Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SELE (selectin E, endothelial adhesion molecule 1)

Identity

Other namesCD62E
ELAM
ELAM-1
ELAM1
ESEL
LECAM2
HGNC (Hugo) SELE
LocusID (NCBI) 6401
Location 1q24.2
Location_base_pair Starts at 169691781 and ends at 169703220 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order centromere....SELP - SELL - SELE - C1orf156 - C1orf112.....telomere
 

DNA/RNA

Note Member of the Selectin family. ELAM and CD62E, two of the alternative gene names, have continued to be used in the literature for this gene.
 
  Exons are represented by solid blue rectangles and introns by black lines.The drawing is in scale.
Description This gene can be found on Chromosome 1 at location 167,958,406-167,969,803. The gene is composed of 14 exons, spanning approximately 12 kb of genomic DNA in the telomere-to-centromere orientation on chromosome region 1q22-1q25. The promoter region is not included.
Transcription NM_000450 3834 bp mRNA. The sequence is supported by several sequences (cDNA clones) and produces, by alternative splicing, 5 different protein isoforms (6 transcripts). The transcripts differ by truncation of the N-terminus, truncation of the C-terminus, presence or absence of an exon.
Pseudogene None

Protein

 
Description Selectin E precursor is composed of 610 amino acids (66655 Da). Subcellular location: Membrane; Single-pass type I membrane protein. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues (Sushi domains). E-Selectin belongs to the selectin family of proteins. Amino acids: 610; Molecular Weight: 66655 Dalton. The phosphorylation on Tyr-603 (cytoplasmic domain) is required for the E-selectin-dependent ERK1 / ERK2 activation.
Expression The endothelial leukocyte adhesion molecule-1 is ubiquitously expressed in normal tissues. SELE is expressed at high level in cytokine-stimulated endothelial cells.
Localisation Single-pass type I membrane protein.
Function E-Selectin is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Homology Using pairwise alignment function of ClustalW2, the corresponding sequences from Mus musculus and Rattus norvegicus match with a score of 72 and 73 respectively.

Mutations

Note Since adhesion molecules such as members of the selectin family participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis, Wenzel et al. (1994) sought DNA polymorphisms in the ELAM1 gene, which appears to be expressed only in activated endothelium. They identified an A-to-C transversion at cDNA nucleotide 561, resulting in an amino acid exchange from serine to arginine at codon 128 (S128R) in the epidermal growth factor-like domain. They found a significantly higher frequency of the mutation in 97 patients aged 50 years or less with angiographically proven severe atherosclerosis (arginine allele frequency, 0.155) compared with an unselected population (arginine allele frequency, 0.088), as well as in 40 patients aged 40 years or less (arginine allele frequency, 0.21). Mutations of the gene may be a risk factor in atherosclerosis. A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).Genomewide linkage and candidate gene-based association studies demonstrated that variation in 3 genes on 1q23 is important in the determination of differences in blood pressure levels: ATP1B1 (182330), RGS5 (603276), and SELE (Takei et al, 2002; 131210). E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype (Alessandro et al, 2007).
 

Implicated in

Entity Recruiting blood leukocytes to the site of inflammation
Note E-selectin plays an important role in recruiting leukocytes to the site of inflammation. E-selectin is expressed on endothelial cells in response to inflammatory cytokines IL-1 and TNF-alpha (Bevilacqua et al., 1989). Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken. For these reasons the protein encoded by this gene is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining.
  
Entity Coronary artery disease
Note Risk of acquiring coronary artery disease in patients with type 2 diabetes mellitus increases significantly in the presence of the 128R mutant allele of the E-selectin gene (Abu Amero et al., 2007). Other authors correlated the G98T mutation in the E-selectin gene with a higher risk of premature coronary artery disease (Zheng et al., 2001). Data from other laboratories confirmed the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage and implicated this adhesion molecule in atherosclerotic complications in a high-risk condition (Malatino et al., 2007)
  
Entity Colon carcinoma
Note Transendothelial migration of colon carcinoma cells
Oncogenesis E-selectin mediates the adhesion of tumor cells to endothelial cells, and this interaction is associated with metastatic dissemination. Alessandro et al.(2007) studied the S128R polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for S128R polymorphism was performed on 172 cancer patients and on an age-matched control population demonstrated that the R128 allele was more prevalent in the metastatic patients group than in the non metastatic group or normal controls. In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signalling of T84 cancer cells compared to WT E-selectin and mock transfected Huvec cells. These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells. These interactions may ultimately modulate the metastatic phenotype.
  
