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PRDM2 (PR domain containing 2, with ZNF domain)

Written2008-03Erika Di Zazzo, Bruno Moncharmont
Dipartimento di Scienze per la Salute, Università degli studi del Molise, Via Francesco De Sanctis - edificio polifunzionale III, 86170 Campobasso, Italia

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPR domain containing 2, with ZNF domain
PR domain 2
Alias_symbol (synonym)RIZ
RIZ1
RIZ2
KMT8
MTB-ZF
HUMHOXY1
Other aliasGATA 3 binding protein
MTB-ZF(MTE-binding protein zinc-finger)
RIZ (retinoblastoma interacting zinc-finger protein)
HGNC (Hugo) PRDM2
LocusID (NCBI) 7799
Atlas_Id 41834
Location 1p36.21  [Link to chromosome band 1p36]
Location_base_pair Starts at 13749381 and ends at 13788079 bp from pter ( according to hg19-Feb_2009)  [Mapping PRDM2.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GALNT18 (11p15.3) / PRDM2 (1p36.21)GALNT18 (11p15.4) / PRDM2 (1p36.21)GATAD2A (19p13.11) / PRDM2 (1p36.21)
PRDM2 (1p36.21) / TFG (3q12.2)ZDHHC21 (9p22.3) / PRDM2 (1p36.21)

DNA/RNA

Description Spans 150 Kb; 5156 bp coding sequence; 13 exons.
Transcription Two promoters localized, respectively, in exon 1 and exon 6 guide the synthesis of two transcripts: the first one encodes for the PR domain-containing product (RIZ1) and the other one for the PR domain-lacking form (RIZ2).

Protein

 
Description RIZ1(280 kDa) and RIZ2(260 kDa) differ only for the presence in the larger form (RIZ1) of the PR domain. In the sequence of both proteins have been identified several domains:
  • PR domain (130 aa), endowed with histone-methyltransferase activity (Lys 9 of histone H3) and implicated in protein-protein interactions;
  • E1A like-domain (100 aa), contains the LXCXE sequence able to interact with the oncosupressor gene Rb;
  • two zinc-finger clusters;
  • proline-rich domain, containing a LXXLL motif mediating the interaction with estrogen receptor.
  • Expression RIZ1 and RIZ2 have an ubiquitous and approximately equimolar expression with higher expression levels in neuroendocrine tissues.
    Localisation nuclear
    Function RIZ Gene products are endowed with DNA-binding as well as transcription factor-binding activities, as evidenced by the independent isolation of RIZ as a retinoblastoma-binding protein (RIZ), a DNA-binding protein (MTB-Zf), or as a GATA3 transcription factor binding protein (G3B).
    MTB-Zf (essentially identical to RIZ2) binds to the MTE DNA element GTCATATGAC of human heme-oxygenase-1 gene and can weakly activate transcription.
    G3B (RIZ) interacts with the transcription factor GATA-3, regulating the expression of several genes critical for T-cell function and development.
    RIZ proteins bind the estrogen receptor in a hormone-dependent manner, acting as a co-activator.
    Estradiol binding to estrogen receptor complex converts RIZ activity from transcriptional repressor into co-activator.
    Specific siRNA silencing of RIZ1 form increases the MCF-7 breast cancer cells growth rate.
    RIZ proteins act as transcriptional repressors binding to GC-rich or Sp-1-binding elements.

    Mutations

    Germinal RIZ1 K.O. mice showed a high incidence of diffuse large B-cell lymphomas and a broad spectrum of unusual tumors.
    Somatic Deletion of the 1p36 region is frequent in several human cancers including neuroblastoma, breast cancer, intestinal tumors, and malignant melanoma.
    Frameshift mutations in the two poly adenine tracts, A(8) and A(9), generating truncated RIZ1/2 proteins lacking the COOH-terminal PR-binding motif, were found in MSI-high (MSI-H) primary cancers occurring in the pancreas, stomach, endometrium and colorectum.
    The single base substitution that changed A563 in the coding sequence (immediately C-terminal to the PR domain) to a G was found specially in diffuse large B-cell lymphomas (DLBL).
    Missense mutation of RIZ1 changing nucleotide G317 to A were discovered in Saos2 human osteosarcoma cells.
    RIZ harbors a naturally occurring CCT insertion/deletion polymorphism in exon 8 producing a proline insertion/deletion, modulating the impact of estradiol on bone mineral density (BMD).

