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NUP98 (nucleoporin 98 kDa)

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated1998-11Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2002-03Lyndal Kearney
Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK

(Note : for Links provided by Atlas : click)

Identity

Alias_namesnucleoporin 98kDa
Alias_symbol (synonym)NUP96
Other alias
HGNC (Hugo) NUP98
LocusID (NCBI) 4928
Atlas_Id 63
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 3675010 and ends at 3797792 bp from pter ( according to hg19-Feb_2009)  [Mapping NUP98.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADD3 (10q25.1) / NUP98 (11p15.4)ANKRD28 (3p25.1) / NUP98 (11p15.4)C11orf49 (11p11.2) / NUP98 (11p15.4)
CACNB2 (10p12.33) / NUP98 (11p15.4)CUX1 (7q22.1) / NUP98 (11p15.4)DDX10 (11q22.3) / NUP98 (11p15.4)
HOXA1 (7p15.2) / NUP98 (11p15.4)HOXA11 (7p15.2) / NUP98 (11p15.4)HOXA13 (7p15.2) / NUP98 (11p15.4)
HOXA9 (7p15.2) / NUP98 (11p15.4)HOXC11 (12q13.13) / NUP98 (11p15.4)HOXC12 (12q13.13) / NUP98 (11p15.4)
HOXC13 (12q13.13) / NUP98 (11p15.4)HOXD1 (2q31.1) / NUP98 (11p15.4)HOXD11 (2q31.1) / NUP98 (11p15.4)
HOXD13 (2q31.1) / NUP98 (11p15.4)KDM5A (12p13.33) / NUP98 (11p15.4)MIA3 (1q41) / NUP98 (11p15.4)
NSD1 (5q35.2) / NUP98 (11p15.4)NSD1 (5q35.3) / NUP98 (11p15.4)NSD3 (8p11.23) / NUP98 (11p15.4)
NUP98 (11p15.4) / ADD3 (10q25.1)NUP98 (11p15.4) / BPTF (17q24.2)NUP98 (11p15.4) / CCDC28A (6q24.1)
NUP98 (11p15.4) / CUX1 (7q22.1)NUP98 (11p15.4) / DDX10 (11q22.3)NUP98 (11p15.4) / FN1 (2q35)
NUP98 (11p15.4) / HHEX (10q23.33)NUP98 (11p15.4) / HMGB3 (Xq28)NUP98 (11p15.4) / HOXA1 (7p15.2)
NUP98 (11p15.4) / HOXA11 (7p15.2)NUP98 (11p15.4) / HOXA13 (7p15.2)NUP98 (11p15.4) / HOXA9 (7p15.2)
NUP98 (11p15.4) / HOXC11 (12q13.13)NUP98 (11p15.4) / HOXC12 (12q13.13)NUP98 (11p15.4) / HOXC13 (12q13.13)
NUP98 (11p15.4) / HOXD1 (2q31.1)NUP98 (11p15.4) / HOXD11 (2q31.1)NUP98 (11p15.4) / HOXD13 (2q31.1)
NUP98 (11p15.4) / IQCG (3q29)NUP98 (11p15.4) / KDM5A (12p13.33)NUP98 (11p15.4) / KMT2A (11q23.3)
NUP98 (11p15.4) / LNP1 (3q12.2)NUP98 (11p15.4) / NSD1 (5q35.2)NUP98 (11p15.4) / NSD1 (5q35.3)
NUP98 (11p15.4) / NSD3 (8p11.23)NUP98 (11p15.4) / NUP98 (11p15.4)NUP98 (11p15.4) / PDC (1q31.1)
NUP98 (11p15.4) / PHF23 (17p13.1)NUP98 (11p15.4) / POU1F1 (3p11.2)NUP98 (11p15.4) / PRRX1 (1q24.2)
NUP98 (11p15.4) / PRRX2 (9q34.11)NUP98 (11p15.4) / PSIP1 (9p22.3)NUP98 (11p15.4) / RAP1GDS1 (4q23)
NUP98 (11p15.4) / RARG (12q13.13)NUP98 (11p15.4) / RHOG (11p15.4)NUP98 (11p15.4) / SET (9q34.11)
NUP98 (11p15.4) / SETBP1 (18q12.3)NUP98 (11p15.4) / SRGAP2B (1p11.2)NUP98 (11p15.4) / TMEM117 (12q12)
NUP98 (11p15.4) / TNFRSF1B (1p36.22)NUP98 (11p15.4) / TOP1 (20q12)NUP98 (11p15.4) / TOP2B (3p24.2)
NUP98 (11p15.4) / ZFP69B (1p34.2)PRRX1 (1q24.2) / NUP98 (11p15.4)PSIP1 (9p22.3) / NUP98 (11p15.4)
RAP1GDS1 (4q23) / NUP98 (11p15.4)SETBP1 (18q12.3) / NUP98 (11p15.4)STIM1 (11p15.4) / NUP98 (11p15.4)
TOP1 (20q12) / NUP98 (11p15.4)TOP2B (3p24.2) / NUP98 (11p15.4)ZNF141 (4p16.3) / NUP98 (11p15.4)
Note see also The nuclear pore complex: structure and function

