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MLF1 (myelodysplasia/myeloid leukemia factor 1)

Written1997-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

HGNC (Hugo) MLF1
HGNC Alias namemyeloid leukemia factor 1 variant 1
 myeloid leukemia factor 1 variant 2
 myeloid leukemia factor 1 variant 3
LocusID (NCBI) 4291
Atlas_Id 18
Location 3q25.32  [Link to chromosome band 3q25]
Location_base_pair Starts at 158571194 and ends at 158606456 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MLF1.png]
Local_order EVI1/MDS1 is more telomeric (in 3q26), BCL6 even more in 3q27
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GFM1 (3q25.32) / MLF1 (3q25.32)MLF1 (3q25.32) / CIZ1 (9q34.11)MLF1 (3q25.32) / NPM1 (5q35.1)
NPM1 (5q35.1) / MLF1 (3q25.32)

DNA/RNA

Transcription alternate splicing: 1.4 and 2.4 kb

Protein

Description 267 amino acids; 31 KDa; do not contain known functional motifs
Expression MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)
Localisation cytoplasmic localisation
Homology none is known, apart from MLF2 (40% homology)

Implicated in

Note
  
Entity /AML or MDS--> NPM1 - MLF1
Disease AML, MDS, BC-CML; trilineage involvement
Prognosis very poor
Cytogenetics location of breakpoints difficult to ascertain
Hybrid/Mutated Gene 5' NPM1-3' MLF1 on der(5)
Abnormal Protein nuclear protein
  

Bibliography

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
Oncogene. 1996 ; 12 (2) : 265-275.
PMID 8570204
 

Citation

This paper should be referenced as such :
Huret, JL
MLF1 (myelodysplasia/myeloid leukemia factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2):67-67.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Acute myeloid leukemia with myelodysplasia related changes
Classification of myelodysplasic syndromes 1999
t(3;5)(q25;q34) NPM1/MLF1


