RANBP2 (RAN binding protein)

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RANBP2 (RAN binding protein)

Identity

Other names	NUP358 (nucleoporin 358 kDa)
HGNC (Hugo)	RANBP2
LocusID (NCBI)	5903
Location	2q12.3
Location_base_pair	Starts at 109335937 and ends at 109402267 bp from pter ( according to hg19-Feb_2009) [Mapping]

Protein

Description	3224 amino acids, 358 kDa; is composed, from N-term to C-term, of: a leucine -rich region with a leucine zipper, 4 RAN-binding domains, , 8 Zn fingers, and an internal repeat region
Function	nuclear export transporter; bind RAN-GTP and exportin-1

Implicated in

Entity	Inflammatory myofibroblastic tumors with t(2;2)(p23;q13)
Disease	rare soft tissue tumour found in children and young adults
Prognosis	good prognosis
Hybrid/Mutated Gene	5' RANBP2 - 3' ALK

External links

	Nomenclature
HGNC (Hugo)	RANBP2 9848
	Cards
Atlas	RANBP2ID483
Entrez_Gene (NCBI)	RANBP2 5903 RAN binding protein 2
GeneCards (Weizmann)	RANBP2
Ensembl (Hinxton)	ENSG00000153201 [Gene_View] chr2:109335937-109402267 [Contig_View] RANBP2 [Vega]
AceView (NCBI)	RANBP2
Genatlas (Paris)	RANBP2
WikiGenes	5903
SOURCE (Princeton)	NM_006267
	Genomic and cartography
GoldenPath (UCSC)	RANBP2 - 2q12.3 chr2:109335937-109402267 + 2q13 [Description] (hg19-Feb_2009)
Ensembl	RANBP2 - 2q13 [CytoView]
Mapping of homologs : NCBI	RANBP2 [Mapview]
OMIM	601181 608033
	Gene and transcription
Genbank (Entrez)	AA971491 AB209483 AK025462 AK025711 AK026993
RefSeq transcript (Entrez)	NM_006267
RefSeq genomic (Entrez)	AC_000134 NC_000002 NC_018913 NG_012210 NT_022171 NW_001838822 NW_004929303
Consensus coding sequences : CCDS (NCBI)	RANBP2
Cluster EST : Unigene	Hs.715056 [ NCBI ]
CGAP (NCI)	Hs.715056
Alternative Splicing : Fast-db (Paris)	GSHG0016756
Alternative Splicing Gallery	ENSG00000153201
Gene Expression	RANBP2 [ NCBI-GEO ] RANBP2 [ SEEK ] RANBP2 [ MEM ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P49792 (Uniprot)
NextProt	P49792 [Medical]
With graphics : InterPro	P49792
Splice isoforms : SwissVar	P49792 (Swissvar)
Catalytic activity : Enzyme	6.3.2.- [ Enzyme-Expasy ] 6.3.2.-6.3.2.- [ IntEnz-EBI ] 6.3.2.- [ BRENDA ] 6.3.2.- [ KEGG ]
Domaine pattern : Prosite (Expaxy)	CSA_PPIASE_1 (PS00170) CSA_PPIASE_2 (PS50072) RANBD1 (PS50196) TPR (PS50005) TPR_REGION (PS50293) ZF_RANBP2_1 (PS01358) ZF_RANBP2_2 (PS50199)
Domains : Interpro (EBI)	Cyclophilin-like_PPIase_dom Cyclophilin-type_PPIase_CS IR1-M PH_like_dom Ran_bind_dom TPR-contain_dom TPR-like_helical TPR_1 TPR_repeat Znf_RanBP2
Related proteins : CluSTr	P49792
Domain families : Pfam (Sanger)	IR1-M (PF12185) Pro_isomerase (PF00160) Ran_BP1 (PF00638) TPR_1 (PF00515) zf-RanBP (PF00641)
Domain families : Pfam (NCBI)	pfam12185 pfam00160 pfam00638 pfam00515 pfam00641
Domain families : Smart (EMBL)	RanBD (SM00160) ZnF_RBZ (SM00547)
DMDM Disease mutations	5903
Blocks (Seattle)	P49792
PDB (SRS)	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E
PDB (PDBSum)	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E
PDB (IMB)	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E
PDB (RSDB)	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E
Human Protein Atlas	ENSG00000153201
Peptide Atlas	P49792
HPRD	03111
IPI	IPI00221325 IPI00915960 IPI00888992 IPI00916333
	Protein Interaction databases
DIP (DOE-UCLA)	P49792
IntAct (EBI)	P49792
FunCoup	ENSG00000153201
BioGRID	RANBP2
InParanoid	P49792
Interologous Interaction database	P49792
IntegromeDB	RANBP2
STRING (EMBL)	RANBP2
	Ontologies - Pathways
Ontology : AmiGO	mitotic cell cycle RNA binding peptidyl-prolyl cis-trans isomerase activity protein binding nuclear pore cytosol carbohydrate metabolic process protein folding protein import into nucleus mitotic nuclear envelope disassembly zinc ion binding Ran GTPase binding hexose transport regulation of glucose transport glucose transport viral process ligase activity protein sumoylation protein sumoylation cytokine-mediated signaling pathway nuclear membrane nuclear inclusion body small molecule metabolic process nuclear pore nuclear basket mRNA transport transmembrane transport
Ontology : EGO-EBI	mitotic cell cycle RNA binding peptidyl-prolyl cis-trans isomerase activity protein binding nuclear pore cytosol carbohydrate metabolic process protein folding protein import into nucleus mitotic nuclear envelope disassembly zinc ion binding Ran GTPase binding hexose transport regulation of glucose transport glucose transport viral process ligase activity protein sumoylation protein sumoylation cytokine-mediated signaling pathway nuclear membrane nuclear inclusion body small molecule metabolic process nuclear pore nuclear basket mRNA transport transmembrane transport
Pathways : BIOCARTA	Mechanism of Protein Import into the Nucleus [Genes] Sumoylation by RanBP2 Regulates Transcriptional Repression [Genes] Cycling of Ran in nucleocytoplasmic transport [Genes]
Pathways : KEGG	RNA transport
REACTOME	RANBP2
Protein Interaction Database	RANBP2
Wikipedia pathways	RANBP2
	Gene fusion - rearrangments
Rearrangement : COSMIC	RANBP2 [2q12.3] - ALK [2p23.2]
Rearrangement : TICdb	ALK [2p23.2] - RANBP2 [2q12.3]
Rearrangement : TICdb	RANBP2 [2q12.3] - ALK [2p23.2]
Rearrangement : TICdb	RANBP2 [2q12.3] - RANBP2 [2q12.3]
Rearrangement : TICdb	RANBP2 [2q12.3] - RANBP2 [2q12.3]
	Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	RANBP2
SNP (GeneSNP Utah)	RANBP2
SNP : HGBase	RANBP2
Genetic variants : HAPMAP	RANBP2
1000_Genomes	RANBP2
ICGC program	ENSG00000153201
Somatic Mutations in Cancer : COSMIC	RANBP2
CONAN: Copy Number Analysis	RANBP2
Mutations and Diseases : HGMD	RANBP2
OMIM	601181 608033
GENETests	RANBP2
Disease Genetic Association	RANBP2
Huge Navigator	RANBP2 [HugePedia] RANBP2 [HugeCancerGEM]
Genomic Variants	RANBP2 RANBP2 [DGVbeta]
Exome Variant	RANBP2
dbVar	RANBP2
ClinVar	RANBP2
snp3D : Map Gene to Disease	5903
	General knowledge
Homologs : HomoloGene	RANBP2
Homology/Alignments : Family Browser (UCSC)	RANBP2
Phylogenetic Trees/Animal Genes : TreeFam	RANBP2
Chemical/Protein Interactions : CTD	5903
Chemical/Pharm GKB Gene	PA34209
Clinical trial	RANBP2
Cancer Resource (Charite)	ENSG00000153201
	Other databases
	Probes
	Litterature
PubMed	132 Pubmed reference(s) in Entrez
CoreMine	RANBP2
iHOP	RANBP2