DNA/RNA

Transcription 3.6, 6.5 , 7.0 kb mRNA

Protein

 
  NUP98 protein; NUP98 contains a Gly-Leu-Phe-Gly (GLFG and FG) repeat in N-term (aa 1-156), a GLEBS-like motif (which binds RAE1, aa 157-213), another FG motif (aa 214-480) and a RNA binding motif in C-term (aa 738-880). NUP98 is involved in nuclear import/export, mitotic progression, and regulation of gene expression
Description 920 amino acids; 97 kDa; contains repeated motifs (GLFG and FG) in N-term and a RNA binding motif in C-term
Expression wide
Localisation nuclear membrane localisation
Function nucleoporin: associated with the nuclear pore complex; role in nucleocytoplasmic transport processes
Homology member of the GLFG nucleoporins

Implicated in

Note
  
Entity inv (11)(p15q22)/ myelodysplasic syndrome (MDS) or acute non lymphocytic leukemia (AML) --> NUP98-DDX10
Disease therapy related MDS (t-MDS) and AML; de novo AML
Hybrid/Mutated Gene 5' NUP98 - 3' DDX10
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the acidic domain of DDX10
  
  
Entity t(1;11)(q23;p15.5) / t-MDS orAML --> NUP98 -PMX1
Disease One case of t-AML
Hybrid/Mutated Gene 5' NUP98 - 3' PMX1
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the homeodomain of PMX1
  
  
Entity t(2;11)(q31;p15)/treatment related leukaemia --> NUP98 -HOXD13
Disease so far, only 1 case of treatment related myelodysplasia evolving towards M6 acute myeloid leukemia
Hybrid/Mutated Gene 5' NUP98 - 3' HOXD13
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the HOXD13 homeodomain
  
  
Entity t(4;11)(q21;p15.5)/ T- acute lymphoblastic leukemia (ALL) --> NUP98 -RAP1GDS1
Disease 3 cases of adult T-ALL
Hybrid/Mutated Gene 5' NUP98 - 3' RAP1GDS1
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the entire coding region of RAP1GDS1. The product, rap1gds, has guanine nucleotide exchange factor activity.
  
  
Entity t(5;11)(q35;p15.5)/ AML--> NUP98 -NSD1
Disease AML. 5 cases reported to date. All were children or young adults (age range 3-18 years). Note that the t(5;11)(q35;p15.5) is not detectable by G-banding. Three cases were reported as cryptic t(5;11) associated with del(5q); a further two cases were identified in apparently normal karyotypes.
Hybrid/Mutated Gene 5' NUP98 - 3' NSD1
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the conserved SET, SAC and PHD finger domains of the NSD1 gene.
  
  
Entity t(7;11)(p15;p15) /AML --> NUP98 -HOXA9
Disease M2-M4 AML mostly; occasionally: CML-like cases
Prognosis mean survival: 15 mths
Cytogenetics sole anomaly most often
Hybrid/Mutated Gene 5' NUP98 - 3' HOXA9
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the HOXA9 homeobox
  
  
Entity t(9;11)(p22;p15.5)/AML--> NUP98 -LEDGF
Disease One case of de novo AML
Hybrid/Mutated Gene 5' NUP98 - 3' LEDGF
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the COOH terminal of the LEDGF gene (encoding transcriptional activators p52 and p75)
  
