| Written | 2002-01 | Fei Chen |
| Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA |
| Identity |
| Alias_names | v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) |
| Alias_symbol (synonym) | REL-B |
| Other alias | I-Rel |
| HGNC (Hugo) | RELB |
| LocusID (NCBI) | 5971 |
| Atlas_Id | 324 |
| Location | 19q13.32 [Link to chromosome band 19q13] |
| Location_base_pair | Starts at 45001449 and ends at 45038198 bp from pter ( according to hg19-Feb_2009) [Mapping RELB.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| CLASRP (19q13.32) / RELB (19q13.32) | PEPD (19q13.11) / RELB (19q13.32) | RELB (19q13.32) / IGSF23 (19q13.31) | |
| RELB (19q13.32) / NECTIN2 (19q13.32) | RELB (19q13.32) / SMIM14 (4p14) | RFX3 (9p24.2) / RELB (19q13.32) | |
| Note | see also, in the Deep Insight section: Upstream Signal Transduction of NF-kB Activation |
| DNA/RNA |
| Description | The gene encoding human RelB has 11 exons spanning ~ 37 kb. Analysis of the 5'-flanking region of human relb gene indicates that RelB transcription is dependent on a TATA-less promoter containing two kB sites. Thus, while relA is constitutively expressed, the expression of both rel and relb is in an inducible fashion and dependent on NF-kB. |
| Protein |
| Description | The human relb gene encodes a protein composed 579 amino acids with an approximately molecular weight of 66 kDa. Although structurally similar with other Rel family proteins containing RHD, NLS and TA domain, RelB contains an additional 121 amino acid region located at the N-terminus of RHD. Original study indicated that RelB failed to associate with RelA(p65) and to interact with DNA. That is the reason why it was named as inhibitive-Rel (I-Rel). In contrast, later studies demonstrated that RelB was able to form a heterodimer with NF-kB p50 or p52 and induce the transcription of target constructs or genes. No DNA binding activity has been suggested for the homodimeric complex of RelB, which may be possibly due to the N-terminal 121 amino acid domain that interfered with the DNA binding of RHD. |
| Expression | wide. |
| Localisation | cytosol, nuclei after activation. |
| Function | regulation of the genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, cell apoptosis, and initiation or acceleration of tumorigenesis. Interaction with: members of IkB family and Rel family. |
| Implicated in |
| Note | |
| Entity | cancer, autoimmune arthritis, glomerulonephritis, asthma, inflammatory bowel disease, septic shock, lung fibrosis, HTLV-1 infection, and AIDS. |
| Bibliography |
| The NF-kappa B and I kappa B proteins: new discoveries and insights. |
| Baldwin AS Jr |
| Annual review of immunology. 1996 ; 14 : 649-683. |
| PMID 8717528 |
| Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins. |
| Bours V, Azarenko V, Dejardin E, Siebenlist U |
| Oncogene. 1994 ; 9 (6) : 1699-1702. |
| PMID 8183565 |
| NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. |
| Ghosh S, May MJ, Kopp EB |
| Annual review of immunology. 1998 ; 16 : 225-260. |
| PMID 9597130 |
| I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. |
| Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA |
| Genes & development. 1992 ; 6 (5) : 745-760. |
| PMID 1577270 |
| Citation |
| This paper should be referenced as such : |
| Chen, F |
| RELB (v-rel reticuloendotheliosis viral oncogene homolog B) |
| Atlas Genet Cytogenet Oncol Haematol. 2002;6(2):102-103. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/RELBID324.html |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ] |
|
t(10;14)(q24;q32) NFKB2/IGH
|
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
t(9;19)(p24;q13) RFX3/RELB
t(19;19)(q13;q13) CLASRP/RELB t(19;19)(q13;q13) RELB/IGSF23 |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 14 12:53:44 CEST 2018 |
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