Entity Angiogenesis
Note E-selectin plays an important role in endostatin-mediated antiangiogenesis. E-selectin is required for the antiangiogenic activity of endostatin in vivo and ex vivo, and is sufficient, via a mechanism requiring the E-selectin cytoplasmic domain, to confer endostatin sensitivity in endothelial cells in vitro (Yu et al., 2004).
  

External links

Nomenclature
HGNC (Hugo)SELE   10718
Cards
AtlasSELEID42247ch1q22
Entrez_Gene (NCBI)SELE  6401  selectin E
GeneCards (Weizmann)SELE
Ensembl (Hinxton)ENSG00000007908 [Gene_View]  chr1:169691781-169703220 [Contig_View]  SELE [Vega]
AceView (NCBI)SELE
Genatlas (Paris)SELE
WikiGenes6401
SOURCE (Princeton)NM_000450
Genomic and cartography
GoldenPath (UCSC)SELE  -  1q24.2   chr1:169691781-169703220 -  1q22-q25   [Description]    (hg19-Feb_2009)
EnsemblSELE - 1q22-q25 [CytoView]
Mapping of homologs : NCBISELE [Mapview]
OMIM131210   145500   161950   
Gene and transcription
Genbank (Entrez)AK314214 AY367062 BC131551 BC142677 BC142711
RefSeq transcript (Entrez)NM_000450
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_012124 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)SELE
Cluster EST : UnigeneHs.82848 [ NCBI ]
CGAP (NCI)Hs.82848
Alternative Splicing : Fast-db (Paris)GSHG0002727
Alternative Splicing GalleryENSG00000007908
Gene ExpressionSELE [ NCBI-GEO ]     SELE [ SEEK ]   SELE [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16581 (Uniprot)
NextProtP16581  [Medical]
With graphics : InterProP16581
Splice isoforms : SwissVarP16581 (Swissvar)
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    SUSHI (PS50923)   
Domains : Interpro (EBI)C-type_lectin    C-type_lectin-like    C-type_lectin_CS    C-type_lectin_fold    EG-like_dom    EGF-like_CS    Selectin_superfamily    Sushi_SCR_CCP   
Related proteins : CluSTrP16581
Domain families : Pfam (Sanger)EGF (PF00008)    Lectin_C (PF00059)    Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00008    pfam00059    pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  CLECT (SM00034)  EGF (SM00181)  
DMDM Disease mutations6401
Blocks (Seattle)P16581
PDB (SRS)1ESL    1G1T    1KJA   
PDB (PDBSum)1ESL    1G1T    1KJA   
PDB (IMB)1ESL    1G1T    1KJA   
PDB (RSDB)1ESL    1G1T    1KJA   
Human Protein AtlasENSG00000007908
Peptide AtlasP16581
HPRD00566
IPIIPI00296542   IPI00514728   IPI00645768   IPI00514342   IPI00514521   
Protein Interaction databases
DIP (DOE-UCLA)P16581
IntAct (EBI)P16581
FunCoupENSG00000007908
BioGRIDSELE
InParanoidP16581
Interologous Interaction database P16581
IntegromeDBSELE
STRING (EMBL)SELE
Ontologies - Pathways
Ontology : AmiGOpositive regulation of receptor internalization  leukocyte migration involved in inflammatory response  positive regulation of leukocyte migration  transmembrane signaling receptor activity  protein binding  extracellular space  plasma membrane  caveola  coated pit  inflammatory response  heterophilic cell-cell adhesion  leukocyte cell-cell adhesion  activation of phospholipase C activity  blood coagulation  integral to membrane  calcium-mediated signaling  actin filament-based process  cortical cytoskeleton  response to lipopolysaccharide  sialic acid binding  response to tumor necrosis factor  phospholipase binding  membrane raft  perinuclear region of cytoplasm  regulation of inflammatory response  leukocyte migration  leukocyte tethering or rolling  oligosaccharide binding  response to interleukin-1  
Ontology : EGO-EBIpositive regulation of receptor internalization  leukocyte migration involved in inflammatory response  positive regulation of leukocyte migration  transmembrane signaling receptor activity  protein binding  extracellular space  plasma membrane  caveola  coated pit  inflammatory response  heterophilic cell-cell adhesion  leukocyte cell-cell adhesion  activation of phospholipase C activity  blood coagulation  integral to membrane  calcium-mediated signaling  actin filament-based process  cortical cytoskeleton  response to lipopolysaccharide  sialic acid binding  response to tumor necrosis factor  phospholipase binding  membrane raft  perinuclear region of cytoplasm  regulation of inflammatory response  leukocyte migration  leukocyte tethering or rolling  oligosaccharide binding  response to interleukin-1  
Pathways : KEGGCell adhesion molecules (CAMs)    TNF signaling pathway    African trypanosomiasis    Malaria   
REACTOMESELE
Protein Interaction DatabaseSELE
Wikipedia pathwaysSELE
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SELE
SNP (GeneSNP Utah)SELE
SNP : HGBaseSELE
Genetic variants : HAPMAPSELE
1000_GenomesSELE 
ICGC programENSG00000007908 
Somatic Mutations in Cancer : COSMICSELE 
CONAN: Copy Number AnalysisSELE 
Mutations and Diseases : HGMDSELE
OMIM131210    145500    161950   
GENETestsSELE
Disease Genetic AssociationSELE
Huge Navigator SELE [HugePedia]  SELE [HugeCancerGEM]
Genomic VariantsSELE  SELE [DGVbeta]
Exome VariantSELE
dbVarSELE
ClinVarSELE
snp3D : Map Gene to Disease6401
General knowledge
Homologs : HomoloGeneSELE
Homology/Alignments : Family Browser (UCSC)SELE
Phylogenetic Trees/Animal Genes : TreeFamSELE
Chemical/Protein Interactions : CTD6401
Chemical/Pharm GKB GenePA35640
Clinical trialSELE
Cancer Resource (Charite)ENSG00000007908
Other databases
Probes
Litterature
PubMed356 Pubmed reference(s) in Entrez
CoreMineSELE
iHOPSELE