  
Entity t(11;12)(p15;q13)/treatment related leukemia (t-AML/MDS)
Disease 1patient with t-MDS/AML
Hybrid/Mutated Gene 5'; NUP98 - 3'; unknown
  
  
Entity t(11;17)(p15.5;q21) t-MDS/AML
Disease 1 patient with t-MDS/AML
Hybrid/Mutated Gene 5' NUP98 - 3' unknown
  
  
Entity t(11;20)(p15.5;q11)/AML, t-MDS/AML--> NUP98 -TOP1
Disease AML, t-MDS/AML
Hybrid/Mutated Gene 5' NUP98 - 3' TOP1
Abnormal Protein fuses the GLFG repeat domains of NUP98 to the catalytic domain of TOP1
  

Breakpoints

 

Bibliography

Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.
Ahuja HG, Felix CA, Aplan PD
Genes, chromosomes & cancer. 2000 ; 29 (2) : 96-105.
PMID 10959088
 
t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).
Ahuja HG, Hong J, Aplan PD, Tcheurekdjian L, Forman SJ, Slovak ML
Cancer research. 2000 ; 60 (22) : 6227-6229.
PMID 11103774
 
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M
Blood. 1997 ; 89 (11) : 3936-3944.
PMID 9166830
 
A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay.
Brown J, Jawad M, Twigg SR, Saracoglu K, Sauerbrey A, Thomas AE, Eils R, Harbott J, Kearney L
Blood. 2002 ; 99 (7) : 2526-2531.
PMID 11895789
 
The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.
Hussey DJ, Nicola M, Moore S, Peters GB, Dobrovic A
Blood. 1999 ; 94 (6) : 2072-2079.
PMID 10477737
 
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.
Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K, Cross NC, Cheng JF, Aplan PD, Kearney L, Boultwood J, Wainscoat JS
Blood. 2001 ; 98 (4) : 1264-1267.
PMID 11493482
 
A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG)
Jaju RJ, Haas OA, Neat M, Harbott J, Saha V, Boultwood J, Brown JM, Pirc-Danoewinata H, Krings BW, Müller U, Morris SW, Wainscoat JS, Kearney L
Blood. 1999 ; 94 (2) : 773-780.
PMID 10397745
 
NUP98 gene fusions in hematologic malignancies.
Lam DH, Aplan PD
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2001 ; 15 (11) : 1689-1695.
PMID 11681408
 
NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).
Nakamura T, Yamazaki Y, Hatano Y, Miura I
Blood. 1999 ; 94 (2) : 741-747.
PMID 10397741
 
The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways.
Powers MA, Forbes DJ, Dahlberg JE, Lund E
The Journal of cell biology. 1997 ; 136 (2) : 241-250.
PMID 9015297
 
NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia.
Raza-Egilmez SZ, Jani-Sait SN, Grossi M, Higgins MJ, Shows TB, Aplan PD
Cancer research. 1998 ; 58 (19) : 4269-4273.
PMID 9766650
 

Citation

This paper should be referenced as such :
Kearney, L
NUP98 (nucleoporin 98 kDa)
Atlas Genet Cytogenet Oncol Haematol. 2002;6(3):193-196.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/NUPID98.html
History of this paper:
Jean-Loup Huret. NUP98 (nucleoporin 98 kDa). Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):7-7.
http://documents.irevues.inist.fr/bitstream/handle/2042/32093/01-1998-NUPID98.pdf
Huret, JL. NUP98 (nucleoporin 98 kDa). Atlas Genet Cytogenet Oncol Haematol. 1999;3(1):15-16.
http://documents.irevues.inist.fr/bitstream/handle/2042/37478/11-1998-NUP98.pdf
Huret, JL. NUP98 (nucleoporin 98 kDa). Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):14-15.
http://documents.irevues.inist.fr/bitstream/handle/2042/37583/02-2000-NUP98.pdf


