Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MYH9 (myosin, heavy polypeptide 9, non-muscle)

Written2003-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesDFNA17
myosin, heavy polypeptide 9, non-muscle
Alias_symbol (synonym)NMMHCA
NMHC-II-A
MHA
FTNS
EPSTS
Other aliasMyosin heavy chain, nonmuscle type A
Nonmuscle myosin heavy chain-A (NMMHC-A)
HGNC (Hugo) MYH9
LocusID (NCBI) 4627
Atlas_Id 481
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 36281277 and ends at 36388067 bp from pter ( according to hg19-Feb_2009)  [Mapping MYH9.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP1 (2q37.2) / MYH9 (22q12.3)ALK (2p23.2) / MYH9 (22q12.3)CHMP2B (3p11.2) / MYH9 (22q12.3)
EEF1G (11q12.3) / MYH9 (22q12.3)FOXRED2 (22q12.3) / MYH9 (22q12.3)GALNT10 (5q33.2) / MYH9 (22q12.3)
IPO7 (11p15.4) / MYH9 (22q12.3)IRX3 (16q12.2) / MYH9 (22q12.3)MYH9 (22q12.3) / ALK (2p23.2)
MYH9 (22q12.3) / ATP6V0B (1p34.1)MYH9 (22q12.3) / C20orf96 (20p13)MYH9 (22q12.3) / CD81 (11p15.5)
MYH9 (22q12.3) / CFDP1 (16q23.1)MYH9 (22q12.3) / CHCHD3 (7q32.3)MYH9 (22q12.3) / EIF3D (22q12.3)
MYH9 (22q12.3) / FAM160A2 (11p15.4)MYH9 (22q12.3) / FLNA (Xq28)MYH9 (22q12.3) / FOXRED2 (22q12.3)
MYH9 (22q12.3) / JUP (17q21.2)MYH9 (22q12.3) / MYH9 (22q12.3)MYH9 (22q12.3) / NCL (2q37.1)
MYH9 (22q12.3) / NUCB1 (19q13.33)MYH9 (22q12.3) / PITHD1 (1p36.11)MYH9 (22q12.3) / PML (15q24.1)
MYH9 (22q12.3) / PSME1 (14q12)MYH9 (22q12.3) / RAPGEF1 (9q34.13)MYH9 (22q12.3) / SERPINA1 (14q32.13)
MYH9 (22q12.3) / SLC44A4 (6p21.33)MYH9 (22q12.3) / TXN2 (22q12.3)MYH9 (22q12.3) / USP6 (17p13.2)
OS9 (12q13.3) / MYH9 (22q12.3)PSMA1 (11p15.2) / MYH9 (22q12.3)PTMS (12p13.31) / MYH9 (22q12.3)
RAB2A (8q12.1) / MYH9 (22q12.3)RPL11 (1p36.11) / MYH9 (22q12.3)RPL13 (16q24.3) / MYH9 (22q12.3)
RPS20 (8q12.1) / MYH9 (22q12.3)SECISBP2 (9q22.2) / MYH9 (22q12.3)SMR3B (4q13.3) / MYH9 (22q12.3)
TGFBI (5q31.1) / MYH9 (22q12.3)TPM2 (9p13.3) / MYH9 (22q12.3)UBTF (17q21.31) / MYH9 (22q12.3)
WDR60 (7q36.3) / MYH9 (22q12.3)

DNA/RNA

Description spans 107 kb; 40 exons
Transcription alternate splicing; transcripts of 4.4, 5.3 and 5.9 kb

Protein

Description 1960 amino acids; 227 kDa (and 1752 aa, 202 kDa, and 1486 aa, 172 kDa; globular head in N-term and a coiled-coil tail in C-term; actin binding site and light chains binding site are present in the globular domain. Myosin forms hexamers with 2 heavy chains, 2 essential (alkali) light chains, and 2 regulatory light chains
Expression in platelets; upregulated during granulocyte differentiation (see below); also expressed in thymus, spleen, kidney, intestine, cochlea ....
Function binds actin; protein of the cytoskeleton; role in cell shape and motility, and in cell division

Mutations

Germinal in autosomal dominant giant-platelet disorders
Somatic in non Hodgkin lymphomas

