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RAP2A (RAP2A, member of RAS oncogene family)

Written2001-05Jean de Gunzburg
Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue d'Ulm, 75248 Paris Cedex 05, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesRAP2
Alias_symbol (synonym)K-REV
Other alias
HGNC (Hugo) RAP2A
LocusID (NCBI) 5911
Atlas_Id 274
Location 13q32.1  [Link to chromosome band 13q32]
Location_base_pair Starts at 97434221 and ends at 97467998 bp from pter ( according to hg19-Feb_2009)  [Mapping RAP2A.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RAP2A (13q32.1) / AFTPH (2p14)

DNA/RNA

 
Description The gene contains 2 coding exons separated by a large (29,418 bp) intron covering a total of 30,065 bp on chromosome 13

Protein

Description Rap2 is a member of the Ras superfamily of monomeric GTPases, closely related to Ras. There are twoisoforms, RAP2A and Rap2B that share 90% identity and are encoded by two different genes. Rap2 proteinsshare 50% identity with Ras proteins, including the regions involved in GDP/GTP binding (hence Rap2A hasvery similar biochemical properties to Ras), C-terminal CAAX domain leading to prenylation (farnesylationfor Rap2A and geranylgeranylation in the case of Rap2B) and palmitoylation. The effector region of Rap2 isvery similar to that of Ras proteins, yet Ras and Rap2 do share seem to share effectors.
Expression ubiquitous ; higher in brain and hemopoIetic tissues
Localisation plasma and/or intracellular membranes (endoplasmic reticulum)
Function unknonw
Homology 90% identical to Rap2B, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal unknown

Implicated in

Note
  
Entity no implication in pathologies characterized so far
  

To be noted

see also RAP family

Bibliography

Post-translational processing and subcellular localization of the Ras-related Rap2 protein.
Béranger F, Tavitian A, de Gunzburg J
Oncogene. 1991 ; 6 (10) : 1835-1842.
PMID 1923507
 
Identification of a specific effector of the small GTP-binding protein Rap2.
Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J
European journal of biochemistry / FEBS. 1998 ; 252 (2) : 290-298.
PMID 9523700
 
The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.
Lerosey I, Chardin P, de Gunzburg J, Tavitian A
The Journal of biological chemistry. 1991 ; 266 (7) : 4315-4321.
PMID 1900290
 
Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.
Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M
Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.
PMID 10913189
 
Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.
Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A
Oncogene. 1988 ; 3 (2) : 201-204.
PMID 3045729
 

Citation

This paper should be referenced as such :
Gunzburg, J de
RAP2A (RAP2A, member of RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(3):176-177.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/RAP2AID274.html