Bibliography

Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.
Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B.
Science. 1989 Mar 3;243(4895):1160-5.
PMID 2466335
 
Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions.
Hession C, Osborn L, Goff D, Chi-Rosso G, Vassallo C, Pasek M, Pittack C,Tizard R, Goelz S, McCarthy K, et al.
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1673-7.
PMID 1689848
 
ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.
Phillips ML, Nudelman E, Gaeta FC, Perez M, Singhal AK, Hakomori S, Paulson JC.
Science. 1990 Nov 23;250(4984):1130-2.
PMID 1701274
 
Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.
Watson ML, Kingsmore SF, Johnston GI, Siegelman MH, Le Beau MM, Lemons RS, Bora NS, Howard TA, Weissman IL, McEver RP, et al.
J Exp Med. 1990 Jul 1;172(1):263-72.
PMID 1694218
 
Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1.
Collins T, Williams A, Johnston GI, Kim J, Eddy R, Shows T, Gimbrone MA Jr, Bevilacqua MP.
J Biol Chem. 1991 Feb 5;266(4):2466-73.
PMID 1703529
 
Cell-cell contact mechanisms.
Ryan US, Worthington RE.
Curr Opin Immunol. 1992 Feb;4(1):33-7. (REVIEW)
PMID 1375831
 
Exogenous tat protein activates human endothelial cells.
Hofman FM, Wright AD, Dohadwala MM, Wong-Staal F, Walker SM.
Blood. 1993 Nov 1;82(9):2774-80.
PMID 7693046
 