    Implicated in

    Note
      
    Entity Breast cancer
    Disease The RIZ gene might have a role in human breast cancer. In fact, RIZ1 expression is decreased or lost in human breast cancer, whereas RIZ2 expression is normal.
      
      
    Entity Gastric cancer
    Disease RIZ1 might be a specific target of inactivation in human gastric cancer. Methylation of the RIZ1 promoter was detected in 37% of 30 cases and inactivation of the second allele occurred through frameshift mutation, loss of heterozygosity (LOH) or promoter methylation. Furthermore frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas.
      
      
    Entity Endometrial carcinoma
    Disease RIZ inactivation is highly selected during the clonal evolution of these tumors. Six (33%) of 18 endometrial carcinomas present frameshift mutation in the two coding polyadenosine tracts of RIZ.
      
      
    Entity Colorectal carcinoma
    Disease RIZ might have a role in human colorectal tumorigenesis. The region 1p36 is frequently deleted in colorectal cancer; Furthermore, 37.5% of microsatellite-unstable colorectal tumors presents frameshift mutation, consisting of 1- or 2-bp deletions of a coding (A)8 or (A)9 tract, of the RIZ gene.
      
      
    Entity Leukaemia
    Disease Suppression of RIZ1 expression or enhancement of RIZ2 expression may have an important role in leukaemogenesis. The expression of RIZ1 was significantly decreased in leukaemia cell lines (14 out of 17, 82%) and in patients with acute myeloblastic leukaemia (8 out of 14, 57%). In contrast, RIZ2 expression was increased in patients with acute lymphoblastic leukaemia (8 out of 11, 73%) compared with normal bone marrow cells.
      
      
    Entity Ovarian carcinoma
    Disease Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation. Decreased expression of RIZ1 was significantly correlated with histological subtypes (P < 0.0001), high tumor grade (P = 0.0153), advanced clinical stage (P = 0.0345), and high Ki67 index (P = 0.0117).
      
      
    Entity Neuroblastoma
    Disease Advanced stages of neuroblastoma is genetically characterized by deletions or LOH for the short arm of chromosome 1 suggesting that in the deleted region there is a locus for putative suppressor gene.
      
      
    Entity Hepatoma
    Disease Hepatomas present deletion of the chromosome 1 short arm suggesting that in this region is localized a gene whose functional loss may be involved in hepatocellular carcinogenesis.
      
      
    Entity Prostate cancer
    Disease RIZ1 may be associated with prostate carcinogenesis. Transcriptional inactivation of RIZ1 gene by aberrant DNA methylation of promoter CpG island is detected in 20 (42.6%) of the 47 prostate cancer tissues.
      
      
    Entity Thyroid carcinoma
    Disease RIZ1 have probably an important role in thyroid tumorigenesis. RIZ1 is lost in thyroid tumor cell line and is also significantly reduced in thyroid carcinomas when compared with normal thyroid tissues and benign tumors. The loss of RIZ1 is mediated by aberrant cytosine methylation of the RIZ1 promoter.
      
      
    Entity Lung cancer
    Disease RIZ polymorphisms may be an important predictive markers for lung cancer susceptibility. In fact, the +92337G > A and +95701C > A polymorphisms are associated with reduced risk of lung adenocarcinomas.
      
      
    Entity Ostheoporosis
    Disease The RIZ P704 insertion (+)/deletion (-) polymorphism modulates the impact of estradiol on bone mineral density (BMD). The RIZ P704 +/+ genotype is a risk factor for low BMD in elderly subjects with low estradiol levels, whereas the RIZ P704 +/+ genotype was associated with high BMD in premenopausal women.
      

    Bibliography

    The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.
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    Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3130-5.
    PMID 10706618
     
    Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation.
    Akahira J, Suzuki F, Suzuki T, Miura I, Kamogawa N, Miki Y, Ito K, Yaegashi N, Sasano H.
    Pathol Int. 2007 Nov;57(11):725-33.
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    Deletion of 1p36 as a primary chromosomal aberration in intestinal tumorigenesis.
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    Cancer Res. 1993 Apr 15;53(8):1895-8.
    PMID 8467511
     
    In vitro analysis of the E1A-hompologous sequences of RIZ.
    Buyse IM, Huang S.
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    PMID 9223517
     
    The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.
    Buyse IM, Shao G, Huang S.
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    PMID 7538672
     
    The tumor suppressor gene RIZ in cancer gene therapy.
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    Oncol Rep. 2002 Jan-Feb;9(1):57-60. (REVIEW)
    PMID 11748455
     
