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MSI2 (musashi homolog 2 (drosophila))

Written2005-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other aliasMSI2H
FLJ36569
MGC3245
LocusID (NCBI) 124540
Atlas_Id 42893
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP5B (12q13.3) / MSI2 (17q22)ATP6V0A1 (17q21.2) / MSI2 (17q22)CFAP46 (10q26.3) / MSI2 (17q22)
CUX1 (7q22.1) / MSI2 (17q22)HOXA9 (7p15.2) / MSI2 (17q22)KSR1 (17q11.1) / MSI2 (17q22)
KSR1 (17q11.2) / MSI2 (17q22)MIR548N (2q31.2) / MSI2 (17q22)MSI2 (17q22) / AKAP1 (17q22)
MSI2 (17q22) / ALDH3A1 (17p11.2)MSI2 (17q22) / CA10 (17q21.33)MSI2 (17q22) / DHX40 (17q23.1)
MSI2 (17q22) / EFCAB5 (17q11.2)MSI2 (17q22) / HOXA9 (7p15.2)MSI2 (17q22) / ICAM2 (17q23.3)
MSI2 (17q22) / PCTP (17q22)MSI2 (17q22) / RAD51C (17q22)MSI2 (17q22) / SAP130 (2q14.3)
MSI2 (17q22) / SLC39A11 (17q24.3)MSI2 (17q22) / TEX2 (17q23.3)MSI2 (17q22) / WIPF2 (17q21.1)
MSI2 (17q22) / WIPF2 (17q21.2)MSI2 (17q22) / YPEL2 (17q22)MYO18A (17q11.2) / MSI2 (17q22)
NR2F2 (15q26.2) / MSI2 (17q22)SLC2A10 (20q13.12) / MSI2 (17q22)STAU2 (8q21.11) / MSI2 (17q22)
STXBP4 (17q22) / MSI2 (17q22)SYNGR2 (17q25.3) / MSI2 (17q22)TM2D2 (8p11.22) / MSI2 (17q22)
TRIM25 (17q22) / MSI2 (17q22)

DNA/RNA

Description The gene spans 424 kb.on plus strand; at least 15 exons.
Transcription alternate splicing; at least 3 transcripts, of which are transcripts of 1,6 and 2,1 kb.

Protein

 
Description 328 amino acids, 35 kDa, and 251 amino acidsThe Musashi (Msi) family genes possess 2 ribonucleoprotein (RNP or ribonucleo particle)-type RNA recognition motifs (RRMs) in the N-term; each RRM comprises 2 highly conserved sequences called RNP1 and RNP2. Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are nuclear proteins implicated in hnRNA (pre-mRNA transcript) processing; Msi2 and Msi1 have similar RNA-binding specificity.
Expression Ubiquitously expressed in various tissues; expressed predominently in precursor cells in the ventricular zone and subventricular zone of the central nervous system (CNS); in CNS stem cells during embryogenesis; in the postnatal and adult CNS, the expression of Msi2 and Msi1 disappear in most post mitotic or migrating cells, but is found in cells of the astrocyte lineage; coexpressed with Msi1.
Function RNA-binding protein. Some RNA-binding proteins are neural-specific. The development of neural cells from precursors may be partly regulated at the post-transcriptional level by mRNA stabilization or translational control in the cytoplasm. Msi2 may have a unique role in CNS stem cells through life.
Homology MSI1

Mutations

Germinal Defective MSI2 might play a role in certain dementia (although this chromosomal region also contain several loci known to be involved in neurological disorders ( NF1 and others).
Somatic see below.

Implicated in

Note
  
Entity Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML) with either a t(7;17)(p15;q23) and a HOXA9 / MSI2 hybrid gene, or a t(7;17)(q32-34;q23) and a ? possible gene of the plexin family/MSI2 hybrid gene.
Hybrid/Mutated Gene 5' MSI2 - 3' HOXA9 in the t(7;17)(p15;q23)
Oncogenesis In the t(7;17)(p15;q23) the fusion protein contains, from N-term to C-term, the 2 RNA recognition motifs of MSI2 and the the IME and the homeobox domain of HOXA9
  

Bibliography

Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences.
Akindahunsi AA, Bandiera A, Manzini G
Computational biology and chemistry. 2005 ; 29 (1) : 13-23.
PMID 15680582
 
A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).
Barbouti A, Höglund M, Johansson B, Lassen C, Nilsson PG, Hagemeijer A, Mitelman F, Fioretos T
Cancer research. 2003 ; 63 (6) : 1202-1206.
PMID 12649177
 
RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.
Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H
Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (23) : 15194-15199.
PMID 12407178
 

Citation

This paper should be referenced as such :
Huret, JL
MSI2 (musashi homolog 2 (drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):308-309.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MSI2ID42893ch17q23.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(7;17)(p15;q23) MSI2/HOXA9
t(7;17)(q32-34;q23) MSI2/?
t(7;17)(p15;q22) MSI2/HOXA9
t(10;17)(q26;q22) CFAP46/MSI2
t(7;17)(p15;q23) MSI2/HOXA9
t(7;17)(q32-34;q23) MSI2/?
t(7;17)(p15;q22) MSI2/HOXA9
t(10;17)(q26;q22) CFAP46/MSI2


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 12 ]
  t(8;17)(p11;q22) TM2D2/MSI2
t(8;17)(q21;q22) STAU2/MSI2
t(15;17)(q26;q22) NR2F2/MSI2
t(17;17)(q11;q22) KSR1/MSI2
t(17;17)(q11;q22) MSI2/EFCAB5
t(17;17)(q11;q22) MYO18A/MSI2
t(17;17)(q21;q22) ATP6V0A1/MSI2
t(17;17)(q21;q22) MSI2/WIPF2
t(17;17)(q22;q23) MSI2/DHX40
t(17;17)(q22;q23) MSI2/ICAM2
t(17;17)(q22;q23) MSI2/TEX2
t(17;17)(q22;q25) SYNGR2/MSI2


External links

Nomenclature
Cards
AtlasMSI2ID42893ch17q23.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)124540
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:44:11 CEST 2018

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