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SERPINB3 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3)

Written2014-06Cristian Turato, Patrizia Pontisso
Department of Medicine, University of Padua, Padua, Italy

Abstract Review on SERPINB3, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

(Note : for Links provided by Atlas : click)

Identity

Alias_namesSCC
SCCA1
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
Alias_symbol (synonym)T4-A
HsT1196
Other aliasSCCA-1
SCCA-PD
HGNC (Hugo) SERPINB3
LocusID (NCBI) 6317
Atlas_Id 42265
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 63655197 and ends at 63661963 bp from pter ( according to hg19-Feb_2009)  [Mapping SERPINB3.png]
Local_order According to Entrez-Gene, SERPINB3 maps to NC_000018.10 in the region between 63655197 and 63661963, complement and span 6767 bases. Flanked by SERPINB4 and SERPINB11.
Note SERPINB3, also known as SCCA1, encodes members of the serpins family. The serpins are a family of protease inhibitors originally grouped together as serine protease inhibitors, most of which are secreted (Silverman et al., 2004). The clade B serpins comprise a number of proteins including SERPINB3. In the early 1990's (Takeshima et al., 1992) it was recognized as circulating "squamous cell carcinoma antigen" (SCCA1) that was present in a substantial fraction of sera from patients bearing squamous cell cancers of the cervix. Later on it was found to be associated with other types of cancer of epithelial or endodermal origins, including lung cancer, head and neck cancer, and hepatocellular carcinoma (Schneider et al., 1995; Pontisso et al., 2004).

DNA/RNA

 
  Figure 1. A) SERPINB3 maps in chromosome 18q21.3 (NC_000018.10) in the region between 63655197 and 63661963. Local order and flanked genes are reported. B) Map of a SERPINB3 transcript mRNA (NM_006919.2) showing its organization in 8 exon.
Description According to the NCBI map viewer, the gene is located on chromosome 18q21.3 (NCBI Reference Sequence: NC_000018.10) and encompasses 6767 bp.
Transcription The SERPINB3 gene comprises eight exons and seven introns which commonly encoded a 1,793 kb mRNA. The ATG start is located in exon 2 with the stop codon in exon 8.
Transcription control is regulated by STAT3. STAT3 occupies the promoter of SERPINB3/B4 and siRNA removal of SERPINB3/B4 mRNA caused cell death in HN13 head and neck cancer cells. Thus persistently activated STAT3 is a required part of the continuous activation of SERPINB3/B4 genes, which protects tumor cells from dying (Ahmed and Darnell, 2009).
Moreover recent mechanistic experiments and ChIP assays reveal that SERPINB3 increased expression in response to hypoxic conditions is specifically mediated by the binding of HIF-2α to the SERPINB3 promoter (Cannito et al., 2014).
Pseudogene No known pseudogene.