    A histone methyltransferase is required for maximal response to female sex hormones.
    Carling T, Kim KC, Yang XH, Gu J, Zhang XK, Huang S.
    Mol Cell Biol. 2004 Aug;24(16):7032-42.
    PMID 15282304
     
    Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis.
    Chadwick RB, Jiang GL, Bennington GA, Yuan B, Johnson CK, Stevens MW, Niemann TH, Peltomaki P, Huang S, de la Chapelle A.
    Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2662-7.
    PMID 10688904
     
    Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.
    Dracopoli NC, Harnett P, Bale SJ, Stanger BZ, Tucker MA, Housman DE, Kefford RF.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4614-8.
    PMID 2734311
     
    Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily.
    Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S.
    Cancer Res. 2001 Nov 15;61(22):8094-9.
    PMID 11719434
     
    Mapping of a minimal deleted region in human hepatocellular carcinoma to 1p36.13-p36.23 and mutational analysis of the RIZ (PRDM2) gene localized to the region.
    Fang W, Piao Z, Simon D, Sheu JC, Huang S.
    Genes Chromosomes Cancer. 2000 Jul;28(3):269-75.
    PMID 10862032
     
    Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas.
    Fong CT, White PS, Peterson K, Sapienza C, Cavenee WK, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM.
    Cancer Res. 1992 Apr 1;52(7):1780-5.
    PMID 1551108
     
    Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation.
    Gazzerro P, Abbondanza C, D'Arcangelo A, Rossi M, Medici N, Moncharmont B, Puca GA.
    Exp Cell Res. 2006 Feb 1;312(3):340-9.
    PMID 16356493
     
    Distal deletion of chromosome Ip in ductal carcinoma of the breast.
    Genuardi M, Tsihira H, Anderson DE, Saunders GF.
    Am J Hum Genet. 1989 Jul;45(1):73-82.
    PMID 2545098
     
    The impact of estradiol on bone mineral density is modulated by the specific estrogen receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism.
    Grundberg E, Akesson K, Kindmark A, Gerdhem P, Holmberg A, Mellström D, Ljunggren O, Orwoll E, Mallmin H, Ohlsson C, Brändström H.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2300-6.
    PMID 17356055
     
    DNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer.
    Hasegawa Y, Matsubara A, Teishima J, Seki M, Mita K, Usui T, Oue N, Yasui W.
    Cancer Sci. 2007 Jan;98(1):32-6.
    PMID 17052263
     
    RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.
    He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S.
    Cancer Res. 1998 Oct 1;58(19):4238-44.
    PMID 9766644
     
    The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers.
    Huang S.
    Font Biosci. 1999 Jun 15;4:D528-32.
    PMID 10369808
     
    Decreased RIZ1 expression but not RIZ2 in hepatoma andsuppression of hepatoma tumorigenicity by RIZ1.
    Jiang G, Liu L, Buyse IM, Simon D, Huang S.
    Int J Cancer 1999 Nov 12;83(4):541-6.
    PMID 10508492
     
    RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.
    Lal G, Padmanabha L, Smith BJ, Nicholson RM, Howe JR, O’Dorisio MS, Domann FE Jr.
    Cancer. 2006 Dec 15;107(12):2752-9.
    PMID 17103461
     
    The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.
    Liu L, Shao G, Steele-Perkins G, Huang S.
    J Biol Chem. 1997 Jan 31;272(5):2984-91.
    PMID 9006946
     
    Identification of a DNA binding protein cooperating with estrogen receptor as RIZ (retinoblastoma interacting zinc finger protein).
    Medici N, Abbondanza C, Nigro V, Rossi V, Piluso G, Belsito A, Gallo L, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA.
    Biochem Biophys Res Commun. 1999 Nov 2;264(3):983-9.
    PMID 10544042
     
    cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene.
    Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S.
    Eur. J. Biochem. 1996 Feb 1;235(3):471-9.
    PMID 8654390
     
    Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer.
    Nagai H, Negrini M, Carter SL, Gillum DR, Rosenberg AL, Schwartz GF, Croce CM.
    Cancer Res. 1995 Apr 15;55(8):1752-7.
    PMID 7712484
     
    Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.
    Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S.
    Cancer Res. 2000 Sep 1;60(17):4701-4.
    PMID 10987271
     
    RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.
    Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A.
    Genes Chromosomes Cancer. 2001 Feb;30(2):207-11.
    PMID 11135439
     
    Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.
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    Br J Haematol. 2002 Dec;119(4):940-8.
    PMID 12472571
     
