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RANBP2 (RAN binding protein)

Identity

Other namesNUP358 (nucleoporin 358 kDa)
HGNC (Hugo) RANBP2
LocusID (NCBI) 5903
Location 2q12.3
Location_base_pair Starts at 109335937 and ends at 109402267 bp from pter ( according to hg19-Feb_2009)  [Mapping]

Protein

Description 3224 amino acids, 358 kDa; is composed, from N-term to C-term, of: a leucine -rich region with a leucine zipper, 4 RAN-binding domains, , 8 Zn fingers, and an internal repeat region
Function nuclear export transporter; bind RAN-GTP and exportin-1

Implicated in

Entity Inflammatory myofibroblastic tumors with t(2;2)(p23;q13)
Disease rare soft tissue tumour found in children and young adults
Prognosis good prognosis
Hybrid/Mutated Gene 5' RANBP2 - 3' ALK
  

External links

Nomenclature
HGNC (Hugo)RANBP2   9848
Entrez_Gene (NCBI)RANBP2  5903  RAN binding protein 2
Cards
AtlasRANBP2ID483
GeneCards (Weizmann)RANBP2
Ensembl (Hinxton)ENSG00000153201 [Gene_View]  chr2:109335937-109402267 [Contig_View]  RANBP2 [Vega]
AceView (NCBI)RANBP2
Genatlas (Paris)RANBP2
SOURCE (Stanford)NM_006267
Genomic and cartography
GoldenPath (UCSC)RANBP2  -  2q12.3   chr2:109335937-109402267 +  2q13   [Description]    (hg19-Feb_2009)
EnsemblRANBP2 - 2q13 [CytoView]
Mapping of homologs : NCBIRANBP2 [Mapview]
OMIM601181   608033   
Gene and transcription
Genbank (Entrez)AA971491 AB209483 AK025462 AK025711 AK026993
RefSeq transcript (SRS)NM_006267
RefSeq transcript (Entrez)NM_006267
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NG_012210 NT_022171 NW_001838822 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_012210 NT_022171 NW_001838822 NW_004078008
Consensus coding sequences : CCDS (NCBI)RANBP2
Cluster EST : UnigeneHs.715056 [ SRS ] Hs.715056 [ NCBI ]
CGAP (NCI)Hs.715056
Alternative Splicing : Fast-db (Paris)GSHG0016756
Alternative Splicing GalleryENSG00000153201
Gene ExpressionRANBP2 [ NCBI-GEO ]   RANBP2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49792 (SRS) P49792 (Uniprot)
NextProtP49792
With graphics : InterProP49792
Splice isoforms : SwissVarP49792(Swissvar)
Domaine pattern : Prosite (SRS)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)    RANBD1 (PS50196)    TPR (PS50005)    TPR_REGION (PS50293)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)    RANBD1 (PS50196)    TPR (PS50005)    TPR_REGION (PS50293)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (SRS)Cyclophilin-like_PPIase_dom    Cyclophilin-type_PPIase_CS    IR1-M    PH_like_dom    Ran_bind_dom    TPR-1    TPR-contain_dom    TPR-like_helical    TPR_repeat    Znf_RanBP2   
Domains : Interpro (EBI)Cyclophilin-like_PPIase_dom    Cyclophilin-type_PPIase_CS    IR1-M    PH_like_dom    Ran_bind_dom    TPR-1    TPR-contain_dom    TPR-like_helical    TPR_repeat    Znf_RanBP2   
Related proteins : CluSTrP49792
Domain families : Pfam (SRS)IR1-M (PF12185)    Pro_isomerase (PF00160)    Ran_BP1 (PF00638)    TPR_1 (PF00515)    zf-RanBP (PF00641)   
Domain families : Pfam (Sanger)IR1-M (PF12185)    Pro_isomerase (PF00160)    Ran_BP1 (PF00638)    TPR_1 (PF00515)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam12185    pfam00160    pfam00638    pfam00515    pfam00641   
Domain families : Smart (EMBL)RanBD (SM00160)  ZnF_RBZ (SM00547)  
DMDM5903
Blocks (Seattle)P49792
PDB (SRS)1RRP    1XKE    1Z5S    3UIN    3UIO    3UIP    4GA0   
PDB (PDBSum)1RRP    1XKE    1Z5S    3UIN    3UIO    3UIP    4GA0   
PDB (IMB)1RRP    1XKE    1Z5S    3UIN    3UIO    3UIP    4GA0   
PDB (RSDB)1RRP    1XKE    1Z5S    3UIN    3UIO    3UIP    4GA0   
Human Protein AtlasENSG00000153201
HPRD03111
IPIIPI00221325   IPI00915960   IPI00888992   IPI00916333   
Protein Interaction databases
DIP (DOE-UCLA)P49792
IntAct (EBI)P49792
FunCoupENSG00000153201
REACTOMERANBP2
Protein Interaction Database5903
BioGRIDRANBP2
InParanoidP49792
Interologous Interaction database P49792
IntegromeDBRANBP2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RANBP2
SNP (GeneSNP Utah)RANBP2
SNP : HGBaseRANBP2
Genetic variants : HAPMAPRANBP2
Somatic Mutations in Cancer : COSMICRANBP2 
CONAN: Copy Number AnalysisRANBP2 
Rearrangement : COSMICRANBP2 [2q12.3]  -  ALK [2p23.2]
Translocation Breakpoints in Cancer : TICdbRANBP2 
Mutations and Diseases : HGMDRANBP2
OMIM601181    608033   
GENETests601181    608033   
Disease Genetic AssociationRANBP2
Huge Navigator RANBP2 [HugePedia]  RANBP2 [HugeCancerGEM]
Genomic VariantsRANBP2  RANBP2 [DGVbeta]
snp3D : Map Gene to Disease5903
General knowledge
Homologs : HomoloGeneRANBP2
Homology/Alignments : Family Browser (UCSC)RANBP2
Phylogenetic Trees/Animal Genes : TreeFamRANBP2
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Chemical/Protein Interactions : CTD5903
Chemical/Pharm GKB GenePA34209
Clinical trialRANBP2
Cancer Resource (Charite)ENSG00000153201
Ontology : AmiGOM phase of mitotic cell cycle  mitotic prometaphase  mitotic cell cycle  peptidyl-prolyl cis-trans isomerase activity  protein binding  nuclear pore  cytosol  carbohydrate metabolic process  protein folding  protein import into nucleus  zinc ion binding  Ran GTPase binding  hexose transport  regulation of glucose transport  glucose transport  viral reproduction  ligase activity  protein sumoylation  protein sumoylation  cytokine-mediated signaling pathway  nuclear membrane  nuclear inclusion body  small molecule metabolic process  nuclear pore nuclear basket  metal ion binding  mRNA transport  transmembrane transport  
Ontology : EGO-EBIM phase of mitotic cell cycle  mitotic prometaphase  mitotic cell cycle  peptidyl-prolyl cis-trans isomerase activity  protein binding  nuclear pore  cytosol  carbohydrate metabolic process  protein folding  protein import into nucleus  zinc ion binding  Ran GTPase binding  hexose transport  regulation of glucose transport  glucose transport  viral reproduction  ligase activity  protein sumoylation  protein sumoylation  cytokine-mediated signaling pathway  nuclear membrane  nuclear inclusion body  small molecule metabolic process  nuclear pore nuclear basket  metal ion binding  mRNA transport  transmembrane transport  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Sumoylation by RanBP2 Regulates Transcriptional Repression [Genes]    Cycling of Ran in nucleocytoplasmic transport [Genes]   
Other databases
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
PubGeneRANBP2
iHOPRANBP2

