| Nomenclature |
|---|
| HGNC (Hugo) | SDHB 10681 |
| Cards |
|---|
| Atlas | SDHBID388 |
| Entrez_Gene (NCBI) | SDHB 6390 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| GeneCards (Weizmann) | SDHB |
| Ensembl hg19 (Hinxton) | ENSG00000117118 [Gene_View] chr1:17345225-17380665 [Contig_View] SDHB [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000117118 [Gene_View] chr1:17345225-17380665 [Contig_View] SDHB [Vega] |
| ICGC DataPortal | ENSG00000117118 |
| cBioPortal | SDHB |
| AceView (NCBI) | SDHB |
| Genatlas (Paris) | SDHB |
| WikiGenes | 6390 |
| SOURCE (Princeton) | SDHB |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | SDHB - chr1:17345225-17380665 - 1p36.1-p35 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | SDHB - 1p36.1-p35 [Description] (hg38-Dec_2013) |
| Ensembl | SDHB - 1p36.1-p35 [CytoView hg19] SDHB - 1p36.1-p35 [CytoView hg38] |
| Mapping of homologs : NCBI | SDHB [Mapview hg19] SDHB [Mapview hg38] |
| OMIM | 115310 171300 185470 606764 606864 612359 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK312056 BC007840 BF796275 BU554163 D10245 |
| RefSeq transcript (Entrez) | NM_003000 |
| RefSeq genomic (Entrez) | AC_000133 NC_000001 NC_018912 NG_012340 NT_032977 NW_001838572 NW_004929289 |
| Consensus coding sequences : CCDS (NCBI) | SDHB |
| Cluster EST : Unigene | Hs.465924 [ NCBI ] |
| CGAP (NCI) | Hs.465924 |
| Alternative Splicing : Fast-db (Paris) | GSHG0001796 |
| Alternative Splicing Gallery | ENSG00000117118 |
| Gene Expression | SDHB [ NCBI-GEO ] SDHB [ SEEK ] SDHB [ MEM ] |
| SOURCE (Princeton) | Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P21912 (Uniprot) |
| NextProt | P21912 [Medical] |
| With graphics : InterPro | P21912 |
| Splice isoforms : SwissVar | P21912 (Swissvar) |
| Catalytic activity : Enzyme | 1.3.5.1 [ Enzyme-Expasy ] 1.3.5.11.3.5.1 [ IntEnz-EBI ] 1.3.5.1 [ BRENDA ] 1.3.5.1 [ KEGG ] |
| Domaine pattern : Prosite (Expaxy) | 2FE2S_FER_1 (PS00197) 2FE2S_FER_2 (PS51085) 4FE4S_FER_1 (PS00198) 4FE4S_FER_2 (PS51379) |
| Domains : Interpro (EBI) | 2Fe-2S_ferredoxin-type 2Fe2S_fd_BS 4Fe4S_Fe-S-bd 4Fe4S_Fe_S_CS Beta-grasp_dom Helical_ferredxn Succ_DH/fum_Rdtase_Fe-S Succ_DH/fum_Rdtase_N |
| Related proteins : CluSTr | P21912 |
| Domain families : Pfam (Sanger) | Fer2_3 (PF13085) |
| Domain families : Pfam (NCBI) | pfam13085 |
| DMDM Disease mutations | 6390 |
| Blocks (Seattle) | P21912 |
| Human Protein Atlas | ENSG00000117118 |
| Peptide Atlas | P21912 |
| HPRD | 01707 |
| IPI | IPI00294911 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P21912 |
| IntAct (EBI) | P21912 |
| FunCoup | ENSG00000117118 |
| BioGRID | SDHB |
| IntegromeDB | SDHB |
| STRING (EMBL) | SDHB |
| Ontologies - Pathways |
|---|
| QuickGO | P21912 |
| Ontology : AmiGO | protein binding mitochondrion mitochondrial inner membrane mitochondrial inner membrane mitochondrial respiratory chain complex II tricarboxylic acid cycle tricarboxylic acid cycle succinate metabolic process succinate dehydrogenase (ubiquinone) activity electron carrier activity aerobic respiration respiratory electron transport chain cellular metabolic process small molecule metabolic process metal ion binding ubiquinone binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding extracellular vesicular exosome |
