Atlas of Genetics and Cytogenetics in Oncology and Haematology
RGS17 (regulator of G-protein signaling 17)
| Identity |
| Other names | RGS-17 |
| RGSZ2 | |
| hRGS17 | |
| HGNC (Hugo) | RGS17 |
| LocusID (NCBI) | 26575 |
| Location | 6q25.2 |
| Location_base_pair | Starts at 153332032 and ends at 153452389 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Description | The RGS17 gene spans over a region of 120 kbp DNA including 4 coding exons and 1 non-coding exon (exon 1). |
| Transcription | The RGS17 gene mRNA consists of about 1472 nucleotides with an open reading frame (ORF) of 633 bases. |
| Pseudogene | RGS17P1 regulator of G-protein signaling 17 pseudogene 1. |
| Protein |
| Note | 210 amino acids; 24 kDa. |
 | |
| Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal. | |
| Description | The RGS17 protein consists of 210 amino acid residues. This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. |
| Expression | Widely expressed in human organs. |
| Localisation | Its cellular localization has not been formally monitored to date. |
| Function | The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. |
| Homology | The RGS17 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish. |
| Mutations |
| Germinal | No germline mutations in this gene have been reported. |
| Somatic | A synonymous-coding somatic mutations of this gene is reported in pancreas cancer at codon 166, P166P (COSMIC). |
| Implicated in |
| Entity | Various cancer |
| Note | Lung cancer, prostate cancer. |
| Disease | RSG17 is overexpressed in lung and prostate cancer (James et al., 2009). Expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Overexpression of RGS17 induce and maintain cell proliferation. |
| Entity | Lung cancer |
| Disease | hsa-mir-182 is involved in the down regulation of RGS17 expression through two conserved sites located in its 3' UTR region (Sun et al., 2010). Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009). |
| Entity | Ovarian cancer |
| Disease | RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in ovarian cancer cells (Hooks et al., 2010). |
| Prognosis | RGS17 loss of expression contributes to the development of chemoresistance in ovarian cancer cells. |
| External links |
| Bibliography |
| RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. |
| James MA, Lu Y, Liu Y, Vikis HG, You M. |
| Cancer Res. 2009 Mar 1;69(5):2108-16. Epub 2009 Feb 24. |
| PMID 19244110 |
| Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. |
| You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW. |
| Clin Cancer Res. 2009 Apr 15;15(8):2666-74. Epub 2009 Apr 7. |
| PMID 19351763 |
| Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells. |
| Hooks SB, Callihan P, Altman MK, Hurst JH, Ali MW, Murph MM. |
| Mol Cancer. 2010 Nov 2;9:289. |
| PMID 21044322 |
| Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro. |
| Sun Y, Fang R, Li C, Li L, Li F, Ye X, Chen H. |
| Biochem Biophys Res Commun. 2010 May 28;396(2):501-7. Epub 2010 Apr 24. |
| PMID 20420807 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 10-2011 | Chenguang Li, Lei Wang, Yihua Sun, Haiquan Chen |
| Department of Thoracic Oncology, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China |
| Citation |
| This paper should be referenced as such : |
| Li C, Wang L, Sun Y, Chen H . RGS17 (regulator of G-protein signaling 17). Atlas Genet Cytogenet Oncol Haematol. October 2011 . URL : http://AtlasGeneticsOncology.org/Genes/RGS17ID47522ch6q25.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/handle/2042/47280/10-2011-RGS17ID47522ch6q25.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed May 1 13:07:05 CEST 2013 |
For comments and suggestions or contributions, please contact us