MYH9 (myosin, heavy polypeptide 9, non-muscle)

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MYH9 (myosin, heavy polypeptide 9, non-muscle)

Written	2003-08	Jean-Loup Huret
		Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_names	DFNA17
	myosin
Alias_symbol (synonym)	NMMHCA
	NMHC-II-A
	MHA
	FTNS
	EPSTS
Other alias	Myosin heavy chain, nonmuscle type A
	Nonmuscle myosin heavy chain-A (NMMHC-A)
HGNC (Hugo)	MYH9
LocusID (NCBI)	4627
Atlas_Id	481
Location	22q12.3 [Link to chromosome band 22q12]
Location_base_pair	Starts at 36281277 and ends at 36388067 bp from pter ( according to hg19-Feb_2009) [Mapping MYH9.png]

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

AGAP1 (2q37.2) / MYH9 (22q12.3)	ALK (2p23.2) / MYH9 (22q12.3)	CHMP2B (3p11.2) / MYH9 (22q12.3)
EEF1G (11q12.3) / MYH9 (22q12.3)	FOXRED2 (22q12.3) / MYH9 (22q12.3)	GALNT10 (5q33.2) / MYH9 (22q12.3)
IPO7 (11p15.4) / MYH9 (22q12.3)	IRX3 (16q12.2) / MYH9 (22q12.3)	MYH9 (22q12.3) / ALK (2p23.2)
MYH9 (22q12.3) / ATP6V0B (1p34.1)	MYH9 (22q12.3) / C20orf96 (20p13)	MYH9 (22q12.3) / CD81 (11p15.5)
MYH9 (22q12.3) / CFDP1 (16q23.1)	MYH9 (22q12.3) / CHCHD3 (7q32.3)	MYH9 (22q12.3) / EIF3D (22q12.3)
MYH9 (22q12.3) / FAM160A2 (11p15.4)	MYH9 (22q12.3) / FLNA (Xq28)	MYH9 (22q12.3) / FOXRED2 (22q12.3)
MYH9 (22q12.3) / JUP (17q21.2)	MYH9 (22q12.3) / MYH9 (22q12.3)	MYH9 (22q12.3) / NCL (2q37.1)
MYH9 (22q12.3) / NUCB1 (19q13.33)	MYH9 (22q12.3) / PITHD1 (1p36.11)	MYH9 (22q12.3) / PML (15q24.1)
MYH9 (22q12.3) / PSME1 (14q12)	MYH9 (22q12.3) / RAPGEF1 (9q34.13)	MYH9 (22q12.3) / SERPINA1 (14q32.13)
MYH9 (22q12.3) / SLC44A4 (6p21.33)	MYH9 (22q12.3) / TXN2 (22q12.3)	MYH9 (22q12.3) / USP6 (17p13.2)
OS9 (12q13.3) / MYH9 (22q12.3)	PSMA1 (11p15.2) / MYH9 (22q12.3)	PTMS (12p13.31) / MYH9 (22q12.3)
RAB2A (8q12.1) / MYH9 (22q12.3)	RPL11 (1p36.11) / MYH9 (22q12.3)	RPL13 (16q24.3) / MYH9 (22q12.3)
RPS20 (8q12.1) / MYH9 (22q12.3)	SECISBP2 (9q22.2) / MYH9 (22q12.3)	SMR3B (4q13.3) / MYH9 (22q12.3)
TGFBI (5q31.1) / MYH9 (22q12.3)	TPM2 (9p13.3) / MYH9 (22q12.3)	UBTF (17q21.31) / MYH9 (22q12.3)
WDR60 (7q36.3) / MYH9 (22q12.3)

DNA/RNA

Description	spans 107 kb; 40 exons
Transcription	alternate splicing; transcripts of 4.4, 5.3 and 5.9 kb

Protein

Description	1960 amino acids; 227 kDa (and 1752 aa, 202 kDa, and 1486 aa, 172 kDa; globular head in N-term and a coiled-coil tail in C-term; actin binding site and light chains binding site are present in the globular domain. Myosin forms hexamers with 2 heavy chains, 2 essential (alkali) light chains, and 2 regulatory light chains
Expression	in platelets; upregulated during granulocyte differentiation (see below); also expressed in thymus, spleen, kidney, intestine, cochlea ....
Function	binds actin; protein of the cytoskeleton; role in cell shape and motility, and in cell division

