| Note | The protein encoded by PDE4DIP is called myomegalin |
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| Description | Large protein; some isoforms having more than 2300 aminoacids (62 kDa and 230-250 kDa proteins in the rat ortholog); mainly composed of alpha-helical and coiled-coil structures; includes a leucine zipper in N-term, a dynactin-centractin binding domain, and a helix-loop-helix. |
| Expression | in heart and skeletal muscles; little expression in other tissues |
| Localisation | Cytoplasm in the Golgi/centrosomal area in non muscle cells and nucleus; in the sarcomeres of muscle cells |
| Function | Interacts with the cyclic nucleotide phosphodiesterase PDE4D, enzymes that degrade and inactivate cAMP; may oligomerize |
| Homology | With the Drosophila centrosomin (a component of the centrosome and the mitotic spindle) |
| Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. |
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