| | CASC3 (17q21.1) / CASC3 (17q21.1) | CASC3 (17q21.1) / CEP112 (17q24.1) | CASC3 (17q21.1) / CTDSP1 (2q35) |
| |
CASC3 (17q21.1) / EXOSC10 (1p36.22) | CASC3 (17q21.1) / MED1 (17q12) | CASC3 (17q21.1) / RGS9 (17q24.1) |
| |
CASC3 (17q21.1) / ZNF254 (19p12) | CHKA (11q13.2) / CASC3 (17q21.1) | IQCD (12q24.13) / CASC3 (17q21.1) |
| |
PTMA (2q37.1) / CASC3 (17q21.1) |
| Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. |
| Bièche I, Tomasetto C, Régnier CH, Moog-Lutz C, Rio MC, Lidereau R |
| Cancer research. 1996 ; 56 (17) : 3886-3890. |
| PMID 8752152 |
| |
| Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer. |
| Degot S, Régnier CH, Wendling C, Chenard MP, Rio MC, Tomasetto C |
| Oncogene. 2002 ; 21 (28) : 4422-4434. |
| PMID 12080473 |
| |
| Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |
| Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC |
| Genomics. 1995 ; 28 (3) : 367-376. |
| PMID 7490069 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | CASC3 17040 |
| Cards |
|---|
| Atlas | MLN51ID241 |
| Entrez_Gene (NCBI) | CASC3 22794 CASC3 exon junction complex subunit |
| Aliases | BTZ; MLN51 |
| GeneCards (Weizmann) | CASC3 |
| Ensembl hg19 (Hinxton) | ENSG00000108349 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000108349 [Gene_View] ENSG00000108349 [Sequence] chr17:40140537-40172171 [Contig_View] CASC3 [Vega] |
| ICGC DataPortal | ENSG00000108349 |
| TCGA cBioPortal | CASC3 |
| AceView (NCBI) | CASC3 |
| Genatlas (Paris) | CASC3 |
| WikiGenes | 22794 |
| SOURCE (Princeton) | CASC3 |
| Genetics Home Reference (NIH) | CASC3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CASC3 - chr17:40140537-40172171 + 17q21.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CASC3 - 17q21.1 [Description] (hg19-Feb_2009) |
| GoldenPath | CASC3 - 17q21.1 [CytoView hg19] CASC3 - 17q21.1 [CytoView hg38] |
| ImmunoBase | ENSG00000108349 |
| Mapping of homologs : NCBI | CASC3 [Mapview hg19] CASC3 [Mapview hg38] |
| OMIM | 606504 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK096126 AK292425 AK296682 AK310635 BC030008 |
| RefSeq transcript (Entrez) | NM_007359 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CASC3 |
| Alternative Splicing Gallery | ENSG00000108349 |
| Gene Expression | CASC3 [ NCBI-GEO ] CASC3 [ EBI - ARRAY_EXPRESS ]
CASC3 [ SEEK ] CASC3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CASC3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 22794 |
| GTEX Portal (Tissue expression) | CASC3 |
| Human Protein Atlas | ENSG00000108349-CASC3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O15234 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O15234 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O15234 |
| Splice isoforms : SwissVar | O15234 |
| PhosPhoSitePlus | O15234 |
| Domains : Interpro (EBI) | Btz_dom CASC3 |
| Domain families : Pfam (Sanger) | Btz (PF09405) |
| Domain families : Pfam (NCBI) | pfam09405 |
| Domain families : Smart (EMBL) | Btz (SM01044) |
| Conserved Domain (NCBI) | CASC3 |
| DMDM Disease mutations | 22794 |
| Blocks (Seattle) | CASC3 |
| PDB (RSDB) | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| PDB Europe | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| PDB (PDBSum) | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| PDB (IMB) | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| Structural Biology KnowledgeBase | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| SCOP (Structural Classification of Proteins) | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| CATH (Classification of proteins structures) | 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ |
| Superfamily | O15234 |
| Human Protein Atlas [tissue] | ENSG00000108349-CASC3 [tissue] |
| Peptide Atlas | O15234 |
| HPRD | 16225 |
| IPI | IPI00289491 IPI00909543 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O15234 |
| IntAct (EBI) | O15234 |
| FunCoup | ENSG00000108349 |
| BioGRID | CASC3 |
| STRING (EMBL) | CASC3 |
| ZODIAC | CASC3 |
| Ontologies - Pathways |
|---|
| QuickGO | O15234 |
