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OLIG2 (oligodendrocyte lineage transcription factor)

Written2004-05David Rowitch
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPRKCBP2
BHLHB1
protein kinase C binding protein 2
Alias_symbol (synonym)RACK17
OLIGO2
bHLHe19
Other aliasRK17
Olg-2
Bhlhb1
HGNC:13226
HGNC (Hugo) OLIG2
LocusID (NCBI) 10215
Atlas_Id 236
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 33025908 and ends at 33029195 bp from pter ( according to hg19-Feb_2009)  [Mapping OLIG2.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GID4 (17p11.2) / OLIG2 (21q22.11)OLIG2 (21q22.11) / TENM4 (11q14.1)

DNA/RNA

Note OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.

Protein

Description 329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).
Expression Olig2 is expressed in the ventral thalamus of developing mice.
Function Required for oligodendrocyte and motor neuron specification in the spinal cord.

Implicated in

Note
  
Entity T-cell lymphoma
Cytogenetics Translocation t(14;21)(q11.2;q22)
Hybrid/Mutated Gene T-cell receptor promoter translocated upstream of OLIG2.
Abnormal Protein none
  
  
Entity Brain cancer
Disease Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis variable
Cytogenetics No known genetic abnormalities in OLIG2.
Hybrid/Mutated Gene n/a
Oncogenesis OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.
  

Bibliography

Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.
Azzarelli B, Miravalle L, Vidal R
Journal of neuropathology and experimental neurology. 2004 ; 63 (2) : 170-179.
PMID 14989603
 
OLIG-1 and 2 gene expression and oligodendroglial tumours.
Hoang-Xuan K, Aguirre-Cruz L, Mokhtari K, Marie Y, Sanson M
Neuropathology and applied neurobiology. 2002 ; 28 (2) : 89-94.
PMID 11972795
 
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.
Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (19) : 10851-10856.
PMID 11526205
 
OLIG2 as a specific marker of oligodendroglial tumour cells.
Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K
Lancet. 2001 ; 358 (9278) : 298-300.
PMID 11498220
 
The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.
Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3497-3502.
PMID 10737801
 

Citation

This paper should be referenced as such :
Rowitch, D
OLIG2 (oligodendrocyte lineage transcription factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):200-200.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/OLIG2ID236.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;21)(q11;q22) TRA/OLIG2