Implicated in

Note
Disease The autosomal dominant giant-platelet disorders, May-Hegglin anomaly (MHA), Fechtner syndrome (FTNS), and Sebastian syndrome (SBS), which share a triad of thrombocytopenia, large platelets (macrothrombocytopenia (MTCP)) and characteristic leukocyte inclusions (Dohle-like bodies), Epstein syndrome, which associates additional Alport-like clinical features (inherited sensorineural deafness, cataracts, nephritis), and MTCP without leukocyte inclusions, as well as a nonsyndromic hereditary hearing impairment are all caused by (germinal) mutations in MYH9. These disorders appear to represent a class of allelic disorders with variable phenotypic diversity. No clear no genotype-phenotype correlation was identified
  
  
Entity Anaplasic large cell lymphoma (ALCL) with t(2;22)(p23;q12) --> ALK- CLTC
Disease ALCL are high grade non Hodgkin lymphomas; ALK+ ALCL are ALCL where ALK is involved in a fusion gene; ALK+ ALCL represent 50 to 60 % of ALCL cases (they are CD30+, ALK+;); belong to the "cytoplasmic ALK+" subset.
Prognosis Althouth presenting as a high grade tumour, a 80% five yr survival is associated with this anomaly
Hybrid/Mutated Gene 5' MYH9 - 3' ALK
Abnormal Protein NH2 MYH9 - COOH ALK
  

Bibliography

Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly.
Kelley MJ, Jawien W, Ortel TL, Korczak JF
Nature genetics. 2000 ; 26 (1) : 106-108.
PMID 10973260
 
Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions.
Kunishima S, Matsushita T, Kojima T, Amemiya N, Choi YM, Hosaka N, Inoue M, Jung Y, Mamiya S, Matsumoto K, Miyajima Y, Zhang G, Ruan C, Saito K, Song KS, Yoon HJ, Kamiya T, Saito H
Journal of human genetics. 2001 ; 46 (12) : 722-729.
PMID 11776386
 
Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.
Lalwani AK, Goldstein JA, Kelley MJ, Luxford W, Castelein CM, Mhatre AN
American journal of human genetics. 2000 ; 67 (5) : 1121-1128.
PMID 11023810
 
Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.
Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E
Genes, chromosomes & cancer. 2003 ; 37 (4) : 427-432.
PMID 12800156
 
Five (un)easy pieces: the MYH9-related giant platelet syndromes.
Martignetti J
Haematologica. 2002 ; 87 (9) : 897-898.
PMID 12217798
 
Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium.
Seri M, Cusano R, Gangarossa S, Caridi G, Bordo D, Lo Nigro C, Ghiggeri GM, Ravazzolo R, Savino M, Del Vecchio M, d'Apolito M, Iolascon A, Zelante LL, Savoia A, Balduini CL, Noris P, Magrini U, Belletti S, Heath KE, Babcock M, Glucksman MJ, Aliprandis E, Bizzaro N, Desnick RJ, Martignetti JA
Nature genetics. 2000 ; 26 (1) : 103-105.
PMID 10973259
 
MYH9-related disease: May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness.
Seri M, Pecci A, Di Bari F, Cusano R, Savino M, Panza E, Nigro A, Noris P, Gangarossa S, Rocca B, Gresele P, Bizzaro N, Malatesta P, Koivisto PA, Longo I, Musso R, Pecoraro C, Iolascon A, Magrini U, Rodriguez Soriano J, Renieri A, Ghiggeri GM, Ravazzolo R, Balduini CL, Savoia A
Medicine. 2003 ; 82 (3) : 203-215.
PMID 12792306
 

Citation

This paper should be referenced as such :
Huret, JL
MYH9 (myosin, heavy polypeptide 9, non-muscle)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(4):228-229.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/MYH9ID481.html

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias AnaplLargeCelLymphID2103 t0222p23q11ID1291

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]

Solid Tumors TT_t0222p23q12ID105420 TT_t0522q31q12ID106580 TT_t1522q25q12ID102067 TT_t1722p13q12ID102979 TT_t2222q12q12ID104867