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 44 ]
  8p11 myeloproliferative syndrome (FGFR1)
inv(11)(p15q22) NUP98/DDX10::t(11;11)(p15;q22) NUP98/DDX10
inv(11)(p15q23) NUP98/KMT2A
t(1;11)(q24;p15) NUP98/PRRX1

t(3;11)(p11;p15) NUP98/POU1F1
t(3;11)(p25;p15) ANKRD28/NUP98
t(3;11)(q12;p15) NUP98/LNP1
t(3;11)(q29;p15) NUP98/IQCG
t(4;11)(q21;p15) NUP98/RAP1GDS1
t(4;11)(q23;p15) NUP98/RAP1GDS1
t(5;11)(q35;p15.5) NUP98/NSD1
t(6;11)(q24.1;p15.5) NUP98/CCDC28A
t(7;11)(p15;p15) NUP98/HOXA9
t(7;11)(p15;p15) NUP98/HOXA13
t(8;11)(p11;p15) NUP98/WHSC1L1
t(9;11)(p22;p15) NUP98/PSIP1
t(9;11)(q34;p15) NUP98/PRRX2
t(X;11)(q28;p15) NUP98/HMGB3
t(10;11)(q25;p15) NUP98/ADD3
t(11;12)(p15;q13) NUP98/HOXC11::t(11;12)(p15;q13) NUP98/HOXC13
t(11;12)(p15;p13) NUP98/KDM5A
t(11;17)(p15;p13) NUP98/PHF23
t(11;17)(p15;q21) NUP98/?
t(11;18)(p15;q12) NUP98/SETBP1
t(11;20)(p15;q11) NUP98/TOP1
t(1;11)(q24;p15) NUP98/PRRX1
t(2;11)(q31;p15) NUP98/HOXD13
t(3;11)(p24;p15) NUP98/TOP2B
t(5;11)(q35;p15) NSD1/NUP98
t(5;11)(q35;p15) NUP98/NSD1
t(6;11)(q24;p15) CCDC28A/NUP98
t(7;11)(p15;p15) NUP98/HOXA11
t(8;11)(p12;p15) NUP98/NSD3
t(9;11)(p22;p15) PSIP1/NUP98
t(10;11)(q23;p15) NUP98/HHEX
t(11;11)(p15;q23) NUP98/CADM1
t(11;12)(p15;q13) NUP98/HOXC13
t(11;12)(p15;q13) NUP98/RARG
t(11;12)(p15;q13) NUP98/HOXC11
t(11;12)(p15;q13) NUP98/HOXC13
t(11;12)(p15;q13) NUP98/RARG
t(11;17)(p15;q24) NUP98/BPTF
t(11;20)(p15;q12) NUP98/TOP1


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(11;11)(p11;p15) C11orf49/NUP98
NUP98/RHOG (11p15)
STIM1/NUP98 (11p15)
t(11;12)(p15;q12) NUP98/TMEM117