External links

Nomenclature
HGNC (Hugo)RAP2A   9861
Cards
AtlasRAP2AID274
Entrez_Gene (NCBI)RAP2A  5911  RAP2A, member of RAS oncogene family
AliasesK-REV; KREV; RAP2; RbBP-30
GeneCards (Weizmann)RAP2A
Ensembl hg19 (Hinxton)ENSG00000125249 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125249 [Gene_View]  chr13:97434221-97467998 [Contig_View]  RAP2A [Vega]
ICGC DataPortalENSG00000125249
TCGA cBioPortalRAP2A
AceView (NCBI)RAP2A
Genatlas (Paris)RAP2A
WikiGenes5911
SOURCE (Princeton)RAP2A
Genetics Home Reference (NIH)RAP2A
Genomic and cartography
GoldenPath hg38 (UCSC)RAP2A  -     chr13:97434221-97467998 +  13q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAP2A  -     13q32.1   [Description]    (hg19-Feb_2009)
EnsemblRAP2A - 13q32.1 [CytoView hg19]  RAP2A - 13q32.1 [CytoView hg38]
Mapping of homologs : NCBIRAP2A [Mapview hg19]  RAP2A [Mapview hg38]
OMIM179540   
Gene and transcription
Genbank (Entrez)AF205602 AF493914 AK090533 AK094586 AK311202
RefSeq transcript (Entrez)NM_021033
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAP2A
Cluster EST : UnigeneHs.508480 [ NCBI ]
CGAP (NCI)Hs.508480
Alternative Splicing GalleryENSG00000125249
Gene ExpressionRAP2A [ NCBI-GEO ]   RAP2A [ EBI - ARRAY_EXPRESS ]   RAP2A [ SEEK ]   RAP2A  [ MEM ]
Gene Expression Viewer (FireBrowse)RAP2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5911
GTEX Portal (Tissue expression)RAP2A
Human Protein AtlasENSG00000125249-RAP2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10114   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10114  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10114
Splice isoforms : SwissVarP10114
PhosPhoSitePlusP10114
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RAP2A
DMDM Disease mutations5911
Blocks (Seattle)RAP2A
PDB (SRS)1KAO    2RAP    3RAP   
PDB (PDBSum)1KAO    2RAP    3RAP   
PDB (IMB)1KAO    2RAP    3RAP   
PDB (RSDB)1KAO    2RAP    3RAP   
Structural Biology KnowledgeBase1KAO    2RAP    3RAP   
SCOP (Structural Classification of Proteins)1KAO    2RAP    3RAP   
CATH (Classification of proteins structures)1KAO    2RAP    3RAP   
SuperfamilyP10114
Human Protein Atlas [tissue]ENSG00000125249-RAP2A [tissue]
Peptide AtlasP10114
HPRD01547
IPIIPI00019346   IPI00980330   
Protein Interaction databases
DIP (DOE-UCLA)P10114
IntAct (EBI)P10114
FunCoupENSG00000125249
BioGRIDRAP2A
STRING (EMBL)RAP2A
ZODIACRAP2A
Ontologies - Pathways
QuickGOP10114
Ontology : AmiGOmagnesium ion binding  positive regulation of protein phosphorylation  GTPase activity  protein binding  GTP binding  GTP binding  cytosol  plasma membrane  GDP binding  microvillus assembly  negative regulation of cell migration  midbody  actin cytoskeleton reorganization  positive regulation of protein autophosphorylation  Rap protein signal transduction  cellular protein localization  cellular response to drug  establishment of protein localization  establishment of epithelial cell apical/basal polarity  regulation of JNK cascade  regulation of dendrite morphogenesis  recycling endosome  recycling endosome membrane  extracellular exosome  protein localization to plasma membrane  
Ontology : EGO-EBImagnesium ion binding  positive regulation of protein phosphorylation  GTPase activity  protein binding  GTP binding  GTP binding  cytosol  plasma membrane  GDP binding  microvillus assembly  negative regulation of cell migration  midbody  actin cytoskeleton reorganization  positive regulation of protein autophosphorylation  Rap protein signal transduction  cellular protein localization  cellular response to drug  establishment of protein localization  establishment of epithelial cell apical/basal polarity  regulation of JNK cascade  regulation of dendrite morphogenesis  recycling endosome  recycling endosome membrane  extracellular exosome  protein localization to plasma membrane  
NDEx NetworkRAP2A
Atlas of Cancer Signalling NetworkRAP2A
Wikipedia pathwaysRAP2A
Orthology - Evolution
OrthoDB5911
GeneTree (enSembl)ENSG00000125249
Phylogenetic Trees/Animal Genes : TreeFamRAP2A
HOVERGENP10114
HOGENOMP10114
Homologs : HomoloGeneRAP2A
Homology/Alignments : Family Browser (UCSC)RAP2A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAP2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAP2A
dbVarRAP2A
ClinVarRAP2A
1000_GenomesRAP2A 
Exome Variant ServerRAP2A
ExAC (Exome Aggregation Consortium)ENSG00000125249
GNOMAD BrowserENSG00000125249
Genetic variants : HAPMAP5911
Genomic Variants (DGV)RAP2A [DGVbeta]
DECIPHERRAP2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAP2A 
Mutations
ICGC Data PortalRAP2A 
TCGA Data PortalRAP2A 
Broad Tumor PortalRAP2A
OASIS PortalRAP2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRAP2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAP2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAP2A
DgiDB (Drug Gene Interaction Database)RAP2A
DoCM (Curated mutations)RAP2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAP2A (select a term)
intoGenRAP2A
NCG5 (London)RAP2A
Cancer3DRAP2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179540   
Orphanet
MedgenRAP2A
Genetic Testing Registry RAP2A
NextProtP10114 [Medical]
TSGene5911
GENETestsRAP2A
Terget ValidationRAP2A
Huge Navigator RAP2A [HugePedia]
snp3D : Map Gene to Disease5911
BioCentury BCIQRAP2A
ClinGenRAP2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5911
Chemical/Pharm GKB GenePA34222
Clinical trialRAP2A
Miscellaneous
canSAR (ICR)RAP2A (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAP2A
EVEXRAP2A
GoPubMedRAP2A
iHOPRAP2A
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 12 16:32:00 CEST 2017

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