Bibliography

A giant nucleopore protein that binds Ran/TC4.
Yokoyama N, Hayashi N, Seki T, Pantˆ© N, Ohba T, Nishii K, Kuma K, Hayashida T, Miyata T, Aebi U
Nature. 1995 ; 376 (6536) : 184-188.
PMID 7603572
 
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Mahajan R, Delphin C, Guan T, Gerace L, Melchior F
Cell. 1997 ; 88 (1) : 97-107.
PMID 9019411
 
Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.
Nothwang HG, Rensing C, Kˆºbler M, Denich D, Brandl B, Stubanus M, Haaf T, Kurnit D, Hildebrandt F
Genomics. 1998 ; 47 (3) : 383-392.
PMID 9480752
 
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
Vetter IR, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A
Nature. 1999 ; 398 (6722) : 39-46.
PMID 10078529
 
GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358.
Yaseen NR, Blobel G
The Journal of biological chemistry. 1999 ; 274 (37) : 26493-26502.
PMID 10473610
 
Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.
Ma Z, Hill DA, Collins MH, Morris SW, Sumegi J, Zhou M, Zuppan C, Bridge JA
Genes, chromosomes & cancer. 2003 ; 37 (1) : 98-105.
PMID 12661011
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written08-2003Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . RANBP2 (RAN binding protein). Atlas Genet Cytogenet Oncol Haematol. August 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/RANBP2ID483.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/38011/1/08-2003-RANBP2ID483.pdf   [ Bibliographic record ]

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indexed on : Wed May 1 13:08:05 CEST 2013

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