Protein

 
  Figure 2. SERPINB3 protein mature chain. Site of Reactive Center Loop (RSL) (blue), and described variants (green) are indicated. Potential site of splicing variant missing amino acids 205-256 are also reported (yellow).
Description SERPINB3 encodes a 390 amino acid 44,56 Kda protein, which shows sequence homology to the ovalbumin family of serine protease inhibitors (Ov-serpin) (Remold-O'Donnell, 1993), a subfamily of the large serpin superfamily. Serpins have a highly ordered tertiary structure defined by the crystal structure of the prototype molecule α1-antitrypsin, consisting of nine α-helices and three β-sheets arranged in a stressed configuration with the reactive center, which has the unusual feature of being the most variable region, located in an exposed loop (Hunt and Dayhoff, 1980).
The mechanism of protease inhibition by serpins involves a profound change in conformation, initiated by interaction of the protease with the reactive site loop of the serpin (RSL) (amino acids 340-368). RSL consists of a loop projecting from the body of the protein, comprising a hinge region and a variable RSL (Huntington et al., 2000).
Biochemical analysis of recombinant SERPINB3 shows that it is a potent cross-class inhibitor of papain-like cysteine proteinases such as cathepsin L, cathepsin S and cathepsin K (Schick et al., 1998).
An isoform produced by alternative splicing has been reported. The sequence of this isoform differs from the canonical sequence for 205-256 amino acid missing (Fig.2).
Expression SERPINB3 is expressed in the spinous and granular layers of normal squamous epithelium, in several organs including: epithelium of the tongue, esophagus, tonsil, cervix uterine, vagina, Hassal's corpuscles of the thymus and some areas of the skin. SERPINB3 was also detected in saliva, respiratory secretions and amniotic fluid samples from healthy individuals (Kato, 1996; Cataltepe et al., 2000). Moreover, SERPINB3 was recently reported to be expressed on CD27+ B lymphocytes (Vidalino et al., 2012).
In particular, immunohistochemistry analysis revealed positive staining in sweat glands in the dermis of the skin, endothelial cells of the veins and arteries walls in the intestine.
Within the normal liver, SERPINB3 protein expression was seen in portal interlobular ducts, in the walls (myocytes of the media) of the large and medium sized hepatic arteries and sometimes in the endothelial cells of the portal veins.
Normal hepatocytes, sinusoidal cells and Kupffer cells do not exhibit any reactivity, except some hepatocytes in the limiting plate that can show focal faint positivity (Turato et al., 2012).
HepCAM positive liver stem cells from both foetal and adult livers also express SERPINB3 (Villano et al., 2014).
Initially, SERPINB3 was discovered as a serological marker for advanced squamous cell tumors in the cervix (Uemura et al., 2000), and was later found to be associated with other types of cancer with epithelial or endodermal origins. Moreover, elevated expression of SERPINB3 is associated with high-grade breast carcinoma and correlates with estrogen receptor/progesterone receptor double negative tumors as well as with a poor prognosis for breast cancer patients (Catanzaro et al., 2011).
Localisation SERPINB3 may be found in cytoplasmic and pericellular locations (Uemura et al., 2000). Moreover an additional surface localization for this serpin has been reported (De Falco et al., 2001; Vidalino et al., 2012).
Although it was initially reported that SERPINB3 is a cytosolic protein, its nuclear localization has been also described recently, expanding the potential range of physiological functions of this molecule. Under certain conditions, such as following exposure to UV irradiation, SERPINB3 is translocated into the nucleus. Although SERPINB3 does not possess a nuclear localization signal, it binds with c-Jun NH2-terminal kinase-1 (JNK1), and upon JNK1 activation SERPINB3 enters the nucleus (Katagiri et al., 2006).
In addition, other studies have shown that SERPINB3 may be secreted in serum and can predict HCC development in patients with cirrhosis (Pontisso et al., 2006).
Function SERPINB3 is physiologically involved in the regulation of differentiation in normal squamous epithelium and is overexpressed in neoplastic tissue of epithelial origin, where it might be involved in the apoptotic pathway as a protease inhibitor (Suminami et al., 1998).
Regarding their role in normal epithelia, it has been suggested that SCCA isoforms may protect from bacterial, viral cystein proteases (Suminami et al., 1998), and mast cell chymase (Schick et al., 1997).
As a protease inhibitor, SERPINB3 is able to inhibit cysteine proteases (cathepsins L, S, K and papain) (Schick et al., 1998), and in cancer cells it confers resistance to drug-induced apoptosis by inhibiting lysosomal cathepsin proteases (Suminami et al., 2000). However, under a variety of stress conditions SERPINB3 displays an anti-apoptotic function unrelated to its proteinase inhibition activity (Vidalino et al., 2009; Ciscato et al., 2014). Indeed, SERPINB3 protects cells from exposure to radiation through an inhibitory effect either on the MAP family of c-Jun terminal kinase (JNK) (Katagiri et al., 2006) and the interaction between SERPINB3 and JNK1 was also supported by the crystallographic study (Zheng et al., 2009); or with a decreased phosphorylation of the proapoptotic p38 mitogen-activated protein kinase on p38 (Murakami et al., 2001). In epithelial ovarian cancer cells exposed to cisplatin, SERPINB3 expression is associated with drug resistance and poor progression-free survival (Ullman et al., 2011; Lim et al., 2012), whereas it inhibits the release of mitochondrial cytochrome c in squamous cell carcinoma after treatment with TNF-α (Hashimoto et al., 2005), or with DNA alkylating agents (Ullman et al., 2011).
Moreover, SERPINB3 expression is associated with poor survival in patients with breast cancer treated with anthracycline-based neoadjuvant chemotherapy (Collie-Duguid et al., 2012) and in patients with epithelial ovarian cancer a high SERPINB3 expression is a prognostic factor for platinum resistance and shorter progression-free survival (Lim et al., 2012).
In addition, recent results, reported that SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I (Ciscato et al., 2014).
Experiments carried out with serum-derived HBV particles have demonstrated that isolated SERPINB3 protein is able to bind preS1 encoded sequence HBV surface protein, allowing virus entry into human hepatocytes and also peripheral blood mononuclear cells, underlying its potential biological role in HBV infection (De Falco et al., 2001; Pontisso et al., 1991; Ruvoletto et al., 2004).
This serpin induces also cell proliferation and deregulation of adhesion processes, leading to epithelial-mesenchymal transition (EMT) with increased invasiveness potential (Quarta et al., 2010). In addition, it has been reported that it induces TGF-β expression (Calabrese et al., 2008; Turato et al., 2010) and promotes fibrogenesis in experimental models (Lunardi et al., 2011).
In addition, SERPINB3 may enhance its oncogenic potential through inhibition of several tumor suppressive miRNAs (Turato et al., 2014a) and could play a role in the development of cancer phenotype.
More recently, it has been reported that increased SERPINB3 expression leads to inhibition of protein turnover, unfolded protein response, activation of NF-kB and is essential for Ras-mediated cytokine production and tumour growth (Catanzaro et al., 2014).
Homology SERPINB3 and SERPINB4 isoforms, also known as squamous cell carcinoma antigen 1 and 2 (SCCA1 and SCCA2) are highly homologous, 91% identical at the amino acid level (Suminami et al., 1991), share conserved tertiary structure, and use a unique conformational rearrangement for their inhibitory activity (Stein et al., 1990). However, SERPINB3 and SERPINB4 show distinct properties and substrates: SERPINB3 inhibits papain-like cysteine proteinases, cathepsins K, L, and S while SCCA2 inhibits chymotrypsin-like serine proteinases, cathepsin G and mast cell chymase (Takeda et al., 1995; Schick et al., 1997).
In mouse, SCCA locus (SERPINB3 and SERPINB4) was expanded and contained four genes, Serpinb3a, -b3b, -b3c, and -b3d, and three pseudogenes, Serpinb3-ps1, -ps-2, and -ps-3. Percentage protein sequences identity: 55-59%) (Askew et al., 2004).
Moreover similarity-to-human data found for SERPINB3 was found in: worm (Caenorhabditis elegans), fruit fly (Drosophila melanogaster), mosquito (Anopheles gambiae), chicken (Gallus gallus), mouse (Mus musculus), rattus (Rattus norvegicus) and chimpanzee (Pan troglodytes).

