| Written | 2001-05 | Jean de Gunzburg |
| Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue d'Ulm, 75248 Paris Cedex 05, France |
| Identity |
| Other alias | |
| HGNC (Hugo) | RAP2B |
| LocusID (NCBI) | 5912 |
| Atlas_Id | 275 |
| Location | 3q25.2 [Link to chromosome band 3q25] |
| Location_base_pair | Starts at 153162212 and ends at 153170624 bp from pter ( according to hg19-Feb_2009) [Mapping RAP2B.png] |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| DUSP5 (10q25.2) / RAP2B (3q25.2) | HNRNPUL1 (19q13.2) / RAP2B (3q25.2) | RAP2B (3q25.2) / GABBR1 (6p22.1) | |
| RAP2B (3q25.2) / RAP2B (3q25.2) |
| DNA/RNA |
 | |
| Description | The gene contains 1 coding exon only covering 644 bp |
| Protein |
| Description | Rap2 is a member of the Ras superfamily of monomeric GTPases, closely related to Ras. There are twoisoforms, Rap2A and Rap2B that share 90% identity and are encoded by two different genes. Rap2 proteinsshare 50% identity with Ras proteins, including the regions involved in GDP/GTP binding (hence Rap2A hasvery similar biochemical properties to Ras), C-terminal CAAX domain leading to prenylation (farnesylationfor Rap2A and geranylgeranylation in the case of Rap2B) and palmitoylation. The effector region of Rap2 isvery similar to that of Ras proteins, yet Ras and Rap2 do share seem to share effectors. |
| Expression | ubiquitous ; higher in brain and hemopoietic tissues (especially rich in platelets and meutrophils) |
| Localisation | plasma and/or intracellular membranes (endoplasmic reticulum) |
| Function | unknown |
| Homology | 90% identical to Rap2A, 60% identical to Rap1, 50 % to Ras proteins |
| Mutations |
| Germinal | unknown |
| Implicated in |
| Note | |
| Entity | no implication in pathologies characterized so far |
| To be noted |
| see also RAP family |
| Bibliography |
| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. |
| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M |
| Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083. |
| PMID 10913189 |
| Citation |
| This paper should be referenced as such : |
| Gunzburg, J de |
| RAP2B (RAP2B, member of RAS oncogene family) |
| Atlas Genet Cytogenet Oncol Haematol. 2001;5(3):178-179. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/RAP2BID275.html |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jul 8 15:20:39 CEST 2019 |
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