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MLF1 (myelodysplasia/myeloid leukemia factor 1)

Written1997-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other alias
LocusID (NCBI) 4291
Atlas_Id 18
Location 3q25.32  [Link to chromosome band 3q25]
Location_base_pair Starts at and ends at bp from pter
Local_order EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GFM1 (3q25.32) / MLF1 (3q25.32)MLF1 (3q25.32) / CIZ1 (9q34.11)MLF1 (3q25.32) / NPM1 (5q35.1)
NPM1 (5q35.1) / MLF1 (3q25.32)


Transcription alternate splicing: 1.4 and 2.4 kb


Description 267 amino acids; 31 KDa; do not contain known functional motifs
Expression MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation cytoplasmic localisation
Homology none is known, apart from MLF2 (40% homology)

Implicated in

Entity t(3;5)(q25;q34)/AML or MDS--> NPM1 - MLF1
Disease AML, MDS, BC-CML; trilineage involvement
Prognosis very poor
Cytogenetics location of breakpoints difficult to ascertain
Hybrid/Mutated Gene 5' NPM1-3' MLF1 on der(5)
Abnormal Protein nuclear protein


The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996 ; 12 (2) : 265-275.
PMID 8570204


This paper should be referenced as such :
Huret, JL
MLF1 (myelodysplasia/myeloid leukemia factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2):67-67.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(3;5)(q25;q34) NPM1/MLF1
t(3;5)(q25;q35) NPM1/MLF1
Acute myeloid leukemia with myelodysplasia related changes
Classification of myelodysplasic syndromes 1999
t(3;5)(q25;q34) NPM1/MLF1
t(3;5)(q25;q35) NPM1/MLF1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  GFM1/MLF1 (3q25)

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4291
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 18 17:43:46 CEST 2018

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