Mutations

Note Maps of different Single-nucleotide polymorphisms (SNP) in human SERPINB3 are reported in Fig.2. Only SNP rs3180227 has beeen well characterised (Turato et al., 2009).
This polymorphic variant (also know as SCCA-PD) presents the 351G/A mutation in the variable reactive site loop (RSL) of the protein (GenBank accession number: AY190327).
The prevalence of SCCA-PD was 24% in the normal population, while in patients with cirrhosis it was 45%, supporting the hypothesis of a higher contribution of this isoform to liver disease progression. In addition, the specific amino acid change detected in the reactive center of this SNP might confer a different biological behavior to the serpin improving the antiprotease activity of SERPINB3 (Turato et al., 2011).

Implicated in

Note
  
Entity Hepatocellular carcinoma
Note Several papers have documented the key role of SERPINB3 in Hepatocellular Carcinoma (HCC).
SERPINB3 is almost undetectable in normal liver but it is expressed in HCC cells and in cells of highly dysplastic nodules and hepatocytes of peri-tumoral cirrhotic tissue, suggesting that SERPINB3 expression may represent a relatively early event in hepatocarcinogenesis (Guido et al., 2008).
SERPINB3 has been proposed as a serological biomarker that, alone or in combination with α-fetoprotein, may improve the sensitivity of HCC diagnosis (Beneduce et al., 2005; Giannelli et al., 2007a). Circulating SERPINB3-IgM immuno-complexes have been described in cirrhotic patients at higher risk of HCC development (Pontisso et al., 2006) and in patients with HCC diagnosis (Beneduce et al., 2005).
Moreover, it has been reported that human hepatoma cells, stably transfected in order to over-express SERPINB3, exhibited a significant increase in proliferation rate and unequivocal evidence of invasiveness and Epithelial to Mesenchimal Transition, then potentially acting as a putative paracrine mediator able to favor cancer cell growth and metastatic invasiveness (Quarta et al., 2010).
In addition a very recent study revealed that high levels of SERPINB3 were detectable in 22% of HCCs specimens from cirrhotic patients and were found to be significantly associated with early tumor recurrence, then representing a candidate prognostic marker able to identify the subset of most aggressive HCCs (Turato et al., 2014b).
  
