| Description | 410 amino acids (RecQ5a), 991 amino acids (RecQ5b), 435 amino acids (RecQ5g). The predicted protein structures of all three polypeptides share seven motifs conserved for DNA helicases. RecQ5b contains a large C-terminal region that includes a domain homologous to the non-helicase domain of the E. coli RecQ DNA helicase. |
| Localisation | RecQ5a and RecQ5g are localized in the cytoplasm, whereas RecQ5b is localized in the nucleus. |
| Function | Unknown |
| Homology | Homologous to RecQ helicases, a subfamily of DExH box-containing DNA and RNA helicases. In particular, similarities with the four known human members in the RecQ subfamily, human RecQL, human RecQL4, human BLM, the product of the Bloom syndrome gene and human WRN, the product of the Werner syndrome gene. |
| Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. |
| Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A |
| Genomics. 1998 ; 54 (3) : 443-452. |
| PMID 9878247 |
| |
| Differential regulation of human RecQ family helicases in cell transformation and cell cycle. |
| Kawabe T, Tsuyama N, Kitao S, Nishikawa K, Shimamoto A, Shiratori M, Matsumoto T, Anno K, Sato T, Mitsui Y, Seki M, Enomoto T, Goto M, Ellis NA, Ide T, Furuichi Y, Sugimoto M |
| Oncogene. 2000 ; 19 (41) : 4764-4772. |
| PMID 11032027 |
| |
| Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. |
| Shimamoto A, Nishikawa K, Kitao S, Furuichi Y |
| Nucleic acids research. 2000 ; 28 (7) : 1647-1655. |
| PMID 10710432 |
| |