Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome
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Don't let the Atlas imminent demise
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RGS17 (regulator of G-protein signaling 17)


Other namesRGS-17
HGNC (Hugo) RGS17
LocusID (NCBI) 26575
Location 6q25.2
Location_base_pair Starts at 153332032 and ends at 153452389 bp from pter ( according to hg19-Feb_2009)  [Mapping]


Description The RGS17 gene spans over a region of 120 kbp DNA including 4 coding exons and 1 non-coding exon (exon 1).
Transcription The RGS17 gene mRNA consists of about 1472 nucleotides with an open reading frame (ORF) of 633 bases.
Pseudogene RGS17P1 regulator of G-protein signaling 17 pseudogene 1.


Note 210 amino acids; 24 kDa.
  Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal.
Description The RGS17 protein consists of 210 amino acid residues. This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region.
Expression Widely expressed in human organs.
Localisation Its cellular localization has not been formally monitored to date.
Function The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Homology The RGS17 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.


Germinal No germline mutations in this gene have been reported.
Somatic A synonymous-coding somatic mutations of this gene is reported in pancreas cancer at codon 166, P166P (COSMIC).

Implicated in

Entity Various cancer
Note Lung cancer, prostate cancer.
Disease RSG17 is overexpressed in lung and prostate cancer (James et al., 2009). Expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Overexpression of RGS17 induce and maintain cell proliferation.
Entity Lung cancer
Disease hsa-mir-182 is involved in the down regulation of RGS17 expression through two conserved sites located in its 3' UTR region (Sun et al., 2010).
Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009).
Entity Ovarian cancer
Disease RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in ovarian cancer cells (Hooks et al., 2010).
Prognosis RGS17 loss of expression contributes to the development of chemoresistance in ovarian cancer cells.

External links

HGNC (Hugo)RGS17   14088
Entrez_Gene (NCBI)RGS17  26575  regulator of G-protein signaling 17
GeneCards (Weizmann)RGS17
Ensembl hg19 (Hinxton)ENSG00000091844 [Gene_View]  chr6:153332032-153452389 [Contig_View]  RGS17 [Vega]
Ensembl hg38 (Hinxton)ENSG00000091844 [Gene_View]  chr6:153332032-153452389 [Contig_View]  RGS17 [Vega]
ICGC DataPortalENSG00000091844
AceView (NCBI)RGS17
Genatlas (Paris)RGS17
SOURCE (Princeton)RGS17
Genomic and cartography
GoldenPath hg19 (UCSC)RGS17  -     chr6:153332032-153452389 -  6q25-q26   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RGS17  -     6q25-q26   [Description]    (hg38-Dec_2013)
EnsemblRGS17 - 6q25-q26 [CytoView hg19]  RGS17 - 6q25-q26 [CytoView hg38]
Mapping of homologs : NCBIRGS17 [Mapview hg19]  RGS17 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA902430 AF202257 AF493938 BC013117 BT006997
RefSeq transcript (Entrez)NM_012419
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_025741 NW_004929328
Consensus coding sequences : CCDS (NCBI)RGS17
Cluster EST : UnigeneHs.166313 [ NCBI ]
CGAP (NCI)Hs.166313
Alternative Splicing : Fast-db (Paris)GSHG0027010
Alternative Splicing GalleryENSG00000091844
Gene ExpressionRGS17 [ NCBI-GEO ]     RGS17 [ SEEK ]   RGS17 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGC6 (Uniprot)
NextProtQ9UGC6  [Medical]
With graphics : InterProQ9UGC6
Splice isoforms : SwissVarQ9UGC6 (Swissvar)
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)RGS    RGS_subdom1   
Related proteins : CluSTrQ9UGC6
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
DMDM Disease mutations26575
Blocks (Seattle)Q9UGC6
PDB (SRS)1ZV4   
PDB (PDBSum)1ZV4   
PDB (IMB)1ZV4   
Human Protein AtlasENSG00000091844
Peptide AtlasQ9UGC6
Protein Interaction databases
IntAct (EBI)Q9UGC6
Ontologies - Pathways
Ontology : AmiGOGTPase activator activity  protein binding  nucleus  cytoplasm  plasma membrane  termination of G-protein coupled receptor signaling pathway  positive regulation of GTPase activity  
Ontology : EGO-EBIGTPase activator activity  protein binding  nucleus  cytoplasm  plasma membrane  termination of G-protein coupled receptor signaling pathway  positive regulation of GTPase activity  
Protein Interaction DatabaseRGS17
DoCM (Curated mutations)RGS17
Wikipedia pathwaysRGS17
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRGS17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS17
Exome Variant ServerRGS17
SNP (GeneSNP Utah)RGS17
Genetic variants : HAPMAPRGS17
Genomic Variants (DGV)RGS17 [DGVbeta]
ICGC Data PortalENSG00000091844 
Somatic Mutations in Cancer : COSMICRGS17 
CONAN: Copy Number AnalysisRGS17 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
DECIPHER (Syndromes)6:153332032-153452389
Mutations and Diseases : HGMDRGS17
NextProtQ9UGC6 [Medical]
Disease Genetic AssociationRGS17
Huge Navigator RGS17 [HugePedia]  RGS17 [HugeCancerGEM]
snp3D : Map Gene to Disease26575
DGIdb (Drug Gene Interaction db)RGS17
General knowledge
Homologs : HomoloGeneRGS17
Homology/Alignments : Family Browser (UCSC)RGS17
Phylogenetic Trees/Animal Genes : TreeFamRGS17
Chemical/Protein Interactions : CTD26575
Chemical/Pharm GKB GenePA34368
Clinical trialRGS17
Cancer Resource (Charite)ENSG00000091844
Other databases
PubMed28 Pubmed reference(s) in Entrez


RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway.
James MA, Lu Y, Liu Y, Vikis HG, You M.
Cancer Res. 2009 Mar 1;69(5):2108-16. Epub 2009 Feb 24.
PMID 19244110
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW.
Clin Cancer Res. 2009 Apr 15;15(8):2666-74. Epub 2009 Apr 7.
PMID 19351763
Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.
Hooks SB, Callihan P, Altman MK, Hurst JH, Ali MW, Murph MM.
Mol Cancer. 2010 Nov 2;9:289.
PMID 21044322
Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro.
Sun Y, Fang R, Li C, Li L, Li F, Ye X, Chen H.
Biochem Biophys Res Commun. 2010 May 28;396(2):501-7. Epub 2010 Apr 24.
PMID 20420807
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI


Written10-2011Chenguang Li, Lei Wang, Yihua Sun, Haiquan Chen
Department of Thoracic Oncology, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China


This paper should be referenced as such :
Li, C ; Wang, L ; Sun, Y ; Chen, H
RGS17 (regulator of G-protein signaling 17)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(3):216-217.
Free journal version : [ pdf ]   [ DOI ]

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indexed on : Sat Mar 28 12:43:55 CET 2015

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