Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ROBO1 (roundabout, axon guidance receptor, homolog 1 (Drosophila))

Written2008-12Oliver Doebler, Joern Groene
Vivantes Clinic Auguste Viktoria, Department of Surgery, Berlin, Germany (OD); Charite - Campus Benjamin Franklin, Department of Surgery, Berlin,Germany (JG)

(Note : for Links provided by Atlas : click)

Identity

Alias_namesroundabout (axon guidance receptor, Drosophila) homolog 1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
Alias_symbol (synonym)DUTT1
FLJ21882
SAX3
Other aliasMGC131599
MGC133277
HGNC (Hugo) ROBO1
LocusID (NCBI) 6091
Atlas_Id 42140
Location 3p12.3  [Link to chromosome band 3p12]
Location_base_pair Starts at 78597238 and ends at 79019459 bp from pter ( according to hg19-Feb_2009)  [Mapping ROBO1.png]
Fusion genes
(updated 2016)
DDX6 (11q23.3) / ROBO1 (3p12.3)RBMS3 (3p24.1) / ROBO1 (3p12.3)ROBO1 (3p12.3) / ACKR3 (2q37.3)
ROBO1 (3p12.3) / GPR162 (12p13.31)ROBO1 (3p12.3) / MED12L (3q25.1)ROBO1 (3p12.3) / OSGIN2 (8q21.3)
ROBO1 (3p12.3) / ROBO1 (3p12.3)ROBO1 (3p12.3) / SEMA5B (3q21.1)ROBO1 (3p12.3) / SSFA2 (2q31.3)
TUBB6 (18p11.21) / ROBO1 (3p12.3)

DNA/RNA

 
Description 30 Exons, 30 coding exons, 992672bp of genomic DNA.
Transcription Two mRNA transcript variants. Transcript variant 1 contains of 6629b coded by 30 exons. Transcript variant 2 utilizes an alternate exon that contains a different 5'UTR and translation start site than that of variant 1. The N-terminus differs from isoform a encoded by variant 1. Transcript variant 2 contains of 6456b coded by 28 exons.
Pseudogene None known.

Protein

Description ROBO1 is a single-pass type 1 membrane protein and interacts with SLIT1 and SLIT2. ROBO1 belongs to the immunglobulin super family of ROBO proteins. It contains of 3 fibronectin type-III domains and 5 immunoglobuline-like C2-type domains. There are 3 protein isoforms existing of ROBO1 produced by alternative splicing.
Expression ROBO1 expression is seen in a number different tissues and organs.
Localisation ROBO1 proteins are located in the cellular membrane as a transmembrane protein.
Function Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Robo1 plays also a role in cell-adhesion. ROBO1 may be required for lung development. It is indicated that ROBO/SLIT is involved in angiogenic mechanisms whereas endothelial cells expressing ROBO1 receptors are attracted by SLIT2 which is secreted by human tumor cells.
Homology There are 3 paralogs of human ROBO1 : ROBO2, ROBO3 and ROBO4. Orthologs have been identified in mouse, rat, cow, dog, chimpanzee.

Implicated in

Note
  
Entity Lung cancer
Oncogenesis A deletion of chromosome 3 allele and dysfunction or lack of ROBO1 receptors might be an early somatic genetic change in lung tumor development (Xian et al., 2001; Dallol et al., 2002b; Tsujiuchi et al., 2004; Xian et al., 2004).
  
  
Entity Breast cancer
Oncogenesis Breast cancer tumors and tumor cell lines show a suppressed expression of ROBO1 gene (Dallol et al., 2002a; Dallol et al., 2002b).
  
  
Entity Prostate cancer
Oncogenesis Human prostate tumors and tumor cell lines show an overexpression of ROBO1 gene (Bonner et al., 2003).
  
  
Entity Angiogenesis of malignant tumors
Oncogenesis ROBO1 gene is highly expressed in tumor vessel endothelium. Blocking of ROBO1 receptors causes loss of microvessel density in tumors e.g. malignant melanoma, colorectal cancer (Wang et al., 2003; Suchting et al., 2005; Groene et al., 2006; Legg et al., 2008).
  
  
Entity Colorectal cancer
Oncogenesis ROBO1 gene is overexpressed in human colorectal cancer tumor probes and colorectal cancer cell lines (Groene et al., 2006).
  
  
Entity Cervical cancer
Oncogenesis Cervical Cancer exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal sites of SLIT-ROBO pathway genes (Narayan et al., 2006).
  
