| Written | 2001-05 | Jean de Gunzburg |
| Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue d'Ulm, 75248 Paris Cedex 05, France |
| Identity |
| Alias_names | RAP2 |
| Alias_symbol (synonym) | K-REV |
| Other alias | |
| HGNC (Hugo) | RAP2A |
| LocusID (NCBI) | 5911 |
| Atlas_Id | 274 |
| Location | 13q32.1 [Link to chromosome band 13q32] |
| Location_base_pair | Starts at 97434221 and ends at 97467998 bp from pter ( according to hg19-Feb_2009) [Mapping RAP2A.png] |
| Fusion genes (updated 2016) | RAP2A (13q32.1) / AFTPH (2p14) |
| DNA/RNA |
 | |
| Description | The gene contains 2 coding exons separated by a large (29,418 bp) intron covering a total of 30,065 bp on chromosome 13 |
| Protein |
| Description | Rap2 is a member of the Ras superfamily of monomeric GTPases, closely related to Ras. There are twoisoforms, RAP2A and Rap2B that share 90% identity and are encoded by two different genes. Rap2 proteinsshare 50% identity with Ras proteins, including the regions involved in GDP/GTP binding (hence Rap2A hasvery similar biochemical properties to Ras), C-terminal CAAX domain leading to prenylation (farnesylationfor Rap2A and geranylgeranylation in the case of Rap2B) and palmitoylation. The effector region of Rap2 isvery similar to that of Ras proteins, yet Ras and Rap2 do share seem to share effectors. |
| Expression | ubiquitous ; higher in brain and hemopoIetic tissues |
| Localisation | plasma and/or intracellular membranes (endoplasmic reticulum) |
| Function | unknonw |
| Homology | 90% identical to Rap2B, 60% identical to Rap1, 50 % to Ras proteins |
| Mutations |
| Germinal | unknown |
| Implicated in |
| Note | |
| Entity | no implication in pathologies characterized so far |
| To be noted |
| see also RAP family |
| Bibliography |
| Post-translational processing and subcellular localization of the Ras-related Rap2 protein. |
| Béranger F, Tavitian A, de Gunzburg J |
| Oncogene. 1991 ; 6 (10) : 1835-1842. |
| PMID 1923507 |
| Identification of a specific effector of the small GTP-binding protein Rap2. |
| Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J |
| European journal of biochemistry / FEBS. 1998 ; 252 (2) : 290-298. |
| PMID 9523700 |
| The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis. |
| Lerosey I, Chardin P, de Gunzburg J, Tavitian A |
| The Journal of biological chemistry. 1991 ; 266 (7) : 4315-4321. |
| PMID 1900290 |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. |
| Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A |
| Oncogene. 1988 ; 3 (2) : 201-204. |
| PMID 3045729 |
| Citation |
| This paper should be referenced as such : |
| Gunzburg, J de |
| RAP2A (RAP2A, member of RAS oncogene family) |
| Atlas Genet Cytogenet Oncol Haematol. 2001;5(3):176-177. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/RAP2AID274.html |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Aug 1 17:35:28 CEST 2017 |
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