Mutations

Germinal	in autosomal dominant giant-platelet disorders
Somatic	in non Hodgkin lymphomas

Implicated in

Note
Disease	The autosomal dominant giant-platelet disorders, May-Hegglin anomaly (MHA), Fechtner syndrome (FTNS), and Sebastian syndrome (SBS), which share a triad of thrombocytopenia, large platelets (macrothrombocytopenia (MTCP)) and characteristic leukocyte inclusions (Dohle-like bodies), Epstein syndrome, which associates additional Alport-like clinical features (inherited sensorineural deafness, cataracts, nephritis), and MTCP without leukocyte inclusions, as well as a nonsyndromic hereditary hearing impairment are all caused by (germinal) mutations in MYH9. These disorders appear to represent a class of allelic disorders with variable phenotypic diversity. No clear no genotype-phenotype correlation was identified


Entity	Anaplasic large cell lymphoma (ALCL) with t(2;22)(p23;q12) --> ALK- CLTC
Disease	ALCL are high grade non Hodgkin lymphomas; ALK+ ALCL are ALCL where ALK is involved in a fusion gene; ALK+ ALCL represent 50 to 60 % of ALCL cases (they are CD30+, ALK+;); belong to the "cytoplasmic ALK+" subset.
Prognosis	Althouth presenting as a high grade tumour, a 80% five yr survival is associated with this anomaly
Hybrid/Mutated Gene	5' MYH9 - 3' ALK
Abnormal Protein	NH2 MYH9 - COOH ALK

Bibliography

Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly.

Kelley MJ, Jawien W, Ortel TL, Korczak JF

Nature genetics. 2000 ; 26 (1) : 106-108.

PMID 10973260

Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions.

Kunishima S, Matsushita T, Kojima T, Amemiya N, Choi YM, Hosaka N, Inoue M, Jung Y, Mamiya S, Matsumoto K, Miyajima Y, Zhang G, Ruan C, Saito K, Song KS, Yoon HJ, Kamiya T, Saito H

Journal of human genetics. 2001 ; 46 (12) : 722-729.

PMID 11776386

Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.

Lalwani AK, Goldstein JA, Kelley MJ, Luxford W, Castelein CM, Mhatre AN

American journal of human genetics. 2000 ; 67 (5) : 1121-1128.

PMID 11023810

Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.

Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E

Genes, chromosomes & cancer. 2003 ; 37 (4) : 427-432.

PMID 12800156

Five (un)easy pieces: the MYH9-related giant platelet syndromes.

Martignetti J

Haematologica. 2002 ; 87 (9) : 897-898.

PMID 12217798

Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium.

Seri M, Cusano R, Gangarossa S, Caridi G, Bordo D, Lo Nigro C, Ghiggeri GM, Ravazzolo R, Savino M, Del Vecchio M, d'Apolito M, Iolascon A, Zelante LL, Savoia A, Balduini CL, Noris P, Magrini U, Belletti S, Heath KE, Babcock M, Glucksman MJ, Aliprandis E, Bizzaro N, Desnick RJ, Martignetti JA

Nature genetics. 2000 ; 26 (1) : 103-105.

PMID 10973259

Seri M, Pecci A, Di Bari F, Cusano R, Savino M, Panza E, Nigro A, Noris P, Gangarossa S, Rocca B, Gresele P, Bizzaro N, Malatesta P, Koivisto PA, Longo I, Musso R, Pecoraro C, Iolascon A, Magrini U, Rodriguez Soriano J, Renieri A, Ghiggeri GM, Ravazzolo R, Balduini CL, Savoia A

Medicine. 2003 ; 82 (3) : 203-215.

PMID 12792306

Citation

This paper should be referenced as such :

Huret, JL

MYH9 (myosin, heavy polypeptide 9, non-muscle)

Atlas Genet Cytogenet Oncol Haematol. 2003;7(4):228-229.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Genes/MYH9ID481.html

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]

Anaplastic large cell lymphoma (ALCL)
t(2;22)(p23;q11) MYH9/ALK

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]

t(2;22)(p23;q12) MYH9/ALK
t(5;22)(q31;q12) TGFBI/MYH9
t(15;22)(q25;q12) MYH9/NTRK3
t(17;22)(p13;q12) MYH9/USP6
MYH9/EIF3D (22q12)