  
Entity Hepatocellular carcinoma
Oncogenesis ROBO1, a member of the immunoglobulin superfamily, is highly expressed in hepatocellular carcinoma, whereas it showes only a limited distribution in normal liver tissue. Strikingly, the ectodomain of ROBO1 was detected not only in the culture medium of liver cancer cell lines (PLC/PRF/5, HepG2, etc.) but also in sera from hepatocellular carcinoma patients (Ito et al., 2006).
  
  
Entity T-acute lymphoblastic leukaemia
Oncogenesis ROBO1 gene alterations were detected in subpopulations with childhood T-acute lymphoblastic leukaemia (Haltrich et al., 2007).
  
  
Entity Nasopharyngeal carcinoma
Oncogenesis In an inducible Epstein-Barr virus (EBV) nasopharyngeal cell line was a increased expression of ROBO1 detected that may be cause a role in this tumor carcinogenesis (Lee et al., 2008).
  
  
Entity Dyslexia
Disease Dyslexia may be caused by partial haplo-insufficiency for ROBO1 in rare families. A slight disturbance in neuronal axon crossing across the midline between brain hemispheres, dendrite guidance, or another function of ROBO1 may manifest as a specific reading disability in humans (Hannula-Jouppi et al., 2005; Fisher and Francks, 2006; McGrath et al., 2006; Shastry, 2007; Paracchini et al., 2007).
  
  
Entity Autism
Disease Gene expression analysis show a reduced expression for ROBO1 in the autistic patient group and may play a role in pathogenesis of autism (Anitha et al., 2008).
  

Bibliography

Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.
Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N.
Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1019-27.
PMID 18270976
 
Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis.
Bonner AE, Lemon WJ, You M.
J Med Genet. 2003 Jun;40(6):408-17.
PMID 12807961
 
SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.
Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER, Latif F.
Cancer Res. 2002a Oct 15;62(20):5874-80.
PMID 12384551
 
Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.
Dallol A, Forgacs E, Martinez A, Sekido Y, Walker R, Kishida T, Rabbitts P, Maher ER, Minna JD, Latif F.
Oncogene. 2002b May 2;21(19):3020-8.
PMID 12082532
 
Genes, cognition and dyslexia: learning to read the genome.
Fisher SE, Francks C.
Trends Cogn Sci. 2006 Jun;10(6):250-7. Epub 2006 May 3. Review
PMID 16675285
 
Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer.
Groene J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S.
Oncol Rep. 2006 Jun;15(6):1437-43.
PMID 16685377
 
Multipoint interphase FISH in childhood T-acute lymphoblastic leukemia detects subpopulations that carry different chromosome 3 aberrations.
Haltrich I, Kost-Alimova M, Kovacs G, Dobos M, Klein G, Fekete G, Imreh S.
Cancer Genet Cytogenet. 2007 Jan 1;172(1):54-60.
PMID 17175380
 
The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia.
Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kaariainen H, Kere J.
PLoS Genet. 2005 Oct;1(4):e50. Epub 2005 Oct 28.
PMID 16254601
 
Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target.
Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanabe A, Hippo Y, Ohtomo T, Iwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H.
Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3257-64.
PMID 16740745
 
Quantification of expression of netrins, slits and their receptors in human prostate tumors.
Latil A, Chene L, Cochant-Priollet B, Mangin P, Fournier G, Berthon P, Cussenot O.
Int J Cancer. 2003 Jan 20;103(3):306-15.
PMID 12471613
 
Amplicons on chromosome 3 contain oncogenes induced by recurrent exposure to 12-O-tetradecanoylphorbol-13-acetate and sodium n-butyrate and Epstein-Barr virus reactivation in a nasopharyngeal carcinoma cell line.
Lee CH, Fang CY, Sheu JJ, Chang Y, Takada K, Chen JY.
Cancer Genet Cytogenet. 2008 Aug;185(1):1-10.
PMID 18656687
 
Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration.
Legg JA, Herbert JM, Clissold P, Bicknell R.
Angiogenesis. 2008;11(1):13-21. Epub 2008 Feb 9. Review
PMID 18264786
 
Breakthroughs in the search for dyslexia candidate genes.
McGrath LM, Smith SD, Pennington BF.
Trends Mol Med. 2006 Jul;12(7):333-41. Epub 2006 Jun 16. Review
PMID 16781891
 
Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3.
Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA.
Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):961-8. Epub 2007 Aug 17.
PMID 17704564
 
Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression.
Narayan G, Goparaju C, Arias-Pulido H, Kaufmann AM, Schneider A, Durst M, Mansukhani M, Pothuri B, Murty VV.
Mol Cancer. 2006 May 15;5:16.
PMID 16700909
 
The genetic lexicon of dyslexia.
Paracchini S, Scerri T, Monaco AP.
Annu Rev Genomics Hum Genet. 2007;8:57-79. Review
PMID 17444811
 
[Genetics of dyslexia]
Schulte-Korne G, Warnke A, Remschmidt H.
Z Kinder Jugendpsychiatr Psychother. 2006 Nov;34(6):435-44. Review
PMID 17094062
 
Developmental dyslexia: an update.
Shastry BS.
J Hum Genet. 2007;52(2):104-9. Epub 2006 Nov 17. Review
PMID 17111266
 
Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration.
Suchting S, Heal P, Tahtis K, Stewart LM, Bicknell R.
FASEB J. 2005 Jan;19(1):121-3. Epub 2004 Oct 14.
PMID 15486058
 
Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Tsujiuchi T, Sasaki Y, Oka Y, Kuniyasu H, Tsutsumi M.
Mol Carcinog. 2004 Aug;40(4):241-6.
PMID 15264215
 
Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity.
Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG.
Cancer Cell. 2003 Jul;4(1):19-29.
PMID 12892710
 
Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis.
Wang LJ, Zhao Y, Han B, Ma YG, Zhang J, Yang DM, Mao JW, Tang FT, Li WD, Yang Y, Wang R, Geng JG.
Cancer Sci. 2008 Mar;99(3):510-7. Epub 2008 Jan 14.
PMID 18201275
 
Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter.
Xian J, Aitchison A, Bobrow L, Corbett G, Pannell R, Rabbitts T, Rabbitts P.
Cancer Res. 2004 Sep 15;64(18):6432-7.
PMID 15374951
 
Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene.
Xian J, Clark KJ, Fordham R, Pannell R, Rabbitts TH, Rabbitts PH.
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15062-6. Epub 2001 Dec 4.
PMID 11734623
 

Citation

This paper should be referenced as such :
Doebler, O ; Groene, J
ROBO1 (roundabout, axon guidance receptor, homolog 1 (Drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2009;13(11):872-874.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ROBO1ID42140ch3p12.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Kidney: Clear cell renal cell carcinoma


