| Entity | Carcinoma with t(15;19)(q14;p13) translocation. |
| Prognosis | Carcinoma with t(15;19) translocation is invariably fatal with a rapid clinical course when located to the midline thoracic, head and neck structures. One tumor, displaying the cytogenetic and molecular cytogenetic features of carcinoma with t(15;19) translocation, but located to the iliac bone has been reported successfully cured.
It has been suggested that a critical prognostic difference exists between BRD4-NUT/t(15;19) positive tumors and tumors where NUT is rearranged but fused to an as yet unknown partner. |
| Cytogenetics | t(15;19)(q14;p13) [reported breakpoints: t(15;19)(q11-15;p13)]. |
| Hybrid/Mutated Gene | The t(15;19)(q14;p13) results in an BRD4-NUT chimeric gene where exon 10 of BRD4 is fused to exon 2 of NUT. |
| Abnormal Protein | The BRD4-NUT fusion is composed of the N-terminal of BRD4 (amino acids 1-720 out of 1372) and almost the entire protein sequence of NUT (amino acids 6-1127). The N-terminal of BRD4 includes bromodomains 1 and 2 and other, less well characterized functional domains. |
| Oncogenesis | It has been suggested that the oncogenic effect of the NUT-BRD4 fusion is caused not only by the abnormal regulation of NUT by BRD4 promoter elements but also by the consequent ectopic expression of NUT in non-germinal tissues. |
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| Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). |
| Kees UR, Mulcahy MT, Willoughby ML |
| The American journal of pediatric hematology/oncology. 1991 ; 13 (4) : 459-464. |
| PMID 1785673 |
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| BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. |
| French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA |
| Cancer research. 2003 ; 63 (2) : 304-307. |
| PMID 12543779 |
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| Midline carcinoma of children and young adults with NUT rearrangement. |
| French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004 ; 22 (20) : 4135-4139. |
| PMID 15483023 |
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| Carcinoma with t(15;19) translocation. |
| Marx A, French CA, Fletcher JA |
| In.. |
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| Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy. |
| Engleson J, Soller M, Panagopoulos I, Dahlˆ©n A, Dictor M, Jerkeman M |
| BMC cancer. 2006 ; 6 : page 69. |
| PMID 16542442 |
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| Successful treatment of a child with t(15;19)-positive tumor. |
| Mertens F, Wiebe T, Adlercreutz C, Mandahl N, French CA |
| Pediatric blood & cancer. 2007 ; 49 (7) : 1015-1017. |
| PMID 16435379 |
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