External links

Nomenclature
HGNC (Hugo)MYH9   7579
LRG (Locus Reference Genomic)LRG_567
Cards
AtlasMYH9ID481
Entrez_Gene (NCBI)MYH9  4627  myosin heavy chain 9
AliasesBDPLT6; DFNA17; EPSTS; FTNS; 
MATINS; MHA; NMHC-II-A; NMMHC-IIA; NMMHCA
GeneCards (Weizmann)MYH9
Ensembl hg19 (Hinxton)ENSG00000100345 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100345 [Gene_View]  ENSG00000100345 [Sequence]  chr22:36281277-36388067 [Contig_View]  MYH9 [Vega]
ICGC DataPortalENSG00000100345
TCGA cBioPortalMYH9
AceView (NCBI)MYH9
Genatlas (Paris)MYH9
WikiGenes4627
SOURCE (Princeton)MYH9
Genetics Home Reference (NIH)MYH9
Genomic and cartography
GoldenPath hg38 (UCSC)MYH9  -     chr22:36281277-36388067 -  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MYH9  -     22q12.3   [Description]    (hg19-Feb_2009)
GoldenPathMYH9 - 22q12.3 [CytoView hg19]  MYH9 - 22q12.3 [CytoView hg38]
ImmunoBaseENSG00000100345
Mapping of homologs : NCBIMYH9 [Mapview hg19]  MYH9 [Mapview hg38]
OMIM155100   160775   603622   
Gene and transcription
Genbank (Entrez)AA420536 AB191263 AB290175 AK025219 AK025393
RefSeq transcript (Entrez)NM_002473
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MYH9
Cluster EST : UnigeneHs.474751 [ NCBI ]
CGAP (NCI)Hs.474751
Alternative Splicing GalleryENSG00000100345
Gene ExpressionMYH9 [ NCBI-GEO ]   MYH9 [ EBI - ARRAY_EXPRESS ]   MYH9 [ SEEK ]   MYH9 [ MEM ]
Gene Expression Viewer (FireBrowse)MYH9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4627
GTEX Portal (Tissue expression)MYH9
Human Protein AtlasENSG00000100345-MYH9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35579   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35579  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35579
Splice isoforms : SwissVarP35579
PhosPhoSitePlusP35579
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    MYOSIN_MOTOR (PS51456)    SH3_LIKE (PS51844)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    Kinesin_motor_dom_sf    Myosin_head_motor_dom    Myosin_IQ_contain_sf    Myosin_N    Myosin_S1_N    Myosin_tail    P-loop_NTPase    RGS_sf   
Domain families : Pfam (Sanger)Myosin_head (PF00063)    Myosin_N (PF02736)    Myosin_tail_1 (PF01576)   
Domain families : Pfam (NCBI)pfam00063    pfam02736    pfam01576   
Domain families : Smart (EMBL)IQ (SM00015)  MYSc (SM00242)  
Conserved Domain (NCBI)MYH9
DMDM Disease mutations4627
Blocks (Seattle)MYH9
PDB (RSDB)2LNK    3ZWH    4CFQ    4CFR    4ETO   
PDB Europe2LNK    3ZWH    4CFQ    4CFR    4ETO   
PDB (PDBSum)2LNK    3ZWH    4CFQ    4CFR    4ETO   
PDB (IMB)2LNK    3ZWH    4CFQ    4CFR    4ETO   
Structural Biology KnowledgeBase2LNK    3ZWH    4CFQ    4CFR    4ETO   
SCOP (Structural Classification of Proteins)2LNK    3ZWH    4CFQ    4CFR    4ETO   
CATH (Classification of proteins structures)2LNK    3ZWH    4CFQ    4CFR    4ETO   
SuperfamilyP35579
Human Protein Atlas [tissue]ENSG00000100345-MYH9 [tissue]
Peptide AtlasP35579
HPRD01177
IPIIPI00019502   IPI00395772   IPI00742780   IPI00878695   IPI00556012   
Protein Interaction databases
DIP (DOE-UCLA)P35579
IntAct (EBI)P35579
FunCoupENSG00000100345
BioGRIDMYH9
STRING (EMBL)MYH9
ZODIACMYH9
Ontologies - Pathways
QuickGOP35579