Modelling the carbohydrate recognition domain of human E-selectin.
Mills A.
FEBS Lett. 1993 Mar 15;319(1-2):5-11.
PMID 7681016
 
Divergent fates of P- and E-selectins after their expression on the plasma membrane.
Subramaniam M, Koedam JA, Wagner DD.
Mol Biol Cell. 1993 Aug;4(8):791-801.
PMID 7694691
 
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK.
Nature. 1994 Feb 10;367(6463):532-8.
PMID 7509040
 
Exogenous tat protein activates central nervous system-derived endothelial cells.
Hofman FM, Dohadwala MM, Wright AD, Hinton DR, Walker SM.
J Neuroimmunol. 1994 Oct;54(1-2):19-28.
PMID 7523444
 
E-selectin polymorphism and atherosclerosis: an association study.
Wenzel K, Felix S, Kleber FX, Brachold R, Menke T, Schattke S, Schulte KL, Gläser C, Rohde K, Baumann G, et al.
Hum Mol Genet. 1994 Nov;3(11):1935-7.
PMID 7533025
 
Circulating adhesion molecules during kidney allograft rejection.
Alcalde G, Merino J, Sanz S, Zubimendi JA, Ruiz JC, Torrijos J, de Francisco AL, Cotorruelo JG, López-Hoyos M, Novo MJ, et al.
Transplantation. 1995 Jun 27;59(12):1695-9.
PMID 7541576
 
Modulation of E-selectin structure/function by metal ions. Studies on limited proteolysis and metal ion regeneration.
Anostario M Jr, Huang KS.
J Biol Chem. 1995 Apr 7;270(14):8138-44.
PMID 7536194
 
Effects of modified low density lipoprotein and hypoxia on the expression of endothelial leukocyte adhesion molecule-1.
Okada M, Sugita O, Miida T, Matsuto T, Inano K.
Presse Med. 1995 Mar 11;24(10):483-8.
PMID 7538217
 
Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin.
Li F, Wilkins PP, Crawley S, Weinstein J, Cummings RD, McEver RP.
J Biol Chem. 1996 Feb 9;271(6):3255-64.
PMID 8621728
 
DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.
Wenzel K, Ernst M, Rohde K, Baumann G, Speer A.
Hum Genet. 1996 Jan;97(1):15-20.
PMID 8557254
 
Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.
Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenzweig A, Resnick N, Gimbrone MA Jr.
J Cell Biol. 1996 Apr;133(2):445-55.
PMID 8609175
 
Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells.
Dhawan S, Puri RK, Kumar A, Duplan H, Masson JM, Aggarwal BB.
Blood. 1997 Aug 15;90(4):1535-44.
PMID 9269771
 
Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.
Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW.
J Cell Biol. 1997 Apr 21;137(2):509-19.
PMID 9128259
 
HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.
Mrowiec T, Melchar C, Górski A.
Arch Immunol Ther Exp (Warsz). 1997;45(2-3):255-9.
PMID 9597096
 
L-selectin from human, but not from mouse neutrophils binds directly to E-selectin.
Zöllner O, Lenter MC, Blanks JE, Borges E, Steegmaier M, Zerwes HG, Vestweber D.
J Cell Biol. 1997 Feb 10;136(3):707-16.
PMID 9024699
 
Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells.
Chirivi RG, Taraboletti G, Bani MR, Barra L, Piccinini G, Giacca M, Bussolino F, Giavazzi R.
Blood. 1999 Sep 1;94(5):1747-54.
PMID 10477700
 
Loss of endothelial surface expression of E-selectin in a patient with recurrent infections.
DeLisser HM, Christofidou-Solomidou M, Sun J, Nakada MT, Sullivan KE.
Blood. 1999 Aug 1;94(3):884-94.
PMID 10419878
 
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A.
Nat Genet. 1999 Jul;22(3):239-47.
PMID 10391210
 
E-selectin gene expression is induced synergistically with the coexistence of activated classic protein kinase C and signals elicited by interleukin-1beta but not tumor necrosis factor-alpha.
Tamaru M, Narumi S.
J Biol Chem. 1999 Feb 5;274(6):3753-63.
PMID 9920928
 
