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RGS17 (regulator of G-protein signaling 17)

Written2011-10Chenguang Li, Lei Wang, Yihua Sun, Haiquan Chen
Department of Thoracic Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)RGS-17
RGSZ2
hRGS17
HGNC (Hugo) RGS17
HGNC Alias symbRGSZ2
RGS-17
HGNC Previous nameregulator of G-protein signalling 17
 regulator of G-protein signaling 17
LocusID (NCBI) 26575
Atlas_Id 47522
Location 6q25.2  [Link to chromosome band 6q25]
Location_base_pair Starts at 153004459 and ends at 153131282 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping RGS17.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RGS17 (6q25.2)::ATF3 (1q32.3)SYNE1 (6q25.1)::RGS17 (6q25.2)SYNE1 (6q25.2)::RGS17 (6q25.2)
TBL1XR1 (3q26.32)::RGS17 (6q25.2)

DNA/RNA

Description The RGS17 gene spans over a region of 120 kbp DNA including 4 coding exons and 1 non-coding exon (exon 1).
Transcription The RGS17 gene mRNA consists of about 1472 nucleotides with an open reading frame (ORF) of 633 bases.
Pseudogene RGS17P1 regulator of G-protein signaling 17 pseudogene 1.

Protein

Note 210 amino acids; 24 kDa.
 
  Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal.
Description The RGS17 protein consists of 210 amino acid residues. This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region.
Expression Widely expressed in human organs.
Localisation Its cellular localization has not been formally monitored to date.
Function The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Homology The RGS17 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.

Mutations

Germinal No germline mutations in this gene have been reported.
Somatic A synonymous-coding somatic mutations of this gene is reported in pancreas cancer at codon 166, P166P (COSMIC).

Implicated in

Note
  
Entity Various cancer
Note Lung cancer, prostate cancer.
Disease RSG17 is overexpressed in lung and prostate cancer (James et al., 2009). Expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Overexpression of RGS17 induce and maintain cell proliferation.
  
  
Entity Lung cancer
Disease hsa-mir-182 is involved in the down regulation of RGS17 expression through two conserved sites located in its 3' UTR region (Sun et al., 2010).
Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009).
  
  
Entity Ovarian cancer
Disease RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in ovarian cancer cells (Hooks et al., 2010).
Prognosis RGS17 loss of expression contributes to the development of chemoresistance in ovarian cancer cells.
  

Bibliography

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.
Hooks SB, Callihan P, Altman MK, Hurst JH, Ali MW, Murph MM.
Mol Cancer. 2010 Nov 2;9:289.
PMID 21044322
 
RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway.
James MA, Lu Y, Liu Y, Vikis HG, You M.
Cancer Res. 2009 Mar 1;69(5):2108-16. Epub 2009 Feb 24.
PMID 19244110
 
Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro.
Sun Y, Fang R, Li C, Li L, Li F, Ye X, Chen H.
Biochem Biophys Res Commun. 2010 May 28;396(2):501-7. Epub 2010 Apr 24.
PMID 20420807
 
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW.
Clin Cancer Res. 2009 Apr 15;15(8):2666-74. Epub 2009 Apr 7.
PMID 19351763
 

Citation

This paper should be referenced as such :
Li, C ; Wang, L ; Sun, Y ; Chen, H
RGS17 (regulator of G-protein signaling 17)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(3):216-217.
Free journal version : [ pdf ]   [ DOI ]


External links

 