| Ontology : AmiGO | "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA splicing, via spliceosome mRNA splicing, via spliceosome RNA binding protein binding nucleus nucleoplasm cytosol RNA export from nucleus mRNA export from nucleus regulation of translation intracellular mRNA localization cytoplasmic stress granule nuclear speck enzyme binding dendrite mRNA 3'-end processing ubiquitin protein ligase binding nuclear membrane exon-exon junction complex exon-exon junction complex identical protein binding perinuclear region of cytoplasm U2-type catalytic step 1 spliceosome" |
| Ontology : EGO-EBI | "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA splicing, via spliceosome mRNA splicing, via spliceosome RNA binding protein binding nucleus nucleoplasm cytosol RNA export from nucleus mRNA export from nucleus regulation of translation intracellular mRNA localization cytoplasmic stress granule nuclear speck enzyme binding dendrite mRNA 3'-end processing ubiquitin protein ligase binding nuclear membrane exon-exon junction complex exon-exon junction complex identical protein binding perinuclear region of cytoplasm U2-type catalytic step 1 spliceosome" |
| Pathways : KEGG | RNA transport mRNA surveillance pathway |
| REACTOME | O15234 [protein] |
| REACTOME Pathways | R-HSA-975957 [pathway] |
| NDEx Network | CASC3 |
| Atlas of Cancer Signalling Network | CASC3 |
| Wikipedia pathways | CASC3 |
| Orthology - Evolution |
|---|
| OrthoDB | 22794 |
| GeneTree (enSembl) | ENSG00000108349 |
| Phylogenetic Trees/Animal Genes : TreeFam | CASC3 |
| HOGENOM | O15234 |
| Homologs : HomoloGene | CASC3 |
| Homology/Alignments : Family Browser (UCSC) | CASC3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CASC3/MED1 [17q21.1/17q12] |
| Fusion : Mitelman | CASC3/ZNF254 [17q21.1/19p12] [t(17;19)(q21;p12)] |
| Fusion Portal | CASC3 17q21.1 MED1 17q12 BRCA |
| Fusion Portal | CASC3 17q21.1 ZNF254 19p12 BRCA |
| Fusion : Fusion_Hub | BCAS3--CASC3 CASC3--AC002386.1 CASC3--ATP6V0E1 CASC3--CASC3 CASC3--CCDC46 CASC3--CDK12 CASC3--CLDN7 CASC3--CLNS1A CASC3--CTDSP1 CASC3--ERBB2 CASC3--EXOSC10 CASC3--HNF1B CASC3--IGKC CASC3--IKBKB CASC3--MED1 |
| CASC3--MED24 CASC3--NFE2L1 CASC3--PIPOX CASC3--PRKD3 CASC3--PSMD3 CASC3--PTPRM CASC3--RARA CASC3--RGS9 CASC3--SFTPA1 CASC3--SIPA1L3 CASC3--SPOP CASC3--SUPT6H CASC3--THRA CASC3--TMOD1 CASC3--TSC2 |
| CASC3--TTC17 CASC3--TUBB3 CASC3--WIPF2 CASC3--ZNF254 CHKA--CASC3 CTH--CASC3 DDX52--CASC3 FOXJ3--CASC3 IQCD--CASC3 PTMA--CASC3 SCD--CASC3 SERINC3--CASC3 SLC25A32--CASC3 SMCHD1--CASC3 SYNRG--CASC3 |
| TNXB--CASC3 |
| Fusion : Quiver | CASC3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CASC3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CASC3 |
| dbVar | CASC3 |
| ClinVar | CASC3 |
| 1000_Genomes | CASC3 |
| Exome Variant Server | CASC3 |
| ExAC (Exome Aggregation Consortium) | ENSG00000108349 |
| GNOMAD Browser | ENSG00000108349 |
| Varsome Browser | CASC3 |
| Genetic variants : HAPMAP | 22794 |
| Genomic Variants (DGV) | CASC3 [DGVbeta] |
| DECIPHER | CASC3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CASC3 |
| Mutations |
|---|
| ICGC Data Portal | CASC3 |
| TCGA Data Portal | CASC3 |
| Broad Tumor Portal | CASC3 |
| OASIS Portal | CASC3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CASC3 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CASC3 |
| Mutations and Diseases : HGMD | CASC3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CASC3 |
| DgiDB (Drug Gene Interaction Database) | CASC3 |
| DoCM (Curated mutations) | CASC3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CASC3 (select a term) |
| intoGen | CASC3 |
| NCG5 (London) | CASC3 |
| Cancer3D | CASC3(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 606504 |
| Orphanet | |
| DisGeNET | CASC3 |
| Medgen | CASC3 |
| Genetic Testing Registry | CASC3
|
| NextProt | O15234 [Medical] |
| TSGene | 22794 |
| GENETests | CASC3 |
| Target Validation | CASC3 |
| Huge Navigator |
CASC3 [HugePedia] |
| snp3D : Map Gene to Disease | 22794 |
| BioCentury BCIQ | CASC3 |
| ClinGen | CASC3 |
| Clinical trials, drugs, therapy |
|---|
| Protein Interactions : CTD | 22794 |
| Pharm GKB Gene | PA134948596 |
| Clinical trial | CASC3 |
| Miscellaneous |
|---|
| canSAR (ICR) | CASC3 (select the gene name) |
| Harmonizome | CASC3 |
| DataMed Index | CASC3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 58 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CASC3 |
| EVEX | CASC3 |
| GoPubMed | CASC3 |
| iHOP | CASC3 |
