Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RPL10 (ribosomal protein L10)

Written2010-08Mohit Goel, Ranjan Tamuli
Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati-781 039, Assam, India

(Note : for Links provided by Atlas : click)


Alias_symbol (synonym)NOV
Other aliasDKFZp686J1851
HGNC (Hugo) RPL10
LocusID (NCBI) 6134
Atlas_Id 42148
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 153626406 and ends at 153630680 bp from pter ( according to hg19-Feb_2009)  [Mapping RPL10.png]
Fusion genes
(updated 2016)
CYB5A (18q22.3) / RPL10 (Xq28)NSDHL (Xq28) / RPL10 (Xq28)RPL10 (Xq28) / CSNK2A2 (16q21)
RPL10 (Xq28) / IQGAP2 (5q13.3)RPL10 (Xq28) / KMT2B (19q13.12)RPL10 (Xq28) / POLA1 (Xp22.11)
RPL10 (Xq28) / POLA2 (11q13.1)RPL10 (Xq28) / RNF213 (17q25.3)RPL10 (Xq28) / SCLY (2q37.3)


Description DNA size 3.96 kb, mRNA size 2172 bp, 7 exons. The RPL10 gene is co-transcribed with the small nucleolar RNA gene U70 that is located in its fifth intron. Multiple processed pseudogenes of the gene RPL10 are dispersed in the genome. Moreover, transcript variants utilizing alternative polyA signals exist; the variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand.


Description 214 amino acids; 24604 Da. The protein is a component of the large ribosomal (60S) subunit and belongs to the L10E family of ribosomal proteins. Three natural variants of the RPL10 protein, VAR_006922 (N202S, dbSNP rs4909 and dbSNP rs12012747), VAR_027795 (L206M), and VAR_027796 (H213Q) have been reported.
Expression Ubiquitous. RPL10 is expressed in a wide variety of embryonic and adult tissues, down-regulated during adipocyte, kidney, and heart differentiation.
Localisation Cytoplasm.
Function The ribosomal protein L10 (RPL10), a member of the L10E family of ribosomal proteins, is a key protein in assembling 60S ribosomal subunit and organizes the architecture of the aminoacyl-tRNA binding site. RPL10 was originally identified as QM, a candidate for a Wilms' tumor suppressor; however, later studies did not support the original hypothesis. In vitro studies have shown the interaction of RPL10 with the transcript regulator the c-Jun, as well as with the proto-oncogene c-Yes; however, these interactions yet to demonstrate in vivo.
Homology The percent identity below represents identity of RPL10 over an aligned region in UniGene.
- Mus musculus: 100 (percent identity)
- Xenopus tropicalis: 99.5
- Monodelphis domestica: 99.5
- Pan troglodytes: 99.5
- Xenopus laevis: 99.1
- Danio rerio: 97.7
- Drosophila melanogaster: 88.9
- Caenorhabditis elegans: 85.5
- Neurospora crassa: 84.7
- Saccharomyces cerevisiae: 78.3


Note Two missense mutations L206M and H213Q at the C-terminal end of RPL10 were identified in two independent families with autism, a disorder of neural development.

Implicated in

Entity Prostatic adenocarcinoma
Note RPL10 gene showed up-regulation in androgen-independent C81 passage cells, derived from the LNCaP cell model that recapitulates prostate cancer progression. In a study using immunohistochemical technique, human prostatic tissues showed expression of RPL10 protein in all normal prostate glands adjacent to prostate cancer and in various intraepithelial neoplasia (PIN). However, in prostate cancer, the staining intensity and stained areas were decreased, compared to the normal glands and PIN lesions. There was an inverse correlation from normal to low-grade tumors and then to high-grade tumors. In high-grade tumors, the positive areas were mostly confined to peripheral aspects of tumors and were particularly strong in foci of perineural invasion. These results suggested that decreased RPL10 expression may be associated with early development of prostate cancer, but later a high level of RPL10 may facilitate progression of the tumors to a more aggressive phenotype.
Entity Ovarian cancer
Note Both adenine (A)/guanine (G) replacement was detected at the 605th nucleotide which changes the coding from serine to asparagines in 17 (58.6%) of the 29 ovarian tumors studied. The frequencies of A/A, G/G and A/G homo- or hetero-zygosity were 3.5%, 37.9% and 58.6%, respectively in cancer tissues but they were 26.1%, 52.2% and 21.7%, respectively in the adjacent normal tissues, indicating a higher heterozygous rate in cancer (58.6% vs 21.7%, p<0.01). These results suggest that high frequencies of loss of the A/G heterozygosity at the 605th nt of the RPL10 gene may be associated with ovarian cancer.
Entity Wilms' tumor
Note RPL10 was originally isolated by subtractive hybridization between a tumorigenic cell line (deleted for part of 11p) and a non-tumorigenic cell line (the tumorigenic cell line carrying an extra t(X;11) translocation chromosome). The RPL10 mRNA level was found modulated between the tumorigenic and nontumorigenic cell lines and suspected to be involved in the maintenance of the nontumorigenic phenotype. However, later study had shown that the RPL10 gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor.


Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma.
Altinok G, Powell IJ, Che M, Hormont K, Sarkar FH, Sakr WA, Grignon D, Liao DJ.
Prostate Cancer Prostatic Dis. 2006;9(1):77-82.
PMID 16331298
The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells.
Dowdy SF, Lai KM, Weissman BE, Matsui Y, Hogan BL, Stanbridge EJ.
Nucleic Acids Res. 1991 Oct 25;19(20):5763-9.
PMID 1658743
An investigation of ribosomal protein L10 gene in autism spectrum disorders.
Gong X, Delorme R, Fauchereau F, Durand CM, Chaste P, Betancur C, Goubran-Botros H, Nygren G, Anckarsater H, Rastam M, Gillberg IC, Kopp S, Mouren-Simeoni MC, Gillberg C, Leboyer M, Bourgeron T.
BMC Med Genet. 2009 Jan 23;10:7.
PMID 19166581
Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells.
Karan D, Kelly DL, Rizzino A, Lin MF, Batra SK.
Carcinogenesis. 2002 Jun;23(6):967-75.
PMID 12082018
Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism.
Klauck SM, Felder B, Kolb-Kokocinski A, Schuster C, Chiocchetti A, Schupp I, Wellenreuther R, Schmotzer G, Poustka F, Breitenbach-Koller L, Poustka A.
Mol Psychiatry. 2006 Dec;11(12):1073-84. Epub 2006 Aug 29.
PMID 16940977
Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer.
Shen XJ, Ali-Fehmi R, Weng CR, Sarkar FH, Grignon D, Liao DJ.
Cancer Biol Ther. 2006 May;5(5):523-8. Epub 2006 May 15.
PMID 16627977
The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor.
van den Ouweland AM, Verdijk M, Mannens MM, van Oost BA.
Hum Genet. 1992 Sep-Oct;90(1-2):144-6.
PMID 1330878


This paper should be referenced as such :
Goel, M ; Tamuli, R
RPL10 (ribosomal protein L10)
Atlas Genet Cytogenet Oncol Haematol. 2011;15(5):425-427.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

