| Description | The human relb gene encodes a protein composed 579 amino acids with an approximately molecular weight of 66 kDa. Although structurally similar with other Rel family proteins containing RHD, NLS and TA domain, RelB contains an additional 121 amino acid region located at the N-terminus of RHD. Original study indicated that RelB failed to associate with RelA(p65) and to interact with DNA. That is the reason why it was named as inhibitive-Rel (I-Rel). In contrast, later studies demonstrated that RelB was able to form a heterodimer with NF-kB p50 or p52 and induce the transcription of target constructs or genes. No DNA binding activity has been suggested for the homodimeric complex of RelB, which may be possibly due to the N-terminal 121 amino acid domain that interfered with the DNA binding of RHD. |
| Expression | wide. |
| Localisation | cytosol, nuclei after activation. |
| Function | regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family. |
| The NF-kappa B and I kappa B proteins: new discoveries and insights. |
| Baldwin AS Jr |
| Annual review of immunology. 1996 ; 14 : 649-683. |
| PMID 8717528 |
| |
| Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins. |
| Bours V, Azarenko V, Dejardin E, Siebenlist U |
| Oncogene. 1994 ; 9 (6) : 1699-1702. |
| PMID 8183565 |
| |
| NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. |
| Ghosh S, May MJ, Kopp EB |
| Annual review of immunology. 1998 ; 16 : 225-260. |
| PMID 9597130 |
| |
| I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. |
| Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA |
| Genes & development. 1992 ; 6 (5) : 745-760. |
| PMID 1577270 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | RELB 9956 |
| Cards |
|---|
| Atlas | RELBID324 |
| Entrez_Gene (NCBI) | RELB 5971 RELB proto-oncogene, NF-kB subunit |
| Aliases | I-REL; IMD53; IREL; REL-B |
| GeneCards (Weizmann) | RELB |
| Ensembl hg19 (Hinxton) | ENSG00000104856 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000104856 [Gene_View] ENSG00000104856 [Sequence] chr19:45001449-45038198 [Contig_View] RELB [Vega] |
| ICGC DataPortal | ENSG00000104856 |
| TCGA cBioPortal | RELB |
| AceView (NCBI) | RELB |
| Genatlas (Paris) | RELB |
| WikiGenes | 5971 |
| SOURCE (Princeton) | RELB |
| Genetics Home Reference (NIH) | RELB |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RELB - chr19:45001449-45038198 + 19q13.32 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RELB - 19q13.32 [Description] (hg19-Feb_2009) |
| GoldenPath | RELB - 19q13.32 [CytoView hg19] RELB - 19q13.32 [CytoView hg38] |
| ImmunoBase | ENSG00000104856 |
| Mapping of homologs : NCBI | RELB [Mapview hg19] RELB [Mapview hg38] |
| OMIM | 604758 617585 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK290594 AL583128 AW137991 BC028013 BI906507 |
| RefSeq transcript (Entrez) | NM_006509 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RELB |
| Cluster EST : Unigene | Hs.654402 [ NCBI ] |
| CGAP (NCI) | Hs.654402 |
| Alternative Splicing Gallery | ENSG00000104856 |
| Gene Expression | RELB [ NCBI-GEO ] RELB [ EBI - ARRAY_EXPRESS ]
RELB [ SEEK ] RELB [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RELB [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5971 |
| GTEX Portal (Tissue expression) | RELB |
| Human Protein Atlas | ENSG00000104856-RELB [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q01201 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q01201 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q01201 |
| Splice isoforms : SwissVar | Q01201 |
| PhosPhoSitePlus | Q01201 |
| Domaine pattern : Prosite (Expaxy) | REL_1 (PS01204) REL_2 (PS50254) |
| Domains : Interpro (EBI) | Ig-like_fold Ig_E-set IPT_dom IPT_NFkappaB NFkB/Dor p53-like_TF_DNA-bd RelB RelB_leu_zip RelB_transact RHD_CS RHD_dimer RHD_DNA_bind_dom RHD_DNA_bind_dom_sf |
| Domain families : Pfam (Sanger) | RelB_leu_zip (PF16180) RelB_transactiv (PF16181) RHD_dimer (PF16179) RHD_DNA_bind (PF00554) |
| Domain families : Pfam (NCBI) | pfam16180 pfam16181 pfam16179 pfam00554 |
| Domain families : Smart (EMBL) | IPT (SM00429) |
| Conserved Domain (NCBI) | RELB |
| DMDM Disease mutations | 5971 |
| Blocks (Seattle) | RELB |
| Superfamily | Q01201 |
| Human Protein Atlas [tissue] | ENSG00000104856-RELB [tissue] |
| Peptide Atlas | Q01201 |
| HPRD | 06886 |
| IPI | IPI00221034 IPI00967958 IPI00967948 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q01201 |
| IntAct (EBI) | Q01201 |
| FunCoup | ENSG00000104856 |
| BioGRID | RELB |
| STRING (EMBL) | RELB |
| ZODIAC | RELB |
| Ontologies - Pathways |
|---|
