Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1b and IL-18 secretion but not to pyroptosis. |
Abdalla H, Srinivasan L, Shah S, Mayer-Barber KD, Sher A, Sutterwala FS, Briken V. |
PLoS One. 2012;7(7):e40722. doi: 10.1371/journal.pone.0040722. Epub 2012 Jul 24. |
PMID 22911706 |
|
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes. |
Abdelaziz DH, Gavrilin MA, Akhter A, Caution K, Kotrange S, Khweek AA, Abdulrahman BA, Grandhi J, Hassan ZA, Marsh C, Wewers MD, Amer AO. |
J Biol Chem. 2011 Feb 4;286(5):3203-8. doi: 10.1074/jbc.M110.197681. Epub 2010 Nov 19. |
PMID 21097506 |
|
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. |
Abdul-Sater AA, Koo E, Hacker G, Ojcius DM. |
J Biol Chem. 2009 Sep 25;284(39):26789-96. doi: 10.1074/jbc.M109.026823. Epub 2009 Jul 31. |
PMID 19648107 |
|
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. |
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. |
Immunity. 2004 Mar;20(3):319-25. |
PMID 15030775 |
|
Macrophages control innate inflammation. |
Akira S, Misawa T, Satoh T, Saitoh T. |
Diabetes Obes Metab. 2013 Sep;15 Suppl 3:10-8. doi: 10.1111/dom.12151. (REVIEW) |
PMID 24003916 |
|
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. |
Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C, Ting JP. |
J Exp Med. 2010 May 10;207(5):1045-56. doi: 10.1084/jem.20100050. Epub 2010 Apr 12. |
PMID 20385749 |
|
Pseudomonas aeruginosa pilin activates the inflammasome. |
Arlehamn CS, Evans TJ. |
Cell Microbiol. 2011 Mar;13(3):388-401. doi: 10.1111/j.1462-5822.2010.01541.x. Epub 2010 Nov 3. |
PMID 20955240 |
|
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. |
Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. |
PLoS Pathog. 2014 Jan;10(1):e1003885. doi: 10.1371/journal.ppat.1003885. Epub 2014 Jan 16. |
PMID 24453977 |
|
Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. |
Aymeric L, Apetoh L, Ghiringhelli F, Tesniere A, Martins I, Kroemer G, Smyth MJ, Zitvogel L. |
Cancer Res. 2010 Feb 1;70(3):855-8. doi: 10.1158/0008-5472.CAN-09-3566. Epub 2010 Jan 19. |
PMID 20086177 |
|
The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. |
Benetti E, Chiazza F, Patel NS, Collino M. |
Mediators Inflamm. 2013;2013:678627. doi: 10.1155/2013/678627. Epub 2013 Jun 13. (REVIEW) |
PMID 23843683 |
|
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. |
Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES. |
J Biol Chem. 2001 Apr 13;276(15):11877-82. Epub 2001 Jan 12. |
PMID 11278692 |
|
CARD games in apoptosis and immunity. |
Bouchier-Hayes L, Martin SJ. |
EMBO Rep. 2002 Jul;3(7):616-21. (REVIEW) |
PMID 12101092 |
|
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. |
Broz P, von Moltke J, Jones JW, Vance RE, Monack DM. |
Cell Host Microbe. 2010 Dec 16;8(6):471-83. doi: 10.1016/j.chom.2010.11.007. |
PMID 21147462 |
|
Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. |
Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. |
J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23. |
PMID 20482797 |
|
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1b activation and severe autoinflammation in mice. |
Chae JJ, Cho YH, Lee GS, Cheng J, Liu PP, Feigenbaum L, Katz SI, Kastner DL. |
Immunity. 2011 May 27;34(5):755-68. doi: 10.1016/j.immuni.2011.02.020. Epub 2011 May 19. |
PMID 21600797 |
|
Methylation of the ASC gene promoter is associated with aggressive prostate cancer. |
Collard RL, Harya NS, Monzon FA, Maier CE, O'Keefe DS. |
Prostate. 2006 May 15;66(7):687-95. |
PMID 16425203 |
|
TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. |
Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM. |
Cancer Res. 2000 Nov 15;60(22):6236-42. |
PMID 11103776 |
|
Methylation mediated silencing of TMS1/ASC gene in prostate cancer. |
Das PM, Ramachandran K, Vanwert J, Ferdinand L, Gopisetty G, Reis IM, Singal R. |
Mol Cancer. 2006 Jul 18;5:28. |
