| Description | The human relb gene encodes a protein composed 579 amino acids with an approximately molecular weight of 66 kDa. Although structurally similar with other Rel family proteins containing RHD, NLS and TA domain, RelB contains an additional 121 amino acid region located at the N-terminus of RHD. Original study indicated that RelB failed to associate with RelA(p65) and to interact with DNA. That is the reason why it was named as inhibitive-Rel (I-Rel). In contrast, later studies demonstrated that RelB was able to form a heterodimer with NF-kB p50 or p52 and induce the transcription of target constructs or genes. No DNA binding activity has been suggested for the homodimeric complex of RelB, which may be possibly due to the N-terminal 121 amino acid domain that interfered with the DNA binding of RHD. |
| Expression | wide. |
| Localisation | cytosol, nuclei after activation. |
| Function | regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family. |
| I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. |
| Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA |
| Genes & development. 1992 ; 6 (5) : 745-760. |
| PMID 1577270 |
| |
| Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins. |
| Bours V, Azarenko V, Dejardin E, Siebenlist U |
| Oncogene. 1994 ; 9 (6) : 1699-1702. |
| PMID 8183565 |
| |
| The NF-kappa B and I kappa B proteins: new discoveries and insights. |
| Baldwin AS Jr |
| Annual review of immunology. 1996 ; 14 : 649-683. |
| PMID 8717528 |
| |
| NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. |
| Ghosh S, May MJ, Kopp EB |
| Annual review of immunology. 1998 ; 16 : 225-260. |
| PMID 9597130 |
| |