A PstI polymorphism detects the mutation of serine128 to arginine in CD 62E gene - a risk factor for coronary artery disease.
Ye SQ, Usher D, Virgil D, Zhang LQ, Yochim SE, Gupta R.
J Biomed Sci. 1999 Jan;6(1):18-21.
PMID 9933738
 
Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.
Sass C, Pallaud C, Zannad F, Visvikis S.
Hum Genet. 2000 Jul;107(1):58-61.
PMID 10982036
 
Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells.
Brown MD, Wick TM, Eckman JR.
Pediatr Pathol Mol Med. 2001 Jan-Feb;20(1):47-72.
PMID 12673844
 
CD44 is a major E-selectin ligand on human hematopoietic progenitor cells.
Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R.
J Cell Biol. 2001 Jun 11;153(6):1277-86.
PMID 11402070
 
Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations.
El-Magadmi M, Alansari A, Teh LS, Ordi J, G¸l A, Inanc M, Bruce I, Hajeer A.
J Rheumatol. 2001 Dec;28(12):2650-2.
PMID 11764211
 
Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions.
Fernandez-Rodriguez J, Dwir O, Alon R, Hansson GC.
Glycoconj J. 2001 Nov-Dec;18(11-12):925-30.
PMID 12820726
 
Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor.
Fischer DC, Winkler M, Ruck P, Poth D, Kemp B, Rath W.
J Perinat Med. 2001;29(6):497-505.
PMID 11776680
 
Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation.
Hu Y, Szente B, Kiely JM, Gimbrone MA Jr.
J Biol Chem. 2001 Dec 21;276(51):48549-53.
PMID 11602579
 
Day-night variations in blood levels of nitric oxide, T-TFPI, and E-selectin.
Kanabrocki EL, George M, Hermida RC, Messmore HL, Ryan MD, Ayala DE, Hoppensteadt DA, Fareed J, Bremner FW, Third JL, Shirazi P, Nemchausky BA.
Clin Appl Thromb Hemost. 2001 Oct;7(4):339-45.
PMID 11697721
 
Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1.
Wild MK, Huang MC, Schulze-Horsel U, van der Merwe PA, Vestweber D.
J Biol Chem. 2001 Aug 24;276(34):31602-12.
PMID 11404363
 
An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease.
Zheng F, Chevalier JA, Zhang LQ, Virgil D, Ye SQ, Kwiterovich PO.
Clin Genet. 2001 Jan;59(1):58-64.
PMID 11168027
 
L and E selectins in acute myeloid leukemia: expression, clinical relevance and relation to patient outcome.
Aref S, Salama O, Al-Tonbary Y, Fouda M, Menessy A, El-Sherbiny M.
Hematology. 2002 Apr;7(2):83-7.
PMID 12186696
 
Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes.
Blüher M, Unger R, Rassoul F, Richter V, Paschke R.
Diabetologia. 2002 Feb;45(2):210-6.
PMID 11935152
 
Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.
Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW.
Blood. 2002 Apr 15;99(8):2890-6.
PMID 11929779
 
The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism.
Cota-Gomez A, Flores NC, Cruz C, Casullo A, Aw TY, Ichikawa H, Schaack J, Scheinman R, Flores SC.
J Biol Chem. 2002 Apr 26;277(17):14390-9.
PMID 11827962
 
Expression of ICAM-1, VCAM-1, E-selectin and TNF-alpha on the endothelium of femoral and iliac arteries in thromboangiitis obliterans.
Halacheva K, Gulubova MV, Manolova I, Petkov D.
Acta Histochem. 2002;104(2):177-84.
PMID 12086338
 
Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in vitro.
Hildebrandt G, Maggiorella L, Rödel F, Rödel V, Willis D, Trott KR.
Int J Radiat Biol. 2002 Apr;78(4):315-25.
PMID 12020443
 
L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts.
Jutila MA, Kurk S, Jackiw L, Knibbs RN, Stoolman LM.
J Immunol. 2002 Aug 15;169(4):1768-73.
PMID 12165498
 