External links

Nomenclature
HGNC (Hugo)NUP98   8068
Cards
AtlasNUPID98
Entrez_Gene (NCBI)NUP98  4928  nucleoporin 98
AliasesADIR2; NUP196; NUP96
GeneCards (Weizmann)NUP98
Ensembl hg19 (Hinxton)ENSG00000110713 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110713 [Gene_View]  ENSG00000110713 [Sequence]  chr11:3675010-3797792 [Contig_View]  NUP98 [Vega]
ICGC DataPortalENSG00000110713
TCGA cBioPortalNUP98
AceView (NCBI)NUP98
Genatlas (Paris)NUP98
WikiGenes4928
SOURCE (Princeton)NUP98
Genetics Home Reference (NIH)NUP98
Genomic and cartography
GoldenPath hg38 (UCSC)NUP98  -     chr11:3675010-3797792 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NUP98  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathNUP98 - 11p15.4 [CytoView hg19]  NUP98 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000110713
Mapping of homologs : NCBINUP98 [Mapview hg19]  NUP98 [Mapview hg38]
OMIM601021   
Gene and transcription
Genbank (Entrez)AB040538 AF071076 AF071077 AF116074 AF231130
RefSeq transcript (Entrez)NM_001365125 NM_001365126 NM_001365127 NM_001365128 NM_001365129 NM_005387 NM_016320 NM_139131 NM_139132
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NUP98
Cluster EST : UnigeneHs.524750 [ NCBI ]
CGAP (NCI)Hs.524750
Alternative Splicing GalleryENSG00000110713
Gene ExpressionNUP98 [ NCBI-GEO ]   NUP98 [ EBI - ARRAY_EXPRESS ]   NUP98 [ SEEK ]   NUP98 [ MEM ]
Gene Expression Viewer (FireBrowse)NUP98 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4928
GTEX Portal (Tissue expression)NUP98
Human Protein AtlasENSG00000110713-NUP98 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52948   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52948  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52948
Splice isoforms : SwissVarP52948
PhosPhoSitePlusP52948
Domaine pattern : Prosite (Expaxy)NUP_C (PS51434)   
Domains : Interpro (EBI)Nucleoporin_S59-like    Nup96    NUP98-NUP96    Peptidase_S59    Peptidase_S59_sf   
Domain families : Pfam (Sanger)Nucleoporin2 (PF04096)    Nup96 (PF12110)   
Domain families : Pfam (NCBI)pfam04096    pfam12110   
Conserved Domain (NCBI)NUP98
DMDM Disease mutations4928
Blocks (Seattle)NUP98
PDB (RSDB)1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
PDB Europe1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
PDB (PDBSum)1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
PDB (IMB)1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
Structural Biology KnowledgeBase1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
SCOP (Structural Classification of Proteins)1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
CATH (Classification of proteins structures)1KO6    2Q5X    2Q5Y    3MMY    4OWR    5A9Q   
SuperfamilyP52948
Human Protein Atlas [tissue]ENSG00000110713-NUP98 [tissue]
Peptide AtlasP52948
HPRD03012
IPIIPI00006038   IPI00216688   IPI00337395   IPI00936708   IPI00337397   IPI00953181   IPI00337396   IPI01011651   IPI00976440   IPI00985139   IPI00977013   IPI00983474   IPI00974141   IPI00980841   
Protein Interaction databases
DIP (DOE-UCLA)P52948
IntAct (EBI)P52948
FunCoupENSG00000110713
BioGRIDNUP98
STRING (EMBL)NUP98
ZODIACNUP98
Ontologies - Pathways
QuickGOP52948
