OLIG2 (oligodendrocyte lineage transcription factor)

2004-05-01   David Rowitch  

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA

Identity

HGNC
OLIG2
LOCATION
21q22.11
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
10215
ALIAS
BHLHB1,OLIGO2,PRKCBP2,RACK17,bHLHe19
FUSION GENES
Show Gene Fusions

DNA/RNA

Note

OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.

Proteins

Description

329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).

Expression

Olig2 is expressed in the ventral thalamus of developing mice.

Function

Required for oligodendrocyte and motor neuron specification in the spinal cord.

Implicated in

Entity name
T-cell lymphoma
Cytogenetics
Translocation t(14;21)(q11.2;q22)
Hybrid gene
T-cell receptor promoter translocated upstream of OLIG2.
Fusion protein
none
Entity name
Brain cancer
Disease
Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis
variable
Cytogenetics
No known genetic abnormalities in OLIG2.
Hybrid gene
n/a
Oncogenesis
OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.

Article Bibliography

Pubmed IDLast YearTitleAuthors
149896032004Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.Azzarelli B et al
119727952002OLIG-1 and 2 gene expression and oligodendroglial tumours.Hoang-Xuan K et al
115262052001Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.Lu QR et al
114982202001OLIG2 as a specific marker of oligodendroglial tumour cells.Marie Y et al
107378012000The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.Wang J et al

Other Information

Locus ID:

NCBI: 10215
MIM: 606386
HGNC: 9398
Ensembl: ENSG00000205927

Variants:

dbSNP: 10215
ClinVar: 10215
TCGA: ENSG00000205927
COSMIC: OLIG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205927ENST00000333337Q13516
ENSG00000205927ENST00000382357Q13516
ENSG00000205927ENST00000430860C9J444

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377486312024OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking.0
377486312024OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking.0
361937542023Identifying an oligodendrocyte enhancer that regulates Olig2 expression.1
370013872023OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM).0
361937542023Identifying an oligodendrocyte enhancer that regulates Olig2 expression.1
370013872023OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM).0
351325662022The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells.0
357362142022OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.4
358568942022Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas.0
359679562022Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.0
351325662022The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells.0
357362142022OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.4
358568942022Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas.0
359679562022Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.0
335395252021OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes.4

Citation

David Rowitch

OLIG2 (oligodendrocyte lineage transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/236/olig2