Atlas of Genetics and Cytogenetics in Oncology and Haematology
MSI2 (musashi homolog 2 (drosophila))
| Identity |
| Other names | MSI2H |
| FLJ36569 | |
| MGC3245 | |
| HGNC | MSI2 |
| Location | 17q23.2 |
| DNA/RNA |
| Description | The gene spans 424 kb.on plus strand; at least 15 exons. |
| Transcription | alternate splicing; at least 3 transcripts, of which are transcripts of 1,6 and 2,1 kb. |
| Protein |
 | |
| Description | 328 amino acids, 35 kDa, and 251 amino acidsThe Musashi (Msi) family genes possess 2 ribonucleoprotein (RNP or ribonucleo particle)-type RNA recognition motifs (RRMs) in the N-term; each RRM comprises 2 highly conserved sequences called RNP1 and RNP2. Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are nuclear proteins implicated in hnRNA (pre-mRNA transcript) processing; Msi2 and Msi1 have similar RNA-binding specificity. |
| Expression | Ubiquitously expressed in various tissues; expressed predominently in precursor cells in the ventricular zone and subventricular zone of the central nervous system (CNS); in CNS stem cells during embryogenesis; in the postnatal and adult CNS, the expression of Msi2 and Msi1 disappear in most post mitotic or migrating cells, but is found in cells of the astrocyte lineage; coexpressed with Msi1. |
| Function | RNA-binding protein. Some RNA-binding proteins are neural-specific. The development of neural cells from precursors may be partly regulated at the post-transcriptional level by mRNA stabilization or translational control in the cytoplasm. Msi2 may have a unique role in CNS stem cells through life. |
| Homology | MSI1 |
| Mutations |
| Germinal | Defective MSI2 might play a role in certain dementia (although this chromosomal region also contain several loci known to be involved in neurological disorders ( NF1 and others). |
| Somatic | see below. |
| Implicated in |
| Entity | Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML) with either a t(7;17)(p15;q23) and a HOXA9 / MSI2 hybrid gene, or a t(7;17)(q32-34;q23) and a ? possible gene of the plexin family/MSI2 hybrid gene. |
| Hybrid/Mutated Gene | 5' MSI2 - 3' HOXA9 in the t(7;17)(p15;q23) |
| Oncogenesis | In the t(7;17)(p15;q23) the fusion protein contains, from N-term to C-term, the 2 RNA recognition motifs of MSI2 and the the IME and the homeobox domain of HOXA9 |
| External links |
| Bibliography |
| Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. |
| Sakakibara S, Nakamura Y, Satoh H, Okano H |
| The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 ; 21 (20) : 8091-8107. |
| PMID 11588182 |
| RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. |
| Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H |
| Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (23) : 15194-15199. |
| PMID 12407178 |
| Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. |
| Barbouti A, Johansson B, Hglund M, Mauritzson N, Strmbeck B, Nilsson PG, Tanke HJ, Hagemeijer A, Mitelman F, Fioretos T |
| Genes, chromosomes & cancer. 2002 ; 35 (2) : 127-137. |
| PMID 12203776 |
| A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). |
| Barbouti A, Hglund M, Johansson B, Lassen C, Nilsson PG, Hagemeijer A, Mitelman F, Fioretos T |
| Cancer research. 2003 ; 63 (6) : 1202-1206. |
| PMID 12649177 |
| Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences. |
| Akindahunsi AA, Bandiera A, Manzini G |
| Computational biology and chemistry. 2005 ; 29 (1) : 13-23. |
| PMID 15680582 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2005 | Jean Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . MSI2 (musashi homolog 2 (drosophila)). Atlas Genet Cytogenet Oncol Haematol. August 2005 . URL : http://AtlasGeneticsOncology.org/Genes/MSI2ID42893ch17q23.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Sep 29 18:42:35 2008 |
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