External links

Nomenclature
HGNC (Hugo)OLIG2   9398
Cards
AtlasOLIG2ID236
Entrez_Gene (NCBI)OLIG2  10215  oligodendrocyte transcription factor 2
AliasesBHLHB1; OLIGO2; PRKCBP2; RACK17; 
bHLHe19
GeneCards (Weizmann)OLIG2
Ensembl hg19 (Hinxton)ENSG00000205927 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205927 [Gene_View]  chr21:33025908-33029195 [Contig_View]  OLIG2 [Vega]
ICGC DataPortalENSG00000205927
TCGA cBioPortalOLIG2
AceView (NCBI)OLIG2
Genatlas (Paris)OLIG2
WikiGenes10215
SOURCE (Princeton)OLIG2
Genetics Home Reference (NIH)OLIG2
Genomic and cartography
GoldenPath hg38 (UCSC)OLIG2  -     chr21:33025908-33029195 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OLIG2  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblOLIG2 - 21q22.11 [CytoView hg19]  OLIG2 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIOLIG2 [Mapview hg19]  OLIG2 [Mapview hg38]
OMIM606386   
Gene and transcription
Genbank (Entrez)AF221520 AK091462 AU130620 BC034681 BC036245
RefSeq transcript (Entrez)NM_005806
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OLIG2
Cluster EST : UnigeneHs.732068 [ NCBI ]
CGAP (NCI)Hs.732068
Alternative Splicing GalleryENSG00000205927
Gene ExpressionOLIG2 [ NCBI-GEO ]   OLIG2 [ EBI - ARRAY_EXPRESS ]   OLIG2 [ SEEK ]   OLIG2 [ MEM ]
Gene Expression Viewer (FireBrowse)OLIG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10215
GTEX Portal (Tissue expression)OLIG2
Human Protein AtlasENSG00000205927-OLIG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13516   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13516  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13516
Splice isoforms : SwissVarQ13516
PhosPhoSitePlusQ13516
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    Olig2   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)OLIG2
DMDM Disease mutations10215
Blocks (Seattle)OLIG2
SuperfamilyQ13516
Human Protein Atlas [tissue]ENSG00000205927-OLIG2 [tissue]
Peptide AtlasQ13516
HPRD07334
IPIIPI00013699   IPI00853262   
Protein Interaction databases
DIP (DOE-UCLA)Q13516
IntAct (EBI)Q13516
FunCoupENSG00000205927
BioGRIDOLIG2
STRING (EMBL)OLIG2
ZODIACOLIG2
Ontologies - Pathways
QuickGOQ13516
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  nucleus  cytoplasm  transcription, DNA-templated  spinal cord motor neuron differentiation  spinal cord oligodendrocyte cell fate specification  thalamus development  myelination  protein homodimerization activity  negative regulation of neuron differentiation  neuron fate commitment  positive regulation of oligodendrocyte differentiation  HMG box domain binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  nucleus  cytoplasm  transcription, DNA-templated  spinal cord motor neuron differentiation  spinal cord oligodendrocyte cell fate specification  thalamus development  myelination  protein homodimerization activity  negative regulation of neuron differentiation  neuron fate commitment  positive regulation of oligodendrocyte differentiation  HMG box domain binding  
NDEx NetworkOLIG2
Atlas of Cancer Signalling NetworkOLIG2
Wikipedia pathwaysOLIG2
Orthology - Evolution
OrthoDB10215
GeneTree (enSembl)ENSG00000205927
Phylogenetic Trees/Animal Genes : TreeFamOLIG2
HOVERGENQ13516
HOGENOMQ13516
Homologs : HomoloGeneOLIG2
Homology/Alignments : Family Browser (UCSC)OLIG2
Gene fusions - Rearrangements
Fusion : MitelmanTRA/OLIG2 [-/21q22.11]  [t(14;21)(q11;q22)]  
Tumor Fusion PortalOLIG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOLIG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OLIG2
dbVarOLIG2
ClinVarOLIG2
1000_GenomesOLIG2 
Exome Variant ServerOLIG2
ExAC (Exome Aggregation Consortium)ENSG00000205927
GNOMAD BrowserENSG00000205927
Genetic variants : HAPMAP10215
Genomic Variants (DGV)OLIG2 [DGVbeta]
DECIPHEROLIG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOLIG2 
Mutations
ICGC Data PortalOLIG2 
TCGA Data PortalOLIG2 
Broad Tumor PortalOLIG2
OASIS PortalOLIG2 [ Somatic mutations - Copy number]
Cancer Gene: CensusOLIG2 
Somatic Mutations in Cancer : COSMICOLIG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOLIG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OLIG2
DgiDB (Drug Gene Interaction Database)OLIG2
DoCM (Curated mutations)OLIG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OLIG2 (select a term)
intoGenOLIG2
NCG5 (London)OLIG2
Cancer3DOLIG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606386   
Orphanet
DisGeNETOLIG2
MedgenOLIG2
Genetic Testing Registry OLIG2
NextProtQ13516 [Medical]
TSGene10215
GENETestsOLIG2
Target ValidationOLIG2
Huge Navigator OLIG2 [HugePedia]
snp3D : Map Gene to Disease10215
BioCentury BCIQOLIG2
ClinGenOLIG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10215
Chemical/Pharm GKB GenePA31919
Clinical trialOLIG2
Miscellaneous
canSAR (ICR)OLIG2 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOLIG2
EVEXOLIG2
GoPubMedOLIG2
iHOPOLIG2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:58:17 CET 2017

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