  
Entity Lung cancer
Note Elevated levels of Squamous cell carcinoma antigen (SCC-Ag) is secreted by non-small cell lung tumours (NSCLC) and can be detected in serum (Mino et al., 1988).
It has been reported that preoperative SCC-Ag level in serum and its postoperative decrease have prognostic significance in NSCLC (Vassilakopoulos et al., 2001).
Moreover, in another study, tumor transcriptome analysis has revealed the predictive and prognostic impact of lysosomal protease inhibitors (SERPINB3 and cystatin C) with clinical response in platinum-based chemotherapy - treated in NSCLC patients (Petty et al., 2006). These molecules potentially represent novel targets for NSCLC therapeutics.
  
  
Entity Ovarian cancer
Note In a model of human epithelial ovarian cancer (EOC) using chickens, the most relevant animal model, SERPINB3 mRNA was induced in cancerous, but not normal ovaries, and it was abundant only in the glandular epithelium of cancerous ovaries of chickens.
In addition, strong expression of SERPINB3 protein was reported as prognostic factor for platinum drug resistance and for poor progression-free survival in patients with EOC (Lim et al., 2012).
  
  
Entity Breast cancer
Note Elevated expression of SERPINB3 is associated with both high grade and advanced stage human breast carcinomas. In addition, it has been reported that SCCA-positive breast tumors have a worse clinical outcome, including decreased overall survival and recurrence free survival (Catanzaro et al., 2011).
Furthermore, SERPINB3 positivity predicted poor survival in patients treated with anthracycline-based chemotherapy (Collie-Duguid et al., 2012).
The implication of SERPINB3 in breast cancer may provide a novel diagnostic approach that will help to understand the initiation and advancement of breast cancer and provide new therapeutic options.
  
  
Entity Hepatoblastoma
Note Hepatoblastoma (HB) is the most common liver malignancy in early childhood and it is considered an embryonal tumour of the liver.
According to a recent paper, SERPINB3 was overexpressed in 79% of the cases of HBs. Moreover, by immunohistochemistry SERPINB3 expression was found mainly in the embryonic, blastemal, small cell undifferentiated (SCUD) components of HB. High SERPINB3 reactivity was also detected in neoplastic cell clusters of portal vein tumour thrombosis. Furthermore a direct correlation was observed between SERPINB3 gene expression and tumour extension, suggesting that this serpin might help in defining the risk profile of children affected by this neoplasm (Turato et al., 2012).
  
  
Entity Autoimmune disorders
Note Alteration in serpin function was shown to associate with deregulation of cell survival as well as with some autoimmune traits, meaning that people carrying serpin dysfunction often display an altered immune response. A recent study explored SERPINB3 expression in patients with impaired immune response to assess the potential involvement of SERPINB3 in the deregulation of B-cell reactivity.
Although serpins mainly act at the intracellular level, membrane-bound expression of SERPINB3 was recently demonstrated also on peripheral blood mononuclear cells, especially on CD27+ B cells. Interestingly, SERPINB3 was found to be absent on autoimmune diseases as SLE (systemic lupus erythematosus) CD27+ B lymphocytes, consistent with its expression being suppressed by high levels of type I interferon, which is a typical finding in SLE (Vidalino et al., 2012).
Since SERPINB3 displays an antiapoptotic behavior, alterations in its expression might contribute to the apoptotic deregulation seen in SLE, thereby increasing the autoantigen burden (Vidalino et al., 2009). Then, SERPINB3 expression and CD27 positivity were found to be directly related, suggesting that this serpin might also be implicated in normal B cell activation. It has to be noted that the peripheral B cell repertoire and particularly CD27+ B cell number is heterogeneously altered in SLE (Korganow et al., 2010).
In summary, these results may suggest a role for SERPINB3 in maintaining immune homeostasis, and that the impairment in serpin function may contribute to the development of autoimmune disorders.
  
