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MLF1 (myelodysplasia/myeloid leukemia factor 1)

Written1997-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other alias
HGNC (Hugo) MLF1
LocusID (NCBI) 4291
Atlas_Id 18
Location 3q25.32  [Link to chromosome band 3q25]
Location_base_pair Starts at 158571164 and ends at 158606460 bp from pter ( according to hg19-Feb_2009)  [Mapping MLF1.png]
Local_order EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27
Fusion genes
(updated 2016)
GFM1 (3q25.32) / MLF1 (3q25.32)MLF1 (3q25.32) / CIZ1 (9q34.11)MLF1 (3q25.32) / NPM1 (5q35.1)
NPM1 (5q35.1) / MLF1 (3q25.32)

DNA/RNA

Transcription alternate splicing: 1.4 and 2.4 kb

Protein

Description 267 amino acids; 31 KDa; do not contain known functional motifs
Expression MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation cytoplasmic localisation
Homology none is known, apart from MLF2 (40% homology)

Implicated in

Note
  
Entity t(3;5)(q25;q34)/AML or MDS--> NPM1 - MLF1
Disease AML, MDS, BC-CML; trilineage involvement
Prognosis very poor
Cytogenetics location of breakpoints difficult to ascertain
Hybrid/Mutated Gene 5' NPM1-3' MLF1 on der(5)
Abnormal Protein nuclear protein
  

Bibliography

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996 ; 12 (2) : 265-275.
PMID 8570204
 

Citation

This paper should be referenced as such :
Huret, JL
MLF1 (myelodysplasia/myeloid leukemia factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2):67-67.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MLF1ID18.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Acute myeloid leukemia with myelodysplasia related changes
Classification of myelodysplasic syndromes 1999
t(3;5)(q25;q34) NPM1/MLF1


External links

Nomenclature
HGNC (Hugo)MLF1   7125
Cards
AtlasMLF1ID18
Entrez_Gene (NCBI)MLF1  4291  myeloid leukemia factor 1
Aliases
GeneCards (Weizmann)MLF1
Ensembl hg19 (Hinxton)ENSG00000178053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178053 [Gene_View]  chr3:158571164-158606460 [Contig_View]  MLF1 [Vega]
ICGC DataPortalENSG00000178053
TCGA cBioPortalMLF1
AceView (NCBI)MLF1
Genatlas (Paris)MLF1
WikiGenes4291
SOURCE (Princeton)MLF1
Genetics Home Reference (NIH)MLF1
Genomic and cartography
GoldenPath hg38 (UCSC)MLF1  -     chr3:158571164-158606460 +  3q25.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLF1  -     3q25.32   [Description]    (hg19-Feb_2009)
EnsemblMLF1 - 3q25.32 [CytoView hg19]  MLF1 - 3q25.32 [CytoView hg38]
Mapping of homologs : NCBIMLF1 [Mapview hg19]  MLF1 [Mapview hg38]
OMIM601402   
Gene and transcription
Genbank (Entrez)AA707847 AK056948 AK096889 AK297488 AK315402
RefSeq transcript (Entrez)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MLF1
Cluster EST : UnigeneHs.85195 [ NCBI ]
CGAP (NCI)Hs.85195
Alternative Splicing GalleryENSG00000178053
Gene ExpressionMLF1 [ NCBI-GEO ]   MLF1 [ EBI - ARRAY_EXPRESS ]   MLF1 [ SEEK ]   MLF1 [ MEM ]
Gene Expression Viewer (FireBrowse)MLF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4291
GTEX Portal (Tissue expression)MLF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58340   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58340  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58340
Splice isoforms : SwissVarP58340
PhosPhoSitePlusP58340
Domains : Interpro (EBI)Myeloid_leukemia_factor   
Domain families : Pfam (Sanger)Mlf1IP (PF10248)   
Domain families : Pfam (NCBI)pfam10248   
Conserved Domain (NCBI)MLF1
DMDM Disease mutations4291
Blocks (Seattle)MLF1
PDB (SRS)3UAL    3UBW   
PDB (PDBSum)3UAL    3UBW   
PDB (IMB)3UAL    3UBW   
PDB (RSDB)3UAL    3UBW   
Structural Biology KnowledgeBase3UAL    3UBW   
SCOP (Structural Classification of Proteins)3UAL    3UBW   
CATH (Classification of proteins structures)3UAL    3UBW   
SuperfamilyP58340
Human Protein AtlasENSG00000178053
Peptide AtlasP58340
HPRD03239
IPIIPI00036554   IPI00171189   IPI00794703   IPI00719604   IPI00744606   IPI00792821   IPI00946907   IPI00946208   IPI00793467   IPI00946526   
Protein Interaction databases
DIP (DOE-UCLA)P58340
IntAct (EBI)P58340
FunCoupENSG00000178053
BioGRIDMLF1
STRING (EMBL)MLF1
ZODIACMLF1
Ontologies - Pathways
QuickGOP58340
Ontology : AmiGOmyeloid progenitor cell differentiation  DNA binding  protein binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  cell cycle arrest  protein domain specific binding  
Ontology : EGO-EBImyeloid progenitor cell differentiation  DNA binding  protein binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  cell cycle arrest  protein domain specific binding  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkMLF1
Atlas of Cancer Signalling NetworkMLF1
Wikipedia pathwaysMLF1
Orthology - Evolution
OrthoDB4291
GeneTree (enSembl)ENSG00000178053
Phylogenetic Trees/Animal Genes : TreeFamMLF1
HOVERGENP58340
HOGENOMP58340
Homologs : HomoloGeneMLF1
Homology/Alignments : Family Browser (UCSC)MLF1
Gene fusions - Rearrangements
Fusion : MitelmanGFM1/MLF1 [3q25.32/3q25.32]  [t(3;3)(q25;q25)]  
Fusion : MitelmanNPM1/MLF1 [5q35.1/3q25.32]  [ins(3;5)(q25;q31q35)]  [t(3;5)(q25;q35)]  
Fusion: TCGAGFM1 3q25.32 MLF1 3q25.32 BRCA
Fusion : TICdbNPM1 [5q35.1]  -  MLF1 [3q25.32]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLF1
dbVarMLF1
ClinVarMLF1
1000_GenomesMLF1 
Exome Variant ServerMLF1
ExAC (Exome Aggregation Consortium)MLF1 (select the gene name)
Genetic variants : HAPMAP4291
Genomic Variants (DGV)MLF1 [DGVbeta]
DECIPHERMLF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLF1 
Mutations
ICGC Data PortalMLF1 
TCGA Data PortalMLF1 
Broad Tumor PortalMLF1
OASIS PortalMLF1 [ Somatic mutations - Copy number]
Cancer Gene: CensusMLF1 
Mutations and Diseases : HGMDMLF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MLF1
DgiDB (Drug Gene Interaction Database)MLF1
DoCM (Curated mutations)MLF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLF1 (select a term)
intoGenMLF1
NCG5 (London)MLF1
Cancer3DMLF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601402   
Orphanet
MedgenMLF1
Genetic Testing Registry MLF1
NextProtP58340 [Medical]
TSGene4291
GENETestsMLF1
Target ValidationMLF1
Huge Navigator MLF1 [HugePedia]
snp3D : Map Gene to Disease4291
BioCentury BCIQMLF1
ClinGenMLF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4291
Chemical/Pharm GKB GenePA30843
Clinical trialMLF1
Miscellaneous
canSAR (ICR)MLF1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMLF1
EVEXMLF1
GoPubMedMLF1
iHOPMLF1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:08:22 CEST 2017

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jlhuret@AtlasGeneticsOncology.org.