| Entity | t(1;19)(q23;p13) /B-ALL --> E2A /PBX1 |
| Disease | pre B ALL mainly; CD19+, CD10+, CD9+ |
| Prognosis | controversial data; associated with poor prognostic features |
| Cytogenetics | two different forms: - the balanced t(1;19); - the unbalanced form, with 2 normal chromosomes 1, a der(19), and a normal chromosome19: --> partial trisomy for 1q23-1qter and monosomy for 19p13.3-pter ; additional anomalies: in half of the cases; they are various |
| Hybrid/Mutated Gene | 5' E2A from 19p13 fused to 3' PBX1; breakpoints are clustered on both genes |
| Abnormal Protein | N-term transcriptional activation domains from E2A fused to the Hox cooperative motif and homeodomain of C-term PBX1 |
| Oncogenesis | potent transcriptional activator; pleiotropic transforming activity |
| | |
| Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. |
| Hunger SP |
| Blood. 1996 ; 87 (4) : 1211-1224. |
| PMID 8608207 |
| |
| Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. |
| Nourse J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD, Cleary ML |
| Cell. 1990 ; 60 (4) : 535-545. |
| PMID 1967982 |
| |
| Molecular analysis of the t(1;19) breakpoint cluster region in pre-B cell acute lymphoblastic leukemias. |
| Mellentin JD, Nourse J, Hunger SP, Smith SD, Cleary ML |
| Genes, chromosomes & cancer. 1990 ; 2 (3) : 239-247. |
| PMID 2078515 |
| |
| A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. |
| Kamps MP, Murre C, Sun XH, Baltimore D |
| Cell. 1990 ; 60 (4) : 547-555. |
| PMID 1967983 |
| |
