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OLIG2 (oligodendrocyte lineage transcription factor)

Written2004-05David Rowitch
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA

(Note : for Links provided by Atlas : click)

Identity

Other aliasRK17
Olg-2
Bhlhb1
RACK17
HGNC:13226
PRKCBP2
BHLHB1
LocusID (NCBI) 10215
Atlas_Id 236
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at and ends at bp from pter
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GID4 (17p11.2) / OLIG2 (21q22.11)OLIG2 (21q22.11) / TENM4 (11q14.1)

DNA/RNA

Note OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.

Protein

Description 329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).
Expression Olig2 is expressed in the ventral thalamus of developing mice.
Function Required for oligodendrocyte and motor neuron specification in the spinal cord.

Implicated in

Note
  
Entity T-cell lymphoma
Cytogenetics Translocation t(14;21)(q11.2;q22)
Hybrid/Mutated Gene T-cell receptor promoter translocated upstream of OLIG2.
Abnormal Protein none
  
  
Entity Brain cancer
Disease Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis variable
Cytogenetics No known genetic abnormalities in OLIG2.
Hybrid/Mutated Gene n/a
Oncogenesis OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.
  

Bibliography

Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.
Azzarelli B, Miravalle L, Vidal R
Journal of neuropathology and experimental neurology. 2004 ; 63 (2) : 170-179.
PMID 14989603
 
OLIG-1 and 2 gene expression and oligodendroglial tumours.
Hoang-Xuan K, Aguirre-Cruz L, Mokhtari K, Marie Y, Sanson M
Neuropathology and applied neurobiology. 2002 ; 28 (2) : 89-94.
PMID 11972795
 
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.
Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (19) : 10851-10856.
PMID 11526205
 
OLIG2 as a specific marker of oligodendroglial tumour cells.
Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K
Lancet. 2001 ; 358 (9278) : 298-300.
PMID 11498220
 
The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.
Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3497-3502.
PMID 10737801
 

Citation

This paper should be referenced as such :
Rowitch, D
OLIG2 (oligodendrocyte lineage transcription factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):200-200.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/OLIG2ID236.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;21)(q11;q22) TRA/OLIG2
t(14;21)(q11;q22) TRA/OLIG2


External links

Nomenclature
Cards
AtlasOLIG2ID236.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)10215
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:46:12 CEST 2018

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