Hydrocortisone reduced in vivo, inflammation-induced slow rolling of leukocytes and their extravasation into human conjunctiva.
Kirveskari J, Helintö M, Moilanen JA, Paavonen T, Tervo TM, Renkonen R.
Blood. 2002 Sep 15;100(6):2203-7.
PMID 12200386
 
Cutting Edge: Internalization of transduced E-selectin by cultured human endothelial cells: comparison of dermal microvascular and umbilical vein cells and identification of a phosphoserine-type di-leucine motif.
Kluger MS, Shiao SL, Bothwell AL, Pober JS.
J Immunol. 2002 Mar 1;168(5):2091-5.
PMID 11859093
 
Down regulation of endothelial adhesion molecules in node positive breast cancer: possible failure of host defence mechanism.
Madhavan M, Srinivas P, Abraham E, Ahmed I, Vijayalekshmi NR, Balaram P.
Pathol Oncol Res. 2002;8(2):125-8.
PMID 12172576
 
Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy.
Malmqvist K, Wallén HN, Held C, Kahan T.
J Hypertens. 2002 Aug;20(8):1563-9.
PMID 12172318
 
An investigation of the interactions of E-selectin with fuco-oligosaccharides of the blood group family.
Martín MJ, Feizi T, Leteux C, Pavlovic D, Piskarev VE, Chai W.
Glycobiology. 2002 Dec;12(12):829-35.
PMID 12499405
 
Serum levels of adhesion molecules correlate with insulin resistance.
Matsumoto K, Sera Y, Miyake S, Ueki Y.
Atherosclerosis. 2002 Mar;161(1):243-4.
PMID 11882338
 
Quantification of the influence of mycophenolic acid on the release of endothelial adhesion molecules.
Raab M, Daxecker H, Pavlovic V, Griesmacher A, Mueller MM.
Clin Chim Acta. 2002 Jun;320(1-2):89-94.
PMID 11983205
 
Enhanced recruitment of Th2 and CLA-negative lymphocytes by the S128R polymorphism of E-selectin.
Rao RM, Haskard DO, Landis RC.
J Immunol. 2002 Nov 15;169(10):5860-5.
PMID 12421968
 
Soluble selectin levels in patients with lung cancer.
Roselli M, Mineo TC, Martini F, Mariotti S, Ambrogi V, Spila A, D'Alessandro R, Basili S, Guadagni F, Ferroni P.
Int J Biol Markers. 2002 Jan-Mar;17(1):56-62.
PMID 11936588
 
Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis.
Satoh T, Kaneko M, Wu MH, Yokozeki H, Nishioka K.
Eur J Immunol. 2002 May;32(5):1274-81.
PMID 11981814
 
Circulating endothelial adhesion molecules (sE-selectin, sVCAM-1 and sICAM-1) during rHuG-CSF-stimulated stem cell mobilization.
Südhoff T, Söhngen D.
J Hematother Stem Cell Res. 2002 Feb;11(1):147-51.
PMID 11847011
 
Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.
Takei T, Iida A, Nitta K, Tanaka T, Ohnishi Y, Yamada R, Maeda S, Tsunoda T, Takeoka S, Ito K, Honda K, Uchida K, Tsuchiya K, Suzuki Y, Fujioka T, Ujiie T, Nagane Y, Miyano S, Narita I, Gejyo F, Nihei H, Nakamura Y.
Am J Hum Genet. 2002 Mar;70(3):781-6.
PMID 11828340
 
17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter.
Tyree CM, Zou A, Allegretto EA.
J Steroid Biochem Mol Biol. 2002 Mar;80(3):291-7.
PMID 11948013
 
Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians.
Weyer C, Yudkin JS, Stehouwer CD, Schalkwijk CG, Pratley RE, Tataranni PA.
Atherosclerosis. 2002 Mar;161(1):233-42.
PMID 11882337
 