PMID 16848908 |
|
Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. |
Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Goss C, Anz D, Simanski M, Glaser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J. |
Sci Transl Med. 2011 May 11;3(82):82ra38. doi: 10.1126/scitranslmed.3002001. |
PMID 21562230 |
|
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. |
Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LA. |
J Biol Chem. 2014 Mar 7;289(10):6429-37. doi: 10.1074/jbc.M113.539692. Epub 2014 Jan 9. |
PMID 24407287 |
|
Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. |
Drexler SK, Bonsignore L, Masin M, Tardivel A, Jackstadt R, Hermeking H, Schneider P, Gross O, Tschopp J, Yazdi AS. |
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18384-9. doi: 10.1073/pnas.1209171109. Epub 2012 Oct 22. |
PMID 23090995 |
|
Inflammasomes as molecular mediators of inflammation and cancer: potential role in melanoma. |
Dunn JH, Ellis LZ, Fujita M. |
Cancer Lett. 2012 Jan 1;314(1):24-33. doi: 10.1016/j.canlet.2011.10.001. Epub 2011 Oct 12. (REVIEW) |
PMID 22050907 |
|
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. |
Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, Meunier C, Turbide C, Gros P, Beauchemin N, Vallance BA, Saleh M. |
Immunity. 2010 Mar 26;32(3):367-78. doi: 10.1016/j.immuni.2010.02.012. Epub 2010 Mar 11. |
PMID 20226691 |
|
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. |
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. |
Cell. 2011 May 27;145(5):745-57. doi: 10.1016/j.cell.2011.04.022. Epub 2011 May 12. |
PMID 21565393 |
|
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. |
Ellebedy AH, Lupfer C, Ghoneim HE, DeBeauchamp J, Kanneganti TD, Webby RJ. |
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2927-32. doi: 10.1073/pnas.1012455108. Epub 2011 Jan 26. |
PMID 21270336 |
|
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. |
Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, Dewamitta SR, Xu Y, Qu H, Alnemri ES, Mitsuyama M. |
J Immunol. 2011 Nov 1;187(9):4890-9. doi: 10.4049/jimmunol.1100381. Epub 2011 Sep 28. |
PMID 21957143 |
|
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. |
Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. |
Nature. 2009 Mar 26;458(7237):509-13. doi: 10.1038/nature07710. Epub 2009 Jan 21. |
PMID 19158676 |
|
Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. |
Franchi L, Kanneganti TD, Dubyak GR, Nunez G. |
J Biol Chem. 2007a Jun 29;282(26):18810-8. Epub 2007 May 9. |
PMID 17491021 |
|
A new twist on the PYRIN Mediterranean coast. |
Franchi L, Nunez G. |
Immunity. 2011 May 27;34(5):695-7. doi: 10.1016/j.immuni.2011.05.004. |
PMID 21616439 |
|
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. |
Franchi L, Stoolman J, Kanneganti TD, Verma A, Ramphal R, Nunez G. |
Eur J Immunol. 2007b Nov;37(11):3030-9. |
PMID 17935074 |
|
Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. |
Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA, Van der Ende A, Van der Poll T, Van de Beek D. |
BMC Infect Dis. 2013 Jul 31;13:358. doi: 10.1186/1471-2334-13-358. |
PMID 23902681 |
|
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J; MGC Project Team. |
Genome Res. 2004 Oct;14(10B):2121-7. |
PMID 15489334 |
|
Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. |
Grant RW, Dixit VD. |
Front Immunol. 2013 Mar 8;4:50. doi: 10.3389/fimmu.2013.00050. eCollection 2013. |
PMID 23483669 |
|
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. |
Griffith JW, Sun T, McIntosh MT, Bucala R. |
J Immunol. 2009 Oct 15;183(8):5208-20. doi: 10.4049/jimmunol.0713552. Epub 2009 Sep 25. |
PMID 19783673 |
|
ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma. |
Guan X, Sagara J, Yokoyama T, Koganehira Y, Oguchi M, Saida T, Taniguchi S. |
Int J Cancer. 2003 Nov 1;107(2):202-8. |
PMID 12949795 |
|
Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. |
Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA. |
Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679. |
PMID 22426419 |
|
Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells. |
Guo X, Dhodapkar KM. |
Hum Immunol. 2012 Sep;73(9):871-8. doi: 10.1016/j.humimm.2012.06.008. Epub 2012 Jun 22. |
PMID 22732093 |
|
Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. |
Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Nunez G. |
J Immunol. 2009 Nov 1;183(9):5823-9. doi: 10.4049/jimmunol.0900444. Epub 2009 Oct 7. |
PMID 19812205 |
|
Mechanism and repertoire of ASC-mediated gene expression. |
Hasegawa M, Imamura R, Motani K, Nishiuchi T, Matsumoto N, Kinoshita T, Suda T. |
J Immunol. 2009 Jun 15;182(12):7655-62. doi: 10.4049/jimmunol.0800448. |
PMID 19494289 |
|
Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. |
He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR. |
J Immunol. 2010 May 15;184(10):5743-54. doi: 10.4049/jimmunol.0903937. Epub 2010 Apr 14. |
PMID 20393140 |
|
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. |
Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. |
Nat Chem Biol. 2013 Jun;9(6):398-405. doi: 10.1038/nchembio.1236. Epub 2013 Apr 21. |
PMID 23603659 |
|
The CARD domain: a new apoptotic signalling motif. |
Hofmann K, Bucher P, Tschopp J. |
Trends Biochem Sci. 1997 May;22(5):155-6. |
PMID 9175472 |
|
Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death. |
Hong S, Hwang I, Lee YS, Park S, Lee WK, Fernandes-Alnemri T, Alnemri ES, Kim YS, Yu JW. |
Cancer Lett. 2013 May 1;331(2):183-91. doi: 10.1016/j.canlet.2012.12.020. Epub 2013 Jan 12. |
PMID 23321501 |
|
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. |
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. |
Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21. |
PMID 19158675 |
|
Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity. |
Hruz P, Eckmann L. |
Curr Opin Gastroenterol. 2008 Mar;24(2):108-14. doi: 10.1097/MOG.0b013e3282f50fdf. (REVIEW) |
PMID 18301258 |
|
Salmonella Promotes ASC Oligomerization-dependent Caspase-1 Activation. |
Hwang I, Park S, Hong S, Kim EH, Yu JW. |
Immune Netw. 2012 Dec;12(6):284-90. doi: 10.4110/in.2012.12.6.284. Epub 2012 Dec 31. |
PMID 23396959 |
|
ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. |
Ikuta T, Kobayashi Y, Kitazawa M, Shiizaki K, Itano N, Noda T, Pettersson S, Poellinger L, Fujii-Kuriyama Y, Taniguchi S, Kawajiri K. |
Carcinogenesis. 2013 Jul;34(7):1620-7. doi: 10.1093/carcin/bgt083. Epub 2013 Mar 1. |
PMID 23455376 |
|
Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. |
Ippagunta SK, Brand DD, Luo J, Boyd KL, Calabrese C, Stienstra R, Van de Veerdonk FL, Netea MG, Joosten LA, Lamkanfi M, Kanneganti TD. |
J Biol Chem. 2010 Apr 16;285(16):12454-62. doi: 10.1074/jbc.M109.093252. Epub 2010 Feb 22. |
PMID 20177071 |
|
Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. |
Jin T, Perry A, Smith P, Jiang J, Xiao TS. |
J Biol Chem. 2013 May 10;288(19):13225-35. doi: 10.1074/jbc.M113.468033. Epub 2013 Mar 25. |
PMID 23530044 |
|
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. |
Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G. |
Nat Med. 2013 Sep;19(9):1132-40. doi: 10.1038/nm.3265. Epub 2013 Aug 18. |
PMID 23955712 |
|
Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers. |
Karthikeyan RS, Priya JL, Leal SM Jr, Toska J, Rietsch A, Prajna V, Pearlman E, Lalitha P. |
PLoS One. 2013 Jun 4;8(6):e64867. doi: 10.1371/journal.pone.0064867. Print 2013. |
PMID 23750216 |
|
Nod1, but not the ASC inflammasome, contributes to induction of IL-1b secretion in human trophoblasts after sensing of Chlamydia trachomatis. |
Kavathas PB, Boeras CM, Mulla MJ, Abrahams VM. |
Mucosal Immunol. 2013 Mar;6(2):235-43. doi: 10.1038/mi.2012.63. Epub 2012 Jul 4. |
