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OLIG2 (oligodendrocyte lineage transcription factor)

Identity

Other namesRK17
Olg-2
Bhlhb1
RACK17
HGNC:13226
PRKCBP2
BHLHB1
HGNC (Hugo) OLIG2
LocusID (NCBI) 10215
Location 21q22.11
Location_base_pair Starts at 34398216 and ends at 34401503 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics

DNA/RNA

Note OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.

Protein

Description 329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).
Expression Olig2 is expressed in the ventral thalamus of developing mice.
Function Required for oligodendrocyte and motor neuron specification in the spinal cord.

Implicated in

Entity T-cell lymphoma
Cytogenetics Translocation t(14;21)(q11.2;q22)
Hybrid/Mutated Gene T-cell receptor promoter translocated upstream of OLIG2.
Abnormal Protein none
  
Entity Brain cancer
Disease Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis variable
Cytogenetics No known genetic abnormalities in OLIG2.
Hybrid/Mutated Gene n/a
Oncogenesis OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.
  

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)OLIG2   9398
Cards
AtlasOLIG2ID236
Entrez_Gene (NCBI)OLIG2  10215  oligodendrocyte lineage transcription factor 2
GeneCards (Weizmann)OLIG2
Ensembl hg19 (Hinxton)ENSG00000205927 [Gene_View]  chr21:34398216-34401503 [Contig_View]  OLIG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000205927 [Gene_View]  chr21:34398216-34401503 [Contig_View]  OLIG2 [Vega]
ICGC DataPortalENSG00000205927
cBioPortalOLIG2
AceView (NCBI)OLIG2
Genatlas (Paris)OLIG2
WikiGenes10215
SOURCE (Princeton)OLIG2
Genomic and cartography
GoldenPath hg19 (UCSC)OLIG2  -     chr21:34398216-34401503 +  21q22.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OLIG2  -     21q22.11   [Description]    (hg38-Dec_2013)
EnsemblOLIG2 - 21q22.11 [CytoView hg19]  OLIG2 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIOLIG2 [Mapview hg19]  OLIG2 [Mapview hg38]
OMIM606386   
Gene and transcription
Genbank (Entrez)AF221520 AK091462 AU130620 BC034681 BC036245
RefSeq transcript (Entrez)NM_005806
RefSeq genomic (Entrez)AC_000153 NC_000021 NC_018932 NG_011834 NT_011512 NW_001838706 NW_004929426
Consensus coding sequences : CCDS (NCBI)OLIG2
Cluster EST : UnigeneHs.732068 [ NCBI ]
CGAP (NCI)Hs.732068
Alternative Splicing : Fast-db (Paris)GSHG0019421
Alternative Splicing GalleryENSG00000205927
Gene ExpressionOLIG2 [ NCBI-GEO ]     OLIG2 [ SEEK ]   OLIG2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13516 (Uniprot)
NextProtQ13516  [Medical]
With graphics : InterProQ13516
Splice isoforms : SwissVarQ13516 (Swissvar)
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom   
Related proteins : CluSTrQ13516
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
DMDM Disease mutations10215
Blocks (Seattle)Q13516
Human Protein AtlasENSG00000205927
Peptide AtlasQ13516
HPRD07334
IPIIPI00013699   IPI00853262   
Protein Interaction databases
DIP (DOE-UCLA)Q13516
IntAct (EBI)Q13516
FunCoupENSG00000205927
BioGRIDOLIG2
IntegromeDBOLIG2
STRING (EMBL)OLIG2
Ontologies - Pathways
QuickGOQ13516
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  cytoplasm  transcription from RNA polymerase II promoter  spinal cord motor neuron differentiation  spinal cord oligodendrocyte cell fate specification  thalamus development  myelination  protein homodimerization activity  negative regulation of neuron differentiation  neuron fate commitment  positive regulation of oligodendrocyte differentiation  HMG box domain binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  cytoplasm  transcription from RNA polymerase II promoter  spinal cord motor neuron differentiation  spinal cord oligodendrocyte cell fate specification  thalamus development  myelination  protein homodimerization activity  negative regulation of neuron differentiation  neuron fate commitment  positive regulation of oligodendrocyte differentiation  HMG box domain binding  
Protein Interaction DatabaseOLIG2
DoCM (Curated mutations)OLIG2
Wikipedia pathwaysOLIG2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerOLIG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OLIG2
dbVarOLIG2
ClinVarOLIG2
1000_GenomesOLIG2 
Exome Variant ServerOLIG2
SNP (GeneSNP Utah)OLIG2
SNP : HGBaseOLIG2
Genetic variants : HAPMAPOLIG2
Genomic VariantsOLIG2  OLIG2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000205927 
Cancer Gene: CensusOLIG2 
Somatic Mutations in Cancer : COSMICOLIG2 
CONAN: Copy Number AnalysisOLIG2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)21:34398216-34401503
Mutations and Diseases : HGMDOLIG2
OMIM606386   
MedgenOLIG2
NextProtQ13516 [Medical]
GENETestsOLIG2
Disease Genetic AssociationOLIG2
Huge Navigator OLIG2 [HugePedia]  OLIG2 [HugeCancerGEM]
snp3D : Map Gene to Disease10215
DGIdb (Drug Gene Interaction db)OLIG2
General knowledge
Homologs : HomoloGeneOLIG2
Homology/Alignments : Family Browser (UCSC)OLIG2
Phylogenetic Trees/Animal Genes : TreeFamOLIG2
Chemical/Protein Interactions : CTD10215
Chemical/Pharm GKB GenePA31919
Clinical trialOLIG2
Cancer Resource (Charite)ENSG00000205927
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
CoreMineOLIG2
GoPubMedOLIG2
iHOPOLIG2

Bibliography

The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.
Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3497-3502.
PMID 10737801
 
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.
Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (19) : 10851-10856.
PMID 11526205
 
OLIG2 as a specific marker of oligodendroglial tumour cells.
Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K
Lancet. 2001 ; 358 (9278) : 298-300.
PMID 11498220
 
OLIG-1 and 2 gene expression and oligodendroglial tumours.
Hoang-Xuan K, Aguirre-Cruz L, Mokhtari K, Marie Y, Sanson M
Neuropathology and applied neurobiology. 2002 ; 28 (2) : 89-94.
PMID 11972795
 
Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.
Azzarelli B, Miravalle L, Vidal R
Journal of neuropathology and experimental neurology. 2004 ; 63 (2) : 170-179.
PMID 14989603
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written05-2004David Rowitch
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA

Citation

This paper should be referenced as such :
Rowitch, D
OLIG2 (oligodendrocyte lineage transcription factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):200-200.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/OLIG2ID236.html

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indexed on : Sun Dec 21 03:17:09 CET 2014

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