| Written | 2005-08 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| Alias (NCBI) | MSI2H | FLJ36569 | MGC3245 |
| HGNC (Hugo) | MSI2 |
| HGNC Previous name | musashi homolog 2 (Drosophila) |
| LocusID (NCBI) | 124540 |
| Atlas_Id | 42893 |
| Location | 17q22 [Link to chromosome band 17q22] |
| Location_base_pair | Starts at 57257019 and ends at 57633183 bp from pter ( according to hg19-Feb_2009) [Mapping MSI2.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| ATP5B (12q13.3) / MSI2 (17q22) | ATP6V0A1 (17q21.2) / MSI2 (17q22) | CFAP46 (10q26.3) / MSI2 (17q22) | |
| CUX1 (7q22.1) / MSI2 (17q22) | HOXA9 (7p15.2) / MSI2 (17q22) | KSR1 (17q11.1) / MSI2 (17q22) | |
| KSR1 (17q11.2) / MSI2 (17q22) | MIR548N (2q31.2) / MSI2 (17q22) | MSI2 (17q22) / AKAP1 (17q22) | |
| MSI2 (17q22) / ALDH3A1 (17p11.2) | MSI2 (17q22) / CA10 (17q21.33) | MSI2 (17q22) / DHX40 (17q23.1) | |
| MSI2 (17q22) / EFCAB5 (17q11.2) | MSI2 (17q22) / HOXA9 (7p15.2) | MSI2 (17q22) / ICAM2 (17q23.3) | |
| MSI2 (17q22) / PCTP (17q22) | MSI2 (17q22) / RAD51C (17q22) | MSI2 (17q22) / SAP130 (2q14.3) | |
| MSI2 (17q22) / SLC39A11 (17q24.3) | MSI2 (17q22) / TEX2 (17q23.3) | MSI2 (17q22) / WIPF2 (17q21.1) | |
| MSI2 (17q22) / WIPF2 (17q21.2) | MSI2 (17q22) / YPEL2 (17q22) | MYO18A (17q11.2) / MSI2 (17q22) | |
| NR2F2 (15q26.2) / MSI2 (17q22) | SLC2A10 (20q13.12) / MSI2 (17q22) | STAU2 (8q21.11) / MSI2 (17q22) | |
| STXBP4 (17q22) / MSI2 (17q22) | SYNGR2 (17q25.3) / MSI2 (17q22) | TM2D2 (8p11.22) / MSI2 (17q22) | |
| TRIM25 (17q22) / MSI2 (17q22) |
| DNA/RNA |
| Description | The gene spans 424 kb.on plus strand; at least 15 exons. |
| Transcription | alternate splicing; at least 3 transcripts, of which are transcripts of 1,6 and 2,1 kb. |
| Protein |
 | |
| Description | 328 amino acids, 35 kDa, and 251 amino acidsThe Musashi (Msi) family genes possess 2 ribonucleoprotein (RNP or ribonucleo particle)-type RNA recognition motifs (RRMs) in the N-term; each RRM comprises 2 highly conserved sequences called RNP1 and RNP2. Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are nuclear proteins implicated in hnRNA (pre-mRNA transcript) processing; Msi2 and Msi1 have similar RNA-binding specificity. |
| Expression | Ubiquitously expressed in various tissues; expressed predominently in precursor cells in the ventricular zone and subventricular zone of the central nervous system (CNS); in CNS stem cells during embryogenesis; in the postnatal and adult CNS, the expression of Msi2 and Msi1 disappear in most post mitotic or migrating cells, but is found in cells of the astrocyte lineage; coexpressed with Msi1. |
| Function | RNA-binding protein. Some RNA-binding proteins are neural-specific. The development of neural cells from precursors may be partly regulated at the post-transcriptional level by mRNA stabilization or translational control in the cytoplasm. Msi2 may have a unique role in CNS stem cells through life. |
| Homology | MSI1 |
| Mutations |
| Germinal | Defective MSI2 might play a role in certain dementia (although this chromosomal region also contain several loci known to be involved in neurological disorders ( NF1 and others). |
| Somatic | see below. |
| Implicated in |
| Note | |
| Entity | Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML) with either a t(7;17)(p15;q23) and a HOXA9 / MSI2 hybrid gene, or a t(7;17)(q32-34;q23) and a ? possible gene of the plexin family/MSI2 hybrid gene. |
| Hybrid/Mutated Gene | 5' MSI2 - 3' HOXA9 in the t(7;17)(p15;q23) |
| Oncogenesis | In the t(7;17)(p15;q23) the fusion protein contains, from N-term to C-term, the 2 RNA recognition motifs of MSI2 and the the IME and the homeobox domain of HOXA9 |
| Bibliography |
| Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences. |
| Akindahunsi AA, Bandiera A, Manzini G |
| Computational biology and chemistry. 2005 ; 29 (1) : 13-23. |
| PMID 15680582 |
| A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). |
| Barbouti A, Höglund M, Johansson B, Lassen C, Nilsson PG, Hagemeijer A, Mitelman F, Fioretos T |
| Cancer research. 2003 ; 63 (6) : 1202-1206. |
| PMID 12649177 |
| RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. |
| Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H |
| Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (23) : 15194-15199. |
| PMID 12407178 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| MSI2 (musashi homolog 2 (drosophila)) |
| Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):308-309. |
| Free journal version : [ pdf ] [ DOI ] |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
t(7;17)(p15;q23) MSI2/HOXA9
t(7;17)(q32-34;q23) MSI2/? t(10;17)(q26;q22) CFAP46/MSI2 |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 12 ] |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Oct 12 12:47:22 CEST 2020 |
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