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    PMID 7590293
     
    Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.
    Steele-Perkins G, Fang W, Yang X, Van Gele M, Carling T, Gu J, Buyse IM, Fletcher JA, Liu J, Bronson R, Chadwick RB, de la Chapelle A, Zhang X, Speleman F, Huang S.
    Genes Dev. 2001 Sep 1;15(17):2250-62.
    PMID 11544182
     
    Biallelic inactivation of the RIZ1 gene in human gastric cancer.
    Tokumaru Y, Nomoto S, JerÓnimo C, Henrique R, Harden S, Trink B and Sidransky D.
    Oncogene. 2003 Oct 9;22(44):6954-8.
    PMID 14534544
     
    Transcriptional repression mediated by the PR domain zinc finger gene RIZ.
    Xie M, Shao G, Buyse IM, Huang S.
    J Biol Chem. 1997 Oct 17;272(42):26360-6.
    PMID 9334209
     
    Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung cancer.
    Yoon KA, Park S, Hwangbo B, Shin HD, Cheong HS, Shin HR, Lee JS.
    Carcinogenesis. 2007 Sep;28(9):1971-7.
    PMID 17693662
     

    Citation

    This paper should be referenced as such :
    Di, Zazzo E ; Montcharmont, B
    PRDM2 (PR domain containing 2, with ZNF domain)
    Atlas Genet Cytogenet Oncol Haematol. 2009;13(1):24-27.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/PRDM2ID41834ch1p36.html


    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
      t(6;9)(p22;q34) DEK/NUP214 in Childhood