Ontology : AmiGOmicrofilament motor activity  meiotic spindle organization  angiogenesis  in utero embryonic development  stress fiber  ruffle  establishment of T cell polarity  immunological synapse  plasma membrane repair  uropod  RNA binding  motor activity  actin binding  integrin binding  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  spindle  actomyosin contractile ring  cytosol  cytosol  plasma membrane  plasma membrane  brush border  cell-cell adherens junction  focal adhesion  membrane protein ectodomain proteolysis  phagocytosis, engulfment  integrin-mediated signaling pathway  myoblast fusion  COP9 signalosome  regulation of cell shape  protein transport  actin cytoskeleton  membrane  myosin II complex  ATPase activity  protein domain specific binding  actin filament-based movement  platelet formation  monocyte differentiation  actin-dependent ATPase activity  actin-dependent ATPase activity  actomyosin structure organization  cell leading edge  actin cytoskeleton reorganization  neuromuscular junction  cleavage furrow  lysosome localization  cytokinetic process  uropod organization  protein-containing complex  actomyosin  protein homodimerization activity  protein membrane anchor  ADP binding  blood vessel endothelial cell migration  regulated exocytosis  cadherin binding  leukocyte migration  actin filament binding  actin filament binding  actin filament binding  establishment of meiotic spindle localization  extracellular exosome  platelet aggregation  myosin II filament  negative regulation of actin filament severing  negative regulation of actin filament severing  positive regulation of protein processing in phagocytic vesicle  regulation of plasma membrane repair  
Ontology : EGO-EBImicrofilament motor activity  meiotic spindle organization  angiogenesis  in utero embryonic development  stress fiber  ruffle  establishment of T cell polarity  immunological synapse  plasma membrane repair  uropod  RNA binding  motor activity  actin binding  integrin binding  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  spindle  actomyosin contractile ring  cytosol  cytosol  plasma membrane  plasma membrane  brush border  cell-cell adherens junction  focal adhesion  membrane protein ectodomain proteolysis  phagocytosis, engulfment  integrin-mediated signaling pathway  myoblast fusion  COP9 signalosome  regulation of cell shape  protein transport  actin cytoskeleton  membrane  myosin II complex  ATPase activity  protein domain specific binding  actin filament-based movement  platelet formation  monocyte differentiation  actin-dependent ATPase activity  actin-dependent ATPase activity  actomyosin structure organization  cell leading edge  actin cytoskeleton reorganization  neuromuscular junction  cleavage furrow  lysosome localization  cytokinetic process  uropod organization  protein-containing complex  actomyosin  protein homodimerization activity  protein membrane anchor  ADP binding  blood vessel endothelial cell migration  regulated exocytosis  cadherin binding  leukocyte migration  actin filament binding  actin filament binding  actin filament binding  establishment of meiotic spindle localization  extracellular exosome  platelet aggregation  myosin II filament  negative regulation of actin filament severing  negative regulation of actin filament severing  positive regulation of protein processing in phagocytic vesicle  regulation of plasma membrane repair  
Pathways : KEGGTight junction    Regulation of actin cytoskeleton    Salmonella infection   
