NIN ninein (GSK3B interacting protein)

Other names	GSK3B-interacting protein
	Glycogen synthase kinase 3 beta-interacting protein
	KIAA1565
	Ninein centrosomal protein.
HGNC (Hugo)	NIN
LocusID (NCBI)	51199
Atlas_Id	176
Location	14q22.1  [Link to chromosome band 14q22]
Location_base_pair	Starts at 51192546 and ends at 51297839 bp from pter ( according to hg19-Feb_2009)  [Mapping NIN.png]
Local_order	SAV1 (SAlvador homolog 1 Drosophila) is more centromeric. C14orf29 (Chromosome 14 Open Reading Frame 29) is more telomeric.
	Genomic structure of NIN. Black boxes indicate exons.

Note	Ninein (GSK3B interacting protein)
	Schematic representation of NIN. LZ: leuzine-zipper domain. Coiled-coil domains are indicated with asterisks.
Description	Homooligomer. Interacts with GSK3B (GSK3-beta) via its C-terminus domain, ait also interacts with C14ORF166 preventing its phosphorylation by GSK3-beta. NIN is a component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. In interphase cells, it is localized in the centrosome. Decreases in metaphase and anaphase and reappears in telophase.
Expression	Ubiquitous. Highly expressed in heart and skeletal muscle.
Localisation	Centrosome.
Function	The centrosome is the major microtubulin-organizing center (MTOC) in most vertebrate cells. In a typical somatic cell, the centrosome is composed of a pair of centrioles surrounded by a mass of amorphous pericentriolar material (PCM) that may be involved in the complex of Y-tubulin, centrin, pericentrin and ninein. This protein play an important role as a microtubule minus-end capping, centriole position, anchoring factor and as a centrosome maturation factor. Localization of this protein to the centrosome requires three of its four leucine zippers in the central coiled-coil domain. In addition it has been suggested that ninein could play a role to ensure equal chromosome segregation prior to telophase/cytokinesis in the division cycle.
Homology	It presents homology in various species. It also belongs to ENSF00000001557 protein family.

Implicated in

Note
Entity	t(5;14)(q33;q24) , 5q33 myeloproliferative disease.
Disease	Chronic myeloproliferative disorder with eosinophilia and skin lesions ( "Atypical CML").
Prognosis	Good. Relative mild disease course over at least 13 years. Imatinib mesylate responsive disease.
Cytogenetics	t(5;14)(q33;q24)
Hybrid/Mutated Gene	5' NIN-PDGFRB 3'
Abnormal Protein	NIN-PDGFRB
	Schematic representation of the fusion NIN-PDGFRB consecuence of the t(5;14)(q33;q24) in a chronic myeloprolifetrative disorder with eosinophilia. From up to down: PDGFRB, NIN and the putative chimeric NIN-PDGFRB structure. TM, transmembrane domain; TK, tyrosine kinase domain; LZ, leuzine-zipper domain. Coiled coil domains on NIN and NIN-PDGFRB are indicated with asterisks.

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