External links

Nomenclature
HGNC (Hugo)MLF1   7125
Cards
AtlasMLF1ID18
Entrez_Gene (NCBI)MLF1    myeloid leukemia factor 1
Aliases
GeneCards (Weizmann)MLF1
Ensembl hg19 (Hinxton)ENSG00000178053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178053 [Gene_View]  ENSG00000178053 [Sequence]  chr3:158571194-158606456 [Contig_View]  MLF1 [Vega]
ICGC DataPortalENSG00000178053
TCGA cBioPortalMLF1
AceView (NCBI)MLF1
Genatlas (Paris)MLF1
SOURCE (Princeton)MLF1
Genetics Home Reference (NIH)MLF1
Genomic and cartography
GoldenPath hg38 (UCSC)MLF1  -     chr3:158571194-158606456 +  3q25.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MLF1  -     3q25.32   [Description]    (hg19-Feb_2009)
GoldenPathMLF1 - 3q25.32 [CytoView hg19]  MLF1 - 3q25.32 [CytoView hg38]
ImmunoBaseENSG00000178053
genome Data Viewer NCBIMLF1 [Mapview hg19]  
OMIM601402   
Gene and transcription
Genbank (Entrez)AA707847 AK056948 AK096889 AK297488 AK315402
RefSeq transcript (Entrez)NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_001369781 NM_001369782 NM_001369783 NM_001369784 NM_001369785 NM_001378845 NM_001378846 NM_001378847 NM_001378848 NM_001378850 NM_001378851 NM_001378852 NM_001378853 NM_001378855 NM_022443
Consensus coding sequences : CCDS (NCBI)MLF1
Alternative Splicing GalleryENSG00000178053
Gene ExpressionMLF1 [ NCBI-GEO ]   MLF1 [ EBI - ARRAY_EXPRESS ]   MLF1 [ SEEK ]   MLF1 [ MEM ]
Gene Expression Viewer (FireBrowse)MLF1 [ Firebrowse - Broad ]
GenevisibleExpression of MLF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4291
GTEX Portal (Tissue expression)MLF1
Human Protein AtlasENSG00000178053-MLF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58340   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58340  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58340
PhosPhoSitePlusP58340
Domains : Interpro (EBI)Myeloid_leukemia_factor   
Domain families : Pfam (Sanger)Mlf1IP (PF10248)   
Domain families : Pfam (NCBI)pfam10248   
Conserved Domain (NCBI)MLF1
PDB (RSDB)3UAL    3UBW   
PDB Europe3UAL    3UBW   
PDB (PDBSum)3UAL    3UBW   
PDB (IMB)3UAL    3UBW   
Structural Biology KnowledgeBase3UAL    3UBW   
SCOP (Structural Classification of Proteins)3UAL    3UBW   
CATH (Classification of proteins structures)3UAL    3UBW   
SuperfamilyP58340
AlphaFold pdb e-kbP58340   
Human Protein Atlas [tissue]ENSG00000178053-MLF1 [tissue]
HPRD03239
Protein Interaction databases
DIP (DOE-UCLA)P58340
IntAct (EBI)P58340
BioGRIDMLF1
STRING (EMBL)MLF1
ZODIACMLF1
Ontologies - Pathways
QuickGOP58340
Ontology : AmiGOmyeloid progenitor cell differentiation  DNA binding  protein binding  nucleus  nucleus  nucleus  cytoplasm  cytoplasm  cilium  transcription, DNA-templated  regulation of transcription, DNA-templated  cell cycle  protein domain specific binding  ciliary basal body  regulation of cell cycle  
Ontology : EGO-EBImyeloid progenitor cell differentiation  DNA binding  protein binding  nucleus  nucleus  nucleus  cytoplasm  cytoplasm  cilium  transcription, DNA-templated  regulation of transcription, DNA-templated  cell cycle  protein domain specific binding  ciliary basal body  regulation of cell cycle  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkMLF1
Atlas of Cancer Signalling NetworkMLF1
Wikipedia pathwaysMLF1
Orthology - Evolution
OrthoDB4291
GeneTree (enSembl)ENSG00000178053
Phylogenetic Trees/Animal Genes : TreeFamMLF1
Homologs : HomoloGeneMLF1
Homology/Alignments : Family Browser (UCSC)MLF1
Gene fusions - Rearrangements
Fusion : MitelmanGFM1/MLF1 [3q25.32/3q25.32]  
Fusion : MitelmanNPM1/MLF1 [5q35.1/3q25.32]  
Fusion PortalGFM1 3q25.32 MLF1 3q25.32 BRCA
Fusion : QuiverMLF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMLF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MLF1
dbVarMLF1
ClinVarMLF1
MonarchMLF1
1000_GenomesMLF1 
Exome Variant ServerMLF1
GNOMAD BrowserENSG00000178053
Varsome BrowserMLF1
Genomic Variants (DGV)MLF1 [DGVbeta]
DECIPHERMLF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMLF1 
Mutations
ICGC Data PortalMLF1 
TCGA Data PortalMLF1 
Broad Tumor PortalMLF1
OASIS PortalMLF1 [ Somatic mutations - Copy number]
Cancer Gene: CensusMLF1 
Somatic Mutations in Cancer : COSMICMLF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMLF1
Mutations and Diseases : HGMDMLF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch MLF1
DgiDB (Drug Gene Interaction Database)MLF1
DoCM (Curated mutations)MLF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MLF1 (select a term)
OncoKBMLF1
NCG6 (London) select MLF1
Cancer3DMLF1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601402   
Orphanet
DisGeNETMLF1
MedgenMLF1
Genetic Testing Registry MLF1
NextProtP58340 [Medical]
GENETestsMLF1
Target ValidationMLF1
Huge Navigator MLF1 [HugePedia]
ClinGenMLF1
Clinical trials, drugs, therapy
MyCancerGenomeMLF1
Protein Interactions : CTDMLF1
Pharm GKB GenePA30843
PharosP58340
Clinical trialMLF1
Miscellaneous
canSAR (ICR)MLF1
HarmonizomeMLF1
DataMed IndexMLF1
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMLF1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 23:50:07 CEST 2021

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.