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Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E1-6.
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J Dermatol Sci. 2003 Jun;32(1):43-54.
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Acta Diabetol. 2004 Sep;41(3):118-22.
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Chem Biol Interact. 2004 Dec 7;150(3):233-41.
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J Immunol. 2004 Feb 1;172(3):1575-81.
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Exp Dermatol. 2004 Feb;13(2):65-9.
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J Cardiovasc Surg (Torino). 2004 Apr;45(2):143-7.
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J Immunol. 2004 Jun 15;172(12):7780-90.
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Am J Physiol Cell Physiol. 2004 Feb;286(2):C239-46.
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Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4.
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Clin Exp Metastasis. 2004;21(3):257-64.
PMID 15387376
 
Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.
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PMID 15194470
 
The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people.
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J Hypertens. 2004 Feb;22(2):305-11.
PMID 15076188
 
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Ital Heart J. 2004 Jan;5(1):42-7.
PMID 15080580
 
Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.
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Carcinogenesis. 2004 Aug;25(8):1335-44.
PMID 14988223
 
Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.
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Kidney Int. 2004 Apr;65(4):1290-300.
PMID 15086468
 
Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase.
Piconi L, Quagliaro L, Da Ros R, Assaloni R, Giugliano D, Esposito K, Szabó C, Ceriello A.
J Thromb Haemost. 2004 Aug;2(8):1453-9.
PMID 15304054
 
Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans.
Pontiroli AE, Pizzocri P, Koprivec D, Vedani P, Marchi M, Arcelloni C, Paroni R, Esposito K, Giugliano D.
Eur J Endocrinol. 2004 Feb;150(2):195-200.
PMID 14763917
 
In vivo evidence for close association of CLA expression and E-selectin binding by T cells in the inflamed skin.
Teraki Y, Miyake A, Takebayashi R, Shiohara T.
J Dermatol Sci. 2004 Oct;36(1):63-5.
PMID 15488708
 
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Uner A, Akcali Z, Unsal D.
Neoplasma. 2004;51(4):269-74.
PMID 15254658
 
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Winkler IG, Snapp KR, Simmons PJ, Lévesque JP.
Blood. 2004 Mar 1;103(5):1685-92.
PMID 14592840
 
E-selectin is required for the antiangiogenic activity of endostatin.
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Proc Natl Acad Sci U S A. 2004 May 25;101(21):8005-10.
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J Cell Mol Med. 2005 Jan-Mar;9(1):153-9.
PMID 15784173
 
Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration.
Bojanowski CM, Tuo J, Chew EY, Csaky KG, Chan CC.
Trans Am Ophthalmol Soc. 2005;103:37-45.
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Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H194-204.
PMID 15331359
 
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Oncogene. 2005 May 12;24(21):3472-83.
PMID 15735663
 
FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
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J Biol Chem. 2005 Jul 29;280(30):27783-91.
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Obes Res. 2005 Mar;13(3):513-8.
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Metabolism. 2005 Mar;54(3):376-80.
PMID 15736116
 
Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis.
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Cell Biochem Funct. 2005 Jul-Aug;23(4):285-9.
PMID 15515123
 
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BMC Med Genet. 2006 Jun 6;7:52.
PMID 16756647
 
HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells.
Burdick MM, Chu JT, Godar S, Sackstein R.
J Biol Chem. 2006 May 19;281(20):13899-905.
PMID 16565092
 
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Fertil Steril. 2006 Oct;86(4):899-904.
PMID 16963035
 
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Nat Med. 2006 Oct;12(10):1185-90.
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Blood. 2006 Feb 15;107(4):1421-6.
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Nature. 2006 May 18;441(7091):315-21.
PMID 16710414
 
A561C polymorphism of E-selectin is associated with ischemic cerebrovascular disease in the Japanese population without diabetes mellitus and hypercholesterolemia.
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Arch Intern Med. 2006 Aug 14-28;166(15):1655-9.
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Hum Immunol. 2006 Aug;67(8):634-8.
PMID 16916660
 
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World J Gastroenterol. 2006 Jun 14;12(22):3609-11.
PMID 16773720
 
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J Rheumatol. 2006 Oct;33(10):1968-72.
PMID 17014013
 
Soluble VCAM-1 and E-selectin in breast cancer: relationship with staging and with the detection of circulating cancer cells.
Silva HC, Garcao F, Coutinho EC, De Oliveira CF, Regateiro FJ.
Neoplasma. 2006;53(6):538-43.
PMID 17167725
 
