OLIG2

Identity

Other names	RK17
	Olg-2
	Bhlhb1
	RACK17
	HGNC:13226
	PRKCBP2
	BHLHB1
Hugo	OLIG2
Location	21q22.11

DNA/RNA

Note	OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.

Protein

Description	329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).
Expression	Olig2 is expressed in the ventral thalamus of developing mice.
Function	Required for oligodendrocyte and motor neuron specification in the spinal cord.

Implicated in

Entity	T-cell lymphoma
Cytogenetics	Translocation t(14;21)(q11.2;q22)
Hybrid/Mutated Gene	T-cell receptor promoter translocated upstream of OLIG2.
Abnormal Protein	none
Entity	Brain cancer
Disease	Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis	variable
Cytogenetics	No known genetic abnormalities in OLIG2.
Hybrid/Mutated Gene	n/a
Oncogenesis	OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.

External links

	Nomenclature
Hugo	OLIG2
GDB	OLIG2
Entrez_Gene	OLIG2  10215  oligodendrocyte lineage transcription factor 2
	Cards
Atlas	OLIG2ID236
GeneCards	OLIG2
Ensembl	OLIG2 [Search_View]   ENSG00000205927 [Gene_View]
Genatlas	OLIG2
GeneLynx	OLIG2
eGenome	OLIG2
euGene	10215
	Genomic and cartography
GoldenPath	OLIG2  -  21q22.11   chr21:33320109-33323370 +  21q22.11   [Description]    (hg18-Mar_2006)
Ensembl	OLIG2 - 21q22.11 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	OLIG2
	Gene and transcription
Genbank	AF221520 [ ENTREZ ]
Genbank	AK091462 [ ENTREZ ]
Genbank	AU130620 [ ENTREZ ]
Genbank	BC034681 [ ENTREZ ]
Genbank	BC036245 [ ENTREZ ]
RefSeq	NM_005806 [ SRS ]    NM_005806 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	OLIG2 AceView - NCBI
Unigene	Hs.176977 [ SRS ]    Hs.176977 [ NCBI ]     HS176977 [ spliceNest ]
Fast-db	1881 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q13516 [ SRS]    Q13516 [ EXPASY ]     Q13516 [ INTERPRO ]
Prosite	PS50888 HLH [ SRS ]    PS50888 HLH [ Expasy ]
Interpro	IPR001092 HLH_basic [ SRS ]    IPR001092 HLH_basic [ EBI ]
Interpro	IPR011598 HLH_DNA_bd [ SRS ]    IPR011598 HLH_DNA_bd [ EBI ]
CluSTr	Q13516
Pfam	PF00010 HLH [ SRS ]    PF00010 HLH [ Sanger ]    pfam00010 [ NCBI-CDD ]
Smart	SM00353 HLH [EMBL]
Blocks	Q13516
HPRD	07334
	Protein Interaction databases
DIP	Q13516
IntAct	Q13516
	Polymorphism : SNP, mutations, diseases
OMIM	606386    [ map ]
GENECLINICS	606386
SNP	OLIG2 [dbSNP-NCBI]
SNP	NM_005806 [SNP-NCI]
SNP	OLIG2 [GeneSNPs - Utah]  OLIG2] [HGBASE - SRS]
HAPMAP	OLIG2 [HAPMAP]
COSMIC	OLIG2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	OLIG2
	General knowledge
Family Browser	OLIG2 [UCSC Family Browser]
SOURCE	NM_005806
SMD	Hs.176977
SAGE	Hs.176977
GO	negative regulation of transcription from RNA polymerase II promoter [Amigo]  negative regulation of transcription from RNA polymerase II promoter
GO	DNA binding [Amigo]  DNA binding
GO	RNA polymerase II transcription factor activity, enhancer binding [Amigo]  RNA polymerase II transcription factor activity, enhancer binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	nervous system development [Amigo]  nervous system development
GO	transcription regulator activity [Amigo]  transcription regulator activity
GO	myelination [Amigo]  myelination
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	neuron fate commitment [Amigo]  neuron fate commitment
GO	oligodendrocyte differentiation [Amigo]  oligodendrocyte differentiation
PubGene	OLIG2
TreeFam	OLIG2
CTD	10215 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	OLIG2 Related clones (RZPD - Berlin)
	PubMed
PubMed	22 Pubmed reference(s) in LocusLink

Bibliography

The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.

Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD

Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3497-3502.

PMID 10737801

Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.

Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM

Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (19) : 10851-10856.

PMID 11526205

OLIG2 as a specific marker of oligodendroglial tumour cells.

Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K

Lancet. 2001 ; 358 (9278) : 298-300.

PMID 11498220

OLIG-1 and 2 gene expression and oligodendroglial tumours.

Hoang-Xuan K, Aguirre-Cruz L, Mokhtari K, Marie Y, Sanson M

Neuropathology and applied neurobiology. 2002 ; 28 (2) : 89-94.

PMID 11972795

Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.

Azzarelli B, Miravalle L, Vidal R

Journal of neuropathology and experimental neurology. 2004 ; 63 (2) : 170-179.

PMID 14989603

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	05-2004	David Rowitch
		Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA

Citation

This paper should be referenced as such :

Rowitch D . OLIG2. Atlas Genet Cytogenet Oncol Haematol. May 2004 . URL : http://AtlasGeneticsOncology.org/Genes/OLIG2ID236.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:25:43 2008