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MLF1 (myelodysplasia/myeloid leukemia factor 1)

Identity

HGNC (Hugo) MLF1
Location 3q25
Location_base_pair Starts at 159771647 and ends at 159806946 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Local_order EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27

DNA/RNA

Transcription alternate splicing: 1.4 and 2.4 kb

Protein

Description 267 amino acids; 31 KDa; do not contain known functional motifs
Expression MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation cytoplasmic localisation
Homology none is known, apart from MLF2 (40% homology)

Implicated in

Entity t(3;5)(q25;q34)/ANLL or MDS--> NPM1 - MLF1
Disease ANLL, MDS, BC-CML; trilineage involvement
Prognosis very poor
Cytogenetics location of breakpoints difficult to ascertain
Hybrid/Mutated Gene 5' NPM1-3' MLF1 on der(5)
Abnormal Protein nuclear protein
  

External links

Nomenclature
HGNC (Hugo)MLF1   7125
Entrez_Gene (NCBI)MLF1  4291  myeloid leukemia factor 1
Cards
AtlasMLF1
GeneCards (Weizmann)MLF1
Ensembl (Hinxton)ENSG00000178053 [Gene_View]  MLF1 [Vega]
AceView (NCBI)MLF1
Genatlas (Paris)MLF1
euGene (Indiana)4291
SOURCE (Stanford)NM_001130156 NM_001130157 NM_022443
Genomic and cartography
GoldenPath (UCSC)MLF1  -  3q25   chr3:159771647-159806946 +  3q25   [Description]    (hg18-Mar_2006)
EnsemblMLF1 - 3q25 [CytoView]
Mapping of homologs : NCBIMLF1 [Mapview]
OMIM601402   601626   
Gene and transcription
Gene : Genbank (Entrez)AA707847 AK056948 AK096889 AK297488 AK315402
Reference sequence (RefSeq transcript) :SRSNM_001130156 NM_001130157 NM_022443
Reference transcript : EntrezNM_001130156 NM_001130157 NM_022443
RefSeq genomic : SRSAC_000046 AC_000135 NC_000003 NT_005612 NW_001838884 NW_921807
RefSeq genomic : EntrezAC_000046 AC_000135 NC_000003 NT_005612 NW_001838884 NW_921807
Consensus coding sequences : CCDS NCBIMLF1
Cluster EST : UnigeneHs.85195 [ SRS ] Hs.85195 [ NCBI ]
Alternative Splicing : Fast-db (Paris)14322
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP58340 (SRS) P58340 (Expasy) P58340 (Uniprot)
With graphics : InterProP58340
Splice isoforms : VarSplice FASTAP58340(VarSplice FASTA)
Related proteins : CluSTrP58340
Domain families : Pfam SRS
Domain families : Pfam Sanger
Domain families : Pfam NCBI
Blocks (Seattle)P58340
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD03239
Protein Interaction databases
DIP (DOE-UCLA)P58340
IntAct (EBI)P58340
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIMLF1
SNP : GeneSNP UtahMLF1
SNP : HGBaseMLF1
Genetic variants : HAPMAPMLF1
Somatic Mutations in Cancer : COSMICMLF1 
Mutations and Diseases : HGMDMLF1
Hereditary diseases : OMIM601402    601626   
Hereditary diseases : GENETests601402    601626   
Diseases : Genetic AssociationMLF1
General knowledge
Homologs : HomoloGeneMLF1
Homology/Alignments : Family Browser UCSCMLF1
Phylogenetic Trees/Animal Genes : TreeFamMLF1
Chemical/Protein Interactions : CTD4291
Keywords Ontology : AmiGOmyeloid progenitor cell differentiation  DNA binding  nucleus  cytoplasm  transcription  cell cycle  cell cycle arrest  multicellular organismal development  protein domain specific binding  cell differentiation  
Keywords Ontology : EGO-EBImyeloid progenitor cell differentiation  DNA binding  nucleus  cytoplasm  transcription  cell cycle  cell cycle arrest  multicellular organismal development  protein domain specific binding  cell differentiation  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesMLF1 Related clones (RZPD - Berlin)
Literature
PubMed13 Pubmed reference(s) in Entrez
PubGeneMLF1

Bibliography

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996 ; 12 (2) : 265-275.
PMID 8570204
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written12-1997Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . MLF1 (myelodysplasia/myeloid leukemia factor 1). Atlas Genet Cytogenet Oncol Haematol. December 1997 .
URL : http://AtlasGeneticsOncology.org/Genes/MLF1.html

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indexed on : Sat Jun 27 16:39:05 CEST 2009
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