Nomenclature
HGNC (Hugo)RGS17   14088
Cards
AtlasRGS17ID47522ch6q25
Entrez_Gene (NCBI)RGS17    regulator of G protein signaling 17
AliasesRGS-17; RGSZ2; hRGS17
GeneCards (Weizmann)RGS17
Ensembl hg19 (Hinxton)ENSG00000091844 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091844 [Gene_View]  ENSG00000091844 [Sequence]  chr6:153004459-153131282 [Contig_View]  RGS17 [Vega]
ICGC DataPortalENSG00000091844
TCGA cBioPortalRGS17
AceView (NCBI)RGS17
Genatlas (Paris)RGS17
SOURCE (Princeton)RGS17
Genetics Home Reference (NIH)RGS17
Genomic and cartography
GoldenPath hg38 (UCSC)RGS17  -     chr6:153004459-153131282 -  6q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGS17  -     6q25.2   [Description]    (hg19-Feb_2009)
GoldenPathRGS17 - 6q25.2 [CytoView hg19]  RGS17 - 6q25.2 [CytoView hg38]
ImmunoBaseENSG00000091844
Genome Data Viewer NCBIRGS17 [Mapview hg19]  
OMIM607191   
Gene and transcription
Genbank (Entrez)AA902430 AF202257 AF493938 BC013117 BT006997
RefSeq transcript (Entrez)NM_012419
Consensus coding sequences : CCDS (NCBI)RGS17
Gene ExpressionRGS17 [ NCBI-GEO ]   RGS17 [ EBI - ARRAY_EXPRESS ]   RGS17 [ SEEK ]   RGS17 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS17 [ Firebrowse - Broad ]
GenevisibleExpression of RGS17 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26575
GTEX Portal (Tissue expression)RGS17
Human Protein AtlasENSG00000091844-RGS17 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGC6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGC6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGC6
PhosPhoSitePlusQ9UGC6
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)RGS    RGS_sf   
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
Conserved Domain (NCBI)RGS17
PDB (RSDB)1ZV4    6AM3   
PDB Europe1ZV4    6AM3   
PDB (PDBSum)1ZV4    6AM3   
PDB (IMB)1ZV4    6AM3   
Structural Biology KnowledgeBase1ZV4    6AM3   
SCOP (Structural Classification of Proteins)1ZV4    6AM3   
CATH (Classification of proteins structures)1ZV4    6AM3   
SuperfamilyQ9UGC6
AlphaFold pdb e-kbQ9UGC6   
Human Protein Atlas [tissue]ENSG00000091844-RGS17 [tissue]
HPRD06223
Protein Interaction databases
DIP (DOE-UCLA)Q9UGC6
IntAct (EBI)Q9UGC6
BioGRIDRGS17
STRING (EMBL)RGS17
ZODIACRGS17
Ontologies - Pathways
QuickGOQ9UGC6
Ontology : AmiGOresponse to amphetamine  GTPase activator activity  protein binding  nucleus  cytoplasm  plasma membrane  G protein-coupled receptor signaling pathway  negative regulation of signal transduction  neuron projection  synapse  regulation of catalytic activity  
Ontology : EGO-EBIresponse to amphetamine  GTPase activator activity  protein binding  nucleus  cytoplasm  plasma membrane  G protein-coupled receptor signaling pathway  negative regulation of signal transduction  neuron projection  synapse  regulation of catalytic activity  
REACTOMEQ9UGC6 [protein]
REACTOME PathwaysR-HSA-418597 [pathway]   
NDEx NetworkRGS17
Atlas of Cancer Signalling NetworkRGS17
Wikipedia pathwaysRGS17
Orthology - Evolution
OrthoDB26575
GeneTree (enSembl)ENSG00000091844
Phylogenetic Trees/Animal Genes : TreeFamRGS17
Homologs : HomoloGeneRGS17
Homology/Alignments : Family Browser (UCSC)RGS17
Gene fusions - Rearrangements
Fusion : MitelmanSYNE1::RGS17 [6q25.1/6q25.2]  
Fusion : MitelmanTBL1XR1::RGS17 [3q26.32/6q25.2]  
Fusion : QuiverRGS17
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS17
dbVarRGS17
ClinVarRGS17
MonarchRGS17
1000_GenomesRGS17 
Exome Variant ServerRGS17
GNOMAD BrowserENSG00000091844
Varsome BrowserRGS17
ACMGRGS17 variants
VarityQ9UGC6
Genomic Variants (DGV)RGS17 [DGVbeta]
DECIPHERRGS17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGS17 
Mutations
ICGC Data PortalRGS17 
TCGA Data PortalRGS17 
Broad Tumor PortalRGS17
OASIS PortalRGS17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS17  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRGS17
Mutations and Diseases : HGMDRGS17
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRGS17
DgiDB (Drug Gene Interaction Database)RGS17
DoCM (Curated mutations)RGS17
CIViC (Clinical Interpretations of Variants in Cancer)RGS17
NCG (London)RGS17
Cancer3DRGS17
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607191   
Orphanet
DisGeNETRGS17
MedgenRGS17
Genetic Testing Registry RGS17
NextProtQ9UGC6 [Medical]
GENETestsRGS17
Target ValidationRGS17
Huge Navigator RGS17 [HugePedia]
ClinGenRGS17
Clinical trials, drugs, therapy
MyCancerGenomeRGS17
Protein Interactions : CTDRGS17
Pharm GKB GenePA34368
PharosQ9UGC6
Clinical trialRGS17
Miscellaneous
canSAR (ICR)RGS17
HarmonizomeRGS17
DataMed IndexRGS17
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRGS17
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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