Bibliography

A giant nucleopore protein that binds Ran/TC4.

Yokoyama N, Hayashi N, Seki T, Pantˆ© N, Ohba T, Nishii K, Kuma K, Hayashida T, Miyata T, Aebi U

Nature. 1995 ; 376 (6536) : 184-188.

PMID 7603572

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.

Mahajan R, Delphin C, Guan T, Gerace L, Melchior F

Cell. 1997 ; 88 (1) : 97-107.

PMID 9019411

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

Nothwang HG, Rensing C, Kˆºbler M, Denich D, Brandl B, Stubanus M, Haaf T, Kurnit D, Hildebrandt F

Genomics. 1998 ; 47 (3) : 383-392.

PMID 9480752

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.

Vetter IR, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A

Nature. 1999 ; 398 (6722) : 39-46.

PMID 10078529

GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358.

Yaseen NR, Blobel G

The Journal of biological chemistry. 1999 ; 274 (37) : 26493-26502.

PMID 10473610

Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.

Ma Z, Hill DA, Collins MH, Morris SW, Sumegi J, Zhou M, Zuppan C, Bridge JA

Genes, chromosomes & cancer. 2003 ; 37 (1) : 98-105.

PMID 12661011

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	08-2003	Jean-Loup Huret, Sylvie Senon

Citation
This paper should be referenced as such :
Huret JL, Senon S . RANBP2 (RAN binding protein). Atlas Genet Cytogenet Oncol Haematol. August 2003 .

URL : http://AtlasGeneticsOncology.org/Genes/RANBP2ID483.html

The various updated versions of this paper are referenced and archived by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/38011/1/08-2003-RANBP2ID483.pdf [ Bibliographic record ]

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indexed on : Wed Apr 16 11:38:30 CEST 2014

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