External links

Nomenclature
HGNC (Hugo)ROBO1   10249
Cards
AtlasROBO1ID42140ch3p12
Entrez_Gene (NCBI)ROBO1  6091  roundabout guidance receptor 1
AliasesDUTT1; SAX3
GeneCards (Weizmann)ROBO1
Ensembl hg19 (Hinxton)ENSG00000169855 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169855 [Gene_View]  chr3:78597238-79019459 [Contig_View]  ROBO1 [Vega]
ICGC DataPortalENSG00000169855
TCGA cBioPortalROBO1
AceView (NCBI)ROBO1
Genatlas (Paris)ROBO1
WikiGenes6091
SOURCE (Princeton)ROBO1
Genetics Home Reference (NIH)ROBO1
Genomic and cartography
GoldenPath hg38 (UCSC)ROBO1  -     chr3:78597238-79019459 -  3p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ROBO1  -     3p12.3   [Description]    (hg19-Feb_2009)
EnsemblROBO1 - 3p12.3 [CytoView hg19]  ROBO1 - 3p12.3 [CytoView hg38]
Mapping of homologs : NCBIROBO1 [Mapview hg19]  ROBO1 [Mapview hg38]
OMIM602430   
Gene and transcription
Genbank (Entrez)AF040990 AK025535 AK095256 AK297481 AK299920
RefSeq transcript (Entrez)NM_001145845 NM_002941 NM_133631
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ROBO1
Cluster EST : UnigeneHs.744218 [ NCBI ]
CGAP (NCI)Hs.744218
Alternative Splicing GalleryENSG00000169855
Gene ExpressionROBO1 [ NCBI-GEO ]   ROBO1 [ EBI - ARRAY_EXPRESS ]   ROBO1 [ SEEK ]   ROBO1 [ MEM ]
Gene Expression Viewer (FireBrowse)ROBO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6091
GTEX Portal (Tissue expression)ROBO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6N7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6N7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6N7
Splice isoforms : SwissVarQ9Y6N7
PhosPhoSitePlusQ9Y6N7
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set    Robo1   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  IGv (SM00406)  
Conserved Domain (NCBI)ROBO1
DMDM Disease mutations6091
Blocks (Seattle)ROBO1
PDB (SRS)2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
PDB (PDBSum)2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
PDB (IMB)2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
PDB (RSDB)2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
Structural Biology KnowledgeBase2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
SCOP (Structural Classification of Proteins)2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
CATH (Classification of proteins structures)2EO9    2V9Q    2V9R    2V9T    3WIH    4HLJ   
SuperfamilyQ9Y6N7
Human Protein AtlasENSG00000169855
Peptide AtlasQ9Y6N7
HPRD03890
IPIIPI00418121   IPI00418122   IPI00980964   IPI00219798   IPI00946477   IPI00829739   IPI00947296   IPI00945863   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6N7
IntAct (EBI)Q9Y6N7
FunCoupENSG00000169855
BioGRIDROBO1
STRING (EMBL)ROBO1
ZODIACROBO1
Ontologies - Pathways
QuickGOQ9Y6N7
Ontology : AmiGOcell migration involved in sprouting angiogenesis  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  nervous system development  axon guidance  heart development  axon guidance receptor activity  cell surface  axon midline choice point recognition  chemorepulsion involved in postnatal olfactory bulb interneuron migration  LRR domain binding  negative regulation of cell migration  axon  negative regulation of mammary gland epithelial cell proliferation  positive regulation of Rho protein signal transduction  Roundabout signaling pathway  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of chemokine-mediated signaling pathway  
Ontology : EGO-EBIcell migration involved in sprouting angiogenesis  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  nervous system development  axon guidance  heart development  axon guidance receptor activity  cell surface  axon midline choice point recognition  chemorepulsion involved in postnatal olfactory bulb interneuron migration  LRR domain binding  negative regulation of cell migration  axon  negative regulation of mammary gland epithelial cell proliferation  positive regulation of Rho protein signal transduction  Roundabout signaling pathway  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of chemokine-mediated signaling pathway  
Pathways : KEGGAxon guidance   
REACTOMEQ9Y6N7 [protein]
REACTOME PathwaysR-HSA-428890 [pathway]   
NDEx NetworkROBO1
Atlas of Cancer Signalling NetworkROBO1
Wikipedia pathwaysROBO1
Orthology - Evolution
OrthoDB6091
GeneTree (enSembl)ENSG00000169855
Phylogenetic Trees/Animal Genes : TreeFamROBO1
HOVERGENQ9Y6N7
HOGENOMQ9Y6N7
Homologs : HomoloGeneROBO1
Homology/Alignments : Family Browser (UCSC)ROBO1
Gene fusions - Rearrangements
Fusion : MitelmanROBO1/MED12L [3p12.3/3q25.1]  
Fusion : MitelmanROBO1/SEMA5B [3p12.3/3q21.1]  [t(3;3)(p12;q21)]  
Fusion : MitelmanTUBB6/ROBO1 [18p11.21/3p12.3]  [t(3;18)(p12;p11)]  
Fusion: TCGAROBO1 3p12.3 MED12L 3q25.1 LUSC
Fusion: TCGAROBO1 3p12.3 SEMA5B 3q21.1 SKCM
Fusion: TCGATUBB6 18p11.21 ROBO1 3p12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROBO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROBO1
dbVarROBO1
ClinVarROBO1
1000_GenomesROBO1 
Exome Variant ServerROBO1
ExAC (Exome Aggregation Consortium)ROBO1 (select the gene name)
Genetic variants : HAPMAP6091
Genomic Variants (DGV)ROBO1 [DGVbeta]
DECIPHERROBO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisROBO1 
Mutations
ICGC Data PortalROBO1 
TCGA Data PortalROBO1 
Broad Tumor PortalROBO1
OASIS PortalROBO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICROBO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDROBO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ROBO1
DgiDB (Drug Gene Interaction Database)ROBO1
DoCM (Curated mutations)ROBO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ROBO1 (select a term)
intoGenROBO1
NCG5 (London)ROBO1
Cancer3DROBO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602430   
Orphanet
MedgenROBO1
Genetic Testing Registry ROBO1
NextProtQ9Y6N7 [Medical]
TSGene6091
GENETestsROBO1
Target ValidationROBO1
Huge Navigator ROBO1 [HugePedia]
snp3D : Map Gene to Disease6091
BioCentury BCIQROBO1
ClinGenROBO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6091
Chemical/Pharm GKB GenePA34620
Clinical trialROBO1
Miscellaneous
canSAR (ICR)ROBO1 (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineROBO1
EVEXROBO1
GoPubMedROBO1
iHOPROBO1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:13:38 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.