External links

	Nomenclature
HGNC (Hugo)	MYH9 7579
LRG (Locus Reference Genomic)	LRG_567
	Cards
Atlas	MYH9ID481
Entrez_Gene (NCBI)	MYH9 4627 myosin heavy chain 9
Aliases	BDPLT6; DFNA17; EPSTS; FTNS;
	MATINS; MHA; NMHC-II-A; NMMHC-IIA; NMMHCA
GeneCards (Weizmann)	MYH9
Ensembl hg19 (Hinxton)	ENSG00000100345 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000100345 [Gene_View] ENSG00000100345 [Sequence] chr22:36281277-36388067 [Contig_View] MYH9 [Vega]
ICGC DataPortal	ENSG00000100345
TCGA cBioPortal	MYH9
AceView (NCBI)	MYH9
Genatlas (Paris)	MYH9
WikiGenes	4627
SOURCE (Princeton)	MYH9
Genetics Home Reference (NIH)	MYH9
	Genomic and cartography
GoldenPath hg38 (UCSC)	MYH9 - chr22:36281277-36388067 - 22q12.3 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	MYH9 - 22q12.3 [Description] (hg19-Feb_2009)
GoldenPath	MYH9 - 22q12.3 [CytoView hg19] MYH9 - 22q12.3 [CytoView hg38]
ImmunoBase	ENSG00000100345
Mapping of homologs : NCBI	MYH9 [Mapview hg19] MYH9 [Mapview hg38]
OMIM	155100 160775 603622
	Gene and transcription
Genbank (Entrez)	AA420536 AB191263 AB290175 AK025219 AK025393
RefSeq transcript (Entrez)	NM_002473
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	MYH9
Cluster EST : Unigene	Hs.474751 [ NCBI ]
CGAP (NCI)	Hs.474751
Alternative Splicing Gallery	ENSG00000100345
Gene Expression	MYH9 [ NCBI-GEO ] MYH9 [ EBI - ARRAY_EXPRESS ] MYH9 [ SEEK ] MYH9 [ MEM ]
Gene Expression Viewer (FireBrowse)	MYH9 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	4627
GTEX Portal (Tissue expression)	MYH9
Human Protein Atlas	ENSG00000100345-MYH9 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P35579 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P35579 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P35579
Splice isoforms : SwissVar	P35579
PhosPhoSitePlus	P35579
Domaine pattern : Prosite (Expaxy)	IQ (PS50096) MYOSIN_MOTOR (PS51456) SH3_LIKE (PS51844)
Domains : Interpro (EBI)	IQ_motif_EF-hand-BS Kinesin_motor_dom_sf Myosin_head_motor_dom Myosin_IQ_contain_sf Myosin_N Myosin_S1_N Myosin_tail P-loop_NTPase RGS_sf
Domain families : Pfam (Sanger)	Myosin_head (PF00063) Myosin_N (PF02736) Myosin_tail_1 (PF01576)
Domain families : Pfam (NCBI)	pfam00063 pfam02736 pfam01576
Domain families : Smart (EMBL)	IQ (SM00015) MYSc (SM00242)
Conserved Domain (NCBI)	MYH9
DMDM Disease mutations	4627
Blocks (Seattle)	MYH9
PDB (RSDB)	2LNK 3ZWH 4CFQ 4CFR 4ETO
PDB Europe	2LNK 3ZWH 4CFQ 4CFR 4ETO
PDB (PDBSum)	2LNK 3ZWH 4CFQ 4CFR 4ETO
PDB (IMB)	2LNK 3ZWH 4CFQ 4CFR 4ETO
Structural Biology KnowledgeBase	2LNK 3ZWH 4CFQ 4CFR 4ETO
SCOP (Structural Classification of Proteins)	2LNK 3ZWH 4CFQ 4CFR 4ETO
CATH (Classification of proteins structures)	2LNK 3ZWH 4CFQ 4CFR 4ETO
Superfamily	P35579
Human Protein Atlas [tissue]	ENSG00000100345-MYH9 [tissue]
Peptide Atlas	P35579
HPRD	01177
IPI	IPI00019502 IPI00395772 IPI00742780 IPI00878695 IPI00556012
	Protein Interaction databases
DIP (DOE-UCLA)	P35579
IntAct (EBI)	P35579
FunCoup	ENSG00000100345
BioGRID	MYH9
STRING (EMBL)	MYH9
ZODIAC	MYH9