  
Entity Lung fibrosis
Note Idiopathic pulmonary fibrosis (IPF), with its histopathological signature of usual interstitial pneumonia is a chronic progressive disorder of interstitial lung disease of unknown etiology with a poor prognosis.
It has been reported overexpression of SERPINB3 in lung tissue of IPF patients compared with other forms of interstitial lung diseases and normal lungs. In IPF, SERPINB3 was abnormally secreted by metaplastic epithelial cells other than bronchial cells where it is normally expressed (Calabrese et al., 2008).
Moreover, mice transgenic for human SERPINB3, showed higher TGF-β expression and more extended pulmonary fibrosis than controls (Lunardi et al., 2011).
In addition, it has been reported that SERPINB3 immunocomplexed is increased in scleroderma patients with lung fibrosis (Giannelli et al., 2007b).
  
  
Entity Cholesteatoma
Note Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear and/or mastoid process.
Recent data suggest that SERPINB3, STAT3, cathepsin K, and cathepsin L are associated with the proliferation and growth of cholesteatoma and that these proteins may be influential factors in cholesteatoma growth (Ho et al., 2012).
  
  
Entity Skin disease
Note Many intrinsic and extrinsic factors are associated with the stratum corneum (SC) barrier disruption. In the study of Katagiri C, it has been reported a high correlation between SERPINB3 and transepidermal water loss (TEWL). This finding was confirmed by means of a barrier disruption study with a topical oleic acid treatment: subjects with high levels of SERPINB3 readily developed impaired SC barrier function. Furthermore, SERPINB3 content showed a very high correlation with the number of parakeratotic cells in the cornified layer of the skin. These findings indicate that SERPINB3 can be considered a marker of parakeratosis and may play an inhibitory role in the process of nuclear digestion (Katagiri et al., 2010).
Psoriatic Skin
It has been also reported that Cathepsin L (a target of SERPINB3) is one of the lysosomal acid proteinases recently identified in psoriatic epidermis (Kawada et al., 1997) together with various proteinases including tryptase, chymase, and cathepsin G (targets of SERPINB4: see homology in previous paragraph) released by degranulation in psoriatic lesion (Harvima et al., 1993).
Takeda A, et al., have shown that SERPINB3/4 isoforms (SERPINB3 and SERPINB4) are indeed predominantly present along the periphery of the intercellular space in the upper spinous cell layer of psoriatic epidermis from patients with a high serum SERPINB3/4 level. In addition, SERPINB3/4 immunoreactivity was detected around the degranulated cells near the dermo-epidermal junction as well as in the granules of filtrated cells. Furthermore, strong positive staining for SERPINB3/4 was also found in nuclei of granular layer cells and a considerable number of cells in the elongated rete rete ridges of psoriatic epidermis. In particular, SERPINB3 mRNA was ubiquitously expressed in all normal skin, and significantly overexpressed in psoriatic skin tissues. On the other hand, SERPINB4 mRNA expression was specific for psoriatic skin tissues, while it was absent in normal epidermis (Takeda et al., 2002)
  
  
Entity Asthma related pathology
Note A protective role of SERPINB3 in asthma was initially suggested by a microarray analysis of human bronchial epithelial cell cultures after stimulation with IL-4 and IL-13 (Hansel and Diette, 2007). This serpin may exert its protective role by inhibiting endogenous proteases associated with the inflammatory response.
Further studies indicated that SERPINB3 serum levels were increased in patients with bronchial asthma, asthma exacerbation and in patients with allergic rhinitis (Izuhara, 2003; Nishi et al., 2005; Suzuki et al., 2010).
  

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Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus.
Ruvoletto MG, Tono N, Carollo D, Vilei T, Trentin L, Muraca M, Marino M, Gatta A, Fassina G, Pontisso P.
J Gen Virol. 2004 Mar;85(Pt 3):621-4.
PMID 14993646
 
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Schick C, Kamachi Y, Bartuski AJ, Cataltepe S, Schechter NM, Pemberton PA, Silverman GA.
J Biol Chem. 1997 Jan 17;272(3):1849-55.
PMID 8999871
 
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Bromme D, Chapman HA, Silverman GA.
Biochemistry. 1998 Apr 14;37(15):5258-66.
PMID 9548757
 
A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.
Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3147-51.
PMID 7724531
 
Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.
Silverman GA, Whisstock JC, Askew DJ, Pak SC, Luke CJ, Cataltepe S, Irving JA, Bird PI.
Cell Mol Life Sci. 2004 Feb;61(3):301-25. (REVIEW)
PMID 14770295
 