Ontology : AmiGOkinetochore  posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery  transcription coactivator activity  RNA binding  mRNA binding  transporter activity  protein binding  nuclear envelope  nuclear envelope  nuclear pore  nuclear pore  nucleoplasm  nucleoplasm  cytosol  DNA replication  RNA export from nucleus  mRNA export from nucleus  proteolysis  protein import into nucleus  nucleocytoplasmic transport  nuclear pore organization  nuclear localization sequence binding  serine-type peptidase activity  viral process  nuclear body  structural constituent of nuclear pore  structural constituent of nuclear pore  structural constituent of nuclear pore  nuclear pore outer ring  nuclear pore outer ring  nuclear membrane  telomere tethering at nuclear periphery  nuclear periphery  nuclear inclusion body  intracellular membrane-bounded organelle  nuclear pore cytoplasmic filaments  nuclear pore nuclear basket  positive regulation of mRNA splicing, via spliceosome  nuclear pore complex assembly  positive regulation of nucleic acid-templated transcription  promoter-specific chromatin binding  ribonucleoprotein complex  
Ontology : EGO-EBIkinetochore  posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery  transcription coactivator activity  RNA binding  mRNA binding  transporter activity  protein binding  nuclear envelope  nuclear envelope  nuclear pore  nuclear pore  nucleoplasm  nucleoplasm  cytosol  DNA replication  RNA export from nucleus  mRNA export from nucleus  proteolysis  protein import into nucleus  nucleocytoplasmic transport  nuclear pore organization  nuclear localization sequence binding  serine-type peptidase activity  viral process  nuclear body  structural constituent of nuclear pore  structural constituent of nuclear pore  structural constituent of nuclear pore  nuclear pore outer ring  nuclear pore outer ring  nuclear membrane  telomere tethering at nuclear periphery  nuclear periphery  nuclear inclusion body  intracellular membrane-bounded organelle  nuclear pore cytoplasmic filaments  nuclear pore nuclear basket  positive regulation of mRNA splicing, via spliceosome  nuclear pore complex assembly  positive regulation of nucleic acid-templated transcription  promoter-specific chromatin binding  ribonucleoprotein complex  
Pathways : KEGGRNA transport    Influenza A   
NDEx NetworkNUP98
Atlas of Cancer Signalling NetworkNUP98
Wikipedia pathwaysNUP98
Orthology - Evolution
OrthoDB4928
GeneTree (enSembl)ENSG00000110713
Phylogenetic Trees/Animal Genes : TreeFamNUP98
HOGENOMP52948
Homologs : HomoloGeneNUP98
Homology/Alignments : Family Browser (UCSC)NUP98
Gene fusions - Rearrangements
Fusion : MitelmanANKRD28/NUP98 [3p25.1/11p15.4]  [t(3;5;11)(p25;q35;p15)]  
Fusion : MitelmanC11orf49/NUP98 [11p11.2/11p15.4]  [t(11;11)(p11;p15)]  
Fusion : MitelmanNSD1/NUP98 [5q35.2/11p15.4]  [t(5;11)(q35;p15)]  
Fusion : MitelmanNUP98/ADD3 [11p15.4/10q25.1]  [t(10;11)(q25;p15)]  
Fusion : MitelmanNUP98/CCDC28A [11p15.4/6q24.1]  [t(6;11)(q24;p15)]  
Fusion : MitelmanNUP98/DDX10 [11p15.4/11q22.3]  [inv(11)(p15q22)]  
Fusion : MitelmanNUP98/HHEX [11p15.4/10q23.33]  [t(10;11)(q23;p15)]  
Fusion : MitelmanNUP98/HOXA11 [11p15.4/7p15.2]  [t(7;11)(p15;p15)]  
Fusion : MitelmanNUP98/HOXA13 [11p15.4/7p15.2]  [t(7;11)(p15;p15)]  
Fusion : MitelmanNUP98/HOXA9 [11p15.4/7p15.2]  [t(7;11)(p15;p15)]  
Fusion : MitelmanNUP98/HOXC11 [11p15.4/12q13.13]  [t(11;12)(p15;q13)]  
Fusion : MitelmanNUP98/HOXC13 [11p15.4/12q13.13]  [t(11;12)(p15;q13)]  
Fusion : MitelmanNUP98/HOXD11 [11p15.4/2q31.1]  [t(2;11)(q31;p15)]  
Fusion : MitelmanNUP98/HOXD13 [11p15.4/2q31.1]  [t(2;11)(q31;p15)]  
Fusion : MitelmanNUP98/IQCG [11p15.4/3q29]  [t(3;11)(q29;p15)]  
Fusion : MitelmanNUP98/KDM5A [11p15.4/12p13.33]  [t(11;12)(p15;p13)]  [t(11;21;12)(p15;p13;p13)]  
