hugo) MLF1
LocusID (NCBI) 4291
Location 3q25.32
Location_base_pair Starts at 158288953 and ends at 158324249 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27

DNA/RNA

Transcription alternate splicing: 1.4 and 2.4 kb

Protein

Description 267 amino acids; 31 KDa; do not contain known functional motifs
Expression MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation cytoplasmic localisation
Homology none is known, apart from MLF2 (40% homology)

Implicated in

Entity t(3;5)(q25;q34)/ANLL or MDS--> NPM1 - MLF1
Disease ANLL, MDS, BC-CML; trilineage involvement
Prognosis very poor
Cytogenetics location of breakpoints difficult to ascertain
Hybrid/Mutated Gene 5' NPM1-3' MLF1 on der(5)
Abnormal Protein nuclear protein
  

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)MLF1   7125
Cards
AtlasMLF1
Entrez_Gene (NCBI)MLF1  4291  myeloid leukemia factor 1
GeneCards (Weizmann)MLF1
Ensembl (Hinxton)ENSG00000178053 [Gene_View]  chr3:158288953-158324249 [Contig_View]  MLF1 [Vega]
ICGC DataPortalENSG00000178053
cBioPortalMLF1
AceView (NCBI)MLF1
Genatlas (Paris)MLF1
WikiGenes4291
SOURCE (Princeton)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443
Genomic and cartography
GoldenPath (UCSC)MLF1  -  3q25.32   chr3:158288953-158324249 +  3q25   [Description]    (hg19-Feb_2009)
EnsemblMLF1 - 3q25 [CytoView]
Mapping of homologs : NCBIMLF1 [Mapview]
OMIM601402   
Gene and transcription
Genbank (Entrez)AA707847 AK056948 AK096889 AK297488 AK315402
RefSeq transcript (Entrez)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_027720 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)MLF1
Cluster EST : UnigeneHs.85195 [ NCBI ]
CGAP (NCI)Hs.85195
Alternative Splicing : Fast-db (Paris)GSHG0021276
Alternative Splicing GalleryENSG00000178053
Gene ExpressionMLF1 [ NCBI-GEO ]     MLF1 [ SEEK ]   MLF1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58340 (Uniprot)
NextProtP58340  [Medical]
With graphics : InterProP58340
Splice isoforms : SwissVarP58340 (Swissvar)
Domains : Interpro (EBI)Myeloid_leukemia_factor [organisation]  
Related proteins : CluSTrP58340
Domain families : Pfam (Sanger)Mlf1IP (PF10248)   
Domain families : Pfam (NCBI)pfam10248   
DMDM Disease mutations4291
Blocks (Seattle)P58340
PDB (SRS)3UAL    3UBW   
PDB (PDBSum)3UAL    3UBW   
PDB (IMB)3UAL    3UBW   
PDB (RSDB)3UAL    3UBW   
Human Protein AtlasENSG00000178053 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP58340
HPRD03239
IPIIPI00036554   IPI00171189   IPI00794703   IPI00719604   IPI00744606   IPI00792821   IPI00946907   IPI00946208   IPI00793467   IPI00946526   
Protein Interaction databases
DIP (DOE-UCLA)P58340
IntAct (EBI)P58340
FunCoupENSG00000178053
BioGRIDMLF1
InParanoidP58340
Interologous Interaction database P58340
IntegromeDBMLF1
STRING (EMBL)MLF1
Ontologies - Pathways
Ontology : AmiGOmyeloid progenitor cell differentiation  DNA binding  protein binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  cell cycle arrest  protein domain specific binding  
Ontology : EGO-EBImyeloid progenitor cell differentiation  DNA binding  protein binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  cell cycle arrest  protein domain specific binding  
Pathways : KEGGTranscriptional misregulation in cancer   
Protein Interaction DatabaseMLF1
Wikipedia pathwaysMLF1
Gene fusion - rearrangments
Rearrangement : TICdbNPM1 [5q35.1]  -  MLF1 [11q23.3]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MLF1
snp3D : Map Gene to Disease4291
SNP (GeneSNP Utah)MLF1
SNP : HGBaseMLF1
Genetic variants : HAPMAPMLF1
Exome VariantMLF1
1000_GenomesMLF1 
ICGC programENSG00000178053 
Cancer Gene: CensusMLF1 
Somatic Mutations in Cancer : COSMICMLF1 
CONAN: Copy Number AnalysisMLF1 
Mutations and Diseases : HGMDMLF1
Genomic VariantsMLF1  MLF1 [DGVbeta]
dbVarMLF1
ClinVarMLF1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601402   
MedgenMLF1
GENETestsMLF1
Disease Genetic AssociationMLF1
Huge Navigator MLF1 [HugePedia]  MLF1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMLF1
Homology/Alignments : Family Browser (UCSC)MLF1
Phylogenetic Trees/Animal Genes : TreeFamMLF1
Chemical/Protein Interactions : CTD4291
Chemical/Pharm GKB GenePA30843
Clinical trialMLF1
Cancer Resource (Charite)ENSG00000178053
Other databases
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
CoreMineMLF1
iHOPMLF1
OncoSearchMLF1

Bibliography

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996 ; 12 (2) : 265-275.
PMID 8570204
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written12-1997Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL
MLF1 (myelodysplasia/myeloid leukemia factor 1);
Atlas Genet Cytogenet Oncol Haematol. December 1997
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/MLF1.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 15:07:17 CEST 2014

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