| Ontology : EGO-EBI | protein binding mitochondrion mitochondrial inner membrane mitochondrial inner membrane mitochondrial respiratory chain complex II tricarboxylic acid cycle tricarboxylic acid cycle succinate metabolic process succinate dehydrogenase (ubiquinone) activity electron carrier activity aerobic respiration respiratory electron transport chain cellular metabolic process small molecule metabolic process metal ion binding ubiquinone binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding extracellular vesicular exosome |
| Pathways : BIOCARTA | Electron Transport Reaction in Mitochondria [Genes] |
| Pathways : KEGG | Citrate cycle (TCA cycle) Oxidative phosphorylation Non-alcoholic fatty liver disease (NAFLD) Alzheimer's disease Parkinson's disease Huntington's disease |
| REACTOME | P21912 [protein] |
| REACTOME Pathways | REACT_111217 Metabolism [pathway] |
| Protein Interaction Database | SDHB |
| DoCM (Curated mutations) | SDHB |
| Wikipedia pathways | SDHB |
| Gene fusion - rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | SDHB [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | SDHB |
| dbVar | SDHB |
| ClinVar | SDHB |
| 1000_Genomes | SDHB |
| Exome Variant Server | SDHB |
| SNP (GeneSNP Utah) | SDHB |
| SNP : HGBase | SDHB |
| Genetic variants : HAPMAP | SDHB |
| Genomic Variants | SDHB SDHB [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | ENSG00000117118 |
| Cancer Gene: Census | SDHB |
| Somatic Mutations in Cancer : COSMIC | SDHB |
| CONAN: Copy Number Analysis | SDHB |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | MSeqDR-LSDB Mitochondrial Disease Locus Specific Database |
| LOVD (Leiden Open Variation Database) | TCA Cycle Gene Mutation Database |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 1:17345225-17380665 |
| Mutations and Diseases : HGMD | SDHB |
| OMIM | 115310 171300 185470 606764 606864 612359 |
| Medgen | SDHB |
| NextProt | P21912 [Medical] |
| GENETests | SDHB |
| Disease Genetic Association | SDHB |
| Huge Navigator |
SDHB [HugePedia] SDHB [HugeCancerGEM] |
| snp3D : Map Gene to Disease | 6390 |
| DGIdb (Drug Gene Interaction db) | SDHB |
| General knowledge |
|---|
| Homologs : HomoloGene | SDHB |
| Homology/Alignments : Family Browser (UCSC) | SDHB |
| Phylogenetic Trees/Animal Genes : TreeFam | SDHB |
| Chemical/Protein Interactions : CTD | 6390 |
| Chemical/Pharm GKB Gene | PA35606 |
| Clinical trial | SDHB |
| Cancer Resource (Charite) | ENSG00000117118 |
| Other databases |
|---|
| Probes |
|---|
| Litterature |
|---|
| PubMed | 144 Pubmed reference(s) in Entrez |
| CoreMine | SDHB |
| GoPubMed | SDHB |
| iHOP | SDHB |
| RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. |
| Guo C, Tommasi S, Liu L, Yee JK, Dammann R, Pfeifer GP |
| Current biology : CB. 2007 ; 17 (8) : 700-705. |
| PMID 17379520 |
| |
| The gene for the iron sulfur protein of succinate dehydrogenase (SDH-IP) maps to human chromosome 1p35-36.1. |
| Leckschat S, Ream-Robinson D, Scheffler IE |
| Somatic cell and molecular genetics. 1993 ; 19 (5) : 505-511. |
| PMID 8291026 |
| |
| Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. |
| Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler IE |
| Gene. 1995 ; 159 (2) : 249-253. |
| PMID 7622059 |
| |
| Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. |
| Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Skˆldberg F, Husebye ES, Eng C, Maher ER |
| American journal of human genetics. 2001 ; 69 (1) : 49-54. |
| PMID 11404820 |
| |
| Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. |
| Baysal BE, Willett-Brozick JE, Lawrence EC, Drovdlic CM, Savul SA, McLeod DR, Yee HA, Brackmann DE, Slattery WH 3rd, Myers EN, Ferrell RE, Rubinstein WS |
| Journal of medical genetics. 2002 ; 39 (3) : 178-183. |
| PMID 11897817 |
| |