The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease.
Testa A, Benedetto FA, Spoto B, Pisano A, Tripepi G, Mallamaci F, Malatino LS, Zoccali C.
Nephrol Dial Transplant. 2006 Jul;21(7):1921-6.
PMID 16554320
 
Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.
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Biochem J. 2006 May 15;396(1):89-98.
PMID 16433632
 
Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation.
Wang JG, Mahmud SA, Nguyen J, Slungaard A.
J Immunol. 2006 Dec 15;177(12):8714-22.
PMID 17142773
 
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The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease.
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BMC Med Genet. 2007 Jun 20;8:35.
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Role of S128R polymorphism of E-selectin in colon metastasis formation.
Alessandro R, Seidita G, Flugy AM, Damiani F, Russo A, Corrado C, Colomba P, Gullotti L, Buettner R, Bruno L, De Leo G.
Int J Cancer. 2007 Aug 1;121(3):528-35.
PMID 17372905
 
HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells.
Bandyopadhyay S, Ashraf MZ, Daher P, Howe PH, DiCorleto PE.
Mol Cell Biol. 2007 Jun;27(12):4207-16.
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Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia.
Derzbach L, Balogh A, Bokodi G, Vásárhelyi B, Rigó J Jr.
J Reprod Med. 2007 Sep;52(9):815-8.
PMID 17939599
 
Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis.
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Scand J Rheumatol. 2007 Sep-Oct;36(5):345-50.
PMID 17963163
 
Periprocedural soluble P- and E-selectin levels fail as predictors of clinical restenosis in patients treated with elective coronary stenting.
Kozinski M, Kubica J, Sukiennik A, Zbikowska-Gotz M, Krzewina-Kowalska A, Radomski M, Rychter M, Bialoszynski T, Jablonski M, Demidowicz K, Grzesk G, Bogdan M, Chojnicki M, Grabczewska S, Dziedziczko A.
Int J Mol Med. 2007 Jan;19(1):187-95.
PMID 17143564
 
The Ser128Arg polymorphism for E-selectin gene and brucellosis.
Rafiei A, Hajilooi M, Vahedi M, Shakib RJ.
Infect Genet Evol. 2007 Jul;7(4):494-8.
PMID 17392035
 
Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.
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Diabetes. 2007 Jul;56(7):1898-904.
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Circulating E-selectin as a risk marker in patients with end-stage renal disease.
Malatino LS, Stancanelli B, Cataliotti A, Bellanuova I, Fatuzzo P, Rapisarda F, Leonardis D, Tripepi G, Mallamaci F, Zoccali C.
J Intern Med. 2007 Oct;262(4):479-87.
PMID 17875185
 
A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding.
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J Biochem. 2007 Jul;142(1):55-64.
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A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells.
Vieira ML, D'Atri LP, Schattner M, Habarta AM, Barbosa AS, de Morais ZM, Vasconcellos SA, Abreu PA, Gomez RM, Nascimento AL.
FEMS Microbiol Lett. 2007 Nov;276(2):172-80.
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Human soluble E-selectin immunoadhesin inhibits leukemic monocyte adhesion to endothelial cells.
Sung BH, Kim SH, Yeo MG, Kim JK, Song WK.
Cell Biochem Funct. 2007 Sep-Oct;25(5):585-9.
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Written05-2008Gregorio Seidita, Giacomo De Leo, Riccardo Alessandro
Dipartimento Biopatologie e Metodologie Biomediche, via divisi, 83 - 90133 Palermo, Italy

Citation

This paper should be referenced as such :
Seidita G, De Leo G, Alessandro R . SELE (selectin E, endothelial adhesion molecule 1). Atlas Genet Cytogenet Oncol Haematol. May 2008 .
URL : http://AtlasGeneticsOncology.org/Genes/SELEID42247ch1q22.html

The various updated versions of this paper are referenced and archived by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/44452/1/05-2008-SELEID42247ch1q22.pdf   [ Bibliographic record ]

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