REACTOMEP35579 [protein]
REACTOME PathwaysR-HSA-5627123 [pathway]   
NDEx NetworkMYH9
Atlas of Cancer Signalling NetworkMYH9
Wikipedia pathwaysMYH9
Orthology - Evolution
OrthoDB4627
GeneTree (enSembl)ENSG00000100345
Phylogenetic Trees/Animal Genes : TreeFamMYH9
HOGENOMP35579
Homologs : HomoloGeneMYH9
Homology/Alignments : Family Browser (UCSC)MYH9
Gene fusions - Rearrangements
Fusion : MitelmanMYH9/ALK [22q12.3/2p23.2]  
Fusion : MitelmanMYH9/EIF3D [22q12.3/22q12.3]  [t(22;22)(q12;q12)]  
Fusion : MitelmanMYH9/USP6 [22q12.3/17p13.2]  [t(17;22)(p13;q12)]  
Fusion : MitelmanTGFBI/MYH9 [5q31.1/22q12.3]  [t(5;22)(q31;q12)]  
Fusion : TICdbMYH9 [22q12.3]  -  ALK [2p23.2]
Fusion Cancer (Beijing)MYH9 [22q12.3]  -  FLNA [Xq28]  [FUSC002461]  [FUSC002461]  [FUSC002461]  [FUSC002461]  [FUSC002461]  [FUSC002461]  [FUSC002461]
Fusion : FusionGDB1055    10556    11258    14283    1479    17750    22996    22997    22998    22999    23000    23001    23002    23003    23004   
23005    23006    23007    23008    23009    23010    23011    23012    23013    23014    23015    23016    23017    23018    23019   
23020    23021    23022    23023    23024    23025    23026    23027    23028    23029    23030    23031    25505    29280    29387   
29958    33106    34973    37897    39227    39273    40187    40630    41876    43822    7105    7560    7995   
Fusion : Fusion_HubAC002094.1--MYH9    AC018630.6--MYH9    ACPP--MYH9    ACTN1--MYH9    ADAM9--MYH9    ADAMTS9--MYH9    AGAP1--MYH9    ALDH3A1--MYH9    ALK--MYH9    ALKBH2--MYH9    APBB1IP--MYH9    ARHGDIB--MYH9    ATP1A1--MYH9    ATP2A2--MYH9    AZU1--MYH9   
BAZ1A--MYH9    BCR--MYH9    BCRP2--MYH9    C7--MYH9    CCDC80--MYH9    CCDC82--MYH9    CCR6--MYH9    CD151--MYH9    CD99--MYH9    CDK6--MYH9    CDKN1A--MYH9    CHD2--MYH9    CHMP2B--MYH9    CPB1--MYH9    CSF2RB--MYH9   
CYTOCHROME_B--MYH9    DBN1--MYH9    DDX17--MYH9    DMXL1--MYH9    DPY19L2--MYH9    DST--MYH9    EEF1A1--MYH9    EEF1G--MYH9    EEF2--MYH9    EIF3D--MYH9    EMP2--MYH9    EPAS1--MYH9    FGFR2--MYH9    FKBP5--MYH9    FLNA--MYH9   
FOXRED2--MYH9    GALNT10--MYH9    GOLIM4--MYH9    GPX3--MYH9    HBA1--MYH9    HIRA--MYH9    HYOU1--MYH9    IFT46--MYH9    IGF2--MYH9    IGFBP3--MYH9    IGFBP5--MYH9    IGHG1--MYH9    IGHM--MYH9    IGKC--MYH9    IL2RB--MYH9   
IPO7--MYH9    IRX3--MYH9    ITGA5--MYH9    KANK1--MYH9    KAT8--MYH9    KRT1--MYH9    KRT14--MYH9    KRT16--MYH9    KRT5--MYH9    LYZ--MYH9    MEG3--MYH9    MGAT1--MYH9    MGEA5--MYH9    MGP--MYH9    MLLT6--MYH9   
MST4--MYH9    MTMR3--MYH9    MYH11--MYH9    MYH9--6-MAR    MYH9--AAAS    MYH9--ACTB    MYH9--ACTG1    MYH9--AGAP3    MYH9--ALK    MYH9--ANKS1A    MYH9--AP2B1    MYH9--APOD    MYH9--ATP6V0B    MYH9--B2M    MYH9--BIRC6   
MYH9--C20ORF96    MYH9--C6ORF228    MYH9--CACNA1C    MYH9--CACNG2    MYH9--CCDC80    MYH9--CCNDBP1    MYH9--CD74    MYH9--CD81    MYH9--CFDP1    MYH9--CFP    MYH9--CHCHD3    MYH9--CNPY2    MYH9--CTSH    MYH9--CXCR4    MYH9--CYB5R3   
MYH9--DDB1    MYH9--DDX21    MYH9--DICER1    MYH9--DMPK    MYH9--DNASE1    MYH9--DOT1L    MYH9--EIF3D    MYH9--EXOC3    MYH9--FAM160A2    MYH9--FLNA    MYH9--FN1    MYH9--FOXRED2    MYH9--GAS6    MYH9--GNAS    MYH9--GPNMB   
MYH9--GRAP2    MYH9--HSP90AA1    MYH9--IGHG1    MYH9--JUP    MYH9--KLK3    MYH9--KRT10    MYH9--KRT14    MYH9--KRT17    MYH9--MAP2K2    MYH9--MITD1    MYH9--MRPS12    MYH9--MYH9    MYH9--MYO18B    MYH9--NARF    MYH9--NAT10   