	Ontologies - Pathways
QuickGO	P35579
Ontology : AmiGO	microfilament motor activity meiotic spindle organization angiogenesis in utero embryonic development stress fiber ruffle establishment of T cell polarity immunological synapse uropod RNA binding motor activity actin binding integrin binding protein binding calmodulin binding ATP binding nucleus cytoplasm spindle actomyosin contractile ring cytosol cytosol plasma membrane plasma membrane brush border cell-cell adherens junction focal adhesion membrane protein ectodomain proteolysis phagocytosis, engulfment integrin-mediated signaling pathway myoblast fusion COP9 signalosome regulation of cell shape protein transport actin cytoskeleton membrane myosin II complex ATPase activity protein domain specific binding actin filament-based movement platelet formation monocyte differentiation actin-dependent ATPase activity actin-dependent ATPase activity actomyosin structure organization cell leading edge actin cytoskeleton reorganization neuromuscular junction cleavage furrow cytokinetic process uropod organization protein-containing complex actomyosin protein homodimerization activity protein membrane anchor ADP binding blood vessel endothelial cell migration cadherin binding leukocyte migration actin filament binding actin filament binding actin filament binding establishment of meiotic spindle localization extracellular exosome platelet aggregation myosin II filament negative regulation of actin filament severing negative regulation of actin filament severing positive regulation of protein processing in phagocytic vesicle
Ontology : EGO-EBI	microfilament motor activity meiotic spindle organization angiogenesis in utero embryonic development stress fiber ruffle establishment of T cell polarity immunological synapse uropod RNA binding motor activity actin binding integrin binding protein binding calmodulin binding ATP binding nucleus cytoplasm spindle actomyosin contractile ring cytosol cytosol plasma membrane plasma membrane brush border cell-cell adherens junction focal adhesion membrane protein ectodomain proteolysis phagocytosis, engulfment integrin-mediated signaling pathway myoblast fusion COP9 signalosome regulation of cell shape protein transport actin cytoskeleton membrane myosin II complex ATPase activity protein domain specific binding actin filament-based movement platelet formation monocyte differentiation actin-dependent ATPase activity actin-dependent ATPase activity actomyosin structure organization cell leading edge actin cytoskeleton reorganization neuromuscular junction cleavage furrow cytokinetic process uropod organization protein-containing complex actomyosin protein homodimerization activity protein membrane anchor ADP binding blood vessel endothelial cell migration cadherin binding leukocyte migration actin filament binding actin filament binding actin filament binding establishment of meiotic spindle localization extracellular exosome platelet aggregation myosin II filament negative regulation of actin filament severing negative regulation of actin filament severing positive regulation of protein processing in phagocytic vesicle