Fusion : MitelmanNUP98/LNP1 [11p15.4/3q12.2]  [t(3;11)(q12;p15)]  
Fusion : MitelmanNUP98/NSD1 [11p15.4/5q35.2]  [ins(5;11)(q35;p15p13)]  [t(5;11)(q35;p15)]  
[t(5;11;12)(q35;p15;q24)]  
Fusion : MitelmanNUP98/PHF23 [11p15.4/17p13.1]  [t(11;17)(p15;p13)]  
Fusion : MitelmanNUP98/POU1F1 [11p15.4/3p11.2]  [t(3;11)(p11;p15)]  
Fusion : MitelmanNUP98/PRRX1 [11p15.4/1q24.2]  [t(1;11)(q24;p15)]  
Fusion : MitelmanNUP98/PRRX2 [11p15.4/9q34.11]  [t(9;11)(q34;p15)]  
Fusion : MitelmanNUP98/PSIP1 [11p15.4/9p22.3]  [t(9;11)(p22;p15)]  
Fusion : MitelmanNUP98/RAP1GDS1 [11p15.4/4q23]  [t(4;11)(q23;p15)]  
Fusion : MitelmanNUP98/RARG [11p15.4/12q13.13]  [t(11;12)(p15;q13)]  
Fusion : MitelmanNUP98/RHOG [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion : MitelmanNUP98/SETBP1 [11p15.4/18q12.3]  [t(11;18)(p15;q12)]  
Fusion : MitelmanNUP98/TMEM117 [11p15.4/12q12]  [t(11;12)(p15;q12)]  
Fusion : MitelmanNUP98/TOP1 [11p15.4/20q12]  [t(11;20)(p15;q12)]  
Fusion : MitelmanNUP98/TOP2B [11p15.4/3p24.2]  [t(3;11)(p24;p15)]  
Fusion : MitelmanNUP98/WHSC1L1 [11p15.4/8p11.23]  [t(8;11)(p12;p15)]  
Fusion : MitelmanPSIP1/NUP98 [9p22.3/11p15.4]  [t(9;11)(p22;p15)]  
Fusion : MitelmanSTIM1/NUP98 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion : COSMICNUP98 [11p15.4]  -  KDM5A [12p13.33]  [fusion_2291]  [fusion_2292]  [fusion_2294]  
Fusion PortalC11orf49 11p11.2 NUP98 11p15.4 PRAD
Fusion PortalNSD1 5q35.2 NUP98 11p15.4 LAML
Fusion PortalNUP98 11p15.4 NSD1 5q35.2 LAML
Fusion PortalNUP98 11p15.4 RHOG 11p15.4 BRCA
Fusion PortalNUP98 11p15.4 TMEM117 12q12 BRCA
Fusion PortalSTIM1 11p15.4 NUP98 11p15.4 LUAD
Fusion : TICdbANKRD28 [3p25.1]  -  NUP98 [11p15.4]
Fusion : TICdbNUP98 [11p15.4]  -  ADD3 [10q25.1]
Fusion : TICdbNUP98 [11p15.4]  -  CCDC28A [6q24.1]
Fusion : TICdbNUP98 [11p15.4]  -  DDX10 [11q22.3]
Fusion : TICdbNUP98 [11p15.4]  -  HHEX [10q23.33]
Fusion : TICdbNUP98 [11p15.4]  -  HMGB3 [Xq28]
Fusion : TICdbNUP98 [11p15.4]  -  HOXA11 [7p15.2]
Fusion : TICdbNUP98 [11p15.4]  -  HOXA13 [7p15.2]
Fusion : TICdbNUP98 [11p15.4]  -  HOXA9 [7p15.2]
Fusion : TICdbNUP98 [11p15.4]  -  HOXC11 [12q13.13]
Fusion : TICdbNUP98 [11p15.4]  -  HOXC13 [12q13.13]
Fusion : TICdbNUP98 [11p15.4]  -  HOXD11 [2q31.1]
Fusion : TICdbNUP98 [11p15.4]  -  HOXD13 [2q31.1]
Fusion : TICdbNUP98 [11p15.4]  -  IQCG [3q29]
Fusion : TICdbNUP98 [11p15.4]  -  KDM5A [12p13.33]
Fusion : TICdbNUP98 [11p15.4]  -  KMT2A [11q23.3]
Fusion : TICdbNUP98 [11p15.4]  -  LNP1 [3q12.2]
Fusion : TICdbNUP98 [11p15.4]  -  NSD1 [5q35.2]
Fusion : TICdbNUP98 [11p15.4]  -  PRRX1 [1q24.2]
Fusion : TICdbNUP98 [11p15.4]  -  PRRX2 [9q34.11]
Fusion : TICdbNUP98 [11p15.4]  -  PSIP1 [9p22.3]
Fusion : TICdbNUP98 [11p15.4]  -  RAP1GDS1 [4q23]
Fusion : TICdbNUP98 [11p15.4]  -  SETBP1 [18q12.3]
Fusion : TICdbNUP98 [11p15.4]  -  TOP1 [20q12]
Fusion : TICdbNUP98 [11p15.4]  -  WHSC1L1 [8p11.23]
Fusion : FusionGDB21855    24908    25253    25254    25255    25256    25257    25258    25259    25260    25261    25262    25263    25264    25265   
25266    25267    25268    31190    36454    43015    4630    5235    9551   
Fusion : Fusion_HubACACB--NUP98    ADD3--NUP98    AMPD3--NUP98    ANKRD28--NUP98    ASAH1--NUP98    BAI3--NUP98    BPTF--NUP98    C11ORF49--NUP98    C6ORF80--NUP98    CACNA2D3--NUP98    CACNB2--NUP98    CASC4--NUP98    CCDC28A--NUP98    CUX1--NUP98    DDX10--NUP98   
