RHOH (Ras homolog gene family, member H)

Identity

Other names	TTF (translocation three four)
	ARHH
Hugo	RHOH
Location	4p13
	RHPH (4p13) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description	spans on a 35 kb genomic fragment; two exons separated by a large intron; small GTPase encoding gene
Transcription	2.2 kb mRNA; coding sequence: 575 bp, located in the second exon

Protein

Description	191 amino acids; 21 kDa; contains a GTP binding motif, a GTPase activity site, and a membrane localisation signal (CAAX box) in the very C-term
Expression	restricted to the hemopoietic tissues
Localisation	plasmic membrane
Function	small GTPase of the Rho subfamily; involved in signal transduction and cytoskeletal reorganization
Homology	with all GTPases of the Ras superfamily

Implicated in

Entity	t(3;4)(q27;p13)/NHL --> BCL6 - RHOH
Disease	follicular NHL
Cytogenetics	observed as a secondary anomaly
Hybrid/Mutated Gene	5' RHOH - 3' BCL6 and 5' BCL6 - 3' RHOH, leading to two fusion transcripts
Abnormal Protein	no fusion protein, but promoter exchange between both partner genes
Entity	t(4;14)(p13;q32)/multiple myeloma --> RHOH - ??
Disease	multiple myeloma
Prognosis	still unknown: only 1 available case
Cytogenetics	observed as a unique anomaly
Hybrid/Mutated Gene	not yet known (under study)

Breakpoints

External links

	Nomenclature
Hugo	RHOH
GDB	RHOH
Entrez_Gene	RHOH  399  ras homolog gene family, member H
	Cards
Atlas	RHOH93
GeneCards	RHOH
Ensembl	RHOH [Search_View]   ENSG00000168421 [Gene_View]
Genatlas	RHOH
GeneLynx	RHOH
eGenome	RHOH
euGene	399
	Genomic and cartography
GoldenPath	RHOH  -  4p13   chr4:39874922-39922676 +  4p13   [Description]    (hg18-Mar_2006)
Ensembl	RHOH - 4p13 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	RHOH
	Gene and transcription
Genbank	AF498975 [ ENTREZ ]
Genbank	AI865435 [ ENTREZ ]
Genbank	BC014261 [ ENTREZ ]
Genbank	BG025818 [ ENTREZ ]
Genbank	CA447396 [ ENTREZ ]
RefSeq	NM_004310 [ SRS ]    NM_004310 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_016297 [ SRS ]    NT_016297 [ ENTREZ ]
RefSeq	NW_922073 [ SRS ]    NW_922073 [ ENTREZ ]
AceView	RHOH AceView - NCBI
Unigene	Hs.694951 [ SRS ]    Hs.694951 [ NCBI ]     HS694951 [ spliceNest ]
Fast-db	3740 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q15669 [ SRS]    Q15669 [ EXPASY ]     Q15669 [ INTERPRO ]
Interpro	IPR003578 GTPase_Rho [ SRS ]    IPR003578 GTPase_Rho [ EBI ]
Interpro	IPR013753 Ras [ SRS ]    IPR013753 Ras [ EBI ]
Interpro	IPR001806 Ras_trnsfrmng [ SRS ]    IPR001806 Ras_trnsfrmng [ EBI ]
Interpro	IPR005225 Small_GTP_bd [ SRS ]    IPR005225 Small_GTP_bd [ EBI ]
CluSTr	Q15669
Pfam	PF00071 Ras [ SRS ]    PF00071 Ras [ Sanger ]    pfam00071 [ NCBI-CDD ]
Smart	SM00174 RHO [EMBL]
Blocks	Q15669
HPRD	03616
	Protein Interaction databases
DIP	Q15669
IntAct	Q15669
	Polymorphism : SNP, mutations, diseases
OMIM	602037    [ map ]
GENECLINICS	602037
SNP	RHOH [dbSNP-NCBI]
SNP	NM_004310 [SNP-NCI]
SNP	RHOH [GeneSNPs - Utah]  RHOH] [HGBASE - SRS]
HAPMAP	RHOH [HAPMAP]
COSMIC	RHOH [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RHOH
	General knowledge
Family Browser	RHOH [UCSC Family Browser]
SOURCE	NM_004310
SMD	Hs.694951
SAGE	Hs.694951
GO	nucleotide binding [Amigo]  nucleotide binding
GO	GTPase inhibitor activity [Amigo]  GTPase inhibitor activity
GO	protein binding [Amigo]  protein binding
GO	GTP binding [Amigo]  GTP binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	small GTPase mediated signal transduction [Amigo]  small GTPase mediated signal transduction
GO	Rho GTPase binding [Amigo]  Rho GTPase binding
GO	kinase inhibitor activity [Amigo]  kinase inhibitor activity
GO	T cell differentiation [Amigo]  T cell differentiation
GO	negative regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO	regulation of transcription [Amigo]  regulation of transcription
KEGG	Leukocyte transendothelial migration
PubGene	RHOH
TreeFam	RHOH
CTD	399 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	Cancer Cytogenetics (Bari)
Probe	RHOH Related clones (RZPD - Berlin)
	PubMed
PubMed	15 Pubmed reference(s) in LocusLink

Bibliography

TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.

Dallery E, Galiˆ®gue-Zouitina S, Collyn-d'Hooghe M, Quief S, Denis C, Hildebrand MP, Lantoine D, Deweindt C, Tilly H, Bastard C

Oncogene. 1995 ; 10 (11) : 2171-2178.

PMID 7784061

Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization.

Dallery-Prudhomme E, Roumier C, Denis C, Preudhomme C, Kerckaert JP, Galiegue-Zouitina S

Genomics. 1997 ; 43 (1) : 89-94.

PMID 9226377

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	02-1998	Sylvie Galiègue-Zouitina

Citation

This paper should be referenced as such :

Galiègue-Zouitina S . RHOH (Ras homolog gene family, member H). Atlas Genet Cytogenet Oncol Haematol. February 1998 . URL : http://AtlasGeneticsOncology.org/Genes/RHOH93.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:26:49 2008