HGNC (Hugo)RPL10   10298
Entrez_Gene (NCBI)RPL10  6134  ribosomal protein L10
AliasesAUTSX5; DXS648; DXS648E; L10; 
GeneCards (Weizmann)RPL10
Ensembl hg19 (Hinxton)ENSG00000147403 [Gene_View]  chrX:153626406-153630680 [Contig_View]  RPL10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000147403 [Gene_View]  chrX:153626406-153630680 [Contig_View]  RPL10 [Vega]
ICGC DataPortalENSG00000147403
TCGA cBioPortalRPL10
AceView (NCBI)RPL10
Genatlas (Paris)RPL10
SOURCE (Princeton)RPL10
Genetics Home Reference (NIH)RPL10
Genomic and cartography
GoldenPath hg19 (UCSC)RPL10  -     chrX:153626406-153630680 +  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RPL10  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblRPL10 - Xq28 [CytoView hg19]  RPL10 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIRPL10 [Mapview hg19]  RPL10 [Mapview hg38]
OMIM300847   312173   
Gene and transcription
Genbank (Entrez)AA187603 AB019572 AF218023 AF486812 AK026568
RefSeq transcript (Entrez)NM_001256577 NM_001256580 NM_001303624 NM_001303625 NM_001303626 NM_006013
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012890 NT_011681 NW_004929448
Consensus coding sequences : CCDS (NCBI)RPL10
Cluster EST : UnigeneHs.739235 [ NCBI ]
CGAP (NCI)Hs.739235
Alternative Splicing GalleryENSG00000147403
Gene ExpressionRPL10 [ NCBI-GEO ]   RPL10 [ EBI - ARRAY_EXPRESS ]   RPL10 [ SEEK ]   RPL10 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6134
GTEX Portal (Tissue expression)RPL10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27635   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27635  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27635
Splice isoforms : SwissVarP27635
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_L10E (PS01257)   
Domains : Interpro (EBI)Ribosomal_L10e    Ribosomal_L10e/L16    Ribosomal_L10e_CS   
Domain families : Pfam (Sanger)Ribosomal_L16 (PF00252)   
Domain families : Pfam (NCBI)pfam00252   
Conserved Domain (NCBI)RPL10
DMDM Disease mutations6134
Blocks (Seattle)RPL10
PDB (SRS)2PA2    5AJ0   
PDB (PDBSum)2PA2    5AJ0   
PDB (IMB)2PA2    5AJ0   
PDB (RSDB)2PA2    5AJ0   
Structural Biology KnowledgeBase2PA2    5AJ0   
SCOP (Structural Classification of Proteins)2PA2    5AJ0   
CATH (Classification of proteins structures)2PA2    5AJ0   
Human Protein AtlasENSG00000147403
Peptide AtlasP27635
IPIIPI00554723   IPI00386498   IPI00853161   IPI00646899   IPI00853485   IPI00894078   IPI00893680   IPI00894342   IPI00894025   
Protein Interaction databases
IntAct (EBI)P27635
Ontologies - Pathways
Ontology : AmiGOribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  structural constituent of ribosome  structural constituent of ribosome  protein binding  endoplasmic reticulum  cytosol  rRNA processing  translation  translation  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  viral transcription  cytosolic large ribosomal subunit  poly(A) RNA binding  
Ontology : EGO-EBIribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  structural constituent of ribosome  structural constituent of ribosome  protein binding  endoplasmic reticulum  cytosol  rRNA processing  translation  translation  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  viral transcription  cytosolic large ribosomal subunit  poly(A) RNA binding  
Pathways : KEGGRibosome   
REACTOMEP27635 [protein]
REACTOME Pathways156827 [pathway]   156902 [pathway]   1799339 [pathway]   192823 [pathway]   2408557 [pathway]   6791226 [pathway]   72689 [pathway]   72706 [pathway]   72764 [pathway]   975956 [pathway]   975957 [pathway]   
NDEx NetworkRPL10
Atlas of Cancer Signalling NetworkRPL10
Wikipedia pathwaysRPL10
Orthology - Evolution
GeneTree (enSembl)ENSG00000147403
Phylogenetic Trees/Animal Genes : TreeFamRPL10
Homologs : HomoloGeneRPL10
Homology/Alignments : Family Browser (UCSC)RPL10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL10
Exome Variant ServerRPL10
ExAC (Exome Aggregation Consortium)RPL10 (select the gene name)
Genetic variants : HAPMAP6134
Genomic Variants (DGV)RPL10 [DGVbeta]
DECIPHER (Syndromes)X:153626406-153630680  ENSG00000147403
CONAN: Copy Number AnalysisRPL10 
ICGC Data PortalRPL10 
TCGA Data PortalRPL10 
Broad Tumor PortalRPL10
OASIS PortalRPL10 [ Somatic mutations - Copy number]
Cancer Gene: CensusRPL10 
Somatic Mutations in Cancer : COSMICRPL10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPL10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch RPL10
DgiDB (Drug Gene Interaction Database)RPL10
DoCM (Curated mutations)RPL10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL10 (select a term)
NCG5 (London)RPL10
Cancer3DRPL10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM300847    312173   
Orphanet23772    23321   
Genetic Testing Registry RPL10
NextProtP27635 [Medical]
Huge Navigator RPL10 [HugePedia]
snp3D : Map Gene to Disease6134
BioCentury BCIQRPL10
ClinGenRPL10 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6134
Chemical/Pharm GKB GenePA34660
Clinical trialRPL10
canSAR (ICR)RPL10 (select the gene name)
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Apr 12 11:38:58 CEST 2017

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