EIF4G3--NUP98    EXOC3--NUP98    FGFR1--NUP98    FOXO1--NUP98    HHEX--NUP98    HMGB3--NUP98    HOX--NUP98    HOX@--NUP98    HOXA1--NUP98    HOXA10--NUP98    HOXA11--NUP98    HOXA13--NUP98    HOXA3--NUP98    HOXA6--NUP98    HOXA9--NUP98   
HOXB3--NUP98    HOXB4--NUP98    HOXC11--NUP98    HOXC12--NUP98    HOXC13--NUP98    HOXD1--NUP98    HOXD11--NUP98    HOXD13--NUP98    HOXD3--NUP98    IQCG--NUP98    JARID1A--NUP98    KDM5A--NUP98    KIAA0368--NUP98    KMT2A--NUP98    LEDGF--NUP98   
LNP1--NUP98    MIA3--NUP98    MLL--NUP98    NEO1--NUP98    NSD1--NUP98    NSD3--NUP98    NUP98--AC087380.14.1    NUP98--ADD3    NUP98--ANKRD28    NUP98--BPTF    NUP98--CCDC28A    NUP98--CHRNA10    NUP98--CUX1    NUP98--DDX10    NUP98--DNHD1   
NUP98--DNM2    NUP98--FKBP5    NUP98--FN1    NUP98--HHEX    NUP98--HMGB3    NUP98--HOX    NUP98--HOXA    NUP98--HOXA1    NUP98--HOXA10    NUP98--HOXA11    NUP98--HOXA13    NUP98--HOXA9    NUP98--HOXC    NUP98--HOXC11    NUP98--HOXC12   
NUP98--HOXC13    NUP98--HOXD    NUP98--HOXD1    NUP98--HOXD11    NUP98--HOXD13    NUP98--IQCG    NUP98--JADE2    NUP98--JARID1A    NUP98--KDM5A    NUP98--KDM5A_ENST00000399788    NUP98--LEDGF    NUP98--LNP1    NUP98--MLL    NUP98--MLXIP    NUP98--NSD   
NUP98--NSD1    NUP98--NSD3    NUP98--NUP98    NUP98--PHF23    NUP98--PIN1    NUP98--PMX1    NUP98--POU1F1    NUP98--PRRX1    NUP98--PRRX2    NUP98--PSIP1    NUP98--RAP1GDS1    NUP98--RARG    NUP98--RHOG    NUP98--RTF1    NUP98--SETBP1   
NUP98--SRGAP2B    NUP98--TMEM117    NUP98--TOP1    NUP98--TOP2B    NUP98--WHSC1L1    P4HB--NUP98    PDS5A--NUP98    PGAP2--NUP98    PHF23--NUP98    PMX1--NUP98    POU1F1--NUP98    PROSC--NUP98    PRRX1--NUP98    PSIP1--NUP98    RAP1GDS1--NUP98   
RARG--NUP98    RCN2--NUP98    SETBP1--NUP98    STIM1--NUP98    STT3A--NUP98    TOP1--NUP98    TOP2B--NUP98    WHSC1L1--NUP98    ZCCHC10--NUP98    ZNF141--NUP98    ZNF195--NUP98    ZNF638--NUP98   
Fusion : QuiverNUP98
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNUP98 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NUP98
dbVarNUP98
ClinVarNUP98
1000_GenomesNUP98 
Exome Variant ServerNUP98
ExAC (Exome Aggregation Consortium)ENSG00000110713
GNOMAD BrowserENSG00000110713
Varsome BrowserNUP98
Genetic variants : HAPMAP4928
Genomic Variants (DGV)NUP98 [DGVbeta]
DECIPHERNUP98 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNUP98 
Mutations
ICGC Data PortalNUP98 
TCGA Data PortalNUP98 
Broad Tumor PortalNUP98
OASIS PortalNUP98 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNUP98  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNUP98
intOGen PortalNUP98
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NUP98
DgiDB (Drug Gene Interaction Database)NUP98
DoCM (Curated mutations)NUP98 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NUP98 (select a term)
intoGenNUP98
NCG5 (London)NUP98
Cancer3DNUP98(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601021   
Orphanet
DisGeNETNUP98
MedgenNUP98
Genetic Testing Registry NUP98
NextProtP52948 [Medical]
TSGene4928
GENETestsNUP98
Target ValidationNUP98
Huge Navigator NUP98 [HugePedia]
snp3D : Map Gene to Disease4928
BioCentury BCIQNUP98
ClinGenNUP98
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4928
Chemical/Pharm GKB GenePA31856
Clinical trialNUP98
Miscellaneous
canSAR (ICR)NUP98 (select the gene name)
DataMed IndexNUP98
Probes
Litterature
PubMed193 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNUP98
EVEXNUP98
GoPubMedNUP98
iHOPNUP98
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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