    External links

    Nomenclature
    HGNC (Hugo)PRDM2   9347
    Cards
    AtlasPRDM2ID41834ch1p36
    Entrez_Gene (NCBI)PRDM2  7799  PR/SET domain 2
    AliasesHUMHOXY1; KMT8; KMT8A; MTB-ZF; 
    RIZ; RIZ1; RIZ2
    GeneCards (Weizmann)PRDM2
    Ensembl hg19 (Hinxton)ENSG00000116731 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000116731 [Gene_View]  chr1:13749381-13788079 [Contig_View]  PRDM2 [Vega]
    ICGC DataPortalENSG00000116731
    TCGA cBioPortalPRDM2
    AceView (NCBI)PRDM2
    Genatlas (Paris)PRDM2
    WikiGenes7799
    SOURCE (Princeton)PRDM2
    Genetics Home Reference (NIH)PRDM2
    Genomic and cartography
    GoldenPath hg38 (UCSC)PRDM2  -     chr1:13749381-13788079 +  1p36.21   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)PRDM2  -     1p36.21   [Description]    (hg19-Feb_2009)
    EnsemblPRDM2 - 1p36.21 [CytoView hg19]  PRDM2 - 1p36.21 [CytoView hg38]
    Mapping of homologs : NCBIPRDM2 [Mapview hg19]  PRDM2 [Mapview hg38]
    OMIM601196   
    Gene and transcription
    Genbank (Entrez)AB208877 AI651991 AK123605 AK124197 AK293725
    RefSeq transcript (Entrez)NM_001007257 NM_001135610 NM_012231 NM_015866
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)PRDM2
    Cluster EST : UnigeneHs.371823 [ NCBI ]
    CGAP (NCI)Hs.371823
    Alternative Splicing GalleryENSG00000116731
    Gene ExpressionPRDM2 [ NCBI-GEO ]   PRDM2 [ EBI - ARRAY_EXPRESS ]   PRDM2 [ SEEK ]   PRDM2 [ MEM ]
    Gene Expression Viewer (FireBrowse)PRDM2 [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)7799
    GTEX Portal (Tissue expression)PRDM2
    Human Protein AtlasENSG00000116731-PRDM2 [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ13029   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtQ13029  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProQ13029
    Splice isoforms : SwissVarQ13029
    Catalytic activity : Enzyme2.1.1.43 [ Enzyme-Expasy ]   2.1.1.432.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   
    PhosPhoSitePlusQ13029
    Domaine pattern : Prosite (Expaxy)SET (PS50280)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
    Domains : Interpro (EBI)RIZ_retinblastoma-bd_prot    SET_dom    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
    Domain families : Pfam (Sanger)SET (PF00856)    zf-C2H2_6 (PF13912)   
    Domain families : Pfam (NCBI)pfam00856    pfam13912   
    Domain families : Smart (EMBL)SET (SM00317)  ZnF_C2H2 (SM00355)  
    Conserved Domain (NCBI)PRDM2
    DMDM Disease mutations7799
    Blocks (Seattle)PRDM2
    PDB (SRS)2JV0    2QPW   
    PDB (PDBSum)2JV0    2QPW   
    PDB (IMB)2JV0    2QPW   
    PDB (RSDB)2JV0    2QPW   
    Structural Biology KnowledgeBase2JV0    2QPW   
    SCOP (Structural Classification of Proteins)2JV0    2QPW   
    CATH (Classification of proteins structures)2JV0    2QPW   
    SuperfamilyQ13029
    Human Protein Atlas [tissue]ENSG00000116731-PRDM2 [tissue]
    Peptide AtlasQ13029
    HPRD03120
    IPIIPI00219556   IPI00759628   IPI00953063   IPI00908472   IPI00016780   IPI00479627   IPI00472974   IPI00965685   IPI00965046   IPI00965749   IPI00964508   IPI00964781   
    Protein Interaction databases
    DIP (DOE-UCLA)Q13029
    IntAct (EBI)Q13029
    FunCoupENSG00000116731
    BioGRIDPRDM2
    STRING (EMBL)PRDM2
    ZODIACPRDM2
    Ontologies - Pathways
    QuickGOQ13029
    Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  Golgi apparatus  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  zinc ion binding  determination of adult lifespan  histone-lysine N-methyltransferase activity  histone lysine methylation  positive regulation of transcription from RNA polymerase II promoter  
    Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  Golgi apparatus  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  zinc ion binding  determination of adult lifespan  histone-lysine N-methyltransferase activity  histone lysine methylation  positive regulation of transcription from RNA polymerase II promoter  
    NDEx NetworkPRDM2
    Atlas of Cancer Signalling NetworkPRDM2
    Wikipedia pathwaysPRDM2
    Orthology - Evolution
    OrthoDB7799
    GeneTree (enSembl)ENSG00000116731
    Phylogenetic Trees/Animal Genes : TreeFamPRDM2
    HOVERGENQ13029
    HOGENOMQ13029
    Homologs : HomoloGenePRDM2
    Homology/Alignments : Family Browser (UCSC)PRDM2
    Gene fusions - Rearrangements
    Fusion : MitelmanGALNT18/PRDM2 [11p15.3/1p36.21]  [t(1;11)(p36;p15)]  
    Fusion: TCGA_MDACCGALNTL4 PRDM2 1p36.21 SKCM
    Tumor Fusion PortalPRDM2
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerPRDM2 [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)PRDM2
    dbVarPRDM2
    ClinVarPRDM2
    1000_GenomesPRDM2 
    Exome Variant ServerPRDM2
    ExAC (Exome Aggregation Consortium)ENSG00000116731
    GNOMAD BrowserENSG00000116731
    Genetic variants : HAPMAP7799
    Genomic Variants (DGV)PRDM2 [DGVbeta]
    DECIPHERPRDM2 [patients]   [syndromes]   [variants]   [genes]  
    CONAN: Copy Number AnalysisPRDM2 
    Mutations
    ICGC Data PortalPRDM2 
    TCGA Data PortalPRDM2 
    Broad Tumor PortalPRDM2
    OASIS PortalPRDM2 [ Somatic mutations - Copy number]
    Somatic Mutations in Cancer : COSMICPRDM2  [overview]  [genome browser]  [tissue]  [distribution]  
    Mutations and Diseases : HGMDPRDM2
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    BioMutasearch PRDM2
    DgiDB (Drug Gene Interaction Database)PRDM2
    DoCM (Curated mutations)PRDM2 (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)PRDM2 (select a term)
    intoGenPRDM2
    NCG5 (London)PRDM2
    Cancer3DPRDM2(select the gene name)
    Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Diseases
    OMIM601196   
    Orphanet
    DisGeNETPRDM2
    MedgenPRDM2
    Genetic Testing Registry PRDM2
    NextProtQ13029 [Medical]
    TSGene7799
    GENETestsPRDM2
    Target ValidationPRDM2
    Huge Navigator PRDM2 [HugePedia]
    snp3D : Map Gene to Disease7799
    BioCentury BCIQPRDM2
    ClinGenPRDM2
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD7799
    Chemical/Pharm GKB GenePA33715
    Clinical trialPRDM2
    Miscellaneous
    canSAR (ICR)PRDM2 (select the gene name)
    Probes
    Litterature
    PubMed73 Pubmed reference(s) in Entrez
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