MSI2 (musashi homolog 2 (drosophila))

2005-08-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
MSI2H
FUSION GENES

DNA/RNA

Description

The gene spans 424 kb.on plus strand; at least 15 exons.

Transcription

alternate splicing; at least 3 transcripts, of which are transcripts of 1,6 and 2,1 kb.

Proteins

Atlas Image

Description

328 amino acids, 35 kDa, and 251 amino acidsThe Musashi (Msi) family genes possess 2 ribonucleoprotein (RNP or ribonucleo particle)-type RNA recognition motifs (RRMs) in the N-term; each RRM comprises 2 highly conserved sequences called RNP1 and RNP2. Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are nuclear proteins implicated in hnRNA (pre-mRNA transcript) processing; Msi2 and Msi1 have similar RNA-binding specificity.

Expression

Ubiquitously expressed in various tissues; expressed predominently in precursor cells in the ventricular zone and subventricular zone of the central nervous system (CNS); in CNS stem cells during embryogenesis; in the postnatal and adult CNS, the expression of Msi2 and Msi1 disappear in most post mitotic or migrating cells, but is found in cells of the astrocyte lineage; coexpressed with Msi1.

Function

RNA-binding protein. Some RNA-binding proteins are neural-specific. The development of neural cells from precursors may be partly regulated at the post-transcriptional level by mRNA stabilization or translational control in the cytoplasm. Msi2 may have a unique role in CNS stem cells through life.

Homology

MSI1

Mutations

Germinal

Defective MSI2 might play a role in certain dementia (although this chromosomal region also contain several loci known to be involved in neurological disorders ( NF1 and others).

Somatic

see below.

Implicated in

Entity name
Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML) with either a t(7;17)(p15;q23) and a HOXA9 / MSI2 hybrid gene, or a t(7;17)(q32-34;q23) and a ? possible gene of the plexin family/MSI2 hybrid gene.
Hybrid gene
5 MSI2 - 3 HOXA9 in the t(7;17)(p15;q23)
Oncogenesis
In the t(7;17)(p15;q23) the fusion protein contains, from N-term to C-term, the 2 RNA recognition motifs of MSI2 and the the IME and the homeobox domain of HOXA9

Bibliography

Pubmed IDLast YearTitleAuthors
156805822005Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences.Akindahunsi AA et al
126491772003A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).Barbouti A et al
124071782002RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.Sakakibara S et al

Other Information

Locus ID:

NCBI: 124540
MIM: 607897
HGNC: 18585
Ensembl: ENSG00000153944

Variants:

dbSNP: 124540
ClinVar: 124540
TCGA: ENSG00000153944
COSMIC: MSI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153944ENST00000284073Q96DH6
ENSG00000153944ENST00000322684Q96DH6
ENSG00000153944ENST00000416426B4DHE8
ENSG00000153944ENST00000442934B4DM51
ENSG00000153944ENST00000579180Q96DH6
ENSG00000153944ENST00000579590J3KTC1
ENSG00000153944ENST00000581776J3QKT5

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206398632010Regulation of myeloid leukaemia by the cell-fate determinant Musashi.133
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
281438722017Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.41
217531872011MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia.39
236675312013The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.39
253802262014Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.37
257748282015Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.37
272740572016Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.35
271218422016Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.33

Citation

Jean-Loup Huret

MSI2 (musashi homolog 2 (drosophila))

Atlas Genet Cytogenet Oncol Haematol. 2005-08-01

Online version: http://atlasgeneticsoncology.org/gene/42893/msi2