Pathways : KEGG	Tight junction Regulation of actin cytoskeleton Salmonella infection
REACTOME	P35579 [protein]
REACTOME Pathways	R-HSA-5627123 [pathway]
NDEx Network	MYH9
Atlas of Cancer Signalling Network	MYH9
Wikipedia pathways	MYH9
	Orthology - Evolution
OrthoDB	4627
GeneTree (enSembl)	ENSG00000100345
Phylogenetic Trees/Animal Genes : TreeFam	MYH9
HOGENOM	P35579
Homologs : HomoloGene	MYH9
Homology/Alignments : Family Browser (UCSC)	MYH9
	Gene fusions - Rearrangements
Fusion : Mitelman	MYH9/ALK [22q12.3/2p23.2]
Fusion : Mitelman	MYH9/EIF3D [22q12.3/22q12.3] [t(22;22)(q12;q12)]
Fusion : Mitelman	MYH9/USP6 [22q12.3/17p13.2] [t(17;22)(p13;q12)]
Fusion : Mitelman	TGFBI/MYH9 [5q31.1/22q12.3] [t(5;22)(q31;q12)]
Fusion : TICdb	MYH9 [22q12.3] - ALK [2p23.2]
Fusion Cancer (Beijing)	MYH9 [22q12.3] - FLNA [Xq28] [FUSC002461] [FUSC002461] [FUSC002461] [FUSC002461] [FUSC002461] [FUSC002461] [FUSC002461]
Fusion : FusionGDB	1055 10556 11258 14283 1479 17750 22996 22997 22998 22999 23000 23001 23002 23003 23004
	23005 23006 23007 23008 23009 23010 23011 23012 23013 23014 23015 23016 23017 23018 23019
	23020 23021 23022 23023 23024 23025 23026 23027 23028 23029 23030 23031 25505 29280 29387
	29958 33106 34973 37897 39227 39273 40187 40630 41876 43822 7105 7560 7995
Fusion : Fusion_Hub	AC002094.1--MYH9 AC018630.6--MYH9 ACPP--MYH9 ACTN1--MYH9 ADAM9--MYH9 ADAMTS9--MYH9 AGAP1--MYH9 ALDH3A1--MYH9 ALK--MYH9 ALKBH2--MYH9 APBB1IP--MYH9 ARHGDIB--MYH9 ATP1A1--MYH9 ATP2A2--MYH9 AZU1--MYH9
	BAZ1A--MYH9 BCR--MYH9 BCRP2--MYH9 C7--MYH9 CCDC80--MYH9 CCDC82--MYH9 CCR6--MYH9 CD151--MYH9 CD99--MYH9 CDK6--MYH9 CDKN1A--MYH9 CHD2--MYH9 CHMP2B--MYH9 CPB1--MYH9 CSF2RB--MYH9
	CYTOCHROME_B--MYH9 DBN1--MYH9 DDX17--MYH9 DMXL1--MYH9 DPY19L2--MYH9 DST--MYH9 EEF1A1--MYH9 EEF1G--MYH9 EEF2--MYH9 EIF3D--MYH9 EMP2--MYH9 EPAS1--MYH9 FGFR2--MYH9 FKBP5--MYH9 FLNA--MYH9
	FOXRED2--MYH9 GALNT10--MYH9 GOLIM4--MYH9 GPX3--MYH9 HBA1--MYH9 HIRA--MYH9 HYOU1--MYH9 IFT46--MYH9 IGF2--MYH9 IGFBP3--MYH9 IGFBP5--MYH9 IGHG1--MYH9 IGHM--MYH9 IGKC--MYH9 IL2RB--MYH9
	IPO7--MYH9 IRX3--MYH9 ITGA5--MYH9 KANK1--MYH9 KAT8--MYH9 KRT1--MYH9 KRT14--MYH9 KRT16--MYH9 KRT5--MYH9 LYZ--MYH9 MEG3--MYH9 MGAT1--MYH9 MGEA5--MYH9 MGP--MYH9 MLLT6--MYH9
	MST4--MYH9 MTMR3--MYH9 MYH11--MYH9 MYH9--6-MAR MYH9--AAAS MYH9--ACTB MYH9--ACTG1 MYH9--AGAP3 MYH9--ALK MYH9--ANKS1A MYH9--AP2B1 MYH9--APOD MYH9--ATP6V0B MYH9--B2M MYH9--BIRC6
	MYH9--C20ORF96 MYH9--C6ORF228 MYH9--CACNA1C MYH9--CACNG2 MYH9--CCDC80 MYH9--CCNDBP1 MYH9--CD74 MYH9--CD81 MYH9--CFDP1 MYH9--CFP MYH9--CHCHD3 MYH9--CNPY2 MYH9--CTSH MYH9--CXCR4 MYH9--CYB5R3
	MYH9--DDB1 MYH9--DDX21 MYH9--DICER1 MYH9--DMPK MYH9--DNASE1 MYH9--DOT1L MYH9--EIF3D MYH9--EXOC3 MYH9--FAM160A2 MYH9--FLNA MYH9--FN1 MYH9--FOXRED2 MYH9--GAS6 MYH9--GNAS MYH9--GPNMB
	MYH9--GRAP2 MYH9--HSP90AA1 MYH9--IGHG1 MYH9--JUP MYH9--KLK3 MYH9--KRT10 MYH9--KRT14 MYH9--KRT17 MYH9--MAP2K2 MYH9--MITD1 MYH9--MRPS12 MYH9--MYH9 MYH9--MYO18B MYH9--NARF MYH9--NAT10
