| Identity |
| Other names | RK17 |
| Olg-2 | |
| Bhlhb1 | |
| RACK17 | |
| HGNC:13226 | |
| PRKCBP2 | |
| BHLHB1 | |
| HGNC (Hugo) | OLIG2 |
| Location | 21q22.11 |
| Location_base_pair | Starts at 33320109 and ends at 33323370 bp from pter ( according to hg18-Mar_2006) [Mapping] |
| DNA/RNA |
| Note | OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development. |
| Protein |
| Description | 329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH). |
| Expression | Olig2 is expressed in the ventral thalamus of developing mice. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord. |
| Implicated in |
| Entity | T-cell lymphoma |
| Cytogenetics | Translocation t(14;21)(q11.2;q22) |
| Hybrid/Mutated Gene | T-cell receptor promoter translocated upstream of OLIG2. |
| Abnormal Protein | none |
| Entity | Brain cancer |
| Disease | Oligodendroglioma, astrocytoma, glioblastoma. |
| Prognosis | variable |
| Cytogenetics | No known genetic abnormalities in OLIG2. |
| Hybrid/Mutated Gene | n/a |
| Oncogenesis | OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated. |
| External links |
| Bibliography |
| The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. |
| Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD |
| Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3497-3502. |
| PMID 10737801 |
| Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. |
| Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (19) : 10851-10856. |
| PMID 11526205 |
| OLIG2 as a specific marker of oligodendroglial tumour cells. |
| Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K |
| Lancet. 2001 ; 358 (9278) : 298-300. |
| PMID 11498220 |
| OLIG-1 and 2 gene expression and oligodendroglial tumours. |
| Hoang-Xuan K, Aguirre-Cruz L, Mokhtari K, Marie Y, Sanson M |
| Neuropathology and applied neurobiology. 2002 ; 28 (2) : 89-94. |
| PMID 11972795 |
| Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. |
| Azzarelli B, Miravalle L, Vidal R |
| Journal of neuropathology and experimental neurology. 2004 ; 63 (2) : 170-179. |
| PMID 14989603 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 05-2004 | David Rowitch |
| Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA |
| Citation |
| This paper should be referenced as such : |
| Rowitch D . OLIG2 oligodendrocyte lineage transcription factor 2. Atlas Genet Cytogenet Oncol Haematol. May 2004 . URL : http://AtlasGeneticsOncology.org/Genes/OLIG2ID236.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 27 10:53:03 CET 2010 |
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