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RGS17 (regulator of G-protein signaling 17)

Identity

Other namesRGS-17
RGSZ2
hRGS17
HGNC (Hugo) RGS17
LocusID (NCBI) 26575
Location 6q25.2
Location_base_pair Starts at 153332032 and ends at 153452389 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description The RGS17 gene spans over a region of 120 kbp DNA including 4 coding exons and 1 non-coding exon (exon 1).
Transcription The RGS17 gene mRNA consists of about 1472 nucleotides with an open reading frame (ORF) of 633 bases.
Pseudogene RGS17P1 regulator of G-protein signaling 17 pseudogene 1.

Protein

Note 210 amino acids; 24 kDa.
 
  Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal.
Description The RGS17 protein consists of 210 amino acid residues. This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region.
Expression Widely expressed in human organs.
Localisation Its cellular localization has not been formally monitored to date.
Function The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Homology The RGS17 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.

Mutations

Germinal No germline mutations in this gene have been reported.
Somatic A synonymous-coding somatic mutations of this gene is reported in pancreas cancer at codon 166, P166P (COSMIC).

Implicated in

Entity Various cancer
Note Lung cancer, prostate cancer.
Disease RSG17 is overexpressed in lung and prostate cancer (James et al., 2009). Expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Overexpression of RGS17 induce and maintain cell proliferation.
  
Entity Lung cancer
Disease hsa-mir-182 is involved in the down regulation of RGS17 expression through two conserved sites located in its 3' UTR region (Sun et al., 2010).
Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009).
  
Entity Ovarian cancer
Disease RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in ovarian cancer cells (Hooks et al., 2010).
Prognosis RGS17 loss of expression contributes to the development of chemoresistance in ovarian cancer cells.
  

External links

Nomenclature
HGNC (Hugo)RGS17   14088
Cards
AtlasRGS17ID47522ch6q25
Entrez_Gene (NCBI)RGS17  26575  regulator of G-protein signaling 17
GeneCards (Weizmann)RGS17
Ensembl (Hinxton)ENSG00000091844 [Gene_View]  chr6:153332032-153452389 [Contig_View]  RGS17 [Vega]
ICGC DataPortalENSG00000091844
cBioPortalRGS17
AceView (NCBI)RGS17
Genatlas (Paris)RGS17
WikiGenes26575
SOURCE (Princeton)NM_012419
Genomic and cartography
GoldenPath (UCSC)RGS17  -  6q25.2   chr6:153332032-153452389 -  6q25-q26   [Description]    (hg19-Feb_2009)
EnsemblRGS17 - 6q25-q26 [CytoView]
Mapping of homologs : NCBIRGS17 [Mapview]
OMIM607191   
Gene and transcription
Genbank (Entrez)AA902430 AF202257 AF493938 BC013117 BT006997
RefSeq transcript (Entrez)NM_012419
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_025741 NW_001838990 NW_004929328
Consensus coding sequences : CCDS (NCBI)RGS17
Cluster EST : UnigeneHs.166313 [ NCBI ]
CGAP (NCI)Hs.166313
Alternative Splicing : Fast-db (Paris)GSHG0027010
Alternative Splicing GalleryENSG00000091844
Gene ExpressionRGS17 [ NCBI-GEO ]     RGS17 [ SEEK ]   RGS17 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGC6 (Uniprot)
NextProtQ9UGC6  [Medical]
With graphics : InterProQ9UGC6
Splice isoforms : SwissVarQ9UGC6 (Swissvar)
Domaine pattern : Prosite (Expaxy)RGS (PS50132)   
Domains : Interpro (EBI)Regulat_G_prot_signal_dom1 [organisation]   Regulat_G_prot_signal_superfam [organisation]   RGS_dom [organisation]  
Related proteins : CluSTrQ9UGC6
Domain families : Pfam (Sanger)RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  
DMDM Disease mutations26575
Blocks (Seattle)Q9UGC6
PDB (SRS)1ZV4   
PDB (PDBSum)1ZV4   
PDB (IMB)1ZV4   
PDB (RSDB)1ZV4   
Human Protein AtlasENSG00000091844 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9UGC6
HPRD06223
IPIIPI00005250   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGC6
IntAct (EBI)Q9UGC6
FunCoupENSG00000091844
BioGRIDRGS17
InParanoidQ9UGC6
Interologous Interaction database Q9UGC6
IntegromeDBRGS17
STRING (EMBL)RGS17
Ontologies - Pathways
Ontology : AmiGOGTPase activator activity  nucleus  cytoplasm  plasma membrane  termination of G-protein coupled receptor signaling pathway  positive regulation of GTPase activity  
Ontology : EGO-EBIGTPase activator activity  nucleus  cytoplasm  plasma membrane  termination of G-protein coupled receptor signaling pathway  positive regulation of GTPase activity  
Protein Interaction DatabaseRGS17
Wikipedia pathwaysRGS17
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RGS17
snp3D : Map Gene to Disease26575
SNP (GeneSNP Utah)RGS17
SNP : HGBaseRGS17
Genetic variants : HAPMAPRGS17
Exome VariantRGS17
1000_GenomesRGS17 
ICGC programENSG00000091844 
Somatic Mutations in Cancer : COSMICRGS17 
CONAN: Copy Number AnalysisRGS17 
Mutations and Diseases : HGMDRGS17
Genomic VariantsRGS17  RGS17 [DGVbeta]
dbVarRGS17
ClinVarRGS17
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM607191   
MedgenRGS17
GENETestsRGS17
Disease Genetic AssociationRGS17
Huge Navigator RGS17 [HugePedia]  RGS17 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneRGS17
Homology/Alignments : Family Browser (UCSC)RGS17
Phylogenetic Trees/Animal Genes : TreeFamRGS17
Chemical/Protein Interactions : CTD26575
Chemical/Pharm GKB GenePA34368
Clinical trialRGS17
Cancer Resource (Charite)ENSG00000091844
Other databases
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
CoreMineRGS17
iHOPRGS17

Bibliography

RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway.
James MA, Lu Y, Liu Y, Vikis HG, You M.
Cancer Res. 2009 Mar 1;69(5):2108-16. Epub 2009 Feb 24.
PMID 19244110
 
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW.
Clin Cancer Res. 2009 Apr 15;15(8):2666-74. Epub 2009 Apr 7.
PMID 19351763
 
Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.
Hooks SB, Callihan P, Altman MK, Hurst JH, Ali MW, Murph MM.
Mol Cancer. 2010 Nov 2;9:289.
PMID 21044322
 
Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro.
Sun Y, Fang R, Li C, Li L, Li F, Ye X, Chen H.
Biochem Biophys Res Commun. 2010 May 28;396(2):501-7. Epub 2010 Apr 24.
PMID 20420807
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written10-2011Chenguang Li, Lei Wang, Yihua Sun, Haiquan Chen
Department of Thoracic Oncology, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

Citation

This paper should be referenced as such :
Li C, Wang L, Sun Y, Chen H
RGS17 (regulator of G-protein signaling 17);
Atlas Genet Cytogenet Oncol Haematol. October 2011
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/RGS17ID47522ch6q25.html

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indexed on : Fri Jul 11 17:17:26 CEST 2014

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