Crystal structure of ovalbumin as a model for the reactive centre of serpins
Stein PE, Leslie AG, Finch JT, Turnell WG, McLaughlin PJ, Carrell RW.
Nature. 1990 Sep 6;347(6288):99-102.
PMID 2395463
 
Inhibition of apoptosis in human tumour cells by the tumour-associated serpin, SCC antigen-1.
Suminami Y, Nagashima S, Vujanovic NL, Hirabayashi K, Kato H, Whiteside TL.
Br J Cancer. 2000 Feb;82(4):981-9.
PMID 10732775
 
Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and Japanese cedar pollen.
Suzuki K, Inokuchi A, Miyazaki J, Kuratomi Y, Izuhara K.
Ann Otol Rhinol Laryngol. 2010 Jan;119(1):22-6.
PMID 20128182
 
Overexpression of serpin squamous cell carcinoma antigens in psoriatic skin.
Takeda A, Higuchi D, Takahashi T, Ogo M, Baciu P, Goetinck PF, Hibino T.
J Invest Dermatol. 2002 Jan;118(1):147-54.
PMID 11851888
 
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Takeda A, Yamamoto T, Nakamura Y, Takahashi T, Hibino T.
FEBS Lett. 1995 Feb 6;359(1):78-80.
PMID 7851535
 
Expression of mRNA of SCC antigen in squamous cells.
Takeshima N, Suminami Y, Takeda O, Abe H, Okuno N, Kato H.
Tumour Biol. 1992;13(5-6):338-42.
PMID 1290029
 
Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD.
Turato C, Biasiolo A, Pengo P, Frecer V, Quarta S, Fasolato S, Ruvoletto M, Beneduce L, Zuin J, Fassina G, Gatta A, Pontisso P.
Exp Biol Med (Maywood). 2011 Mar;236(3):281-90. doi: 10.1258/ebm.2011.010229. Epub 2011 Mar 7.
PMID 21383048
 
Over-expression of SERPINB3 in hepatoblastoma: a possible insight into the genesis of this tumour?
Turato C, Buendia MA, Fabre M, Redon MJ, Branchereau S, Quarta S, Ruvoletto M, Perilongo G, Grotzer MA, Gatta A, Pontisso P.
Eur J Cancer. 2012 May;48(8):1219-26. doi: 10.1016/j.ejca.2011.06.004. Epub 2011 Jul 5.
PMID 21737255
 
SERPINB3 modulates TGF-beta expression in chronic liver disease.
Turato C, Calabrese F, Biasiolo A, Quarta S, Ruvoletto M, Tono N, Paccagnella D, Fassina G, Merkel C, Harrison TJ, Gatta A, Pontisso P.
Lab Invest. 2010 Jul;90(7):1016-23. doi: 10.1038/labinvest.2010.55. Epub 2010 Mar 8.
PMID 20212457
 
Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease.
Turato C, Ruvoletto MG, Biasiolo A, Quarta S, Tono N, Bernardinello E, Beneduce L, Fassina G, Cavalletto L, Chemello L, Merkel C, Gatta A, Pontisso P.
Dig Liver Dis. 2009 Mar;41(3):212-6. doi: 10.1016/j.dld.2008.06.001. Epub 2008 Jul 25.
PMID 18657489
 
MicroRNAs and SerpinB3 in hepatocellular carcinoma.
Turato C, Simonato D, Quarta S, Gatta A, Pontisso P.
Life Sci. 2014a Mar 28;100(1):9-17. doi: 10.1016/j.lfs.2014.01.073. Epub 2014 Feb 2. (REVIEW)
PMID 24496037
 
SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis.
Turato C, Vitale A, Fasolato S, Ruvoletto M, Terrin L, Quarta S, Ramirez Morales R, Biasiolo A, Zanus G, Zali N, Tan PS, Hoshida Y, Gatta A, Cillo U, Pontisso P.
Br J Cancer. 2014b May 27;110(11):2708-15. doi: 10.1038/bjc.2014.246. Epub 2014 May 8.
PMID 24809782
 
Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.
Uemura Y, Pak SC, Luke C, Cataltepe S, Tsu C, Schick C, Kamachi Y, Pomeroy SL, Perlmutter DH, Silverman GA.
Int J Cancer. 2000 Jul 20;89(4):368-77.
PMID 10956412
 
Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.
Ullman E, Pan JA, Zong WX.
Mol Cell Biol. 2011 Jul;31(14):2902-19. doi: 10.1128/MCB.05452-11. Epub 2011 May 16.
 
Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer.
Vassilakopoulos T, Troupis T, Sotiropoulou C, Zacharatos P, Katsaounou P, Parthenis D, Noussia O, Troupis G, Papiris S, Kittas C, Roussos C, Zakynthinos S, Gorgoulis V.
Lung Cancer. 2001 May;32(2):137-44.
PMID 11325484
 
SERPINB3 expression on B-cell surface in autoimmune diseases and hepatitis C virus-related chronic liver infection.
Vidalino L, Doria A, Quarta SM, Crescenzi M, Ruvoletto M, Frezzato F, Trentin L, Turato C, Parolin MC, Ghirardello A, Iaccarino L, Cavalletto L, Chemello L, Gatta A, Pontisso P.
Exp Biol Med (Maywood). 2012 Jul;237(7):793-802. doi: 10.1258/ebm.2012.012024. Epub 2012 Jul 24.
PMID 22829702
 
Hepatic progenitor cells express SerpinB3.
Villano G, Turato C, Quarta S, Ruvoletto M, Ciscato F, Terrin L, Semeraro R, Paternostro C, Parola M, Alvaro D, Bernardi P, Gatta A, Pontisso P.
BMC Cell Biol. 2014 Feb 11;15:5. doi: 10.1186/1471-2121-15-5.
PMID 24517394
 
Crystal structure of SCCA1 and insight about the interaction with JNK1.
Zheng B, Matoba Y, Kumagai T, Katagiri C, Hibino T, Sugiyama M.
Biochem Biophys Res Commun. 2009 Feb 27;380(1):143-7. doi: 10.1016/j.bbrc.2009.01.057. Epub 2009 Jan 21.
PMID 19166818
 

Citation

This paper should be referenced as such :
C Turato, P Pontisso
SERPINB3 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3)
Atlas Genet Cytogenet Oncol Haematol. 2015;19(3):202-209.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/SERPINB3ID42265ch18q21.html