	MYH9--NCL MYH9--NDE1 MYH9--NDUFA7 MYH9--NDUFV1 MYH9--NFYC MYH9--NPTX2 MYH9--NUCB1 MYH9--ORAOV1 MYH9--PCSK7 MYH9--PGS1 MYH9--PIH1D1 MYH9--PITHD1 MYH9--PKM2 MYH9--PLA2G6 MYH9--PLAT
	MYH9--PLIN4 MYH9--PML MYH9--PRH1 MYH9--PRH1-PRR4 MYH9--PRH2 MYH9--PSMD1 MYH9--PSME1 MYH9--PVALB MYH9--PXDN MYH9--QSOX1 MYH9--RAPGEF1 MYH9--RBBP7 MYH9--RBM10 MYH9--RP5-1119A7.14.1 MYH9--RPL13A
	MYH9--RPS19 MYH9--SERPINA1 MYH9--SFTPA2 MYH9--SFTPC MYH9--SLC44A4 MYH9--SMR3B MYH9--SREBF2 MYH9--SSR3 MYH9--TAF1C MYH9--TAGLN MYH9--TG MYH9--TNNT2 MYH9--TPM2 MYH9--TRB@ MYH9--TTC28
	MYH9--TXN2 MYH9--UBB MYH9--USP5 MYH9--USP6 MYH9--VIM MYH9--VMP1 MYH9--WSB1 MYH9--ZNF362 MYL9--MYH9 NPC1--MYH9 NUBP2--MYH9 OS9--MYH9 PDLIM7--MYH9 PIGR--MYH9 PLAT--MYH9
	PLS3--MYH9 PLXNB3--MYH9 PPARA--MYH9 PPARD--MYH9 PPP1R7--MYH9 PRKRA--MYH9 PROM2--MYH9 PROSC--MYH9 PSMA1--MYH9 PTMS--MYH9 PTPN18--MYH9 RAB2A--MYH9 RAC2--MYH9 RASAL3--MYH9 RBFOX2--MYH9
	RNF220--MYH9 RPL11--MYH9 RPL13--MYH9 RPS19BP1--MYH9 RPS20--MYH9 RPS24--MYH9 SDC1--MYH9 SECISBP2--MYH9 SELM--MYH9 SMR3B--MYH9 SPRED2--MYH9 SPTB--MYH9 SUMF2--MYH9 TAGLN--MYH9 TGFBI--MYH9
	TMEM41A--MYH9 TNKS1BP1--MYH9 TPM2--MYH9 TPT1--MYH9 TSPAN3--MYH9 TTN-AS1--MYH9 UBTF--MYH9 USP15--MYH9 USP6--MYH9 WDR46--MYH9 WDR60--MYH9 XRCC5--MYH9 ZKSCAN1--MYH9
Fusion : Quiver	MYH9
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	MYH9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	MYH9
dbVar	MYH9
ClinVar	MYH9
1000_Genomes	MYH9
Exome Variant Server	MYH9
ExAC (Exome Aggregation Consortium)	ENSG00000100345
GNOMAD Browser	ENSG00000100345
Varsome Browser	MYH9
Genetic variants : HAPMAP	4627
Genomic Variants (DGV)	MYH9 [DGVbeta]
DECIPHER	MYH9 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	MYH9
	Mutations
ICGC Data Portal	MYH9
TCGA Data Portal	MYH9
Broad Tumor Portal	MYH9
OASIS Portal	MYH9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	MYH9 [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	MYH9
intOGen Portal	MYH9
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMuta	search MYH9
DgiDB (Drug Gene Interaction Database)	MYH9
DoCM (Curated mutations)	MYH9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	MYH9 (select a term)
intoGen	MYH9
NCG5 (London)	MYH9
Cancer3D	MYH9(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	155100 160775 603622
Orphanet	18198 12046
DisGeNET	MYH9
Medgen	MYH9
Genetic Testing Registry	MYH9
NextProt	P35579 [Medical]
TSGene	4627
GENETests	MYH9
Target Validation	MYH9
Huge Navigator	MYH9 [HugePedia]
snp3D : Map Gene to Disease	4627
BioCentury BCIQ	MYH9
ClinGen	MYH9
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	4627
Chemical/Pharm GKB Gene	PA31377
Clinical trial	MYH9
	Miscellaneous
canSAR (ICR)	MYH9 (select the gene name)
DataMed Index	MYH9
	Probes
	Litterature
PubMed	382 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	MYH9
EVEX	MYH9
GoPubMed	MYH9
iHOP	MYH9

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Jul 8 15:16:54 CEST 2019

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