| Written | 2002-04 | Mounira Amor-Guéret |
| Institut Curie - Section de Recherche, UMR 2027 CNRS, Bâtiment 110, Centre Universitaire, F-91405 Orsay Cedex, France |
| Identity |
| Alias_symbol (synonym) | RecQ5 |
| FLJ90603 | |
| Other alias | |
| HGNC (Hugo) | RECQL5 |
| LocusID (NCBI) | 9400 |
| Atlas_Id | 286 |
| Location | 17q25.1 [Link to chromosome band 17q25] |
| Location_base_pair | Starts at 75626845 and ends at 75667189 bp from pter ( according to hg19-Feb_2009) [Mapping RECQL5.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| RECQL5 (17q25.1) / CACNA1G (17q21.33) | RECQL5 (17q25.1) / IVNS1ABP (1q25.3) | RECQL5 (17q25.1) / RECQL5 (17q25.1) | |
| RECQL5 (17q25.1) / SEC14L1 (17q25.2) | RECQL5 (17q25.1) / WBP2 (17q25.1) | SLC41A3 (3q21.2) / RECQL5 (17q25.1) | |
| DNA/RNA |
| Transcription | Three different transcripts : 3715 bases (RecQ5a), 3703 bases (RecQ5b), 1749 bases (RecQ5g). |
| Protein |
| Description | 410 amino acids (RecQ5a), 991 amino acids (RecQ5b), 435 amino acids (RecQ5g). The predicted protein structures of all three polypeptides share seven motifs conserved for DNA helicases. RecQ5b contains a large C-terminal region that includes a domain homologous to the non-helicase domain of the E. coli RecQ DNA helicase. |
| Localisation | RecQ5a and RecQ5g are localized in the cytoplasm, whereas RecQ5b is localized in the nucleus. |
| Function | Unknown |
| Homology | Homologous to RecQ helicases, a subfamily of DExH box-containing DNA and RNA helicases. In particular, similarities with the four known human members in the RecQ subfamily, human RecQL, human RecQL4, human BLM, the product of the Bloom syndrome gene and human WRN, the product of the Werner syndrome gene. |
| Mutations |
| Note | Not described yet, and correlation with genetic disorder, if any, is unknown. |
| Bibliography |
| Differential regulation of human RecQ family helicases in cell transformation and cell cycle. |
| Kawabe T, Tsuyama N, Kitao S, Nishikawa K, Shimamoto A, Shiratori M, Matsumoto T, Anno K, Sato T, Mitsui Y, Seki M, Enomoto T, Goto M, Ellis NA, Ide T, Furuichi Y, Sugimoto M |
| Oncogene. 2000 ; 19 (41) : 4764-4772. |
| PMID 11032027 |
| Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. |
| Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A |
| Genomics. 1998 ; 54 (3) : 443-452. |
| PMID 9878247 |
| Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. |
| Shimamoto A, Nishikawa K, Kitao S, Furuichi Y |
| Nucleic acids research. 2000 ; 28 (7) : 1647-1655. |
| PMID 10710432 |
| Citation |
| This paper should be referenced as such : |
| Amor-Guéret, M |
| RECQL5 (RecQ protein-like 5) |
| Atlas Genet Cytogenet Oncol Haematol. 2002;6(3):201-201. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/RECQL5ID286.html |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
t(17;17)(q21;q25) RECQL5/CACNA1G
RECQL5/SEC14L1 (17q25) RECQL5/WBP2 (17q25) |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jan 17 19:06:44 CET 2019 |
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