External links

Nomenclature
HGNC (Hugo)SERPINB3   10569
Cards
AtlasSERPINB3ID42265ch18q21
Entrez_Gene (NCBI)SERPINB3  6317  serpin family B member 3
AliasesHsT1196; SCC; SCCA-1; SCCA-PD; 
SCCA1; SSCA1; T4-A
GeneCards (Weizmann)SERPINB3
Ensembl hg19 (Hinxton)ENSG00000057149 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000057149 [Gene_View]  chr18:63655197-63661963 [Contig_View]  SERPINB3 [Vega]
ICGC DataPortalENSG00000057149
TCGA cBioPortalSERPINB3
AceView (NCBI)SERPINB3
Genatlas (Paris)SERPINB3
WikiGenes6317
SOURCE (Princeton)SERPINB3
Genetics Home Reference (NIH)SERPINB3
Genomic and cartography
GoldenPath hg38 (UCSC)SERPINB3  -     chr18:63655197-63661963 -  18q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERPINB3  -     18q21.33   [Description]    (hg19-Feb_2009)
EnsemblSERPINB3 - 18q21.33 [CytoView hg19]  SERPINB3 - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBISERPINB3 [Mapview hg19]  SERPINB3 [Mapview hg38]
OMIM600517   
Gene and transcription
Genbank (Entrez)AB046399 AF428135 AF428136 AF428137 AF428138
RefSeq transcript (Entrez)NM_006919
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERPINB3
Cluster EST : UnigeneHs.227948 [ NCBI ]
CGAP (NCI)Hs.227948
Alternative Splicing GalleryENSG00000057149
Gene ExpressionSERPINB3 [ NCBI-GEO ]   SERPINB3 [ EBI - ARRAY_EXPRESS ]   SERPINB3 [ SEEK ]   SERPINB3 [ MEM ]
Gene Expression Viewer (FireBrowse)SERPINB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6317
GTEX Portal (Tissue expression)SERPINB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29508   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29508  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29508
Splice isoforms : SwissVarP29508
PhosPhoSitePlusP29508
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
Conserved Domain (NCBI)SERPINB3
DMDM Disease mutations6317
Blocks (Seattle)SERPINB3
PDB (SRS)2ZV6    4ZK0    4ZK3   
PDB (PDBSum)2ZV6    4ZK0    4ZK3   
PDB (IMB)2ZV6    4ZK0    4ZK3   
PDB (RSDB)2ZV6    4ZK0    4ZK3   
Structural Biology KnowledgeBase2ZV6    4ZK0    4ZK3   
SCOP (Structural Classification of Proteins)2ZV6    4ZK0    4ZK3   
CATH (Classification of proteins structures)2ZV6    4ZK0    4ZK3   
SuperfamilyP29508
Human Protein AtlasENSG00000057149
Peptide AtlasP29508
HPRD02745
IPIIPI00022204   IPI00307466   
Protein Interaction databases
DIP (DOE-UCLA)P29508
IntAct (EBI)P29508
FunCoupENSG00000057149
BioGRIDSERPINB3
STRING (EMBL)SERPINB3
ZODIACSERPINB3
Ontologies - Pathways
QuickGOP29508
Ontology : AmiGOvirus receptor activity  protease binding  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  extracellular region  extracellular space  nucleus  cytoplasm  positive regulation of cell proliferation  negative regulation of peptidase activity  positive regulation of epithelial to mesenchymal transition  positive regulation of endopeptidase activity  negative regulation of endopeptidase activity  positive regulation of cell migration  cytoplasmic vesicle  vesicle  autocrine signaling  azurophil granule lumen  paracrine signaling  negative regulation of catalytic activity  neutrophil degranulation  negative regulation of JUN kinase activity  negative regulation of proteolysis  viral entry into host cell  extracellular exosome  
Ontology : EGO-EBIvirus receptor activity  protease binding  serine-type endopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  extracellular region  extracellular space  nucleus  cytoplasm  positive regulation of cell proliferation  negative regulation of peptidase activity  positive regulation of epithelial to mesenchymal transition  positive regulation of endopeptidase activity  negative regulation of endopeptidase activity  positive regulation of cell migration  cytoplasmic vesicle  vesicle  autocrine signaling  azurophil granule lumen  paracrine signaling  negative regulation of catalytic activity  neutrophil degranulation  negative regulation of JUN kinase activity  negative regulation of proteolysis  viral entry into host cell  extracellular exosome  
Pathways : KEGGAmoebiasis   
REACTOMEP29508 [protein]
REACTOME PathwaysR-HSA-6798695 [pathway]   
NDEx NetworkSERPINB3
Atlas of Cancer Signalling NetworkSERPINB3
Wikipedia pathwaysSERPINB3
Orthology - Evolution
OrthoDB6317
GeneTree (enSembl)ENSG00000057149
Phylogenetic Trees/Animal Genes : TreeFamSERPINB3
HOVERGENP29508
HOGENOMP29508
Homologs : HomoloGeneSERPINB3
Homology/Alignments : Family Browser (UCSC)SERPINB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERPINB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERPINB3
dbVarSERPINB3
ClinVarSERPINB3
1000_GenomesSERPINB3 
Exome Variant ServerSERPINB3
ExAC (Exome Aggregation Consortium)SERPINB3 (select the gene name)
Genetic variants : HAPMAP6317
Genomic Variants (DGV)SERPINB3 [DGVbeta]
DECIPHERSERPINB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERPINB3 
Mutations
ICGC Data PortalSERPINB3 
TCGA Data PortalSERPINB3 
Broad Tumor PortalSERPINB3
OASIS PortalSERPINB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERPINB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSERPINB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERPINB3
DgiDB (Drug Gene Interaction Database)SERPINB3
DoCM (Curated mutations)SERPINB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERPINB3 (select a term)
intoGenSERPINB3
NCG5 (London)SERPINB3
Cancer3DSERPINB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600517   
Orphanet
MedgenSERPINB3
Genetic Testing Registry SERPINB3
NextProtP29508 [Medical]
TSGene6317
GENETestsSERPINB3
Target ValidationSERPINB3
Huge Navigator SERPINB3 [HugePedia]
snp3D : Map Gene to Disease6317
BioCentury BCIQSERPINB3
ClinGenSERPINB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6317
Chemical/Pharm GKB GenePA35538
Clinical trialSERPINB3
Miscellaneous
canSAR (ICR)SERPINB3 (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERPINB3
EVEXSERPINB3
GoPubMedSERPINB3
iHOPSERPINB3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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