| Identity |
| Other names | NUP358 (nucleoporin 358 kDa) |
| HGNC (Hugo) | RANBP2 |
| LocusID (NCBI) | 5903 |
| Location | 2q12.3 |
| Location_base_pair | Starts at 109335937 and ends at 109402267 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| Protein |
| Description | 3224 amino acids, 358 kDa; is composed, from N-term to C-term, of: a leucine -rich region with a leucine zipper, 4 RAN-binding domains, , 8 Zn fingers, and an internal repeat region |
| Function | nuclear export transporter; bind RAN-GTP and exportin-1 |
| Implicated in |
| Entity | Inflammatory myofibroblastic tumors with t(2;2)(p23;q13) |
| Disease | rare soft tissue tumour found in children and young adults |
| Prognosis | good prognosis |
| Hybrid/Mutated Gene | 5' RANBP2 - 3' ALK |
| External links |
| Bibliography |
| A giant nucleopore protein that binds Ran/TC4. |
| Yokoyama N, Hayashi N, Seki T, Pantˆ© N, Ohba T, Nishii K, Kuma K, Hayashida T, Miyata T, Aebi U |
| Nature. 1995 ; 376 (6536) : 184-188. |
| PMID 7603572 |
| A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. |
| Mahajan R, Delphin C, Guan T, Gerace L, Melchior F |
| Cell. 1997 ; 88 (1) : 97-107. |
| PMID 9019411 |
| Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12. |
| Nothwang HG, Rensing C, Kˆºbler M, Denich D, Brandl B, Stubanus M, Haaf T, Kurnit D, Hildebrandt F |
| Genomics. 1998 ; 47 (3) : 383-392. |
| PMID 9480752 |
| Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. |
| Vetter IR, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A |
| Nature. 1999 ; 398 (6722) : 39-46. |
| PMID 10078529 |
| GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358. |
| Yaseen NR, Blobel G |
| The Journal of biological chemistry. 1999 ; 274 (37) : 26493-26502. |
| PMID 10473610 |
| Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor. |
| Ma Z, Hill DA, Collins MH, Morris SW, Sumegi J, Zhou M, Zuppan C, Bridge JA |
| Genes, chromosomes & cancer. 2003 ; 37 (1) : 98-105. |
| PMID 12661011 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2003 | Jean-Loup Huret, Sylvie Senon |
| Citation |
| This paper should be referenced as such : |
| Huret JL, Senon S . RANBP2 (RAN binding protein). Atlas Genet Cytogenet Oncol Haematol. August 2003 . |
| URL : http://AtlasGeneticsOncology.org/Genes/RANBP2ID483.html |
The various updated versions of this paper are referenced and archived by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/38011/1/08-2003-RANBP2ID483.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Dec 3 19:53:25 CET 2013 |
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