| QuickGO | Q01201 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific stimulatory C-type lectin receptor signaling pathway chromatin binding DNA-binding transcription factor activity transcription corepressor activity protein binding nucleus nucleoplasm nucleoplasm nucleoplasm centrosome cytosol cytosol cytosol inflammatory response I-kappaB kinase/NF-kappaB signaling transcriptional repressor complex antigen processing and presentation protein kinase binding lymphocyte differentiation negative regulation of interferon-beta production circadian regulation of gene expression protein-containing complex response to cytokine NIK/NF-kappaB signaling NIK/NF-kappaB signaling identical protein binding myeloid dendritic cell differentiation T-helper 1 cell differentiation positive regulation of transcription by RNA polymerase II cellular response to osmotic stress |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific stimulatory C-type lectin receptor signaling pathway chromatin binding DNA-binding transcription factor activity transcription corepressor activity protein binding nucleus nucleoplasm nucleoplasm nucleoplasm centrosome cytosol cytosol cytosol inflammatory response I-kappaB kinase/NF-kappaB signaling transcriptional repressor complex antigen processing and presentation protein kinase binding lymphocyte differentiation negative regulation of interferon-beta production circadian regulation of gene expression protein-containing complex response to cytokine NIK/NF-kappaB signaling NIK/NF-kappaB signaling identical protein binding myeloid dendritic cell differentiation T-helper 1 cell differentiation positive regulation of transcription by RNA polymerase II cellular response to osmotic stress |
| Pathways : KEGG | MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation HTLV-I infection Epstein-Barr virus infection |
| REACTOME | Q01201 [protein] |
| REACTOME Pathways | R-HSA-5676590 [pathway] |
| NDEx Network | RELB |
| Atlas of Cancer Signalling Network | RELB |
| Wikipedia pathways | RELB |
| Orthology - Evolution |
|---|
| OrthoDB | 5971 |
| GeneTree (enSembl) | ENSG00000104856 |
| Phylogenetic Trees/Animal Genes : TreeFam | RELB |
| HOGENOM | Q01201 |
| Homologs : HomoloGene | RELB |
| Homology/Alignments : Family Browser (UCSC) | RELB |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CLASRP/RELB [19q13.32/19q13.32] [t(19;19)(q13;q13)] |
| Fusion : Mitelman | RELB/IGSF23 [19q13.32/19q13.31] [t(19;19)(q13;q13)] |
| Fusion : Mitelman | RFX3/RELB [9p24.2/19q13.32] [t(9;19)(p24;q13)] |
| Fusion Portal | CLASRP 19q13.32 RELB 19q13.32 BRCA |
| Fusion Portal | RELB 19q13.32 IGSF23 19q13.31 LUAD |
| Fusion Portal | RFX3 9p24.2 RELB 19q13.32 BRCA |
| Fusion : FusionGDB | 10325 30932 30933 31065 |
| Fusion : Fusion_Hub | CBLC--RELB CEACAM8--RELB CLASRP--RELB DNM2--RELB FLNB--RELB PEPD--RELB PKD1--RELB RELB--BCL3 RELB--C4ORF34 RELB--CLPTM1 RELB--ERCC2 RELB--FAM177A1 RELB--IGSF23 RELB--PVRL2 RELB--ZNF227 |
| RELB--ZNF876P RFX3--RELB ZNF876P--RELB |
| Fusion : Quiver | RELB |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RELB [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RELB |
| dbVar | RELB |
| ClinVar | RELB |
| 1000_Genomes | RELB |
| Exome Variant Server | RELB |
| ExAC (Exome Aggregation Consortium) | ENSG00000104856 |
| GNOMAD Browser | ENSG00000104856 |
| Varsome Browser | RELB |
| Genetic variants : HAPMAP | 5971 |
| Genomic Variants (DGV) | RELB [DGVbeta] |
| DECIPHER | RELB [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RELB |
| Mutations |
|---|
| ICGC Data Portal | RELB |
| TCGA Data Portal | RELB |
| Broad Tumor Portal | RELB |
| OASIS Portal | RELB [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RELB [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | RELB |
| Mutations and Diseases : HGMD | RELB |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search RELB |
| DgiDB (Drug Gene Interaction Database) | RELB |
| DoCM (Curated mutations) | RELB (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RELB (select a term) |
| intoGen | RELB |
| NCG5 (London) | RELB |
| Cancer3D | RELB(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 604758 617585 |
| Orphanet | |
| DisGeNET | RELB |
| Medgen | RELB |
| Genetic Testing Registry | RELB
|
| NextProt | Q01201 [Medical] |
| TSGene | 5971 |
| GENETests | RELB |
| Target Validation | RELB |
| Huge Navigator |
RELB [HugePedia] |
| snp3D : Map Gene to Disease | 5971 |
| BioCentury BCIQ | RELB |
| ClinGen | RELB |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5971 |
| Chemical/Pharm GKB Gene | PA34322 |
| Clinical trial | RELB |
| Miscellaneous |
|---|
| canSAR (ICR) | RELB (select the gene name) |
| DataMed Index | RELB |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 180 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RELB |
| EVEX | RELB |
| GoPubMed | RELB |
| iHOP | RELB |