MYH9--NCL    MYH9--NDE1    MYH9--NDUFA7    MYH9--NDUFV1    MYH9--NFYC    MYH9--NPTX2    MYH9--NUCB1    MYH9--ORAOV1    MYH9--PCSK7    MYH9--PGS1    MYH9--PIH1D1    MYH9--PITHD1    MYH9--PKM2    MYH9--PLA2G6    MYH9--PLAT   
MYH9--PLIN4    MYH9--PML    MYH9--PRH1    MYH9--PRH1-PRR4    MYH9--PRH2    MYH9--PSMD1    MYH9--PSME1    MYH9--PVALB    MYH9--PXDN    MYH9--QSOX1    MYH9--RAPGEF1    MYH9--RBBP7    MYH9--RBM10    MYH9--RP5-1119A7.14.1    MYH9--RPL13A   
MYH9--RPS19    MYH9--SERPINA1    MYH9--SFTPA2    MYH9--SFTPC    MYH9--SLC44A4    MYH9--SMR3B    MYH9--SREBF2    MYH9--SSR3    MYH9--TAF1C    MYH9--TAGLN    MYH9--TG    MYH9--TNNT2    MYH9--TPM2    MYH9--TRB@    MYH9--TTC28   
MYH9--TXN2    MYH9--UBB    MYH9--USP5    MYH9--USP6    MYH9--VIM    MYH9--VMP1    MYH9--WSB1    MYH9--ZNF362    MYL9--MYH9    NPC1--MYH9    NUBP2--MYH9    OS9--MYH9    PDLIM7--MYH9    PIGR--MYH9    PLAT--MYH9   
PLS3--MYH9    PLXNB3--MYH9    PPARA--MYH9    PPARD--MYH9    PPP1R7--MYH9    PRKRA--MYH9    PROM2--MYH9    PROSC--MYH9    PSMA1--MYH9    PTMS--MYH9    PTPN18--MYH9    RAB2A--MYH9    RAC2--MYH9    RASAL3--MYH9    RBFOX2--MYH9   
RNF220--MYH9    RPL11--MYH9    RPL13--MYH9    RPS19BP1--MYH9    RPS20--MYH9    RPS24--MYH9    SDC1--MYH9    SECISBP2--MYH9    SELM--MYH9    SMR3B--MYH9    SPRED2--MYH9    SPTB--MYH9    SUMF2--MYH9    TAGLN--MYH9    TGFBI--MYH9   
TMEM41A--MYH9    TNKS1BP1--MYH9    TPM2--MYH9    TPT1--MYH9    TSPAN3--MYH9    TTN-AS1--MYH9    UBTF--MYH9    USP15--MYH9    USP6--MYH9    WDR46--MYH9    WDR60--MYH9    XRCC5--MYH9    ZKSCAN1--MYH9   
Fusion : QuiverMYH9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMYH9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MYH9
dbVarMYH9
ClinVarMYH9
1000_GenomesMYH9 
Exome Variant ServerMYH9
ExAC (Exome Aggregation Consortium)ENSG00000100345
GNOMAD BrowserENSG00000100345
Varsome BrowserMYH9
Genetic variants : HAPMAP4627
Genomic Variants (DGV)MYH9 [DGVbeta]
DECIPHERMYH9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMYH9 
Mutations
ICGC Data PortalMYH9 
TCGA Data PortalMYH9 
Broad Tumor PortalMYH9
OASIS PortalMYH9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMYH9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMYH9
Mutations and Diseases : HGMDMYH9
intOGen PortalMYH9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MYH9
DgiDB (Drug Gene Interaction Database)MYH9
DoCM (Curated mutations)MYH9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MYH9 (select a term)
intoGenMYH9
NCG5 (London)MYH9
Cancer3DMYH9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM155100    160775    603622   
Orphanet18198    12046   
DisGeNETMYH9
MedgenMYH9
Genetic Testing Registry MYH9
NextProtP35579 [Medical]
TSGene4627
GENETestsMYH9
Target ValidationMYH9
Huge Navigator MYH9 [HugePedia]
snp3D : Map Gene to Disease4627
BioCentury BCIQMYH9
ClinGenMYH9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4627
Chemical/Pharm GKB GenePA31377
Clinical trialMYH9
Miscellaneous
canSAR (ICR)MYH9 (select the gene name)
DataMed IndexMYH9
Probes
Litterature
PubMed409 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMYH9
EVEXMYH9
GoPubMedMYH9
iHOPMYH9
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jan 27 14:00:03 CET 2020
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.