PMID 22763410 |
|
Human keratinocytes express AIM2 and respond to dsDNA with IL-1b secretion. |
Kopfnagel V, Wittmann M, Werfel T. |
Exp Dermatol. 2011 Dec;20(12):1027-9. doi: 10.1111/j.1600-0625.2011.01382.x. |
PMID 22092578 |
|
Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. |
Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S. |
J Virol. 2013 Apr;87(7):3655-67. doi: 10.1128/JVI.02667-12. Epub 2013 Jan 9. |
PMID 23302887 |
|
Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. |
Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK. |
Diabetes. 2013 Jan;62(1):194-204. doi: 10.2337/db12-0420. Epub 2012 Oct 18. |
PMID 23086037 |
|
Inhibition of UV-induced uric acid production using allopurinol prevents suppression of the contact hypersensitivity response. |
Leighton S, Kok LF, Halliday GM, Byrne SN. |
Exp Dermatol. 2013 Mar;22(3):189-94. doi: 10.1111/exd.12096. Epub 2013 Feb 6. |
PMID 23387472 |
|
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. |
Liepinsh E, Barbals R, Dahl E, Sharipo A, Staub E, Otting G. |
J Mol Biol. 2003 Oct 3;332(5):1155-63. |
PMID 14499617 |
|
Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma. |
Liu W, Luo Y, Dunn JH, Norris DA, Dinarello CA, Fujita M. |
J Invest Dermatol. 2013 Feb;133(2):518-27. doi: 10.1038/jid.2012.317. Epub 2012 Aug 30. |
PMID 22931929 |
|
Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human. |
Lo YH, Huang YW, Wu YH, Tsai CS, Lin YC, Mo ST, Kuo WC, Chuang YT, Jiang ST, Shih HM, Lai MZ. |
Blood. 2013 Apr 18;121(16):3185-94. doi: 10.1182/blood-2012-05-432104. Epub 2013 Feb 21. |
PMID 23430110 |
|
Novel role of PKR in inflammasome activation and HMGB1 release. |
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundback P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. |
Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290. |
PMID 22801494 |
|
Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. |
Machida EO, Brock MV, Hooker CM, Nakayama J, Ishida A, Amano J, Picchi MA, Belinsky SA, Herman JG, Taniguchi S, Baylin SB. |
Cancer Res. 2006 Jun 15;66(12):6210-8. |
PMID 16778195 |
|
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. |
Man SM, Hopkins LJ, Nugent E, Cox S, Gluck IM, Tourlomousis P, Wright JA, Cicuta P, Monie TP, Bryant CE. |
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7403-8. doi: 10.1073/pnas.1402911111. Epub 2014 May 6. |
PMID 24803432 |
|
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1b production. |
Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE. |
J Immunol. 2013 Nov 15;191(10):5239-46. doi: 10.4049/jimmunol.1301581. Epub 2013 Oct 11. |
PMID 24123685 |
|
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. |
Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM. |
Nature. 2004 Jul 8;430(6996):213-8. Epub 2004 Jun 9. |
PMID 15190255 |
|
Gout-associated uric acid crystals activate the NALP3 inflammasome. |
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. |
Nature. 2006 Mar 9;440(7081):237-41. Epub 2006 Jan 11. |
PMID 16407889 |
|
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. |
Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Nunez G, Inohara N. |
Biochem Biophys Res Commun. 2003 Mar 28;303(1):69-73. |
PMID 12646168 |
|
A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC. |
Matsushita K, Takeoka M, Sagara J, Itano N, Kurose Y, Nakamura A, Taniguchi S. |
Mediators Inflamm. 2009;2009:287387. doi: 10.1155/2009/287387. Epub 2009 Sep 15. |
PMID 19759850 |
|
Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. |
McConnell BB, Vertino PM. |
Cancer Res. 2000 Nov 15;60(22):6243-7. |
PMID 11103777 |
|
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. |
Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross PJ, Parks RJ, Tschopp J. |
Nature. 2008 Mar 6;452(7183):103-7. doi: 10.1038/nature06664. Epub 2008 Feb 20. |
PMID 18288107 |
|
Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection. |
Nagarajan UM, Sikes JD, Yeruva L, Prantner D. |
J Immunol. 2012 Mar 15;188(6):2866-75. doi: 10.4049/jimmunol.1103461. Epub 2012 Feb 13. |
PMID 22331066 |
|
Impaired NLRP3 inflammasome expression and function in atopic dermatitis due to Th2 milieu. |
Niebuhr M, Baumert K, Heratizadeh A, Satzger I, Werfel T. |
Allergy. 2014 Aug;69(8):1058-67. doi: 10.1111/all.12428. Epub 2014 Jun 4. |
PMID 24894535 |
|
Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. |
Nour AM, Yeung YG, Santambrogio L, Boyden ED, Stanley ER, Brojatsch J. |
Infect Immun. 2009 Mar;77(3):1262-71. doi: 10.1128/IAI.01032-08. Epub 2009 Jan 5. |
PMID 19124602 |
|
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. |
Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW. |
Nat Cell Biol. 2004 Feb;6(2):121-8. Epub 2004 Jan 18. |
PMID 14730312 |
|
Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. |
Okamoto M, Liu W, Luo Y, Tanaka A, Cai X, Norris DA, Dinarello CA, Fujita M. |
J Biol Chem. 2010 Feb 26;285(9):6477-88. doi: 10.1074/jbc.M109.064907. Epub 2009 Dec 28. |
PMID 20038581 |
|
Complete sequencing and characterization of 21,243 full-length human cDNAs. |
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S. |
Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. |
PMID 14702039 |
|
Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells. |
Parsons MJ, Patel P, Brat DJ, Colbert L, Vertino PM. |
Cancer Res. 2009 Mar 1;69(5):1706-11. doi: 10.1158/0008-5472.CAN-08-2351. Epub 2009 Feb 17. |
PMID 19223547 |
|
PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. |
Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. |
Trends Biochem Sci. 2001 Feb;26(2):85-7. |
PMID 11166558 |
|
The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis. |
Pereira MS, Marques GG, Dellama JE, Zamboni DS. |
Front Microbiol. 2011 Feb 15;2:33. doi: 10.3389/fmicb.2011.00033. eCollection 2011. |
PMID 21687424 |
|
AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer. |
Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, Choubey D. |
Mol Cancer Res. 2013 Oct;11(10):1193-202. doi: 10.1158/1541-7786.MCR-13-0145. Epub 2013 Jul 17. |
PMID 23864729 |
|
The domains of apoptosis: a genomics perspective. |
Reed JC, Doctor KS, Godzik A. |
Sci STKE. 2004 Jun 22;2004(239):re9. (REVIEW) |
PMID 15226512 |
|
Methylation-induced silencing of ASC/TMS1, a pro-apoptotic gene, is a late-stage event in colorectal cancer. |
Riojas MA, Guo M, Glockner SC, Machida EO, Baylin SB, Ahuja N. |
Cancer Biol Ther. 2007 Nov;6(11):1710-6. Epub 2007 Aug 3. |
PMID 17986858 |
|
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. |
Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C. |
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20459-64. doi: 10.1073/pnas.1010337107. Epub 2010 Nov 8. |
PMID 21059925 |
|
Caspase-5 expression is upregulated in lesional psoriatic skin. |
Salskov-Iversen ML, Johansen C, Kragballe K, Iversen L. |
J Invest Dermatol. 2011 Mar;131(3):670-6. doi: 10.1038/jid.2010.370. Epub 2010 Dec 30. |
PMID 21191419 |
|
ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. |
Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge DC, Wewers MD. |
J Immunol. 2006 Apr 15;176(8):4979-86. |
PMID 16585594 |
|
NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation. |
Satoh T, Kambe N, Matsue H. |
Cell Death Dis. 2013 May 23;4:e644. doi: 10.1038/cddis.2013.169. |
PMID 23703389 |
|
Caspase-1 dependent IL-1b secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. |
Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M. |
PLoS One. 2011;6(6):e21477. doi: 10.1371/journal.pone.0021477. Epub 2011 Jun 23. |
PMID 21731762 |
|
Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. |
Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL. |
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13501-6. Epub 2003 Oct 31. |
