| Note | |
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| Entity | Alzheimer's disease |
| Disease | Alzheimer's disease is the most common cause of dementia. Dementia is a collective name for progressive degenerative brain syndromes, which affect memory, thinking, behavior and emotion. Symptoms may include: 1) lose of memory ; 2) difficulty in finding the right words or understanding what people are saying; 3) difficulty in performing previously routine tasks; 4) personality and mood changes. |
| Prognosis | The probable outcome is poor. The disorder is usually not acute, but progresses steadily. Total disability is common. Death normally occurs within 15 years, usually from an infection or a failure of other body systems. The duration of illness, from onset of symptoms to death, averages 8 to 10 years |
| Hybrid/Mutated Gene | NDRG2 is upregulated at both the RNA and protein levels in AD brains. Expression of NDRG2 in affected brains was revealed in : (1) cortical pyramidal neurons, (2) senile plaques and (3) cellular processes of dystrophic neurons. NDRG2 upregulation is associated with disease pathogenesis in the human brain |
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| Entity | Liver cancers |
| Disease | Liver cancers are primary liver tumors (hepatoma/hepatocellular carcinoma, bile duct cancer/cholangio-carcinoma) or metastatic liver tumor. |
| Oncogenesis | Compared with adjacent normal tissues, the expression levels of NDRG2 mRNA in liver cancer tissues reduced significantly, but the mutation in the whole coding region of NDRG2 was not found. |
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| Entity | Glioblastoma |
| Disease | Glioblastoma multiforme (GBM) is the most aggressive form of the primary brain tumors known collectively as gliomas. These tumors arise from the supporting, glial cells of the brain during childhood and in adults. These growths do not spread throughout the body like other forms of cancer, but cause symptoms by invading the brain.NDRG2 gene was first found in this tissue by using subtraction cloning. |
| Oncogenesis | Ndrg2 is present at low levels in human GBM tissues and glioblastoma cell lines comparing with normal tissue and cells. Transient transfection exogenous NDRG2 gene will inhibits glioblastoma U373 and U138 cells proliferation. |
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| Entity | Gastric cancer |
| Disease | Gastric cancer is the result of cell changes in the lining of the stomach. The most common types of stomach cancer start in the glandular cells of the stomach lining and are known as adenocarcinomas. These are rare cancers that usually start from the cells of the muscle layer of the stomach. The most common type of sarcoma to affect the stomach is a leiomyosarcoma. Another type of sarcoma is a gastrointestinal stromal tumour (GIST). |
| Oncogenesis | Ndrg2 is present at low level in some stomach cancer tissue and cell lines. |
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