| Description | Rap2 is a member of the Ras superfamily of monomeric GTPases, closely related to Ras. There are twoisoforms, Rap2A and Rap2B that share 90% identity and are encoded by two different genes. Rap2 proteinsshare 50% identity with Ras proteins, including the regions involved in GDP/GTP binding (hence Rap2A hasvery similar biochemical properties to Ras), C-terminal CAAX domain leading to prenylation (farnesylationfor Rap2A and geranylgeranylation in the case of Rap2B) and palmitoylation. The effector region of Rap2 isvery similar to that of Ras proteins, yet Ras and Rap2 do share seem to share effectors. |
| Expression | ubiquitous ; higher in brain and hemopoietic tissues (especially rich in platelets and meutrophils) |
| Localisation | plasma and/or intracellular membranes (endoplasmic reticulum) |
| Function | unknown |
| Homology | 90% identical to Rap2A, 60% identical to Rap1, 50 % to Ras proteins |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| |