PMID 14595024 |
|
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. |
Stehlik C, Fiorentino L, Dorfleutner A, Bruey JM, Ariza EM, Sagara J, Reed JC. |
J Exp Med. 2002 Dec 16;196(12):1605-15. |
PMID 12486103 |
|
Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. |
Stimson KM, Vertino PM. |
J Biol Chem. 2002 Feb 15;277(7):4951-8. Epub 2001 Dec 3. |
PMID 11733524 |
|
Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma. |
Stone AR, Bobo W, Brat DJ, Devi NS, Van Meir EG, Vertino PM. |
Am J Pathol. 2004 Oct;165(4):1151-61. |
PMID 15466382 |
|
Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcd. |
Suzuki S, Franchi L, He Y, Munoz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, Nunez G. |
PLoS Pathog. 2014 Feb 6;10(2):e1003926. doi: 10.1371/journal.ppat.1003926. eCollection 2014. |
PMID 24516390 |
|
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. |
Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nuez G. |
PLoS Pathog. 2007 Aug 10;3(8):e111. |
PMID 17696608 |
|
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. |
Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP. |
J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12. |
PMID 21487011 |
|
Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. |
Taxman DJ, Zhang J, Champagne C, Bergstralh DT, Iocca HA, Lich JD, Ting JP. |
J Immunol. 2006 Oct 1;177(7):4252-6. |
PMID 16982856 |
|
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. |
Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti TD, Lamkanfi M. |
Nat Commun. 2014;5:3209. doi: 10.1038/ncomms4209. |
PMID 24492532 |
|
Pyrin Modulates the Intracellular Distribution of PSTPIP1. |
Waite AL, Schaner P, Richards N, Balci-Peynircioglu B, Masters SL, Brydges SD, Fox M, Hong A, Yilmaz E, Kastner DL, Reinherz EL, Gumucio DL. |
PLoS One. 2009 Jul 7;4(7):e6147. doi: 10.1371/journal.pone.0006147. |
PMID 19584923 |
|
Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. |
Watanabe H, Gaide O, Petrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE. |
J Invest Dermatol. 2007 Aug;127(8):1956-63. Epub 2007 Apr 12. |
PMID 17429439 |
|
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. |
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP. |
Nat Immunol. 2011 May;12(5):408-15. doi: 10.1038/ni.2022. Epub 2011 Apr 10. |
PMID 21478880 |
|
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? |
Wen H, Ting JP, O'Neill LA. |
Nat Immunol. 2012 Mar 19;13(4):352-7. doi: 10.1038/ni.2228. (REVIEW) |
PMID 22430788 |
|
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. |
Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP. |
Cell Host Microbe. 2007 Sep 13;2(3):147-59. |
PMID 18005730 |
|
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. |
Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD. |
J Immunol. 2010 Oct 15;185(8):4912-20. doi: 10.4049/jimmunol.1002046. Epub 2010 Sep 20. |
PMID 20855874 |
|
Enterohemorrhagic Escherichia coli specific enterohemolysin induced IL-1? in human macrophages and EHEC-induced IL-1b required activation of NLRP3 inflammasome. |
Zhang X, Cheng Y, Xiong Y, Ye C, Zheng H, Sun H, Zhao H, Ren Z, Xu J. |
PLoS One. 2012;7(11):e50288. doi: 10.1371/journal.pone.0050288. Epub 2012 Nov 27. |
PMID 23209696 |
|
A role for mitochondria in NLRP3 inflammasome activation. |
Zhou R, Yazdi AS, Menu P, Tschopp J. |
Nature. 2011 Jan 13;469(7329):221-5. doi: 10.1038/nature09663. Epub 2010 Dec 1. |
PMID 21124315 |
|
Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC). |
de Alba E. |
J Biol Chem. 2009 Nov 20;284(47):32932-41. doi: 10.1074/jbc.M109.024273. Epub 2009 Sep 15. |
PMID 19759015 |
|
NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia. |
van Lieshout MH, Scicluna BP, Florquin S, van der Poll T. |
Am J Respir Cell Mol Biol. 2014 Apr;50(4):699-712. doi: 10.1165/rcmb.2013-0015OC. |
PMID 24164497 |
|